ライフサイエンスコーパス: endothelium-derived

1 al NOS (eNOS) activity, and in aortic rings, endothelium-derived and eNOS-mediated relaxation (EDRF)

2 ecanoate (4alpha-PDD) (5 micromol/L) and the endothelium-derived arachidonic acid metabolite 11,12 ep

3 Epoxyeicosatrienoic acids (EETs) are endothelium-derived arachidonic acid metabolites of cyto

4 lcium-activated potassium channels (KCa) and endothelium-derived autacoids to CVD.

5 We confirm that TG2 activity is modulated by endothelium-derived bioactive NO in young rat aorta.

6 We then demonstrate that endothelium-derived bioactive NO primarily mediates its

7 poxic pulmonary vasculature and suggest that endothelium-derived BMP4 plays a direct, paracrine role

8 ated by those that do not; (iii) PQ inhibits endothelium-derived, but not NO-induced, relaxations of

9 an mass in the legs and higher levels of the endothelium-derived C-terminal-pro-endothelin-1 (both p

10 hese results demonstrate a novel function of endothelium-derived Cat S in angiogenesis.

11 A combination of prothrombin time, endothelium-derived CD105-microparticles, and platelet c

12 thelial cells, aortic endothelial cells, and endothelium-derived cell line (ECV304).

13 s both resting and stimulated HUVEC, and the endothelium-derived chemokine CCL2 (monocyte chemoattrac

14 To date, however, the contribution of endothelium-derived chemokines found in these lesion to

15 We measured endothelium-derived clotting factors and assayed platele

16 Endothelium-derived CNP is involved in the regulation of

17 In contrast, TGF-beta1 did not decrease endothelium-derived constitutive NOS mRNA in organs of r

18 Estrogen also affects endothelium-derived constrictor factors.

19 cessive primary tumor growth but depended on endothelium-derived EETs at the site of metastasis.

20 tion of these routes is determined by venous endothelium-derived endothelin-1, acting through its spe

21 Endothelium-derived epoxyeicosatrienoic acids (EETs) rel

22 Further characterization revealed that endothelium-derived EVs (EC-EVs) suppressed monocyte act

23 Researchers recently found elevated pigment endothelium-derived factor (PEDF) associated with active

24 rived Vegf-A, and identify Hgf as a putative endothelium-derived factor that mediates the reciprocal

25 rmation and suggesting that Hgf serves as an endothelium-derived factor that signals to the epitheliu

26 ations to bradykinin by increased release of endothelium-derived factors other than nitric oxide.

27 endothelium with a higher mitotic index than endothelium derived from local sources.

28 ndings indicate novel potential functions of endothelium-derived GABA.

29 Endothelium-derived gene products play a critical role i

30 Thus, endothelium-derived HS chains and mast cell-derived hepa

31 responses were instead abolished by blocking endothelium derived hyperpolarising factor (EDHF) with a

32 rate that 10 mM propionate relaxes RMSAs via endothelium-derived hyperpolarising factor (EDHF).

33 These localized Ca(2+) events result in endothelium-derived hyperpolarization (and SMC relaxatio

34 Evidence from animal models has identified endothelium-derived hyperpolarization (EDH) as a potenti

35 In striking contrast to the endothelium-derived hyperpolarization (EDH) characterist

36 arteries, RA-2 inhibited bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxat

37 ATPase in humans, consistent with a role for endothelium-derived hyperpolarization in functional symp

38 present in arterial endothelium to generate endothelium-derived hyperpolarization.

39 Dilations to endothelium-derived hyperpolarizing factor (EDHF) are si

40 It has been proposed that endothelium-derived hyperpolarizing factor (EDHF) contri

41 ch as acetylcholine release an unidentified, endothelium-derived hyperpolarizing factor (EDHF) which

42 r relaxation is mediated by nitric oxide and endothelium-derived hyperpolarizing factor (EDHF), and b

43 is remaining vasorelaxation activity, termed endothelium-derived hyperpolarizing factor (EDHF), is mo

44 prostanoids, but involves the release of an endothelium-derived hyperpolarizing factor (EDHF), possi

45 l compounds, including prostacyclin, NO, and endothelium-derived hyperpolarizing factor (EDHF), that

46 (NO) synthase or K(+) channels that mediate endothelium-derived hyperpolarizing factor (EDHF)-depend

47 we investigated and compared NO release and endothelium-derived hyperpolarizing factor (EDHF)-mediat

48 severe HHcy impaired nitric oxide (NO)- and endothelium-derived hyperpolarizing factor (EDHF)-mediat

49 gen peroxide (H2O2), which is proposed as an endothelium-derived hyperpolarizing factor (EDHF).

50 relaxations that are widely attributed to an endothelium-derived hyperpolarizing factor (EDHF).

51 l toxins reported to block the release of an endothelium-derived hyperpolarizing factor (EDHF).

52 derives from hyperpolarization and is termed endothelium-derived hyperpolarizing factor (EDHF).

53 crucial component of dilation resulting from endothelium-derived hyperpolarizing factor (EDHF).

54 Thus, enhanced endothelium-derived hyperpolarizing factor activity in c

55 on in VHF rats, and blunted prostacyclin and endothelium-derived hyperpolarizing factor components in

56 This is consistent with a role for endothelium-derived hyperpolarizing factor in FID of the

57 ified C-type natriuretic peptide (CNP) as an endothelium-derived hyperpolarizing factor in the mesent

58 r-dependent effects on NO, prostacyclin, and endothelium-derived hyperpolarizing factor production, t

59 l cell surface contributes to control of the endothelium-derived hyperpolarizing factor response, alt

60 effects of nitric oxide, prostaglandins, and endothelium-derived hyperpolarizing factor were inhibite

61 increased involvement of prostaglandins and endothelium-derived hyperpolarizing factor(s).

62 ently by enhanced production of the putative endothelium-derived hyperpolarizing factor(s).

63 (e.g., endothelium-derived relaxing factor, endothelium-derived hyperpolarizing factor, and prostagl

64 n endothelial cells to produce nitric oxide, endothelium-derived hyperpolarizing factor, or prostagla

65 like" SKA-31 (half-life of 12 h) potentiated endothelium-derived hyperpolarizing factor-mediated dila

66 sent a marker for the endothelial effects of endothelium-derived hyperpolarizing factor.

67 e vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor.

68 for how hydrogen peroxide can operate as an endothelium-derived hyperpolarizing factor.

69 potassium ion (K(+)) have been identified as endothelium-derived hyperpolarizing factors (EDHFs) in a

70 nd hydrogen peroxide (H2O2) both function as endothelium-derived hyperpolarizing factors (EDHFs) in t

71 on of vascular smooth muscle are mediated by endothelium-derived hyperpolarizing factors (EDHFs).

72 y cytochrome P-450 monooxygenase (P450), are endothelium-derived hyperpolarizing factors (EDHFs).

73 nd epoxyeicosatrienoic acid release and that endothelium-derived hyperpolarizing factors compensate f

74 We hypothesized that endothelium-derived hyperpolarizing factors contribute t

75 ioisomers, which were recently identified as endothelium-derived hyperpolarizing factors in coronary

76 hanism contributes to the effects of EETs as endothelium-derived hyperpolarizing factors to hyperpola

77 We assessed the contribution of endothelium-derived hyperpolarizing factors to resting a

78 ctivating TEA-inhibitable K(+)(Ca) channels, endothelium-derived hyperpolarizing factors, together wi

79 Hence, like EETs, DHETs may function as endothelium-derived hyperpolarizing factors.

80 time points (2-8 hours) after AECA addition, endothelium-derived interleukin-1 (IL-1) accounted for t

81 residual responses were mediated by another endothelium-derived mediator or NO released despite trea

82 ia-cell injury may result in an imbalance in endothelium-derived mediators, favouring vasoconstrictio

83 act by inducing the release of at least two endothelium-derived mediators, one (as-yet-unidentified)

84 take place in the occlusive lesions and that endothelium-derived mesenchymal cells can further differ

85 salt rats were resistant to the blocking of endothelium derived nitric oxide (EDNO) with L-NAME and

86 rabbits, oral L-arginine (the substrate for endothelium derived nitric oxide) attenuates endothelial

87 fts has been attributed in part to increased endothelium-derived nitric oxide (.NO) production.

88 Loss of endothelium-derived nitric oxide (EDNO) contributes to t

89 The effective action of endothelium-derived nitric oxide (EDNO) is impaired in p

90 endothelium-dependent vasodilator function, endothelium-derived nitric oxide (EDNO) production, and

91 y a role in the modulation of the release of endothelium-derived nitric oxide (EDNO).

92 n action and vasodilation may be mediated by endothelium-derived nitric oxide (EDNO).

93 portant for shear stress-mediated release of endothelium-derived nitric oxide (NO) and lowering pulmo

94 Loss of endothelium-derived nitric oxide (NO) and prostacyclin c

95 We tested the hypothesis that endothelium-derived nitric oxide (NO) and vasodilating p

96 a key role in the endogenous suppression of endothelium-derived nitric oxide (NO) bioactivity and ha

97 Endothelium-derived nitric oxide (NO) contributes to epi

98 Ageing is associated with impaired endothelium-derived nitric oxide (NO) function in human

99 bination of other nutrients known to enhance endothelium-derived nitric oxide (NO) in patients with s

100 Endothelium-derived nitric oxide (NO) is a potent vasodi

101 Endothelium-derived nitric oxide (NO) is an important re

102 Endothelium-derived nitric oxide (NO) is an important re

103 ntal stress-induced vasodilation mediated by endothelium-derived nitric oxide (NO) is defective in co

104 Endothelium-derived nitric oxide (NO) is synthesised fro

105 Endothelium-derived nitric oxide (NO) may be an importan

106 The reduced bioavailability of endothelium-derived nitric oxide (NO) may play a role in

107 The bioactivity of endothelium-derived nitric oxide (NO) reflects its rates

108 Endothelium-derived nitric oxide (NO) selectively enhanc

109 Endothelium-derived nitric oxide (NO) selectively enhanc

110 Many angiogenic factors require endothelium-derived nitric oxide (NO) to exert their eff

111 Cerebral blood flow is regulated by endothelium-derived nitric oxide (NO), and endothelial N

112 flow is a potent stimulus for the release of endothelium-derived nitric oxide (NO).

113 mutations affect vasorelaxation mediated by endothelium-derived nitric oxide (NO).

114 taken during hand hyperemia (a stimulus for endothelium-derived nitric oxide [NO] release in the ups

115 .47 mN/mm; P=0.004) attributable to impaired endothelium-derived nitric oxide activity.

116 ssociated with atherosclerosis by preserving endothelium-derived nitric oxide activity.

117 In particular, the production of endothelium-derived nitric oxide and activation of solub

118 e (ADMA), correlate with decreased levels of endothelium-derived nitric oxide and subsequent endothel

119 at is likely to be related to a reduction in endothelium-derived nitric oxide bioavailability and/or

120 gh a mechanism that is not caused by loss of endothelium-derived nitric oxide but may involve oxidati

121 Inactivation of endothelium-derived nitric oxide by oxygen-derived free

122 Oxidatively mediated degradation of endothelium-derived nitric oxide contributes to abnormal

123 Endothelium-derived nitric oxide contributes to basal sy

124 is investigation sought to determine whether endothelium-derived nitric oxide contributes to hypoxia-

125 Endothelium-derived nitric oxide contributes to systemic

126 stress is associated with impaired action of endothelium-derived nitric oxide in patients with athero

127 dy was undertaken to investigate the role of endothelium-derived nitric oxide in the regulation of fo

128 nthase (Nos3), which suggests that decreased endothelium-derived nitric oxide is not a sufficient mec

129 rovide a mechanism by which FXR may increase endothelium-derived nitric oxide levels through modulati

130 Decreased availability of endothelium-derived nitric oxide may contribute to the h

131 The reduced bioavailability of endothelium-derived nitric oxide may play a role in endo

132 There are some data indicating that endothelium-derived nitric oxide mediates changes in vas

133 To study the effect of endogenous endothelium-derived nitric oxide on TF expression and ac

134 Oxidative degradation of endothelium-derived nitric oxide plays a major role in e

135 ese data suggest that enhanced production of endothelium-derived nitric oxide reduces endotoxin- and

136 Stimulation of endothelium-derived nitric oxide with acetylcholine resu

137 ndothelium-dependent relaxation (mediated by endothelium-derived nitric oxide) is depressed during th

138 L-arginine is the precursor of endothelium-derived nitric oxide, an endogenous vasodila

139 n molecules and decreased bioavailability of endothelium-derived nitric oxide, an important regulator

140 Hemoglobin inactivates endothelium-derived nitric oxide, participates in free-r

141 sodilates skeletal muscle vasculature via an endothelium-derived nitric oxide-dependent mechanism.

142 nt mechanism whereby hyperglycemia decreases endothelium-derived nitric oxide.

143 e endothelial dysfunction: essential role of endothelium-derived nitric oxide.

144 ized by a decrease in the bioavailability of endothelium-derived nitric oxide.

145 ial artery cannula to assess vasodilation to endothelium-derived nitric oxide.

146 sodilator function that depends partially on endothelium-derived nitric oxide.

147 structural and functional factors, including endothelium-derived nitric oxide.

148 d cANF(4-23) were enhanced in the absence of endothelium-derived nitric oxide.

149 Although endothelium derived NO has been shown to be of prime imp

150 at estradiol may stimulate the production of endothelium-derived NO and thereby reduce the contractil

151 Both p21 and endothelium-derived NO appear to have protective roles i

152 -coupled receptor-mediated, or shear-induced endothelium-derived NO bioactivity) is understood to inv

153 d antioxidant status has been shown to alter endothelium-derived NO bioactivity.

154 d the role of intracellular ascorbic acid in endothelium-derived NO bioactivity.

155 Endothelium-derived NO controls the contractility and gr

156 Endothelium-derived NO has been shown to be of crucial i

157 Endothelium-derived NO is considered to be primarily an

158 The endothelium-derived NO is detected amperometrically at a

159 nvolve, at least in part, the attenuation of endothelium-derived NO production through a calcineurin-

160 may protect against vasospasm by stimulating endothelium-derived NO release and inhibiting coronary a

161 In these cells, VEGF and the endothelium-derived NO synergistically up-regulated the

162 nation reaction of plasma oxyhemoglobin with endothelium-derived NO to form bioinactive nitrate.

163 nyl thiol redox switch to decrease pulmonary endothelium-derived NO(.) and promote PAH.

164 ions of bradykinin, a well-known stimulus of endothelium-derived NO, activated nitric oxide synthase

165 hypertrophy through the paracrine action of endothelium-derived NO, which triggers the degradation o

166 e contributes to impairment of the action of endothelium-derived NO.

167 onstriction via the possible facilitation of endothelium-derived NO.

168 that this effect of exercise is meditated by endothelium-derived NO.

169 tivation, with apparently less of a role for endothelium-derived NO.

170 vascular endothelium as a result of loss of endothelium-derived NO.

171 d in part by .O2-, likely via degradation of endothelium-derived NO.

172 t exert its action through direct effects on endothelium-derived NO.

173 nd resistance vessels is mediated in part by endothelium-derived NO.

174 reases the production and bioavailability of endothelium-derived NO.

175 it refractoriness and repriming depends upon endothelium-derived NO.

176 poxanthine/xanthine oxidase system inhibited endothelium-derived .NO-mediated arterial relaxation eli

177 However, although endothelium-derived PDGF-BB appears vital for the develo

178 The endothelium-derived peptide endothelin-1 (ET-1) causes v

179 Endothelin-1 (ET-1) is an endothelium-derived peptide that constricts coronary ves

180 ciated with increased expression of ET-1, an endothelium-derived peptide with vasoconstricting, mitog

181 We tested the role of an endothelium-derived phosphatidylserine-binding opsonin,

182 The vasomotor effect of endothelium-derived prostacyclin was examined by monitor

183 portant physiological platelet inhibitors is endothelium-derived prostacyclin which stimulates the pl

184 ulated release and proteolytic processing of endothelium-derived Reelin.

185 isolated arteries, focusing our attention on endothelium-derived relaxation and on its antioxidant pr

186 within the current framework of NO biology, endothelium-derived relaxation factor activity (ie, G pr

187 Well over 2 decades have passed since the endothelium-derived relaxation factor was reported to be

188 y, imbalance in the relative contribution of endothelium-derived relaxing and contracting factors, an

189 The discovery of endothelium-derived relaxing factor (EDRF) and its impor

190 or -2 regulates serum ADMA (S(ADMA)) and/or endothelium-derived relaxing factor (EDRF)/NO.

191 We sought to determine whether endothelium-derived relaxing factor (nitric oxide) exert

192 Nitric oxide (NO) is identified as the endothelium-derived relaxing factor and a neurotransmitt

193 he production and the degradation of NO, the endothelium-derived relaxing factor and a primary mediat

194 nitric oxide (NO) is considered an important endothelium-derived relaxing factor and may function to

195 The superoxide radical can scavenge endothelium-derived relaxing factor and produce potent o

196 e (Hcy) decreases the biological activity of endothelium-derived relaxing factor and that this decrea

197 The identification of endothelium-derived relaxing factor as nitric oxide (NO)

198 cular endothelium accounts in large part for endothelium-derived relaxing factor bioactivity.

199 taglandin I2, staurosporine, wortmannin, the endothelium-derived relaxing factor congener S-nitroso-N

200 an impaired nitric oxide synthase-dependent endothelium-derived relaxing factor response and paradox

201 The vasorelaxant effects of the endothelium-derived relaxing factor S-nitrosocysteine (S

202 As an endothelium-derived relaxing factor, a mediator of immun

203 by signals arising in the endothelium (e.g., endothelium-derived relaxing factor, endothelium-derived

204 e (NO), the biologically active component of endothelium-derived relaxing factor, has critical roles

205 wing the discovery that NO is the prototypic endothelium-derived relaxing factor, this signaling mole

206 tes that pHi may modulate the release of the endothelium-derived relaxing factor.

207 act on the endothelium to cause synthesis of endothelium-derived relaxing factor.

208 have also been shown to influence release of endothelium-derived relaxing factor.

209 A number of endothelium-derived relaxing factors have been identifie

210 this study was to discover and identify new endothelium-derived relaxing factors involved in the reg

211 ienoic acids as new members of the family of endothelium-derived relaxing factors.

212 dependent on the addition of exogenous Zn2+, endothelium-derived S-SMase was partially active even in

213 These factors will serve as endothelium derived signaling molecules in the tumor mic

214 ine mechanisms involving the upregulation of endothelium-derived stabilizing factors and the recruitm

215 Endothelial microparticles (EMPs) are endothelium-derived submicron vesicles that are released

216 indings have highlighted the contribution of endothelium-derived substances to blood flow control in

217 raction; local metabolic, red blood cell and endothelium-derived substances; and the sympathetic nerv

218 We recently identified TL1A, an endothelium-derived T cell costimulator and a ligand for

219 DAMTS-13, a metalloprotease that cleaves the endothelium-derived ultra-large multimers of von Willebr

220 Endothelin-1 (ET-1) is an endothelium-derived vasoactive peptide with mitogenic pr

221 Cyclooxygenase-dependent, endothelium-derived vasoconstrictor release modulates ac

222 ) influx, (2) the release (by hypoxia) of an endothelium-derived vasoconstrictor, or (3) endothelium-

223 ion is characterized by an imbalance between endothelium-derived vasodilating and vasoconstricting fa

224 increased intima/media ratio, and maintained endothelium-derived vasodilation.

225 hyporeactivity in large part mediated by the endothelium-derived vasodilator nitric oxide.

226 is that they improve the bioactivity of the endothelium-derived vasodilator NO by enhancing NO synth

227 entation of L-arginine, the precursor of the endothelium-derived vasodilator NO, reverses coronary en

228 drogen sulfide (H(2)S), a recently described endothelium-derived vasodilator, is produced by the enzy

229 constrictors, such as endothelin, antagonize endothelium-derived vasodilators and contribute to endot

230 Epoxyeicosatrienoic acids (EETs) are potent endothelium-derived vasodilators formed from cytochrome

231 In the present study, the roles of endothelium-derived vasodilators, guanylyl cyclase, and

232 ular tone of mouse cerebral arteries through endothelium-derived vasodilatory mechanisms.