ライフサイエンスコーパス: engagement

1 rase Ezh2 to Suz12 and reduce PRC2 chromatin engagement.

2 ffect of the antibodies on reovirus receptor engagement.

3 es students' active, exploratory, generative engagement.

4 of action, oral bioavailability, and target engagement.

5 tween brain-to-brain synchrony and classroom engagement.

6 tudies demonstrate effective cellular target engagement.

7 while recognizing risks associated with such engagement.

8 nhibition alone as sole mechanism for active engagement.

9 ues, suggesting an uncommon mode of receptor engagement.

10 n adverse reactions associated with FcgammaR engagement.

11 l nervous system (CNS), demonstrating target engagement.

12 ampens NK cell effector functions upon Clr-g engagement.

13 h proteolytic cleavage in response to ligand engagement.

14 nd a distinct pattern of activation upon TCR engagement.

15 um of behaviours fluctuating from full to no engagement.

16 ender them functionally competent upon NKG2D engagement.

17 rent routes of rho-GEF triggering upon CXCR4 engagement.

18 and synthesis, before DNA polymerase epsilon engagement.

19 ed with ability of BCR to induce signal upon engagement.

20 cency with wide international acceptance and engagement.

21 probably via direct interference with glycan engagement.

22 h both types of homozygotes during cognitive engagement.

23 omics and finance; and political and broader engagement.

24 uld show upregulation of IDO mediated by AhR engagement.

25 d act as competitive inhibitors of gp120-CD4 engagement.

26 al function, and therefore cellular receptor engagement.

27 ned leukocytes, suggesting peptide-dependent engagement.

28 Fc is not a strict requirement for hFcgammaR engagement.

29 as9 variant and the resulting repair pathway engagement.

30 y used in healthcare, and patient and family engagement.

31 on of specific PorB loop sequences in immune engagement.

32 ch claims are indispensable are human social engagements.

33 Radiology's engagement across a broad spectrum of care provides an e

34 s effect results from differential cognitive engagement across decision frames.SIGNIFICANCE STATEMENT

35 ult networks, with a differential pattern of engagement across deviant types (P<0.0001).

36 talizing on these opportunities will require engagement across many research areas and stakeholder gr

37 The molecular basis of how cargo engagement affects the balance between kinesin-1's activ

38 into the CNS and show robust in vivo target engagement after oral dosing.

39 receptors through target-specific one-to-one engagement and a micromagnetic tweezers (muMT) that remo

40 These molecular insights into ligand engagement and action have enabled new computational met

41 ral gene expression and replication, through engagement and activation of epidermal growth factor rec

42 ty, as quantified by ISC, has been linked to engagement and attentional modulation in earlier studies

43 oaches, we propose a mechanism for substrate engagement and catalysis by E. coli Lnt.

44 The results demonstrate target engagement and clinical effects.

45 cience (SEA-PHAGES) is an iREC that promotes engagement and continued involvement in science among be

46 To confirm target engagement and discern analogues with off-target activit

47 y to directly image and quantify drug-target engagement and drug distribution with subcellular resolu

48 sponses (ASSRs) may be biomarkers for target engagement and early therapeutic effects.

49 compounds were advanced into in vivo target engagement and efficacy models.

50 s is up-regulated upon B-cell receptor (BCR) engagement and IL-4 treatment.

51 is for further understanding the cooperative engagement and interplay between Cse4p protein and the A

52 While the shift from engagement and involvement to co-production in health ca

53 (SOCE), occurs downstream of immunoreceptor engagement and is critical for cytotoxic lymphocyte sign

54 cific conformation of the ATPase ring for RP engagement and is released in a shoehorn-like fashion in

55 rage of an integrated strategy for community engagement and maternal and child health immunisation ca

56 s included efforts to facilitate stakeholder engagement and ownership, strengthen coordination at all

57 classical-solitary meditation with regard to engagement and perceived social connectedness.

58 ormational switch might control DNA template engagement and release, modulating replisome progression

59 xibility of the approach, the high levels of engagement and responsiveness of patients, families and

60 aluable tools to study small molecule target engagement and selectivity in cells.

61 We demonstrate effective target engagement and selectivity with IKKalpha in U2OS cells t

62 starkly different strategies for co-receptor engagement and signal activation.

63 across students predicts both student class engagement and social dynamics.

64 ut are weaker agonists for the beta-arrestin engagement and subsequent endocytosis toward the oxytoci

65 l health and social care services to improve engagement and uptake of services.

66 romodomain, high solubility, cellular target engagement, and >/=18000-fold selectivity over the BET f

67 y, 2) advancing interoperability, 3) patient engagement, and 4) value-based oncology.

68 ly implemented in EMR due to the motivation, engagement, and cooperation of immunization staff and de

69 ]-HC), which serves as a biomarker of target engagement, and CSF protein biomarkers were evaluated.

70 ining, IRB roles/responsibilities, community engagement, and dissemination of disaster research resul

71 to support brain maturation, intense social engagement, and emotional control.

72 rk architectures that underlie external task engagement, and highlight selective changes in brain con

73 utism spectrum disorder, disinhibited social engagement, and inattention and overactivity through to

74 suppressive polarization was reverted by TLR engagement, and M1-oriented macrophages fully activated

75 ght the importance of prompt diagnosis, care engagement, and optimum management of comorbidities in r

76 improved partner coordination and government engagement, and the establishment of a Polio Emergency O

77 , and major changes in antigenicity upon CD4 engagement appear to be restricted to the coreceptor sit

78 stimulation to show that changes in control engagement are captured by a self-adjusting reinforcemen

79 hould consider the possible effect of social engagement as a modifiable risk factor.

80 These results implicate social visual engagement as a neurodevelopmental endophenotype not onl

81 clusion of the patient voice through patient engagement as part of methods in cost-effectiveness rese

82 to patient openness (beta=-0.18, p<0.05) and engagement (beta=-0.11, p</=0.05).

83 social skills negatively influenced patient engagement (beta=-0.19, p=0.019) and nurse openness (bet

84 A and elucidate potential disease and target engagement biomarkers for use in future clinical trials.

85 d produced interferon-gamma upon Fc-receptor engagement but not following combined interleukin-12 (IL

86 ated at the hemITAM-embedded tyrosine 7 upon engagement by antibodies or KACL homodimers.

87 on (F) envelope glycoproteins; upon receptor engagement by H, the prefusion F undergoes a structural

88 ominant (HSP90 >/= HSP70) increase in mutant engagement by HSP90.

89 s a strong NK cell-activating receptor, with engagement by ligands triggering granule release and cyt

90 Emerging evidence indicates that receptor engagement by phagosomal cargo, as well as inflammatory

91 pectrometry to quantify intracellular kinase engagement by the approved drug, dasatinib.

92 ic signaling receptors in macrophages, after engagement by the receptors of activating and inhibitory

93 complex assembly in trans, as well as SNARE engagement by the SNARE-binding chaperone Sec17/alphaSNA

94 of IFN production required Fc gamma receptor engagement, bypassed fusion, and initiated signaling thr

95 Behavioural engagement can enhance sensory perception.

96 Thus, behavioural engagement can prepare cortical circuits for sensory pro

97 of cellular potency and intracellular target engagement, compared with biochemical potency measuremen

98 novations in informatics, data uses, patient engagement, continuous learning culture, and incentives

99 of adaptive immunity that extend beyond TCR engagement, costimulation, and priming cytokine producti

100 Contrary to popular wisdom, engagement did not distort the average perception of tim

101 very, monitoring, communications & community engagement, disease surveillance & data analysis, techni

102 tantly, ISAV hemagglutinin-esterase receptor engagement does not initiate conformational rearrangemen

103 is the first report demonstrating that TIM-3 engagement during Ag stimulation directly influences T c

104 y walls, to identify neural markers of group engagement during dynamic real-world group interactions.

105 nm steps, behaviors inconsistent with serial engagement during initial TCR triggering.

106 behavioral measure of the juvenile's social engagement during tutor experiences, mirroring the relat

107 cortical regions [9-12], suggesting that PFC engagement during working memory is dependent on the deg

108 All three MAPKs were activated by ICAM-1 engagement, either through lymphocyte adhesion or Ab-med

109 ify a global cortical representation of task engagement encoded in the activity dynamics of both sing

110 h sustainable financing, greater multisector engagement, enhanced accountability and transparency, an

111 Productive HspQ-Lon engagement enhances degradation of multiple new and know

112 ponse was associated with taxane drug-target engagement, evidenced by decreased percent androgen rece

113 -binding domain of IGFBP-1, through integrin engagement, focal adhesion kinase, and integrin-linked k

114 te as an objective outcome measure of target engagement for clinical trials with glucagon-like peptid

115 lso point to a potential biomarker of target engagement for early clinical studies.

116 rease even further with OPV cessation, early engagement from the cessation planning phase and conside

117 nforcing, with China shaping a unique global engagement impacting powerfully on the contours of globa

118 Divergent somatic and presynaptic engagement in both projections during early action learn

119 may help guide treatment decisions regarding engagement in CBT or SSRIs, especially among individuals

120 Consistent with USP7 target engagement in cells, FT671 destabilizes USP7 substrates

121 atients and families or described a model of engagement in critical care and other vulnerable populat

122 is differentially clustered following ligand engagement in different cellular contexts.

123 Engagement in frank and transparent communication with o

124 Addressing the causes of low engagement in health care is a prerequisite for reducing

125 Incarceration provides an opportunity for engagement in HIV care but is associated with poor HIV t

126 onsequences of multi-valent Fcgamma-receptor engagement in in vitro and in vivo systems.

127 ent and severe social disability, defined as engagement in less than 30 h per week of structured acti

128 using other methodologies showing cerebellar engagement in linguistic prediction and suggest that int

129 Cross-sectional associations between engagement in mentally stimulating activities and decrea

130 Compound 42 exhibited robust target engagement in mouse liver following oral dosing, leading

131 et of principles that will guide association engagement in pursuit of this goal.

132 Patient and family engagement in research is variable and typically inadequ

133 diol is an integral part of the hypothalamic engagement in response to elevated circulating E2 Collec

134 potentially leading to both a broad and deep engagement in science.

135 These findings suggest that greater engagement in self-care behaviors is associated with bet

136 ole of safety culture and patient and family engagement in successful quality improvement initiatives

137 ng proximal signaling events of TCR and CD28 engagement in T cells.

138 unction with the ability to establish target engagement in the brain through the use of multiple neur

139 his is a step towards real-time inference of engagement in the classroom.

140 th caused by map65-3 because of restoring MT engagement in the spindle midzone.

141 argely resist this process because prior TCR engagement in the thymus has initiated their commitment

142 NA-capping activity in facilitating Pol II's engagement in transcriptional elongation, thus decipheri

143 effect of complement-dependent effector-cell engagement in various therapeutic settings.

144 ional models to search for other examples of engagement in vulnerable populations.

145 able environments is associated with reduced engagement in weight management behaviors and a greater

146 at institutions that lack a robust community engagement infrastructure, can be daunting.

147 pounded deprivation, racial cleavages, civic engagement, institutional cynicism, and segregated patte

148 Since target engagement is a function of both the thermodynamics and

149 is a binary stabilization switch, and ligand engagement leads to depalmitoylation and lysosomal degra

150 ture CEA studies should consider how patient engagement may impact economic models and their implemen

151 Engagement measures included compliance (ie, the mean [9

152 recent paper [14] found that "social visual engagement"-namely, gaze to eyes and mouths of faces-is

153 type 1alpha2 subunit (COL1A2), requires the engagement of a far-upstream enhancer, whose activation

154 eptive Adelta fiber stimulation demonstrated engagement of a multi-segmental motor program coincident

155 Here, we show that engagement of A2A adenosine receptor (A2AR) acts as a ch

156 scale-up of short-course treatment regimens, engagement of affected communities and medical providers

157 e these new tools to monitor pharmacological engagement of Bcl-2 protein inhibitors, and uncover inhi

158 gned UC-rich and CU-rich 10-nt sequences for engagement of both RRM2 and RRM3 and demonstrated that t

159 ognitive functions, requires the coordinated engagement of brain areas in local and large-scale netwo

160 Target engagement of BRPF1B and BRPF2 with 16 was demonstrated

161 hages, whereby a reduction in CD44 levels or engagement of CD44 by its ligand (HA) or a CD44-specific

162 Origin firing depends on MCM engagement of Cdc45 and GINS to form the CMG holo-helica

163 ctional rearrangements needed for productive engagement of circulating platelets, resulting in errati

164 ransition from inflammatory signaling to the engagement of death pathways is modulated.

165 during L. amazonensis infection occurs upon engagement of Dectin-1, a C-type lectin receptor that si

166 Selective disruption of trans engagement of E-cadherin in an otherwise cohesive cell m

167 Specific engagement of erythrocyte receptors defines target cell

168 Engagement of Fcgamma-receptors triggers a range of down

169 allows the direct characterization of target engagement of fluorescently labeled drugs, using fluorop

170 Differential engagement of FRS and non-FRS intracellular adapters dow

171 This activation involves engagement of G protein-coupled receptors (GPCR) on plat

172 In vitro engagement of hexameric-Fc with FcgammaRs showed complex

173 na program was designed to foster state-wide engagement of hospitals in a voluntary, collaborative im

174 ucation is the process through which chronic engagement of inhibitory NK cell receptors by self MHC-I

175 increases cell-ECM contact area and enhances engagement of integrin receptors, locally amplifying ECM

176 Engagement of integrins by the extracellular matrix init

177 gh focal adhesions or hemidesmosomes via the engagement of integrins with fibrillar ECM proteins.

178 aling, which mediates T cell suppression via engagement of its inhibitory ligands, PD-L1 or PD-L2, is

179 c and administrative infrastructure enabling engagement of large numbers of students at different typ

180 Moreover, robust target engagement of LDHA by lead compounds was demonstrated us

181 ISG15 engagement of LFA-1 led to the activation of SRC family

182 we provide a characterization of the initial engagement of microbial symbionts along ciliated tissues

183 cognitive performance.SIGNIFICANCE STATEMENT Engagement of neural regions and circuits important in e

184 PDGF-DD engagement of NKp44 triggered NK cell secretion of inter

185 Incomplete engagement of patients along the care cascade translates

186 The engagement of photoprotective processes in chloroplast e

187 sicles containing PLA2R provides a route for engagement of PLA2R with the immune system.

188 te recruitment to the endothelium, and Mac-1 engagement of platelet GPIbalpha is required for injury

189 rgeting to ADH1 and consequently reduces the engagement of Pol II in transcriptional elongation, lead

190 es chromatin transcription that enhances the engagement of Pol II into transcriptional elongation) to

191 urn, triggers inflammatory responses and the engagement of previously quiescent autoreactive T cells

192 n receptor (BCR), it remains unclear whether engagement of self-antigen provides a positive impact fo

193 put patterns enable a behaviorally selective engagement of short-latency effector pathways.

194 Finally, engagement of Siglec-8 on IL-5-primed eosinophils result

195 We demonstrated that MeV engagement of SLAMF1 induces dramatic but transient morp

196 Engagement of specific FcgammaR types on effector leukoc

197 ate, and this is mainly achieved through the engagement of specific transcriptional programs.

198 However, chronic engagement of such responses promotes psychological, car

199 gand, likely through optimization of bitopic engagement of the allosteric and orthosteric binding sit

200 alpha-dependent activation of NUAK1 supports engagement of the AMPK-TORC1 metabolic checkpoint, there

201 internal poly(dA:dT) tracts do not block the engagement of the ATPase motor with SHL2, yet they promo

202 the features of anergy induced by continual engagement of the B-cell receptor (BCR), such as high ex

203 We hypothesized that Env engagement of the CD4 receptor on T-helper cells results

204 n chronic pain, possibly reflecting top-down engagement of the circuitry alongside altered reward pro

205 in patients with photosensitive epilepsy is engagement of the circuitry that produces gamma oscillat

206 Mechanistically, CX3CL1-mediated engagement of the CX3CR1 receptor induced upregulation o

207 gory, which in turn associated with stronger engagement of the dorsal anterior cingulate cortex.

208 Engagement of the DUSP1-TTP regulatory axis by PGE2 is l

209 uc4 potentiates tumor progression is via its engagement of the ErbB2/HER2 receptor tyrosine kinase, o

210 he classical pathway without any concomitant engagement of the Fcgamma receptor (FcgammaR).

211 ntermediate fructose 6-phosphate, leading to engagement of the hexosamine biosynthetic pathway (HBP),

212 The engagement of the HIV-1 gp120 glycoprotein to the host C

213 These properties required the engagement of the IL-1 decoy receptor 8 (IL-1R8) and the

214 tic ductal adenocarcinoma (PDAC), additional engagement of the immune response could be game changing

215 Discussion: Improving the engagement of the informal sector and lower-level clinic

216 ed by the sensing of infection by DAI/ZBP-1, engagement of the kinase RIPK3, and subsequent membrane

217 The requirements for engagement of the N-RNA template of VSV by its polymeras

218 These findings further support engagement of the phosphoinositide 3-kinase-AKT signalin

219 These observations suggest that symmetrical engagement of the Rad50 catalytic head domains with ATP

220 s has largely been studied in the context of engagement of the receptor by ligands expressed on the s

221 Interestingly, p21 repression was through engagement of the REST-coREST-LSD1-repressor complex and

222 n-dependent malignant transformation through engagement of the synergy site that enhances integrin ad

223 , which is present in the plasmalemma before engagement of the target particle, is transiently enrich

224 nd access to the site of action; the second, engagement of the target; and the third, induction of ti

225 Client-SGTA engagement of the targeting module induces rapid, privat

226 RICD is triggered by re-engagement of the TCR on a cycling effector T cell, resu

227 sm' to deactivate IRE1 immediately following engagement of the UPR, in order to limit prolonged IRE1

228 a similar effect as AEA; however, CP acts by engagement of the vanilloid receptor TRPV1, causing loca

229 pendent cellular effector functions, through engagement of their Fc-gamma receptors.

230 Engagement of these receptors is important not only for

231 in human metastatic osteosarcoma cell lines; engagement of this autocrine loop leads to tumor cell pr

232 in the activation of innate immunity through engagement of TLR7 with papaya mosaic virus (PapMV)-like

233 After engagement of TLR7/8 or TLR9, BCMA was detected also on

234 ctional demonstration, tolerance elicited by engagement of TRPV1 can be transferred to naive nonobese

235 al that the WRC is activated by simultaneous engagement of two Rac1 molecules, suggesting a mechanism

236 deviant types suggest potential differential engagement of underlying generator mechanisms.

237 vealed favorable pharmacokinetics as well as engagement on both targets in vivo.

238 ted Nod1, providing a positive effect of BCR engagement on development of most B cells.

239 However, the contribution of innate receptor engagement on epithelial or dendritic cells by HDMs that

240 cally address the impact of anti-TIM-3/TIM-3 engagement on human Ag-specific CD8 T cells during a nor

241 engagement on radioresistant cells and PAFR engagement on radioresistant and radiosensitive cells in

242 bone marrow chimeric mice revealed that CD36 engagement on radioresistant cells and PAFR engagement o

243 particularly Lck, downstream of target cell engagement or NKp30 ligation.

244 tokine production in response to target cell engagement or receptor ligation.

245 me common, but few appear to include patient engagement or the patient perspective.

246 ompound 20, which was advanced into a target engagement pharmacodynamic model where it exhibited robu

247 TDP2 recruitment through a "split-SIM" SUMO2 engagement platform.

248 se of the possibility to (1) increase target engagement, potency, and selectivity through van der Waa

249 Here we show that this measure of neural engagement predicted the duration of time that viewers w

250 a structured team communication and patient engagement program in the ICU was associated with a redu

251 effectiveness of a patient-centered care and engagement program in the medical ICU.

252 icit the unanticipated finding that Siglec-8 engagement promotes rapid beta2-integrin-dependent eosin

253 achieved through alphavbeta6 and alpha9beta1 engagement, rather than alpha5beta1.

254 2 phosphorylation cycle stimulated by target engagement regulates miRNA:target interactions to mainta

255 d, their physiological role and mechanism of engagement remain to be determined.

256 This capacity-social visual engagement-shapes typical infant development from birth

257 Contemplative dyads elicited engagement similar to classical contemplative practices

258 ded as one of the most successsful community engagement strategies in public health for its role in p

259 neutrophil trans-epithelial migration (CD18 engagement) substantially impacts this process both qual

260 ically determines language control networks' engagement: switching under external constraints heavily

261 quirements complemented by greater community engagement targeting biologically and socioeconomically

262 opportunity exists to document processes of engagement that reflect a changing paradigm of healthcar

263 flow to the creation of programs for patient engagement, the development of new clinical decision-mak

264 Upon receptor engagement, the hemITAM undergoes phosphotyrosinylation

265 their sensitivity, the need for practitioner engagement, the need for reaction to escalation and the

266 zation, and inhibits SHP-1 activity upon BCR engagement, thus supporting that IL4I1 negatively contro

267 ssitating a mechanism that regulates control engagement to align it with changing environmental deman

268 n through larger scale patient and clinician engagement to determine whether it is preferable to the

269 tion between enzymatic inhibition and target engagement, together with efficacy in a cellular synergy

270 Structured patient-centered care and engagement training program and web-based technology inc

271 to directly measure drug exposure and target engagement, two critical pharmacological questions, with

272 Furthermore, we find that 3D ECM engagement uncouples MCAK-mediated regulation of MT grow

273 Analyses revealed that external task engagement was characterized by a significant change in

274 Target engagement was confirmed with genetic knockdown and the

275 n wild-type mice, and confirmation of target engagement was demonstrated, with LRRK2-pSer935 IC50 val

276 ormational changes that occur after receptor engagement will help researchers to develop an immunogen

277 nd improvements in participant diversity and engagement will maximize yield from consented participan

278 ereby potentially allowing for an inhibitory engagement with Clr-g-expressing activated DCs during im

279 cells bearing memory markers despite lack of engagement with cognate Ag); however, little is known ab

280 vitro, regulating fibroblast interaction and engagement with collagen in the contracting matrix.

281 Conclusion Target engagement with depletion of arginine was maintained thr

282 a competitive format, small-molecule target engagement with endogenous proteins in live cells can be

283 chore regulation has differential effects on engagement with growing and shrinking microtubules.

284 5 ligands inhibit infection by blocking CCR5 engagement with HIV gp120.

285 emains large for women, despite their better engagement with HIV-care services.

286 ferentiation required signals delivered upon engagement with intact antigen.

287 s, human illness shifted their effort, their engagement with natural resources, and the sustainabilit

288 to complement existing initiatives, welcome engagement with new partners, and be open to developing

289 Early engagement with NITAGs also ensures that the adoption of

290 Its engagement with PARylated PARP1 activates ALC1 at sites

291 allergy development and that inhibiting HDM engagement with PC receptors in the lung protects agains

292 plex, 3) a HOPS:4-SNARE trans-complex, 4) an engagement with Sec17, and 5) the rapid lipid rearrangem

293 identification persists and can lead to non-engagement with services and poor response to treatment.

294 rses' own smoking behaviours influence their engagement with smoking cessation interventions is neede

295 The overall level of nurses' engagement with the delivery of smoking cessation interv

296 sitive affect denotes a state of pleasurable engagement with the environment eliciting positive emoti

297 o stimulate basal transcription, its initial engagement with the PIC generates a transcriptionally in

298 ioritization of some regions for intensified engagement with the private sector.

299 How does engagement with the story cause this distorted perceptio

300 cipants to be accounted for, enabling fuller engagement with those who typically may not be invited t