ライフサイエンスコーパス: engineer

1 abolism is extremely difficult to rationally engineer.

2 gaps are of great interest to scientists and engineers.

3 er experts, retinal histologists, and optics engineers.

4 lities that are visually detectable has been engineered.

5 ization to solving problems in chemistry and engineering.

6 body domains in isolation would aid in their engineering.

7 aking them interesting targets for metabolic engineering.

8 ndamental interest in biological science and engineering.

9 scaffolds for drug delivery and bone tissue engineering.

10 and simulations to mechanobiology and tissue engineering.

11 ctured scaffold design for functional tissue engineering.

12 otential to enable new strategies for genome engineering.

13 an be tailored through artificial structural engineering.

14 ly attached to receptors by metabolic glycan engineering.

15 ons is at the heart of (applied) science and engineering.

16 iences, material sciences and high-precision engineering.

17 a covalent linker between gp120 and gp41, an engineered 201-433 disulfide bond, and density correspon

18 We engineered a mechanism-based SCF partial agonist that im

19 rstand the role of oncogenic KRAS in CRC, we engineered a mouse model of metastatic CRC that harbors

20 To address this question, we engineered a mutant of MYO6, MYO6+, which undergoes plus

21 We engineered a stable Rca hexamer ring and analyzed its fu

22 ll these advantages can only be reached when engineering a complex type of material, nanocomposites,

23 lementation (AiFC) method for RNA imaging by engineering a green fluorescence protein (GFP)-mimicking

24 We rewrote the entire ImageJ codebase, engineering a redesigned plugin mechanism intended to fa

25 zed that exogenous forces can be applied for engineering a variety of significantly different MSC sha

26 facile and effective strategy with which to engineer advanced graphene-based functional nanocomposit

27 r of materials is the key to fundamental and engineering advances in materials' performance.

28 This information can be used to engineer allergen mutants with reduced IgE Ab binding fo

29 We engineered alphaS mutants incapable of multimerization,

30 Another engineered alphaS variant added hydrophobicity to the hy

31 ping technology makes it possible to quickly engineer alternatives to conventional automation infrast

32 t-phenotype mapping provides a framework for engineering AMPAR gating using auxiliary subunits.

33 We engineered an armored CAR T cell capable of constitutive

34 We engineered an H3.3 knockdown in Arabidopsis thaliana and

35 We believe that this example of engineering an adaptive Li/electrolyte interface brings

36 Here we have engineered and developmentally differentiated NKX2-1GFP

37 on during gliomagenesis, we used genetically engineered and GL261-induced mouse models in combination

38 synthetic excitable tissues from genetically engineered and immortalized HEK293 cells with well-chara

39 allowing peptide and linker to be separately engineered and then assembled in a combinatorial fashion

40 prompt a revolution in mitochondrial genome engineering and biological understanding.

41 Based on the engineering and characterization of a minimal CPC, we su

42 Recent advances in enzyme engineering and design have expanded nature's catalytic

43 roach to emerging RGENs should enhance their engineering and optimization for therapeutic and other a

44 a complex phenotype through multiplex genome engineering and predictive modeling.

45 ogels should find use in a variety of tissue engineering and regenerative medicine applications.

46 rous scaffolds play a pivotal role in tissue engineering and regenerative medicine by functioning as

47 h may be amenable to numerous enzymes and to engineering and screening approaches to identify activat

48 latform technology that combines recombinant engineering and site-specific conjugation to create mult

49 loped using the design principles of crystal engineering and structure-property correlations, resulti

50 pplications in different fields in medicine, engineering and technology but their enhanced mechanical

51 d blockers with strong, specific binding for engineering and therapeutic applications.

52 advances in bioreactor technology, metabolic engineering, and analytical instrumentation are improvin

53 in the selection of optimal T cells, genetic engineering, and cell manufacturing are poised to broade

54 arge numbers of college science, technology, engineering, and mathematics (STEM) faculty to include a

55 ittee of the National Academies of Sciences, Engineering, and Medicine has made 14 recommendations th

56 various interdisciplinary areas of science, engineering, and medicine.

57 nfrared imaging, chemical sensing, materials engineering, and quantum information processing.

58 ic strategies including cell therapy, tissue engineering, and regenerative medicine and are frequentl

59 creens, we identify prion-curing mutants and engineer "anti-prion drives" that reverse the non-Mendel

60 ed a high-diversity phage display library to engineer antibody fragments (Fabs) that can modulate the

61 Here we have designed a novel class of engineered antibody-based reagents ('Seldegs') that indu

62 A method to locally strain-engineer antimonide-based membranes is theoretically ill

63 inciple results open a pathway for directing engineered antiviral T cells into these viral sanctuarie

64 ication of nanocomposite hydrogels in tissue engineering applications are described, with specific at

65 as systems have potential for many microbial engineering applications, including bacterial strain typ

66 lular urethra bioscaffolds for future tissue engineering applications, using bioscaffolds or bioscaff

67 Herein, we demonstrate a new microstructural engineering approach for producing low-cost titanium all

68 s of gene expression dynamics with a reverse engineering approach to infer data-driven dynamic networ

69 are distinct from commonly leveraged stealth engineering approaches such as nanoparticle surface func

70 and dicot genomes using a variety of genome engineering approaches.

71 recent advances regarding terpene metabolic engineering are highlighted, with a special focus on tob

72 wild and domesticated animals, and are being engineered as vectors for vaccines and cancer therapy.

73 Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE).

74 These results demonstrate the utility of engineered bacteria for querying pathogen behavior in vi

75 brids that host various types of genetically engineered bacterial cells.

76 meability geologic formations and clay-based engineered barrier systems.

77 Additionally, we engineered base editors containing mutated cytidine deam

78 Here we describe genome-engineering based evaluation of RNA regulatory element a

79 s of ultimate tensile strength (UTS) for two engineered beta-solenoid protein mutant fibril structure

80 actions enable the rapid characterization of engineered binding proteins and interaction networks.

81 Engineered biomaterials with smart and tunable propertie

82 Here, an overview of the latest studies on engineering biomaterials for the enhancement of anticanc

83 enzyme, and it offers novel insight into the engineered biosynthesis of prenylated natural products.

84 Here, the authors engineer BoNT/B to improve its affinity to human recepto

85 Here, we review advances in engineering both imaging modalities and material propert

86 lowering kappaL , but also the importance of engineering both thermal and electronic transport simult

87 as9 endonucleases are widely used for genome engineering, but our understanding of Cas9 specificity r

88 se and human epidermal progenitors that were engineered by CRISPR-mediated genome editing to controll

89 GBAi was engineered by introducing modifications in Galphai that

90 By engineering C-terminal charges, we develop CRY2high and

91 Tissue-engineering can serve as an alternative to conventional

92 Solid-phase fixation of the engineered capsular polymerases enabled rapid production

93 ack carbon (fossil fuel soot, biomass char), engineered carbons (biochar, activated carbon), and rela

94 zed against phase separation by deliberately engineering carrier diffusion lengths and injected carri

95 In addition, an engineered Cas9-VQR variant with 5'-NGA PAM specificitie

96 and fisheries, and those in professional and engineering categories had higher relative mortality ris

97 signaling on transferred CD8(+) T cells, we engineered CD200R immunomodulatory fusion proteins (IFPs

98 anipulate gene and cell state can be used to engineer cell functionality, simplify quality assessment

99 It makes live vaccines and engineered cells inherently unreliable and unpredictable

100 molecular functions of the ATG8 proteins, we engineered cells lacking genes for each subfamily as wel

101 In cardiac tissue engineering cells are seeded within porous biomaterial s

102 rotein design and discuss best practices for engineering chromatin to assist scientists in advancing

103 roposal by characterizing a quantum resource engineered combining two-photon hyperentanglement and ph

104 me of pulp regeneration mediated by a tissue-engineered construct as compared with traditional revasc

105 realizing clinical implementation of tissue-engineered constructs for wound regeneration, perhaps th

106 We use tissue engineered constructs to control the cellular-level dama

107 ons among plumbing components that undermine engineering controls for opportunistic pathogens (OPs).

108 Functional regulatory compliant tissue-engineered corneal endothelial graft substitute can alle

109 used in basic plant research and genetically engineered crops (1-4) .

110 Engineered crystallizable fragment (Fc) regions of antib

111 logy, quality improvement, cognitive systems engineering (CSE), and applied cognitive psychology.

112 iples of the conformational entropy model to engineer curvature sensitivity into a series of multi-co

113 By using novel engineered DBP immunogens, we validate that the prime ta

114 In addition, such engineered DCs, when pulsed with a myelin antigen, led t

115 Correspondingly, engineered deletion of Fes accelerated tumor progression

116 Recombinant viruses harboring engineered deletions of specific virulence-associated ge

117 o improve the fuel economy of vehicles using engineering design modifications that compromise other p

118 Materials scientists and engineers desire to have an impact.

119 synthetic biology has been reinvented as an engineering discipline to design new organisms as well a

120 GP with picomolar affinity, suggesting that engineered ebolavirus vaccines could trigger rare bNAb p

121 cadia and sheds light on their metabolism in engineered ecosystems.

122 to plant growth and defense will help lignin engineering efforts to improve the production of biofuel

123 Our work provides general guidelines for engineering electromagnetic illusions but can be extende

124 Engineered escape variants had high levels of fitness.

125 ed mouse models (GEMMs), wild-type organoids engineered ex vivo, or from patient-derived human CRC or

126 idenced by X-ray crystallography and used to engineer examples of bsAbs for cancer therapy.

127 The data herein support the hypothesis that engineered expression of alphaLNNd can overcome polymeri

128 e current standard of care and proposes that engineered expression of broadly neutralizing antibodies

129 s consistently outperform methods using hand-engineered features, suggesting that the 3DCNN framework

130 cel based bottom-up model is developed using engineering first-principles to calculate mass and energ

131 TLR5 agonists, bacterial flagellin and engineered flagellin derivatives, have been shown to hav

132 a novel concept that immunogenic DCs can be engineered for myelin-specific therapy for MS.

133 ol and has formed the foundation of cellular engineering for adoptive cell therapy in cancer and othe

134 DSDs have applications in metabolic engineering for the production of valuable protocatechua

135 In contrast to the endogenous sTie2, an engineered form of sTie2, which presents dimeric ligand

136 This data suggests that the FN networks we engineered formed an incompressible material with a Pois

137 rotein immobilization strategies is vital to engineering functional hydrogels.

138 ately describe and predict the behaviours of engineered gene circuits.

139 gulatory grammar and hampering the design of engineered genes for synthetic biology applications.

140 a rich interplay of fundamental science and engineering, give rise to fascinating everyday effects (

141 )H NMR data, demonstrating that model-driven engineering has considerable potential in supramolecular

142 Protein engineering has enabled the optimization of existing enz

143 Organoid technology and organ-on-a-chip engineering have emerged as two distinct approaches for

144 The approach and results can help engineer highly scalable data-driven algorithmic managem

145 Finally, we examine possibilities of engineering hormone cross talk for improvement of plant

146 ATOs initiated with TCR-engineered HSPCs produced T cells with antigen-specific

147 utilize an improved CD34+ culture system to engineer human red blood cells that express these chimer

148 In this review we survey engineered human liver platforms within the needs of dif

149 f delivery of immunomodulatory therapeutics, engineering immune cells, and constructing immune-modula

150 ight is that high-performing circuits can be engineered in the absence of intensive purification and/

151 Genetic engineering in mice enables the time-controlled labeling

152 hieved in Escherichia coli through molecular engineering, including manipulation of the protein trans

153 , configuration disorder was compositionally engineered into single lattices, leading to the discover

154 Strain engineering is a promising method for next-generation ma

155 de prepared from wild-type M13, Y3E peptides engineered M13 and without M13.

156 ices can transform the cell membrane into an engineered material that can mimic, manipulate, and meas

157 New engineered materials have critical applications in diffe

158 rent capabilities of the widely used protein engineering method, expressed protein ligation.

159 To gain understanding of MRN in cancer, we engineered mice with B lymphocytes lacking MRN, or harbo

160 omes from environmental, host associated and engineered microbiome samples.

161 PVP) gel, with the mixture filled into laser engineered micromoulds by high-speed centrifugation (30m

162 To enable iterative genome engineering, Millstone allows users to design oligonucle

163 ugh binding studies and crystallography, the engineered monomer retained the same overall structure o

164 visualize TRPV1-lineage axons, a genetically engineered mouse model was used in which a fluorophore i

165 ved using organoids derived from genetically engineered mouse models (GEMMs), wild-type organoids eng

166 t tumors has been established in genetically engineered mouse models and human tumor cells.

167 We used genetically engineered mouse models of glioma and quantitative metab

168 In xenograft and genetically engineered mouse models, the WDR4/PML axis elevates intr

169 We investigated the anti-arthritic effect of engineered MSCs in a collagen-induced arthritis (CIA) mo

170 This system, termed memory by engineered mutagenesis with optical in situ readout (MEM

171 PR solves the major problem of animal genome engineering, namely the inefficiency of targeted DNA cas

172 the montmorillonite for preparation of nano-engineered nano/biomaterials for food and pharmaceutical

173 on, and a number of other characteristics of engineered nanomaterials (ENM) in environmental matrices

174 the time-dependent accumulation of metallic engineered nanomaterials (ENMs) across environmental med

175 With the increasing diversity of engineered nanomaterials being considered for large-scal

176 gnant tissue growth, regenerating organs and engineering new-age medical devices.

177 res emerging upon vortex beam propagation in engineered nonlinear colloidal medium.

178 er and interpret metabolic functions, and to engineer novel network structures.

179 Here, we demonstrate controlled strain engineering of 2D semiconductors during synthesis by uti

180 Here we report the engineering of a cytochrome P450 enzyme by directed evol

181 Here we report the engineering of a protein scaffold for preferential bindi

182 es such chromophores are rare, and molecular engineering of absorbers having such properties has prov

183 resent a transformational approach to genome engineering of herpes simplex virus type 1 (HSV-1), whic

184 chemistry, thereby permitting the bottom-up engineering of increasingly complex reaction networks fr

185 benzene as a versatile aromatic scaffold for engineering of molecular materials with tailored and exp

186 r coexistence is a promising route in defect engineering of MoS2 to fabricate suitable devices for el

187 These results may guide the rational engineering of multilayer and core-shell oxide nanomater

188 ally "noisy" bioenvironments require careful engineering of nanoscale components that are highly sens

189 Facet engineering of oxide nanocrystals represents a powerful

190 ect extraction, recent progress in metabolic engineering of plants offers an alternative supply optio

191 synthetic biology that involve the multistep engineering of plastid genomes.

192 ht and matter are strongly coupled, allowing engineering of rapid changes in the force landscape, sto

193 This concept of bending strain engineering of spins via topological nanomechanical arch

194 aling will allow improved strategies for the engineering of staple crops to accumulate additional bio

195 rther understanding of stem cell biology and engineering of stem cells for therapeutic applications.

196 s exciting opportunities for molecular-level engineering of stress-responsive properties of polymers.

197 ays, and also examine sample problems in the engineering of these pathways.

198 lications presented, a vision for the future engineering of wood-based materials to promote continuou

199 The insights we obtain are important for engineering opto-spintronic devices that rely on optical

200 unity or self-targeted cell killing, and the engineering or control of metabolic pathways for improve

201 chieved in the three domains without feature engineering or the use of knowledge sources.

202 Here we use an engineered organotypic model of perfused microvessels to

203 used for bone tissue regeneration as tissue engineered periosteum in a femoral allograft mouse model

204 of ambitious research projects seeking to re-engineer photosynthetic biochemistry.

205 date, conservation investment has emphasized engineering practices or vegetative strategies centered

206 roperties in ceramics through grain boundary engineering, precise mechanical characterization of indi

207 Here, we define the engineering principles impacting biological activity, de

208 h breeding and through biotechnology and the engineering principles on which increased phytonutrient

209 These cell engineering processes need to be carefully controlled an

210 As the field of tissue engineering progresses ever-further toward realizing cli

211 ied that may be exploited for photosynthesis engineering projects in the future.

212 Neuromorphic engineering promises to have a revolutionary impact in o

213 a Bayesian inference scheme, we can reverse engineer promoter activity from the bioluminescence.

214 y novel electron transport layers (ETLs) and engineered quantum dots (QDs).

215 This work presents the use of wild-type and engineered recombinant albumins with either decreased or

216 E to site saturation mutagenesis for protein engineering, reconstruction of adaptive laboratory evolu

217 of biomedical applications including tissue engineering, regenerative medicine, and cell and therape

218 as a platform for synthetic biology, strain engineering remains slow and laborious.

219 as advanced materials in biomedicine, tissue engineering, renewable energy, environmental science, na

220 nce might benefit from deeper involvement in engineering research in the area of health.

221 Dormancy was also reduced by engineering seed-specific accumulation of jasmonic acid

222 three-dimensional (3D) materials by printing engineered self-patterning bacteria on permeable membran

223 tensively used molecular building blocks for engineering self-assembling materials.

224 hanical manipulation of DNA hairpins with an engineered sequence is used to detect ligand binding as

225 These engineered sgRNAs enable multicolour labelling of low-re

226 rovements in plant photosynthesis by genetic engineering show considerable potential towards this goa

227 Engineered single CLCb-expressing NSCLC cells, as well a

228 pplications such as medical implants, tissue engineering, soft robotics, and wearable electronics.

229 ors use synthetic momentum-space lattices to engineer spatially and dynamically controlled disorder t

230 ting effects frustrate efforts to design and engineer stable, active enzymes without laborious high-t

231 expression of actin results from mating this engineered strain with a strain containing the wild-type

232 subtilis cells with and without dnaA, using engineered strains in which dnaA is not essential.

233 oduced from diacylglycerol (DAG), successful engineering strategies to enhance TAG levels have focuse

234 Here, we demonstrate a novel dissipation engineering strategy that can support stable oscillation

235 antibody specificity as an emerging antibody engineering strategy.

236 tween phase change and time response through engineered sub-micron scaffold.

237 We engineered substitutions at their equivalent positions i

238 We engineered synthekine ligands that assembled IL-2Rbeta/I

239 We have engineered synthethic cytokines (synthekines) that drive

240 Important implications of our findings for engineering synthetic circuits are: (i) sRNAs can potent

241 Engineering synthetic pathways for production of alpha-m

242 stems and how they compare and contrast with engineered systems.

243 to correct disease-causing gene mutations or engineer T cells for cancer immunotherapy.

244 Engineered T cells are applicable in principle to many c

245 Engineering T cells with an Akt-insensitive Ezh2 mutant

246 duced diabetic mouse model and a genetically engineered T2DM rat model.

247 ly applicable as scaffolds in cardiac tissue engineering (TE).

248 Band-engineering techniques should aim to a full control of t

249 Here we engineer the carbon metabolism of Synechococcus elongatu

250 we used a structure-based design approach to engineer the lactonase SsoPox from Sulfolobus solfataric

251 Plants engineer the rhizosphere to their advantage by secreting

252 molecule with high accuracy and also reverse-engineer the smell of a molecule.

253 The ability to engineer the thermal conductivity of materials allows us

254 We re-engineered the Cdt1-based sensor from the original Fucci

255 define this critical interaction, we have re-engineered the extracellular regions of beta, designated

256 In this study, we engineered the transporter to dissect interdomain commun

257 NV protease binding affinity, as revealed by engineering the binding loop of aprotinin, a small prote

258 dipose-derived stem/stromal cells (ASCs) for engineering the pulmonary vasculature in a decellularize

259 rical rules are inherently less reliable for engineering the structures of molecular solids.

260 e material system with reduced dimension via engineering the surface boundary conditions.

261 ernative grafting-from strategy for directly engineering the surfaces of live yeast and mammalian cel

262 d control protein function, and to precisely engineer therapeutics.

263 w understanding has emerged renewed hope for engineering these assembly lines to produce new material

264 iency and specificity of the Cas9 strains we engineered, they can be used for high-throughput reverse

265 However, engineering this transformation deliberately using ion i

266 Cytochrome P450 enzymes have been engineered to catalyze abiological C-H bond amination re

267 ExECs that were engineered to constitutively express anti-mullerian horm

268 The EGR1 promoter was engineered to enhance trans-activation capacity and opti

269 xons that encode bnAb precursors), have been engineered to evaluate novel immunogens/regimens for eff

270 Adoptive transfer of T cells engineered to express a hepatitis B virus-specific (HBV-

271 The oncolytic adenovirus ICOVIR-15K was engineered to express an EGFR-targeting BiTE (cBiTE) ant

272 PIV5 was engineered to express either the RSV fusion protein (F)

273 CRC lines (HCT116 and SW480) were engineered to express inducible tagged SPDEF or vector (

274 These CAR T cells are engineered to express synthetic receptors that redirect

275 in vivo A LGR5-rainbow (LBOW) mouse line was engineered to express three different LGR5 isoforms alon

276 xpress low endogenous levels of MT1-MMP were engineered to express wild-type MT1-MMP, a phosphomimeti

277 self-propelled microscale Janus particles is engineered to have contactless particle-particle interac

278 n fluorescent protein) that non-sRNAs can be engineered to have different proportions of nucleoid and

279 vironment and how CAR T cells can be further engineered to maintain efficacy.

280 Microbial factories have been engineered to produce lipids from carbohydrate feedstock

281 Although cyanobacteria have been engineered to produce various compounds, production effi

282 ently, Acidaminococcus sp BV3L6 (AsCpf1) was engineered to recognize altered DNA sequences as the pro

283 optical characteristics of an EC cell can be engineered to suit a variety of applications without cha

284 ein-based biosensors or activators have been engineered to visualize molecular signals or manipulate

285 so present a possible strategy based on loss engineering to achieve more control over the mode select

286 d will facilitate CAM-into-C3 photosynthesis engineering to enhance water-use efficiency in crops.

287 properties of neuronal dynamics and in neuro-engineering to implement closed-loop applications.

288 An engineered TOG1-2-5 array fully supported Msps-dependent

289 Since engineering trimers can be limited by the difficulty of

290 itudinal analysis of cell populations within engineered tumor models.

291 creened an existing combinatorial library of engineered ubiquitin variants for inhibitors of 53BP1.

292 al viral properties, efforts are underway to engineer viruses to respond to endogenous stimuli in new

293 s in metal-free catalysis or organic crystal engineering, where double-H-bonding donor boronic acids

294 -mismatched constituents also enables strain-engineering, which can be used to further enhance materi

295 Here, we use bacteria engineered with a strong Allee effect to investigate how

296 rthogonal chemistry with the use of proteins engineered with adhesive and morphogenetic solid-binding

297 erent bacteria using specific bacteriophages engineered with gene encoding for appropriate enzymes.

298 a coli (E. coli) using the T7 bacteriophages engineered with lacZ operon encoding for beta-galactosid

299 validates the promising combination of plant engineering with microbial chassis development for the p

300 Feeding A. aegypti with the engineered yeasts resulted in silenced target gene expre