ライフサイエンスコーパス: engineering of

1 Rational surface engineering of 2D nanoarchitectures-based electrode mate

2 Here, we demonstrate controlled strain engineering of 2D semiconductors during synthesis by uti

3 ing expands the possibilities for electronic engineering of 2DEGs at LaAlO3/SrTiO3 interfaces.

4 Engineering of a bivalent CA4910 nanobody resulted in a

5 Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficien

6 Here we report the engineering of a cytochrome P450 enzyme by directed evol

7 Engineering of a functional miniprotein substrate onto t

8 This study demonstrates coenzyme engineering of a hyperthermophilic 6PGDH and its applica

9 Crystal engineering of a layered perovskite has recently resulte

10 Here, we describe the engineering of a light-activated human caspase-3 (Caspas

11 Compositional engineering of a mixed cation/mixed halide perovskite in

12 Here, we describe the engineering of a new class of ECHs through the functiona

13 We report the engineering of a new reversibly switching chromogenic pr

14 rid scaffolds, but could also foreshadow the engineering of a novel class of hierarchical corannulene

15 Here we report the engineering of a protein scaffold for preferential bindi

16 Here we describe the genome engineering of a RF1 mutant strain that enhances suppres

17 Here we describe the biology-inspired engineering of a simple 2-in-1 reporter nanoparticle tha

18 y combining theory and experiments, with the engineering of a synthetic bacterial community in which

19 on a plant FBP appears useful for metabolic engineering of a wide range of crops to enhance the cont

20 AV genome packaging and will also inform the engineering of AAV capsid variants for improved tropism,

21 d level, information for rational structural engineering of AAV vectors with improved therapeutic eff

22 ipid remodeling as a possible target for the engineering of abiotic stress-resilient crops.

23 es such chromophores are rare, and molecular engineering of absorbers having such properties has prov

24 ategy may also serve as a blue-print for the engineering of addressable machineries that apply tailor

25 Together, these results demonstrate that engineering of an IgA antibody can significantly improve

26 Here we describe the engineering of an organotypic colon cancer model by rece

27 Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone

28 Our findings have implications for engineering of antiviral IgG therapeutics with tailored

29 ent tissues are fundamental to the metabolic engineering of artemisinin.

30 n achieving reliable and predictable forward-engineering of artificial biological circuits.

31 ity in the biology of real organisms and the engineering of artificial microswimmers.

32 The engineering of bioadhesives to bind and conform to the c

33 relevant to the modelling, elucidation, and engineering of biochemical pathways with compartmentaliz

34 k and is important for plant fitness and the engineering of bioenergy feedstocks.

35 rovides a comprehensive protocol for forward engineering of biological actuators and 3D-printed skele

36 Reverse engineering of biological pathways involves an iterative

37 e spatial patterning is a major goal for the engineering of biological systems.

38 ological processes as well as more effective engineering of biological systems.

39 f Anthozoan PCFPs and will facilitate future engineering of bright and low-blinking variants suitable

40 Here we report the engineering of brighter and more photostable variants, m

41 used by researchers for characterization and engineering of bulk heterojunctions to realize large pho

42 provide promising new targets for metabolic engineering of C5-yeasts and point to iron as a potentia

43 ovide a list of candidate genes for targeted engineering of CAM into C3 photosynthesis crop species.

44 ory control of carotenogenesis and metabolic engineering of carotenoids in light of plastid types in

45 ver, the structural constraints limiting the engineering of Cas9 have not been determined.

46 the HNH domain can be exploited for rational engineering of Cas9 variants with enhanced specificity.

47 nalities and provides useful data for future engineering of Cas9.

48 Reverse-engineering of causal pathways that implicate diseases a

49 l contexts will be essential for the precise engineering of cell identity.

50 orating cell surfaces with biomolecules, the engineering of cell surfaces with particles has been a l

51 developed a replicon-based system for genome engineering of cereal crops using a deconstructed versio

52 This process can be manipulated by molecular engineering of chimeric toxins.

53 Here, we report the engineering of chimeric VLPs, derived from rabbit hemorr

54 Employing dispersion and shape engineering of chiral nanoparticles leads to remarkable

55 el therapeutic strategies, and to enable the engineering of complex artificial gene networks.

56 ental prerequisite is the capacity for rapid engineering of complex gene networks, such as natural bi

57 Current methods do not enable precise engineering of complex genotypes that can be easily trac

58 es to predict these pathways will enable the engineering of complex materials using a much wider rang

59 The precise engineering of core-shell nanostructures demonstrated in

60 variants, providing a basis for the further engineering of CRISPR-Cpf1.

61 mining of this proteomic resource may enable engineering of crops and their microbial partners to inc

62 onses, allowing for more efficient, rational engineering of crops that are more robust or resistant t

63 om domestication and breeding to the genetic engineering of crops, plants provide food, fuel, fibers,

64 to new electronic applications based on the engineering of crystal phases.

65 Unfortunately, the engineering of cyanobacteria to create efficient cell fa

66 mplex metabolic network renders the rational engineering of cyanobacterial metabolism for the generat

67 r timing and temporal separation, and 3) the engineering of delivery systems that allow for temporal

68 Based on subtle elastic strain engineering of depositing L10-FePt films on pre-stretche

69 y are considered promising templates for the engineering of designed bionanoreactors for biotechnolog

70 is often overlooked as a design element for engineering of DNA-based devices, potentially limiting t

71 r kinetically and thermodynamically balanced engineering of DNA-binding proteins.

72 Codon re-engineering of dosR exaggerates hypoxia-induced changes

73 We used CRISPR/Cas9 genome engineering of Drosophila legless (lgs) and human BCL9 a

74 ablishes chirality as a design parameter for engineering of dynamic DNA nanotechnology, thereby expan

75 rtemisinin and other drugs through metabolic engineering of edible plants.

76 ccess to RNA-binding antibodies requires the engineering of effective Fab libraries guided by the kno

77 These data and analyses will facilitate the engineering of efficient biosynthetic and degradative pa

78 Here, we demonstrate engineering of electrically and chemically responsive, c

79 lectricity, are of crucial importance in the engineering of electronic devices.

80 hape global agriculture through the targeted engineering of endogenous pathways or the introduction o

81 erroelectric domain-wall devices through the engineering of energy landscape using defect-induced int

82 Engineering of enzyme modules 1 &2, 1 &3 and 1, 2 &4 in

83 However, the engineering of enzymes is severely hampered due to their

84 homojunctions by the flux-controlled, phase-engineering of few-layer MoTe2 from Mo nanoislands is re

85 try breaking paves the way for deterministic engineering of fractional quantum Hall states, while our

86 We report on the engineering of full thermally activated delayed fluoresc

87 achieved by optical management and interface engineering of fully optimized high-performance front an

88 dge is instrumental for design and synthetic engineering of functional carboxysomes into higher plant

89 atorial and native-like scaffolds for tissue engineering of functional organs.

90 istribution present challenges in the tissue engineering of functional TMJ discs.

91 lectricity will be essential for the quantum engineering of future nanoelectronic devices.

92 trates the feasibility of rapid and advanced engineering of gene networks in LAB, fostering their app

93 ers (e.g. Sox2-V5 and Sox2-mCherry); and (4) engineering of glioma mutations (TP53 deletion; H3F3A po

94 Therapeutic engineering of glucagon-like peptide 1 (GLP-1) has enabl

95 chemical and enzymatic synthesis and by the engineering of glycosylation pathways.

96 The strain engineering of GNRs is promising for potential electroni

97 lts constitute the first example of rational engineering of Gram selectivity at the (macro)molecular

98 The effect of edge engineering of graphene nanoribbons (GNRs) on their ultr

99 anosheets provide an ideal substrate for the engineering of guest components (e.g., proteins and nano

100 resent a transformational approach to genome engineering of herpes simplex virus type 1 (HSV-1), whic

101 Indeed, in this study we show that Fc engineering of hIgG1 for altered binding to FcRn also in

102 The engineering of high-performance enzymes for future seque

103 Here, we report the engineering of highly potent and selective inhibitors of

104 has been successfully fabricated by surface engineering of hollow structures with suitable corona an

105 These are based on genetic engineering of human genomic safe harbors combined with

106 Here we report the engineering of humanized intestinal grafts by repopulati

107 The design and engineering of hybrid materials exhibiting tailored phon

108 itical step in viral pathogenesis and foster engineering of improved oncolytic viral vectors.

109 ivity, providing a highly soluble parent for engineering of improved or new function.

110 accessible surfaces can guide the design and engineering of improved recombinant antigen-based vaccin

111 cid substitutions that will aid in advancing engineering of improved Rubisco in crop systems.

112 chemistry, thereby permitting the bottom-up engineering of increasingly complex reaction networks fr

113 ision breeding of plants and animals and the engineering of industrial microbes.

114 protein design, and paves the way to further engineering of insulin and other therapeutic proteins.

115 ing mathematical modelling and the molecular engineering of insulin itself and its potency, towards a

116 f chromosomal deletions and targeted somatic engineering of inter-chromosomal translocations, offerin

117 We study the isotope engineering of lamellar compounds by synthesizing hexago

118 Compositional engineering of large-bandgap ( approximately 1.8 eV) per

119 This review focuses on structural engineering of lasers from the macroscale to the nanosca

120 This study provides a template for molecular engineering of ligands, enabling studies of drug targeti

121 cling scheme opens new avenues for metabolic engineering of lipid composition in algae.

122 g as promising alternatives to the metabolic engineering of living cells.

123 As a result, reverse engineering of LMWH for biosimilar LMWH has become an ac

124 We demonstrate here that engineering of low-avidity T cells recognizing a natural

125 obtain, offers an insight into the spectral engineering of LSP mediated fluorescence and may lead to

126 e of ARTs, facilitating their use in genetic engineering of macaque monkeys for basic and translation

127 a universally applicable technology for the engineering of macroscale human myocardium for disease m

128 (>100 000 bp) remains a limiting step in the engineering of mammalian cells and the development of hu

129 poson system has proven effective in genomic engineering of mammalian cells for preclinical applicati

130 In this study we demonstrate rapid engineering of markerless knock-ins, knock-outs and poin

131 earch for robust light states by topological engineering of material properties.

132 s has focused mainly on strain-accommodating engineering of materials, or blending of nanofibres or n

133 es over unstimulated controls, may allow the engineering of mechanically robust biological replacemen

134 SrtA transpeptidation facilitated surface re-engineering of medical devices in situ after in vivo imp

135 of co-translational integration and for the engineering of membrane proteins with enhanced membrane

136 any efforts are being made in the design and engineering of metalloenzymes with catalytic properties

137 Metabolic engineering of microorganisms such as Escherichia coli a

138 Metabolic engineering of microorganisms to produce desirable produ

139 Genetic engineering of model organisms and cultured cells has fo

140 ovides a stepping stone towards the rational engineering of molecular interaction(s) with acid sites

141 We apply this understanding to advance the engineering of molecular interactions at the nanoscale.

142 benzene as a versatile aromatic scaffold for engineering of molecular materials with tailored and exp

143 sessment pipeline enabled by high-throughput engineering of molecularly barcoded gene variant express

144 trate how this method can facilitate pathway engineering of molecules of pharmaceutical interest, pro

145 ition (CVD) method has enabled morphological engineering of monolayer TMDC catalysts toward developme

146 teractions to enable the reliable and robust engineering of morphogenesis.

147 r coexistence is a promising route in defect engineering of MoS2 to fabricate suitable devices for el

148 The engineering of mouse models of inherited aortopathies ha

149 hain orthogonal assembly approach allows the engineering of multiblock copolymer scaffolds featuring

150 these findings present a new approach to the engineering of multicomponent optogenetic tools to manip

151 particles to solid tumors either through the engineering of multifunctional nanosystems or through ma

152 These results may guide the rational engineering of multilayer and core-shell oxide nanomater

153 io-acoustic levitational assembly method for engineering of multilayered, 3D brainlike constructs is

154 s solids that has been revolutionized by the engineering of multilevel pore architectures, which comb

155 opulation-level dynamics through the genetic engineering of multiple cooperative strains points the w

156 ible for these particles could allow reverse engineering of nab-paclitaxel binding antibodies, creati

157 closed nanoshells is a necessary step toward engineering of nanocontainers, which will have far-reach

158 are expected to arise from precise chemical engineering of nanoscale building blocks and interfaces.

159 ally "noisy" bioenvironments require careful engineering of nanoscale components that are highly sens

160 The re-engineering of natural photosynthetic pathways can provi

161 Hence, mapping of AAV antigenic sites and engineering of neutralization-escaping vectors are impor

162 -assembly is a powerful design principle for engineering of new biomolecules.

163 lism and opens the possibility for metabolic engineering of new compounds based on this scaffold.

164 d micropores, which is crucial to systematic engineering of new functional materials such as tunable

165 zation of protein-DNA interaction before the engineering of new homing endonucleases is essential for

166 psin pore model via crystal structure-guided engineering of next-generation light-activated chloride

167 inimization and potentially accelerating the engineering of next-generation thermoelectric devices.

168 Bandgap engineering of non-stoichiometric silicon nitride using

169 ion of more complex plant-derived alkaloids, engineering of nonnatural derivatives, identification of

170 bility of using yeast to accelerate rational engineering of nonribosomal peptide antibiotics.

171 dimethyl group formation, with a goal toward engineering of novel compounds containing this moiety, t

172 the structural mechanisms that could enable engineering of novel non-ribosomal peptide synthetases.

173 or future nanoelectronic devices and for the engineering of novel quantum phases.

174 tions to spontaneous translocation, rational engineering of novel SMTPs will remain difficult, provid

175 The nanoscale engineering of nucleic acids has led to exciting molecul

176 ave important implications for science-based engineering of numerous platelet-matrix composites and s

177 Thus, the structure-based engineering of OaAEP1 described here provides a unique a

178 ously impact the molecular design and device engineering of OFETs.

179 as potentially broad applications in genetic engineering of oleaginous crops and microorganisms.

180 study also provides novel prospects for the engineering of oleaginous microalgae for biotechnologica

181 l system for the rational design and precise engineering of optical processes.

182 QMM will facilitate the design and metabolic engineering of organisms for biofuels and other chemical

183 Facet engineering of oxide nanocrystals represents a powerful

184 mprove PA production further via the pathway engineering of P. jensenii.

185 used as a partner of experiment for eventual engineering of P450 BM3 with site-selective C-H function

186 mRNA TCR engineering of peripheral blood lymphocytes from healthy

187 ion offers an entirely new pathway to strain engineering of perovskite-based complex oxide thin films

188 Here we report the engineering of personalized tumour ecosystems that conte

189 a comprehensive protocol to perform genetic engineering of phage, liter-scale amplification, purific

190 ation reaction is developed for the textural engineering of phenolic resin (PR) with a robust mesopor

191 This method permits the engineering of PKS pathways as modular building blocks f

192 rs and their cognate binding elements in the engineering of plant gene expression.

193 ect extraction, recent progress in metabolic engineering of plants offers an alternative supply optio

194 nocots, which can serve as the basis for the engineering of plants with enhanced biomass conversion p

195 he manipulation of stomatal development, the engineering of plants with high WUE remains a challenge.

196 pected to support rapid, precise, and robust engineering of plants.

197 synthetic biology that involve the multistep engineering of plastid genomes.

198 Thus, boosting ST8SIA2 and engineering of polySia are promising strategies for impr

199 This step will enable further engineering of postmortem facial grafts, thereby offerin

200 roach is a simple and effective strategy for engineering of pre-vascularized dental pulp constructs o

201 We used CRISPR/Cas9 genome engineering of primary adult and umbilical cord blood CD

202 to natural evolutionary processes and to the engineering of protein therapeutics, which constitute an

203 osts provided proof of concept for metabolic engineering of pseudolaratriene.

204 o resolve this contradiction, the design and engineering of quantum hardware can benefit from a 'bott

205 Moreover, engineering of R. eutropha enabled production of the fus

206 ht and matter are strongly coupled, allowing engineering of rapid changes in the force landscape, sto

207 promising opportunities for the control and engineering of reactivity.

208 Here we report the engineering of recombinant antibody-based bifunctional s

209 tificial chromosome technologies has enabled engineering of recombinant cytomegaloviruses (CMVs) from

210 evelop and implement strategies for in vitro engineering of replacement kidney tissue, and to devise

211 ssues can help in the development of genetic engineering of resistance against this pathogen.

212 able to other NLR proteins and should enable engineering of resistance in plants to diseases for whic

213 Here we report the metabolic engineering of Saccharomyces cerevisiae to produce n-but

214 his bottom-up approach may enable controlled engineering of scalable many-body systems for quantum in

215 lies in cell biology and (3) molecular-level engineering of self-assembled recombinant IDP-rich mater

216 eveloped a screening strategy for the direct engineering of self-complementing split FPs.

217 rse organelles and can inform the design and engineering of shells with new functionalities.

218 overy reveals a potential new route to local engineering of significant property enhancements and con

219 se results may present a new avenue for band engineering of silicene nanoribbons and benefit the desi

220 y providing a new approach for the materials engineering of solid ion conductors.

221 design methods have made possible extensive engineering of soluble proteins, but designed beta-barre

222 nt studies have demonstrated transcriptional engineering of some metabolic pathways.

223 ed here provide a valuable tool to guide the engineering of specific Env glycoforms for HIV vaccine d

224 gulators of stem cell shape and the targeted engineering of specific MSC shapes through biomechanical

225 constitutes an important gene source for the engineering of specific phenylpropanoid components.

226 This concept of bending strain engineering of spins via topological nanomechanical arch

227 installation method in the pore environment engineering of stable MOFs with multiple functional grou

228 aling will allow improved strategies for the engineering of staple crops to accumulate additional bio

229 Our results are relevant to the quantum engineering of states of matter at large length scales,

230 rther understanding of stem cell biology and engineering of stem cells for therapeutic applications.

231 To conclude, mRNA-based engineering of stem cells is a rapid and integration-fre

232 s exciting opportunities for molecular-level engineering of stress-responsive properties of polymers.

233 ities because they offer fresh approaches to engineering of structural hierarchy and adaptive functio

234 Genetic engineering of structure-designed bromodomain and plant

235 Many of these projects will require the engineering of substantial changes in fluxes of central

236 article system from 0.1 to 0.7 h(-1) and the engineering of superstructures that can release two diff

237 ral method for the preparation and molecular engineering of supported trifunctional catalysts and the

238 mechanical durability through the nanoscale engineering of surfaces in the form of nanorod-polymer c

239 its metabolism will help researchers in the engineering of SYK-6 for the production of value-added c

240 e-based therapeutics, and aid in the reverse-engineering of synthetic exosomes.

241 tric cancer immunotherapies through improved engineering of synthetic immunotherapies and by combinin

242 se genes are potential candidates for future engineering of synthetic mammalian gene circuits requiri

243 rrangement of molecular features enables the engineering of synthetic nanostructures and the understa

244 -five years after its inception, the genetic engineering of T cells is now a therapeutic modality pur

245 approach offers new strategies for metabolic engineering of terpenoid production.

246 Also investigated in parallel was the re-engineering of the 23S rRNA of Escherichia coli, guided

247 ocol on DNA-nanostructure-based programmable engineering of the biomolecular recognition interface, w

248 We recount recent progress in the re-engineering of the carboxysome shell and core to offer a

249 In the present study, complex engineering of the carotenoid pathway has been performed

250 ts and a conceptual framework for functional engineering of the complex.

251 Engineering of the constant Fc part of monoclonal human

252 Cpf1 and establish a framework for rational engineering of the CRISPR-Cpf1 toolbox.

253 The continuous phase engineering of the effective nonlinear polarizability en

254 Here we report on the engineering of the electro-thermal properties of semicon

255 Here, we demonstrate that the engineering of the electronic structure of a ferromagnet

256 -type semiconductor photocathode through the engineering of the enzyme-materials interface.

257 ategy to block Abeta42 neurotoxicity through engineering of the Heat shock protein 70 (Hsp70), a chap

258 sitivity enhancement of LSPR sensors through engineering of the material dispersion function.

259 Previous engineering of the NAAAR from Amycolatopsis Ts-1-60 was

260 This study demonstrated that engineering of the native DGAT enzyme is an effective st

261 Here, we show that strain engineering of the outermost surface of cobalt(II) oxide

262 Systematic engineering of the pore structure, which is achieved by

263 Atomically precise engineering of the position of molecular adsorbates on s

264 brid nano-antennas for comprehensive spatial engineering of the properties of optical fields.

265 al space is therefore required for efficient engineering of the required material properties.

266 ically show that these devices allow precise engineering of the resistance states, thus enabling larg

267 Here we demonstrate the engineering of the small-ribosomal subunit (16S) RNA of

268 f electronic structures, via computer-guided engineering of the surface and (electro)chemical propert

269 dicine in a precise manner through molecular engineering of the underlying building blocks.

270 Here, we present engineering of the unexplored, extreme alkaliphile Bacil

271 nd provides a platform for further study and engineering of their metabolism.

272 d may provide improved strategies for future engineering of their production.

273 portant characteristic that enables rational engineering of their recognition and binding properties.

274 essing the quality of the gates used for the engineering of their state.

275 fect in ferroelectric materials by nanoscale engineering of their structure and composition.

276 sponses to disease and aid in the design and engineering of therapeutic molecules.

277 ch can assist in rapid and efficient genetic engineering of these bacteria in the future.

278 Successful engineering of these defects can lead to modifications i

279 emonstrates the feasibility of the metabolic engineering of these insecticidal metabolites in plants

280 rsified and sets the foundation for rational engineering of these intriguing natural products.

281 Engineering of these loop regions can alter protein stab

282 cant challenges in advancing the science and engineering of these metals.

283 ays, and also examine sample problems in the engineering of these pathways.

284 uxiliary subunit-specific compounds, because engineering of this hotspot induces opposing functional

285 undation for future genetic manipulation and engineering of this strain.

286 modelling indicates that the nanoscale pore engineering of this transition metal oxide enables an un

287 n of betalain-related genes also allowed the engineering of tobacco plants and cell cultures to produ

288 Although engineering of transcription factors and DNA-modifying e

289 Reverse engineering of transcriptional networks using gene expre

290 nthesized and incorporated in the design and engineering of TSL.

291 However, the active engineering of ultranarrow resonances across the visible

292 zyme competition is a limiting factor in the engineering of unusual FAs in heterologous plant systems

293 BirA in the cytoplasm of maize plants and on engineering of Ustilago maydis strains to secrete Avitag

294 vaccines relies on the identification and/or engineering of vaccine adjuvants capable of supporting t

295 open novel and fascinating scenarios for the engineering of wave propagation and light-matter interac

296 for food use, as hosts for complex metabolic engineering of wax esters for lubricant applications.

297 development of new materials, as well as the engineering of well-characterized materials for the repu

298 tibody-like scaffold termed an "i-body," the engineering of which produces an i-body library possessi

299 n be a viable complementary approach akin to engineering of wild-type SaSrtA.

300 lications presented, a vision for the future engineering of wood-based materials to promote continuou