1 d lipogenesis occurred at a concentration of englitazone (30 micromol/l) that did not affect MAPK act

2 m rats on the high-fat diet for 3 weeks, but englitazone (50 mg/kg for the last 7 days) normalized th

3                                     Although englitazone alone did not activate PI 3-kinase, it did e

4                                 In addition, englitazone decreased insulin-stimulated lipogenesis in

5                                              Englitazone did not affect the expression of the peroxis

6                                              Englitazone did not increase IR, IRS-1/IRS-2, pp60, or M

7                                              Englitazone did not reverse this decrease in IRS-1 and P

8 wo other thiazolidinediones, ciglitazone and englitazone, exhibited similar inhibitory effect on chol

9                    Cells were incubated with englitazone for 48 h or with insulin for 10 or 30 min, o

10                                     However, englitazone had a biphasic effect on lipogenesis (163 +/

11                               The effects of englitazone in male Wistar rats fed a high-fat diet (59%

12                                              Englitazone increased 2DG uptake in a concentration-depe

13                                     However, englitazone inhibits insulin-stimulated lipogenesis with

14                                              Englitazone normalized oral glucose (1 g/kg body wt) int

15 ts of insulin and the insulinomimetic agent, englitazone, on functional end points and putative media

16                                  In summary, englitazone prevented the insulin resistance associated

17 ner by up to sixfold, and preincubation with englitazone significantly enhanced insulin-stimulated 2D

18                                         Thus englitazone stimulates 2DG uptake without affecting PI 3

19 m rats on the high-fat diet for 3 weeks, but englitazone treatment did not reverse the defect in GLUT

20 on of other lipogenic enzymes are altered by englitazone via peroxisome proliferator activated recept