ライフサイエンスコーパス: engraftment

1 ost-HSCT (7/7), as early as day +14 (myeloid engraftment).

2 manipulations required to improve xenoislet engraftment.

3 induction, migration, maintenance, and niche engraftment.

4 usly to improve the efficiency of donor HSPC engraftment.

5 l proliferation and increased the latency of engraftment.

6 ier islet vascularization and improved islet engraftment.

7 olation and maintain CXCL10 production after engraftment.

8 ers that confer protection against CDI after engraftment.

9 5 gene-edited HSPCs are capable of long-term engraftment.

10 tory responses following PITx thus improving engraftment.

11 ation is limited by low levels of donor cell engraftment.

12 nce of cardiovascular events and death after engraftment.

13 on and predict dopamine neuron content after engraftment.

14 being sufficient for robust allogeneic cell engraftment.

15 leads to a significant reduction in leukemic engraftment.

16 ing but requires robust T-cell expansion and engraftment.

17 h dramatically compromised their bone marrow engraftment.

18 icent cells restored both cell migration and engraftment.

19 increased long-term multilineage donor cell engraftment.

20 osteolytic disease in vivo after intratibial engraftment.

21 patients experience graft failure or delayed engraftment.

22 may actively condition the niche to promote engraftment.

23 d the development of the disease after their engraftment.

24 ming to BM have been assessed to improve UCB engraftment.

25 ents in their 80th year or longer at time of engraftment.

26 Pak2) has been implicated in HSPC homing and engraftment.

27 correlated with the extent of hematopoietic engraftment.

28 ETs) as a family of lipids that enhance HSPC engraftment.

29 long development time and low efficiency of engraftment.

30 rrhythmic effects of HC at various levels of engraftment.

31 -replete monocytes was sufficient to restore engraftment.

32 ssociated with any adverse events or delayed engraftment.

33 ue, which was also able to support human HSC engraftment.

34 ) after transient multi-organ failure or non-engraftment.

35 icient availability, and lack of appropriate engraftment.

36 , in addition to sustained hypoxia following engraftment.

37 After initially robust engraftment, 3 of these patients experienced declining d

38 expressing HSC showed significantly enhanced engraftment ability.

39 All 25 patients achieved primary neutrophil engraftment after a median of 12 days.

40 effective strategy to improve BM homing and engraftment after allogeneic UCB transplantation.

41 , enforced fucosylation, intended to improve engraftment after donor unrelated cord blood (UCB) trans

42 endpoint was detection of early subclinical engraftment after HSCT with (18)F-FLT PET or CT.

43 ration and detection of patterns of cellular engraftment after HSCT.

44 OPN knockout niche results in a decrease in engraftment, an increase in long-term HSC frequency and

45 serve as adjuvant modalities to enhance HSC engraftment and accelerate hematopoietic recovery in the

46 ts undergoing HSCT, drawing blood samples at engraftment and at 2, 6, and 10 months after the HSCT.

47 ght to delineate the effects CD4(+) cells on engraftment and blood formation in a model that simulate

48 caused marrow inflammation and inhibited HSC engraftment and blood formation.

49 Importantly, Sunitinib also increased engraftment and differentiation of FSHD myoblasts in reg

50 asper, prkdc mutant zebrafish, for efficient engraftment and direct visualization of fluorescently la

51 h IFN-alpha enhanced long-term hematopoietic engraftment and donor chimerism.

52 al would result in high levels of allogeneic engraftment and donor hemoglobin (Hb) expression with su

53 Coinfusion of young ECs augmented aged HSC engraftment and enhanced overall survival in lethally ir

54 ollowing total body irradiation improved HSC engraftment and enhanced survival.

55 uced-intensity conditioning, there was rapid engraftment and expansion of a polyclonal pool of transg

56 opeptide (AAGP) would enhance posttransplant engraftment and function and protect against tacrolimus

57 ese genome-edited HSPCs support multilineage engraftment and generate progeny capable of trafficking

58 motherapy and stimulated neuroblastoma tumor engraftment and growth in immunodeficient mice, indicati

59 not of EP300, has additional cell-intrinsic engraftment and growth-promoting effects.

60 ts, we found significantly improved rates of engraftment and GVHD following TLI/ATS/CTX compared with

61 In this study, we assess the engraftment and immunogenicity of allogeneic bilayered b

62 ibodies did not interfere with hematopoietic engraftment and improved immune reconstitution in allo-H

63 trategies to overcome barriers to successful engraftment and increase the clinical promise of IUHCT.

64 haplocord stem cell transplant assures good engraftment and leads to acceptable toxicity and disease

65 lasmic reticulum (ER) stress induces low MSC engraftment and limits their therapeutic efficacy.

66 hMSCs) proved to be superior in terms of HSC engraftment and long-term maintenance when implanted in

67 islets (NPIs) in vitro and determined islet engraftment and metabolic outcomes when cotransplanted i

68 The in vivo engraftment and migration of human PS-cell-derived ENS p

69 a significant improvement of syngeneic islet engraftment and of allogeneic islet graft survival.

70 The degree of myeloid cell engraftment and of platelet reconstitution correlated wi

71 ryl trinitrate (GTN) on the efficacy of cell engraftment and on liver repopulation in the mdr2-knocko

72 Long-term multilineage engraftment and persistent VCN and vector expression was

73 vitro colony-forming assays reveal that the engraftment and proliferative capacities of TECs diminis

74 ld enhance allogeneic bone marrow cell (BMC) engraftment and promote tolerance induction.

75 -beta/Fc had a synergistic effect to promote engraftment and resulted in significantly higher donor c

76 ect intraossicle transplantation accelerated engraftment and resulted in the detection of substantial

77 ietic stem cells, and can be used for clonal engraftment and serial primary and secondary multi-linea

78 nsplant recipients with severe sepsis during engraftment and subsequent admissions with a non-hematop

79 cing methods, the clonal dynamics of initial engraftment and subsequent serial propagation of primary

80 hematopoietic niche remodels to promote HSPC engraftment and suggests that cxcl8/cxcr1 signaling is a

81 erefore, have the potential to improve islet engraftment and survival.

82 phin-1 as a powerful cytokine promoting cell engraftment and thus improving cell therapy of the infar

83 ut were readily expressed after subcutaneous engraftment and tumor growth.

84 sing hydrogel-based strategies for improving engraftment and viability of transplanted stem cells and

85 Engraftment and/or expansion of HSPCs was dependent on t

86 d hearts of immunodeficient mice showed good engraftment, and echocardiography showed significant fun

87 CCs exhibited increased persistence, engraftment, and expression of early commitment markers

88 rove the efficiency of DA neuron production, engraftment, and function.

89 ilored scaffolding maintained hMSC stemness, engraftment, and led to robust motosensory improvement,

90 iche requirements for tumor organoid growth, engraftment, and metastasis.

91 the EET effects on enhancing HSPC homing and engraftment are conserved in mammals.

92 omplete understanding of how HSPC homing and engraftment are regulated is still elusive.

93 Synergistic engraftment augmentation is observed when BOP is co-admi

94 HSC infusion, which was up to 20 days before engraftment became clinically evident.

95 matopoietic stem and progenitor cells during engraftment but also improves transplantation outcome wi

96 .3 years; P = 0.80) and diabetes duration at engraftment but with significant different mean HbA1c le

97 y enhanced thymopoiesis and periphery T-cell engraftment, but also significantly increased class swit

98 daptive immune systems, complete with tissue engraftment by human mast cells that are competent to mo

99 ia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts

100 icient strategy to amplify the migratory and engraftment capacities of ECFCs and their beneficial imp

101 l for hematopoietic cell maintenance and HSC engraftment capacity in adult hematopoiesis.

102 s, expansion of HPCs, and impaired long-term engraftment capacity were found to be associated with hi

103 tivated RAC1, a RhoGTPase that regulates HSC engraftment capacity.

104 r, there is a higher rate of donor stem cell engraftment compared with marrow HCT and an increase in

105 hematopoietic CD34+ progenitor cells; their engraftment confirmed and then subjected to 30% total bo

106 Poor survival and engraftment coupled to inadequate cardiac commitment of

107 es aging of old HSCs, resulting in increased engraftment, decreased HSC frequency, increased stem cel

108 Tumour engraftment did not occur in one of the five immunised T

109 Successful engraftment does not appear to correlate with clinicopat

110 em to primary human hepatocytes, focusing on engraftment efficiency and posttransplant proliferation

111 for cardiac reconstruction, we compared the engraftment efficiency of intramyocardially-injected und

112 king of stem cells that demonstrate a higher engraftment efficiency than those mobilized by G-CSF.

113 enesis and supports leukemic cell homing and engraftment, facilitating interactions between leukemic

114 ncluding transplant-related mortality (TRM), engraftment failure, and autologous recovery.

115 ssociated with an increased risk of platelet engraftment failure.

116 tation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dys

117 homing of donor HSCs and enhanced long-term engraftment following IUHCT in an allogeneic mouse model

118 n estimated 5-year survival rate of 55% post-engraftment for an 80-year-old patient is in our opinion

119 stitution method, in addition to lung tissue engraftment, giving altogether a realistic model to stud

120 spectively evaluated the epidemiology of pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) an

121 Pre-engraftment GNB is an independent factor associated with

122 The cumulative incidence of pre-engraftment GNB was 17.3% in allo-HSCT and 9% in auto-HS

123 , donor type and stem cell source, toxicity, engraftment, GVHD, chimerism, viral reactivation, post-H

124 Although long-term engraftment has been demonstrated following in utero hem

125 ment for tumor-expressed CXCR3 in metastatic engraftment has been demonstrated, the role of monocyte-

126 w that transplant toxicity has decreased and engraftment has improved, resulting in a 5-year overall

127 nables direct histologic comparison of early engraftment immunobiology.

128 330-fold increase in CD34+ cells and led to engraftment in 17/17 patients at a median of 15 days for

129 serial dilution experiments which showed CNS engraftment in 5 of 6 mice after transplant of as few as

130 that MEIS1 promotes leukemic cell homing and engraftment in bone marrow and enhances cell-cell intera

131 d CXCR4 inhibitors impair SOX11-enhanced MCL engraftment in bone marrow.

132 differentiated kidney tissue, strategies for engraftment in experimental animals, and development of

133 th cell-free scaffolds, and the rate of cell engraftment in hCMP-treated animals was 24.5% at week 1

134 1 is a novel major regulator of adhesion and engraftment in human HSPCs through mechanisms that, at l

135 biologic scaffold sustained allogeneic islet engraftment in immunosuppressed recipients.

136 and N0) and patient-derived xenograft (PDX) engraftment in locally advanced tumors (T3-T4 or N+) pre

137 exocytosis, improved apoptosis, and improved engraftment in mice by decreasing expression of interleu

138 TWIST1 expression led to increased tumour engraftment in mice, as well as cisplatin resistance in

139 arized approach supports marginal mass islet engraftment in mice.

140 city to promote multi-lineage haematopoietic engraftment in mouse hosts.

141 ion proteins to the conditioning resulted in engraftment in nearly 100% of recipients.

142 E225 + nilotinib reduced CD34(+) CP-CML cell engraftment in NSG mice and, upon administration to EGFP

143 (1) transmigration into the alveoli, and (2) engraftment in the alveoli.

144 Intraomental islet engraftment in the biologic scaffold was confirmed by ac

145 -matched iPSC-derived neurons provide better engraftment in the brain, with a lower immune response a

146 ed MSCs in immunodeficient mice led to their engraftment in the injected and uninjected contralateral

147 onocytes/macrophages in the process of tumor engraftment in the lung.

148 ely, F573 significantly improved mouse islet engraftment in the PV and DL site (P < 0.05 and P < 0.05

149 general utility as a strategy to promote HSC engraftment in transplantation.

150 s less than 5 minutes, shows efficient tumor engraftment in two-thirds of mice, and can be achieved u

151 ergetics, cell death and abrogation of T-ALL engraftment in vivo.

152 dering poor cell survival, functionality and engraftment in vivo.

153 L blast proliferation and a reduction in AML engraftment in vivo.

154 tion, as well as tumorigenesis in orthotopic engraftments in mice.

155 he novel processes that regulate stable HSPC engraftment into an ablated host.

156 Similarly, engraftment into dystrophic mice of canine MiPs from dys

157 tial increase in S/G2-phase human HSCs after engraftment into immunodeficient (NSG) mice, a phenotype

158 % human cell marking were observed following engraftment into mice.

159 zation of 3D bioprinted cardiac patches with engraftment into native rat myocardium.

160 Engraftment into optically clear casper, prkdc-mutant ze

161 l network establishment and support neuronal engraftment into the brain.

162 okines that improve mesenchymal stromal cell engraftment into the heart both in normal conditions and

163 Delayed engraftment is a major limitation of cord blood transpla

164 Allogeneic BMC engraftment is enhanced with TGF-beta/Fc fusion protein

165 Umbilical cord blood (UCB) engraftment is in part limited by graft cell dose, gener

166 proves glucose tolerance, although long-term engraftment is not observed.

167 ematopoietic stem and progenitor cell (HSPC) engraftment is paramount to improving transplant outcome

168 Their role in overcoming barriers to HSC engraftment is thought to be particularly critical when

169 ce resulted in significantly lower long-term engraftment levels, associated with a reduced capacity o

170 host disease incidence and severity, time to engraftment, lineage-specific chimerism, immune reconsti

171 ycolide) (PLG) scaffold niche for successful engraftment, long-term survival, and maturation of lung

172 expansion of HPCs, and defects in long-term engraftment, mimicking the effects observed in mice with

173 human and mouse islet apoptosis and improves engraftment most effectively in the portal and DL subcut

174 Engraftment occurred in 4 of the 5 patients.

175 We also observed robust engraftment of acute promyelocytic leukemia (APL) and my

176 of PEG to ALG in MicroMix capsules improved engraftment of allogeneic islets in the IP site, but res

177 achieved by immune regulation without actual engraftment of BMSCs.

178 down of BCL11A profoundly impaired long-term engraftment of both human and mouse hematopoietic stem c

179 Engraftment of C57BL/6 mice with TIB-49 AML led to an ex

180 Engraftment of cardiotrophin-1-treated mesenchymal strom

181 round (NSGS mice), we demonstrate remarkable engraftment of CMML and JMML providing the first example

182 Engraftment of CMML and JMML resulted in overt phenotypi

183 ononuclear cells (n = 10) resulted in robust engraftment of CMML in BM, spleen, liver, and lung of re

184 Through the orthotopic engraftment of colon organoids we describe a broadly usa

185 CD45-saporin (SAP), enabled efficient (>90%) engraftment of donor cells and full correction of a sick

186 pact HSC activity, blood reconstitution, and engraftment of donor HSCs.

187 PD-L1 signaling is not required for engraftment of embryonic HSCs.

188 We found improved engraftment of fully allogeneic BALB/c islets in Micro c

189 viving patients exhibited high-level, stable engraftment of functionally corrected lymphoid cells.

190 e therapy studies have failed to demonstrate engraftment of gene-corrected hematopoietic stem and pro

191 A in erythroid cells led to stable long-term engraftment of gene-modified cells.

192 Efficacy was assessed by measuring engraftment of gene-modified hematopoietic stem/progenit

193 esenchymal stromal cells, enables the robust engraftment of healthy human hematopoietic stem and prog

194 Activation of Gs-coupled receptors enhances engraftment of hematopoietic stem and progenitor cells (

195 T cells are widely used to promote engraftment of hematopoietic stem cells (HSCs) during an

196 Engraftment of hiPSC-derived adipocytes in mice produces

197 Treprostinil stimulates the engraftment of human and murine hematopoietic stem cells

198 PJ-68 also inhibited long-term engraftment of human CML CD34+ cells in immunodeficient

199 Engraftment of human hematopoietic cells can be evaluate

200 le human niche model for studying homing and engraftment of human hematopoietic cells in normal and n

201 e model can be further humanized through the engraftment of human hematopoietic stem cells (HSCs) tha

202 n adeno-associated virus vector, followed by engraftment of human hematopoietic stem cells.

203 In this report, we demonstrated successful engraftment of human induced pluripotent stem cell (iPSC

204 nts and structure to support the seeding and engraftment of human induced pluripotent stem cell-deriv

205 Some of the recognized challenges are poor engraftment of implanted cells and, in the case of human

206 a simple yet robust approach to improve the engraftment of iPS-H, and may be applicable to many stem

207 cell therapy are still unclear, and limited engraftment of iPSC-derived cardiomyocytes is well known

208 th dexamethasone and dasatinib also impaired engraftment of leukemia cells in vivo.

209 on of CD4(+) T cells greatly facilitated the engraftment of lymphoma cells in serial transplantation

210 t(W-sh/W-sh) mice was elevated following the engraftment of mast cells, indicating that mast cells co

211 addition, brentuximab-vedotin suppressed the engraftment of MCPV-1.1 cells in NSG mice.

212 ssue regeneration, and markedly enhanced the engraftment of muscle stem cells in injured and noninjur

213 mmunodeficient mice resulted in reproducible engraftment of myeloid, lymphoid, and CD34(+) cells.

214 nged depending on the context to improve the engraftment of nonengrafting acute myeloid leukemia (AML

215 proliferation, and self-renewal signals for engraftment of normal and malignant blood cells.

216 Successful engraftment of organ transplants has traditionally relie

217 form mature pancreatic endocrine cells after engraftment of PDX1(+)/NKX6.1(+) pancreatic progenitors

218 , and find that in AML, TRC105 prevented the engraftment of primary AML blasts and inhibited leukemia

219 Furthermore, engraftment of primary FLT3/ITD(+) patient samples is re

220 CD93 expression is functionally required for engraftment of primary human AML LSCs and leukemogenesis

221 herefore, allow for accelerated and superior engraftment of primary patient-derived acute myeloid leu

222 Notably, treatment with UC-961 inhibited engraftment of ROR1+ leukemia cells in immune-competent

223 Engraftment of SA CMCs was negligible, which implies a p

224 croenvironment, and they enable only limited engraftment of samples from some human malignancies.

225 microbiota rapidly diversified, with durable engraftment of spores and no outgrowth of non-spore-form

226 Engraftment of the human cellular immune system appeared

227 Stimulation of LTbetaR augmented the engraftment of therapeutically injected ADSCs, which was

228 elial growth factor (VEGF) enhances vascular engraftment of transplanted cells but the efficacy is lo

229 preconditioning of the host liver to enhance engraftment of transplanted hepatocytes.

230 The engraftment of transplants was tracked over time, illust

231 R) signaling promotes homing to BM and early engraftment of UCB CD34(+) cells.

232 Successful engraftments of JMML primary samples were also achieved

233 Aspergillus fumigatus M-CSF treatment during engraftment or after infection efficiently protected fro

234 e functional improvements, such as increased engraftment or survival of transplanted cells.

235 wed that, while MLVs did not affect cellular engraftment or survival, they did inhibit OL differentia

236 ct risk for chronic GVHD, hematopoietic cell engraftment, overall mortality, or nonrelapse mortality.

237 Tumour engraftment permits dynamic imaging of neovascularizatio

238 in combination with CD34 expression revealed engraftment potential of GPR56(+)cells in both the CD34(

239 -deficiency (decreased HSPC numbers, reduced engraftment potential of HSPC, and Mitomycin C (MMC) -se

240 liferation, cytokine-directed migration, and engraftment potential of MEC1 cells in immune-deficient

241 (Hi) HSC fraction demonstrates no observable engraftment potential, but directly matures into megakar

242 on, these cells lacked hematopoietic in vivo engraftment potential.

243 The engraftment procedure takes less than 5 minutes, shows e

244 ults suggested that day 20 CMs had very high engraftment, proliferation, and therapeutic potential in

245 or T cell expansion, localization, and novel engraftment protocols.

246 culture bioassays as surrogates for in vivo engraftment quality.

247 a sufficient amount of cells due to the low engraftment rate after transplantation.

248 Despite high engraftment rates and attenuated disease progression (ch

249 transient reduction in EPO with encouraging engraftment rates and kinetics.

250 Poor survival and vascular engraftment rates of transplanted cells force them to wo

251 obilized cells achieving superior short-term engraftment rates, with similar numbers of CD34+ cells t

252 after initial differentiation by tracing the engraftment ratio (ER) using in vivo bioluminescence ima

253 EC differentiation, capillary engraftment, reduced capillary permeability, and re-esta

254 whereas the receptivity of the thymus to TEC engraftment remains relatively constant with age.

255 B1 mutant HSCs leads to persistent long-term engraftment restricted to myeloid lineage.

256 tive molecule identified by this competitive engraftment screening was cardiotrophin-1, a member of t

257 ng, estimation of HUVEC retention within the engraftment site 4 hr post-administration was 24.5 +/- 3

258 A heterotopic kidney engraftment site was used for comparison to immune activ

259 dial recovery; however, low efficacy of cell engraftment still limits therapeutic benefit.

260 Here, we developed an engraftment strategy to examine age-associated human isl

261 requires a large number of islets to achieve engraftment success and diabetes reversal, due to hypoxi

262 ory distress syndrome cases met criteria for engraftment syndrome and 15 for diffuse alveolar hemorrh

263 For successful donor-HSC engraftment, the niche must be emptied via myeloablative

264 To promote cell engraftment through impairments in native KC, recipients

265 glandin E2 (PGE2) stimulates HSC renewal and engraftment through, for example, induction of the cAMP

266 ineered fibers showed enhanced potential for engraftment, tissue regeneration and self-renewal after

267 Transplacental maternal engraftment (TME), the presence of maternal T cells in p

268 operties of MLL-AF9 cells and promoted their engraftment to bone marrow.

269 Tumor engraftment to lung was impaired in CXCR3(-/-) mice, and

270 unction in vitro but does improve CAR T-cell engraftment, tumor clearance, and survival in human xeno

271 Selective bone marrow (BM) engraftment using marrow protective strategies are curre

272 al GvHD, and stable, disease-free full donor engraftment using reduced intensity conditioning and mob

273 The median time to platelet engraftment was 27 days.

274 Engraftment was assessed by flow cytometry.

275 Engraftment was assessed in vivo and histologically by t

276 Colonization with these groups at engraftment was associated with a 60% lower risk of CDI,

277 AH1206 engraftment was associated with low abundance of residen

278 ke in dsDNA production around day +14 during engraftment was associated with subsequent TA-TMA develo

279 Results Engraftment was comparable between both groups.

280 dult hepatocytes were then transplanted, and engraftment was compared between embolized (n = 19) and

281 a murine model of metastatic-like melanoma, engraftment was coordinate with CXCR3(+) monocyte/macrop

282 tes failed to provide a robust tool, because engraftment was dependent on mice strain and cell line s

283 Engraftment was durable in the majority of chimeras and

284 However, cell engraftment was not correlated with functional improveme

285 e release syndrome nor delayed hematopoietic engraftment was observed in either trial.

286 CNS engraftment was seen in 23 of 29 diagnostic samples (79%

287 n these conditions, transplanted hepatocytes engraftment was significantly higher than that in contro

288 After tumor engraftment, we observed systemic activation of the comp

289 Median times to neutrophil and platelet engraftment were 17 (IQR, 15-35) and 16 (IQR, 13-50) day

290 collected from adult recipients allo-HSCT at engraftment were analyzed; 16S ribosomal RNA genes were

291 Similar levels of engraftment were seen upon serial transplantation of hum

292 s-mediated chemotaxis, homing, and long-term engraftment when these cells were transplanted into prim

293 cal cord blood stem cells that promote rapid engraftment while maintaining capacity for long-term hem

294 urther demonstrated successful hematopoietic engraftment with a normal human donor to model allogenei

295 em cell factor (huNSG) mice exhibited robust engraftment with functional human T and B lymphocytes an

296 Local engraftment with MCs protected Sash mice from exacerbate

297 Bioluminescence imaging showed stable engraftment with no significant cell loss between week 2

298 All the patients had gene-marked cells after engraftment, with no evidence of preferential integratio

299 erism) and reproducible myeloid and lymphoid engraftment, with T cells arising 12 wk after transplant

300 use bone marrow niche and afforded donor-HSC engraftment without chemoirradiative myeloablation.