ライフサイエンスコーパス: engrail

1 ntegrin-perturbed embryos (orthodenticle and engrailed).

2 s in the expression of dpp, Distal-less, and Engrailed.

3 development, including the selector protein Engrailed.

4 thorax play essential roles in repression by Engrailed.

5 Gal4 or the repressor domain from Drosophila Engrailed.

6 sted these two models at the PcG target gene engrailed.

7 s not determine the transcriptional state of engrailed.

8 erichia coli AraC or Drosophila melanogaster engrailed.

9 g the mdFP into two microdomains, defined by engrailed 1 (En1) and developing brain homeobox 1 (Dbx1)

10 We identify engrailed 1 (En1) as a necessary regulator of cell movem

11 Along the dorsal/ventral axis, loss of engrailed 1 (En1) expression in the non-ridge ectoderm o

12 res the function of the transcription factor Engrailed 1 (EN1) in the ventral ectoderm.

13 Here, we show that the homeoprotein engrailed 1 (EN1) is expressed during embryonic and peri

14 at the neural-specific transcription factor, Engrailed 1 (EN1), is exclusively overexpressed in these

15 ly step in Renshaw cell development, whereas Engrailed 1 (En1), which is genetically downstream of Pa

16 regulate the expression of Nurr1 (Nr4a2) and engrailed 1 in immature neurons and the expression of ar

17 uronal precursors into dopaminergic neurons (Engrailed 1) and for the oligodendrocyte fate acquisitio

18 ery early stage of development using an En1 (engrailed 1) promoter-driven cre recombinase gene.

19 regulates the 5-HT neuron maturation factor Engrailed 1, which suggests Pet-1 orchestrates maturatio

20 uture development, potentially by regulating engrailed 1, which was previously shown to be critical f

21 Moreover, in engrailed 1/2 mutants with shorter folia, clone cell num

22 Investigation of Engrailed-1 (En1) expression in the AER of limb buds in

23 eart myoblast induction can be visualized by engrailed-1 (en1) staining in anterior trunk somites, wh

24 scription factors, including Pax2, Pax5, and engrailed-1 (En1), measurements of DA release, the prese

25 Heterozygosity for Engrailed-1 (En1), one of the key factors for programmin

26 We conclude that Engrailed-1 expression marks a class of inhibitory inter

27 detect lateral fin folds in dogfish embryos, Engrailed-1 expression suggests that the body is compart

28 We found that Engrailed-1 expression uniquely marks a class of ascendi

29 n part from Snf2l compensation that restores Engrailed-1 expression.

30 urons and postsynaptic cells reveal that the Engrailed-1 neurons produce monosynaptic, strychnine-sen

31 ol of either the dopamine transporter or the engrailed-1 promoters, we generated mice with the condit

32 pecifically express the transcription factor engrailed-1, a property that permits genetic labeling of

33 ouse studies, including Nurr1, Pitx3, Lmx1b, Engrailed-1, and Engrailed-2.

34 is revealed more abundant messages for FGF8, engrailed-1, and erythropoietin in lowered O(2).

35 The mouse homeodomain protein, Engrailed-1, is generally viewed as an essential player

36 Individual Engrailed-1-positive cells are multifunctional, playing

37 2 expression apparent only in the absence of Engrailed-1.

38 in the homeodomain transcription factor gene ENGRAILED 2 (EN2) are significantly associated with auti

39 ENGRAILED 2 (En2), a homeobox transcription factor, func

40 tent with the homeobox transcription factor, ENGRAILED 2 (EN2), being an ASD susceptibility gene.

41 We show that JARID1d and Ring6a occupy human Engrailed 2 gene and regulate its expression and H3K4 me

42 zed the conformational properties of chicken Engrailed 2 homeodomain (En2HD) in aqueous solution and

43 ential role of the homeobox-containing gene, Engrailed-2 (En-2), in the mouse, which is specifically

44 the homeobox-containing transcription factor Engrailed-2 (En2) as a candidate gene for autism spectru

45 c and mouse behavioral analyses suggest that ENGRAILED-2 (EN2) contributes to neurodevelopmental diso

46 Engrailed-2 and ephrin-As, normally in posterior > anter

47 oral and/or spatial change in the pattern of Engrailed-2 expression apparent only in the absence of E

48 Significantly, no change in the Engrailed-2 mutant phenotype occurs after a similar back

49 and/or enhanced expression of a target gene, engrailed-2, in a Xenopus embryo assay.

50 luding Nurr1, Pitx3, Lmx1b, Engrailed-1, and Engrailed-2.

51 ression of the mid/hindbrain boundary marker engrailed-2.

52 d induction of the midbrain/hindbrain marker engrailed-2.

53 , and we demonstrate that it regulates human Engrailed, a homeodomain protein that regulates neuronal

54 th the same transcription factors, including Engrailed and C15, to provide these proteins with maxima

55 proteins are required for gene silencing of engrailed and CD4, respectively.

56 s activity of the transcriptional regulators Engrailed and Dachshund.

57 g pancreatic development, we expressed Gata4-Engrailed and Gata6-Engrailed dominant repressor fusion

58 ns in developing zebrafish that also express engrailed and have very similar anatomy and functions.

59 The runt gene is expressed in AMG, represses engrailed and maintains AMG gene expression.

60 For example, the Drosophila genes engrailed and orthodenticle and the onychophoran gene Ul

61 Detailed analysis of engrailed and pair-rule gene expression in various mutan

62 Our findings also suggest a link between engrailed and Parkinson's disease.

63 lusive interactions between the filopodia of engrailed and patched cells.

64 lusive stripes within each segment using the engrailed and patched promoters.

65 dence for this model has been limited to the engrailed and sox family of developmental regulators, an

66 ed three genes from Pristina, one homolog of engrailed and two homologs of orthodenticle, and charact

67 overexpression of the wingless target genes engrailed and Ultrabithorax.

68 The adjacent expression of the engrailed and wingless stripes suggests that the regulat

69 val of imaginal cells, and the expression of engrailed and wingless.

70 signalling at the anterior of the domains of engrailed (and hedgehog) expression represses groove for

71 bryos, both cofactors interact directly with Engrailed, and both stimulate repression by Engrailed in

72 0 potential direct targets of Atro including engrailed, and components of the Dpp and Notch signaling

73 tribute constituents to the pathway-patched, engrailed, and hh.

74 txa, otxb, otxc, pax6, pax2/5/8a, pax2/5/8b, engrailed, and hox1) in Oikopleura dioica (Subphylum Uro

75 tergite borders and the dorsal expression of engrailed, and suggest that this association represents

76 on patterns of the genes even-skipped (eve), engrailed, and wingless in a centipede, Lithobius atkins

77 r representatives of this family, MATalpha2, engrailed, Antennapedia, and NK-2, and truncated forms o

78 In the centipede, the genes wingless and engrailed are expressed in stripes along the middle and

79 he partially disordered transcription factor Engrailed at 11 different frequencies.

80 ired and paired with respect to wingless and engrailed at the parasegment boundary is conserved betwe

81 Expression of GATA4-engrailed blocked GATA4- and GATA6-directed transcriptio

82 fused to the repressor domain of Drosophila engrailed blocked neural crest formation, thereby mimick

83 ey intermediate in the initial activation of engrailed by Eve in odd-numbered parasegments.

84 mutant combinations shows how eve activates engrailed by repressing these engrailed repressors, and

85 In addition, engrailed can direct midline glia to a PMG-like non-ensh

86 Regulatory DNA from the Drosophila gene engrailed causes silencing of a linked reporter gene (mi

87 When Wingless is misexpressed in engrailed cells in hedgehog heterozygous mutant embryos,

88 ur well prior to the expression of the leech engrailed-class gene in the N lineage.

89 Our study suggests that an ;engrailed code' is integral to partitioning the tectum a

90 Using time-controlled activation of Engrailed combined with tools that block its transfer, w

91 e of binding tightly and specifically to the engrailed consensus sequence, TAATTA.

92 e used to confirm that the segmentation gene engrailed contains paused Pol II as seen for heat-shock

93 ed, Serrate, dpp) and transcription factors (engrailed, dead ringer).

94 We then searched for the engrailed-dependent agent responsible for these repellen

95 ment, we expressed Gata4-Engrailed and Gata6-Engrailed dominant repressor fusion proteins in the panc

96 elial cell development, we expressed a GATA6-Engrailed dominant-negative fusion protein in the distal

97 the correspondence between the expression of engrailed during late embryonic to postembryonic stages,

98 es, oenocytes are induced from a Spalt major/Engrailed ectodermal zone by MAPK signaling.

99 Conversely, the majority of transgenic Gata4-Engrailed embryos do not have a pancreatic phenotype.

100 At e17.5, transgenic Gata6-Engrailed embryos exhibit two distinct phenotypes: a com

101 ter, which express the transcription factors Engrailed (En) and Invected (Inv), form mixed electrical

102 dic expression of the segment polarity genes engrailed (en) and wingless (wg) via regulation of secon

103 Even skipped (Eve) and Engrailed (En) are homeodomain-containing transcriptiona

104 The transcription factor Engrailed (En) controls axon pathfinding and synaptic ta

105 The transcription factor Engrailed (En) controls the topography of axonal project

106 istent with a role for Draf in regulation of engrailed (en) expression in imaginal discs.

107 nymphs and is attributed to an alteration in engrailed (en) expression.

108 he posterior border of slp stripes, allowing engrailed (en) gene expression to be initiated in odd-nu

109 male and female mice, we tested whether the Engrailed (En) homeobox genes are a common genetic subst

110 We have identified the Engrailed (En) homeobox genes as being crucial to produc

111 The engrailed (En) homeobox transcription factors are candid

112 ression pattern of the segment polarity gene engrailed (en) in a basal annelid, the polychaete Chaeto

113 nes decapentaplegic (dpp), patched (ptc) and engrailed (en) in a dose-responsive manner.

114 he Drosophila melanogaster segmentation gene engrailed (en) in odd-numbered parasegments and is assoc

115 Analysis of constitutive Engrailed (En) null mice previously implicated the two E

116 Engrailed (En) protein expression in neurons of the meso

117 find that H is important for maintenance of engrailed (en) repression as was previously demonstrated

118 g either the establishment or maintenance of engrailed (en) repression by Runt.

119 compartments based on the expression of the engrailed (en) segmentation gene.

120 ipes within the Ftz domain, but posterior to engrailed (en) stripes, suggesting a parasegmental borde

121 Genetic analysis shows that Engrailed (En), a homeodomain-containing transcription f

122 gues of the arthropod segment polarity genes engrailed (en), hedgehog (hh), and wingless (wg/Wnt1) in

123 the expression of four key patterning genes, engrailed (en), hedgehog (hh), patched (ptc), and optomo

124 combination with the posterior selector gene engrailed (en), represses dally expression in the poster

125 Engrailed (En), the best-characterized Ftz/Ftz-F1 downst

126 th the promoter regions of wingless (wg) and engrailed (en), two other pivotal targets of the pair-ru

127 ain expression of the segment polarity genes engrailed (en), wingless (wg), and hedgehog (hh), contri

128 the segment-polarity genes wingless (wg) and engrailed (en).

129 g of the Wg signaling source anterior to the Engrailed (En)/Hedgehog (Hh) domain.

130 Here we show that engrailed enhancers can act over large distances, even s

131 Third, the long-distance action of engrailed enhancers requires a combination of the engrai

132 engrailed exists in a gene complex with invected, which

133 s was blocked with a dominant-negative GATA4-engrailed-expressing adenovirus.

134 Then, the engrailed-expressing cells flanking the boundary undergo

135 uble segment periodicity, but shortly before engrailed expression and overt segmentation, the interca

136 dentities: cells expressing engrailed induce engrailed expression in neighbor cells.

137 Both intercellular signaling and engrailed expression play an important role in the segme

138 By using Engrailed expression to monitor dorsal ridge development

139 even skipped coding region can rescue normal engrailed expression, as well as all other aspects of se

140 le segment periodicity: segmental stripes of engrailed expression, which mark the posterior of each s

141 JNK signaling, induces this misregulation of engrailed expression.

142 form at the posterior edge of each stripe of engrailed expression.

143 ht, at least 14-16 hours before the onset of engrailed expression.

144 We suggest a model in which Engrailed, Extradenticle and Homothorax function as a co

145 Homeoproteins of the Engrailed family are involved in the patterning of mesen

146 er for the expression of the Wnt target gene engrailed, for subsequent midbrain-hindbrain boundary fo

147 Engrailed-FoxD3, but not VP16-FoxD3, was identical to na

148 ), we tested the activities of each of these engrailed fragments in a construct designed to detect PR

149 ransfection of a construct expressing GATA-6-engrailed fusion protein inhibited basal expression of t

150 In addition, a Tead2-Engrailed fusion protein is able to repress retinoic aci

151 t-negative (DN) allele of Lef1, or of a Lef1-engrailed fusion protein, led to the inhibition of expre

152 an electroporation construct encoding a Pax3-Engrailed fusion protein, which represses Pax3 target ge

153 ctivating (Vp16 fusion) or trans-repressing (engrailed fusion) forms of Meis1 to define its biochemic

154 Engrailed-GAL4 directed expression causes loss of the wi

155 the 2 kb PRE fragment within the endogenous engrailed gene causes a loss-of-function phenotype, show

156 iptional repression module of the Drosophila Engrailed gene in order to perturb gene function.

157 The engrailed gene is expressed in PMG, represses runt and m

158 this 2 kb fragment in the regulation of the engrailed gene itself.

159 t cell progeny that are known to express the engrailed gene, or their lineal precursors.

160 activity of a 181 bp PRE from the Drosophila engrailed gene.

161 The engrailed genes (En1 and En2) are expressed in all cereb

162 These findings show that the engrailed genes are expressed by midbrain dopaminergic n

163 However, the engrailed genes control the survival of midbrain dopamin

164 Expression of engrailed genes in a subset of 5HT neurons in the rostra

165 ted a continued and species specific role of Engrailed genes in MbDA neuron development.

166 The mouse Engrailed genes, En1 and En2, play an important role in

167 /Hes/Runx) and internal eh1 motifs (FxIxxIL; Engrailed/Goosecoid/Pax/Nkx).

168 n patterns of segment polarity genes such as engrailed have been shown to be similar in Drosophila me

169 Remarkably, the consensus-HD binds the engrailed-HD cognate DNA in a similar mode as the engrai

170 higher than that of the naturally occurring engrailed-HD from Drosophila melanogaster.

171 iled-HD cognate DNA in a similar mode as the engrailed-HD with approximately 100-fold higher affinity

172 report that primary segment polarity genes (engrailed, hedgehog and wingless) are not involved in sp

173 s, several segment polarity genes (wingless, engrailed, hedgehog, and patched) are required for the p

174 domain proteins: Rd-apocytochrome b(562) and engrailed homeo domain.

175 than that at 20% O(2), whereas EN1 (encoding engrailed homeobox 1) expression is enhanced fivefold.

176 ed are the B domain of protein A (1BDC), the Engrailed Homeodomain (1ENH), the peripheral sub-unit-bi

177 We have studied the denatured state of Engrailed Homeodomain (En-HD) under mildly and strongly

178 lations of a three helix bundle protein, the engrailed homeodomain (En-HD), which folds via the diffu

179 interface is engineered onto the Drosophila Engrailed homeodomain (ENH), allowing the dimerized prot

180 amino-acid fragment of the monomeric protein engrailed homeodomain (ENH), we had instead generated a

181 The Engrailed Homeodomain (EnHD) transcription factor of Dro

182 lar dynamics simulations of 32 copies of the Engrailed homeodomain (EnHD), an ultrafast-folding and -

183 Mutants of engrailed homeodomain (HD) that retain DNA-binding activ

184 e results together with our earlier study of Engrailed Homeodomain and recent experimental studies pr

185 omprising helices alpha2 and alpha3 from the engrailed homeodomain and the consensus EF-hand Ca-bindi

186 second-time scale-folding simulations of the engrailed homeodomain and to observe thousands of comple

187 Sequence designs using engrailed homeodomain as a scaffold produced similar res

188 rystal structure of a complex containing the engrailed homeodomain Gln50 --> Ala variant (QA50) bound

189 The ultrafast folding pathway of the engrailed homeodomain has been exceptionally well charac

190 on (PrP) octarepeat Cu-binding site into the engrailed homeodomain helix-turn-helix motif (HTH).

191 C2 symmetry based on a monomeric Drosophila engrailed homeodomain scaffold.

192 gineered a mutant of Drosophila melanogaster Engrailed homeodomain that folds and unfolds reversibly

193 mulations of C(2)H(2) zinc fingers (ZFs) and engrailed homeodomain transcription factors (TFs), we sh

194 We have investigated in mice the role of the engrailed homeodomain transcription factors, En-1 and En

195 mentally constructing and analyzing a set of engrailed homeodomain variants whose binary patterns wer

196 sults for the folding time of protein A, the Engrailed Homeodomain, and 1EBD C-chain are in agreement

197 These methods are applied to the engrailed homeodomain.

198 lation results on the folding pathway of the engrailed homeodomain.

199 cid residue protein, Drosophila melanogaster engrailed homeodomain.

200 structure in the denatured ensemble, as with engrailed homeodomain.

201 ng pathway of the three-helix bundle protein Engrailed homeodomain.

202 a set of designed variants of the Drosophila engrailed homeodomain.

203 ermining the affinity and specificity of the engrailed homeodomain.

204 rite outgrowth as well as regulate the human engrailed homeotic genes, important regulators of brain

205 erved homeodomain, Nkx6 also has a candidate Engrailed homology 1 (Eh1) domain that is conserved amon

206 F-interacting regions was the tinman (TN) or engrailed homology-1 motif (EH-1), residues 29-35 (FLIQD

207 es of complementary repression strategies in engrailed homology-1 motif-containing homeodomain factor

208 Engrailed, and both stimulate repression by Engrailed in cultured cells.

209 rt activity, levels of Wg targets (including Engrailed in embryos lacking maternal and zygotic srt, a

210 ; it is required in both insects to activate engrailed in odd-numbered parasegments and wingless (wg)

211 about the dorsoventral expression domains of engrailed in the trunk of exceptionally preserved trilob

212 Hedgehog and Lethal of scute activate Engrailed in these anterior cells.

213 ion of new cell identities: cells expressing engrailed induce engrailed expression in neighbor cells.

214 used to the repressor domain from Drosophila Engrailed inhibits posterior neural and neural crest gen

215 teins, including Engrailed, we asked whether Engrailed intercellular transfer was also involved in br

216 ern of three genes, sine oculis, period, and engrailed into the lineage atlas.

217 cluding butterfly homologs of the Drosophila Engrailed/Invected and Spalt proteins, that are deployed

218 teins and expressing them specifically where engrailed is "ON" or "OFF", we determined that component

219 Engrailed is a key transcriptional regulator in the nerv

220 for Eve function suggest that activation of engrailed is indirect, but these models have not been fu

221 s, expression of the posterior selector gene engrailed is silenced through an autoregulatory silencin

222 are bound to an engrailed PRE in cells where engrailed is transcribed.

223 , disruption of the Pbx-interacting motif in Engrailed, known to strongly reduce the gain-of-function

224 When the engrailed-LMO4 fusion protein was expressed under contro

225 in mammary gland development, we created an engrailed-LMO4 fusion protein.

226 cer-promoter communication at the Drosophila engrailed locus.

227 y the enhancer-promoter communication at the engrailed locus.

228 We find that high levels of Engrailed make the epidermal cells inhospitable to brist

229 Engrailed-mediated active repression, antisense oligonuc

230 Surprisingly, Vp16-Meis1 (but not engrailed-Meis1) functioned as an autonomous oncoprotein

231 In addition, Engrailed must be expressed at the anterior side of each

232 Thus, two signaling pathways and runt-engrailed mutual repression initiate and maintain two di

233 positive (of interneuronal fate); and one is Engrailed negative (of efferent fate).

234 Engrailed-negative midline cells develop into unpaired m

235 n the expression of developmental genes like engrailed or cubitus interruptus.

236 phalic-mesencephalic boundary (DMB) requires Engrailed paracrine activity.

237 Two transcription factor genes, runt and engrailed, play important roles in AMG and PMG developme

238 oding the Pmar1 factor, and mRNA encoding an Engrailed-Pmar1 (En-Pmar1) repressor domain fusion.

239 ons that counteract silencing mediated by an engrailed Polycomb-group response element.

240 duces two neurons of asymmetric type: one is Engrailed positive (of interneuronal fate); and one is E

241 Engrailed-positive midline cells develop into ventral un

242 The repressive action of the engrailed PRE can also act over a distance.

243 ajor PcG protein complexes are present at an engrailed PRE in both the "ON" and "OFF" transcriptional

244 xamined whether PcG proteins are bound to an engrailed PRE in cells where engrailed is transcribed.

245 Our data are consistent with the model that engrailed PREs bring chromatin together, allowing both p

246 ly member Spps binds specifically to Ubx and engrailed PREs, and that Spps binds to polytene chromoso

247 iled enhancers requires a combination of the engrailed promoter and sequences within or closely linke

248 agments can facilitate the activation of the engrailed promoter by distant enhancers.

249 2.4 kb to -395 bp upstream of the Drosophila engrailed promoter contains a multipartite PRE that can

250 over other transcription units, choosing the engrailed promoter over those of neighboring genes.

251 property is similar to that reported for the engrailed promoter.

252 ed by the repressor domain of the Drosophila Engrailed protein (En(r)).

253 Here, we alter the amount of Engrailed protein and manipulate the Hedgehog signalling

254 ining the repressor domain of the Drosophila Engrailed protein induces partial oncogenic transformati

255 structure of an altered specificity mutant, Engrailed Q50K (EnQ50K).

256 d-expressing cell that we observe within the engrailed region of segments A1-A5, and provide evidence

257 on of GATA4 to the transcriptional repressor engrailed repressed expression of Vascular Endothelial G

258 ction of RNA encoding SOX3DeltaC-EnR, a SOX3-engrailed repression domain chimera.

259 Inhibition of Xlim5 function using an Engrailed repressor construct or a morpholino oligonucle

260 ve allele of RaxL comprising a fusion of the engrailed repressor domain and a region of RaxL (EnRaxLD

261 ithelium of a fusion protein composed of the Engrailed repressor domain and the Erm DNA-binding domai

262 A chimeric protein consisting only of the Engrailed repressor domain and the Even-skipped homeodom

263 into dominant repressors by construction of Engrailed repressor domain fusions; (3) ectopic expressi

264 pression of foxD5a constructs fused with the engrailed repressor domain or with the VP16 activation d

265 omprised of Neptune's DBD and the Drosophila engrailed repressor domain suppresses the induction of g

266 imeric protein containing the Eve HD and the Engrailed repressor domain.

267 We fused the VP16 activation and Engrailed repressor domains to both So and Optix, and at

268 Like native Gsc, ventral injection of an Engrailed repressor fusion (Eng-Gsc) induced a partial a

269 plasmic domain of cadherin or a beta-catenin-engrailed repressor fusion construct prevented endoderm

270 A dominant negative otx2-engrailed repressor fusion protein (otx2-En) ablates end

271 We find that expression of an HNF3beta-Engrailed repressor fusion protein induces ectopic axes

272 The Engrailed repressor fusion was found to mimic the effect

273 rs of hypertrophy, a dominant negative GATA4-engrailed repressor fusion-encoding adenovirus was gener

274 bition of dril1 by either a morpholino or an engrailed repressor-dril1 DNA binding domain fusion cons

275 the absence of endogenous Nkx2.2, the Nkx2.2-Engrailed-repressor derivative is sufficient to fully re

276 eve activates engrailed by repressing these engrailed repressors, and further indicates that mutual

277 Stabilization of the normally unstable engrailed RNA and protein preserved the localized stripe

278 In contrast, engrailed RNAi in Oncopeltus produces cuticular and appe

279 borders required for expression of the first engrailed stripe and the formation of the mandibular seg

280 First, early acting engrailed stripe enhancers exhibit promoter specificity.

281 for the fusion step, but is dispensable for Engrailed stripe extension.

282 ateral extension of the maxillary and labial Engrailed stripes (posterior compartments) during dorsal

283 thers lack the even-numbered (ftz-dependent) engrailed stripes and show strong ftz-like segmentation

284 e even skipped (eve) is required to activate engrailed stripes and to organize odd-numbered parasegme

285 embryo, even skipped is required to activate engrailed stripes and to organize odd-numbered parasegme

286 or activation of both odd- and even-numbered engrailed stripes.

287 nterneurons express the transcription factor engrailed, supporting a probable homology with interneur

288 Homothorax function as a complex to repress Engrailed target genes.

289 domain has homology to a repression motif in Engrailed - the eh1 motif.

290 emove either of them abrogate the ability of Engrailed to repress its target genes in embryos, both c

291 ent segmentation proteins, Sloppy paired and Engrailed, to repress the Hox target gene Distalless in

292 ns alter the ability of CBTF122 fusions with engrailed transcription repressor and VP16 transcription

293 erization domain of NFI-A and the Drosophila engrailed transcriptional repression domain (NFIen) was

294 This effect was mimicked by an Iro3-Engrailed transcriptional repressor domain fusion, where

295 EnR-dlx3bhd mRNA; dlx3b homeodomain fused to Engrailed transcriptional repressor domain).

296 in-of-function phenotype, also downregulates Engrailed transfer, thus revealing an unsuspected partic

297 The distribution of motions in Engrailed varies smoothly along the protein sequence and

298 racrine activity of homeoproteins, including Engrailed, we asked whether Engrailed intercellular tran

299 eobox genes, such as SIX, LHX, PAX, DLX, and Engrailed, were highly methylated as well.

300 the expression of the segment polarity gene engrailed, which at embryonic and early postembryonic st