ライフサイエンスコーパス: enhanceosome

1 ene-specific activation complex known as an "enhanceosome".

2 ively to adjacent sites and form a bacterial enhanceosome.

3 at these factors may function together as an enhanceosome.

4 ay a role in the transcriptionally active mu enhanceosome.

5 ription factors in formation of the IFN-beta enhanceosome.

6 endogenous IFN-beta enhancers as part of the enhanceosome.

7 ctivation of transcription from the IFN beta enhanceosome.

8 YGO2, are constitutive components of the Wnt enhanceosome.

9 more distally involving the canonical CIITA enhanceosome.

10 n of beta-catenin, a co-activator of IFNbeta enhanceosome.

11 assembles a nucleoprotein complex termed MHC enhanceosome.

12 promoting the formation of a Foxp3-specific enhanceosome.

13 ater moved to the promoter to form the c-Rel enhanceosome.

14 main components of the human interferon-beta enhanceosome.

15 1 complex is part of the trichome initiation enhanceosome.

16 s the key DNA-binding component of the MHCII enhanceosome.

17 of the mammalian interferon-beta (IFN-beta) enhanceosome.

18 cific multiprotein complex, termed the MHCII enhanceosome.

19 oid X receptor from a distal RARE to form an enhanceosome.

20 as the recruitment of other proteins to the enhanceosome.

21 iated chromatin-modifying enzymes to form an enhanceosome.

22 ation and appears to recycle to maintain the enhanceosome.

23 otein complexes, leading to the formation of enhanceosomes.

24 or complexes forming secondary structures or enhanceosomes.

25 he regulated assembly and disassembly of the enhanceosome, a higher-order nucleoprotein complex forme

26 These are mediated by the Wnt enhanceosome, a multiprotein complex binding to the Pygo

27 Thus, in the context of the enhanceosome, acetylation of HMG I by CBP, but not by P/

28 HMGI(Y) by CBP at lysine-65 destabilizes the enhanceosome, acetylation of HMGI(Y) by PCAF/GCN5 at lys

29 romoters or activators, the natural IFN-beta enhanceosome activates transcription by causing a dramat

30 Here, we show that the IFN-beta enhanceosome activates transcription by directing the or

31 The enhanceosome activates transcription by recruiting the h

32 tracts fully restores the speed by which the enhanceosome activates transcription.

33 T cell enhanceosome activation of class I transcription is syne

34 is is the first description of an RA-induced enhanceosome and demonstrates that GABP and p300 are ess

35 We propose a model of stochastic enhanceosome and preinitiation complex formation that in

36 potentiates transcription by stabilizing the enhanceosome and preventing acetylation by CBP.

37 tion of CIITA through a disruption of MHC-II enhanceosome and relevant coactivator-transcription fact

38 I gene expression is enhanced by the T cell enhanceosome and results from a direct interaction of th

39 t least in part, to interactions between the enhanceosome and the transcriptional coactivator CREB, c

40 ed by the dynamic interplay between specific enhanceosomes and specific local chromatin structure.

41 The analysis favours a hybrid between "enhanceosome" and "smorgasbord" models of enhancer funct

42 Thus, AP-1 is part of the TonEBP/OREBP enhanceosome, and its role in high NaCl-induced activati

43 eg cell development is controlled by a c-Rel enhanceosome, and strategies targeting Rel-NF-kappaB can

44 IITA, the assembly of CIITA, NF-YB, and RFX5 enhanceosome, and the extent of H3 acetylation at the MH

45 Wnt-dependent docking of beta-catenin to the enhanceosome apparently causes a rearrangement that appo

46 ining half to assemble a complete picture of enhanceosome architecture in the vicinity of the DNA.

47 ivators, bind to Ealpha as part of an active enhanceosome assembled during pre-TCR signaling.

48 The presence of vIRF-3 in the enhanceosome assembled on the IFNA promoters increases b

49 ity complex class II (MHC-II) by stabilizing enhanceosome assembly at the proximal promoter.

50 Transcription factor (TF)-directed enhanceosome assembly constitutes a fundamental regulato

51 We find that enhanceosome assembly is hierarchically ordered with kin

52 IFN-beta gene activation via multifactorial enhanceosome assembly is potentiated in LPS-stimulated c

53 However, we show that completion of the enhanceosome assembly process requires protein-protein i

54 n accessible IFN-beta core promoter prior to enhanceosome assembly results in major changes in the ge

55 t a highly dynamic yet intrinsically ordered enhanceosome assembly to maintain the finely balanced tr

56 sential architectural component required for enhanceosome assembly, at distinct lysine residues, caus

57 Here, we demonstrate that the first step in enhanceosome assembly, i.e. HMG I(Y)-dependent recruitme

58 e HMG-I/Y protein, proposed as orchestrating enhanceosome assembly, interacts specifically with the P

59 different transcription factors required for enhanceosome assembly.

60 Y), the architectural component required for enhanceosome assembly.

61 th the p300 bromodomain, thereby stabilizing enhanceosome assembly.

62 ain regulates p300 recruitment or stabilizes enhanceosome assembly.

63 reshold set by architectural requirements of enhanceosome assembly.

64 Enhanceosomes bearing IRF-2 cannot activate transcriptio

65 cruitment of the CBP-PolII holoenzyme by the enhanceosome, because its depletion from the extract dec

66 r that participates in the formation of this enhanceosome, binding specifically to the positive regul

67 pts the association of CIITA with the MHC-II enhanceosome by binding to the components of the RFX com

68 tor interacts with the components of the EGF-enhanceosome (co-activators: glucocorticoid-receptor-int

69 r may involve the binding of a multi-protein enhanceosome complex at the CRX triplet and the PCE-1-li

70 sequent alteration of the composition of the enhanceosome complex binding to IFNA promoters in vivo,

71 s, these results suggest the existence of an enhanceosome complex comprised of p300 and multiple semi

72 es on the dynamic assembly of a multiprotein enhanceosome complex that is initiated by the activation

73 d histone acetyltransferase Ep300 to form an enhanceosome complex that promoted Gata2 expression.

74 -protein and protein-DNA contacts within the enhanceosome complex.

75 activation and recruitment of hnRNPA2 to the enhanceosome complex.

76 mily of factors contributing to the putative enhanceosome complex.

77 p300, and RNA polymerase II (Pol II) to form enhanceosome complexes that contain HIF1alpha, STAT3, CB

78 recruiting coactivators CBP and p300 to form enhanceosome complexes that contain HIF2alpha, USF2, CBP

79 rect interactions with a preassembled MHC-II enhanceosome consisting of cyclic AMP response element-b

80 ation of class I transcription by the T cell enhanceosome consisting of Runx1, CBFbeta, and LEF1.

81 such as TCR genes, are regulated by a T cell enhanceosome consisting of RUNX1, CBFbeta, LEF1, and Aly

82 virus infection requires the assembly of an enhanceosome, consisting of the transcriptional activato

83 virus infection requires the assembly of an enhanceosome, consisting of the transcriptional activato

84 This enhanceosome contained c-Rel, p65, NFAT, Smad, and CREB.

85 beta (IFN-beta) gene requires assembly of an enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NF

86 beta (IFN-beta) gene requires assembly of an enhanceosome containing the transcription factors ATF-2/

87 1 and -2 mediate cooperative formation of an enhanceosome containing ZEBRA and cellular Sp1.

88 Furthermore, the enhanceosome contains c-Jun/c-Fos and OCT-1 constitutive

89 co-repressor, and also to the Chip/LDB1-SSDP enhanceosome core complex via an evolutionary conserved

90 the activation domains in the context of the enhanceosome decreases both recruitment of CBP and trans

91 iments showed that the formation of a stable enhanceosome-dependent preinitiation complex require coo

92 presence of a domain in IRF-2 that prevents enhanceosome-dependent recruitment of the CBP-Pol II hol

93 Here, we investigate the mechanisms of enhanceosome-dependent transcriptional synergy during pr

94 of HMG I by CBP, but not by P/CAF, leads to enhanceosome destabilization and disassembly.

95 STAT3-dependent, glucocorticoid-supplemented enhanceosome for the alpha2-macroglobulin (alpha2-M) gen

96 binding to the cyclin D1 promoter led to an enhanceosome formation and facilitated cyclin D1 express

97 transactivator (CIITA), which is crucial for enhanceosome formation and gene activation.

98 A dominant negative p300 construct disrupts enhanceosome formation and reduces the RA responsiveness

99 t emerged from studying how HMGB1 stimulates enhanceosome formation by the Epstein-Barr viral activat

100 RFX is capable of mediating enhanceosome formation on a methylated promoter, thereby

101 itectural transcription factors facilitating enhanceosome formation on a variety of mammalian promote

102 exhibited a weaker binding to STAT3, and the enhanceosome formation on the socs3 promoter was inhibit

103 bility group protein I(Y) in interferon beta enhanceosome formation remains elusive.

104 and an alternative model of IFNgamma-driven enhanceosome formation that may allow for other adaptors

105 noise originate from the complexity of IFNB1 enhanceosome formation, which leads to a range up to man

106 s suggests that nuclear cFLIPL prevents IRF3 enhanceosome formation.

107 n factors, is often critical for stabilizing enhanceosomes formed from trans-acting proteins separate

108 Assembly of interferon-beta enhanceosome from its individual protein components and

109 Multi-protein assemblages known as enhanceosomes govern gene expression by local committee

110 e insights into the assembly of the IFN-beta enhanceosome in mammals.

111 ression and recruitment of E2A to the Ealpha enhanceosome in T cells.

112 coactivators (p160 members and CBP) form an enhanceosome in the enhancer region of the hSP-B gene.

113 These studies reveal a unique role of enhanceosomes in the cooperative assembly of the transcr

114 A-binding proteins associated with the CIITA enhanceosome including RFX, CREB1/ATF1 and NFY.

115 thin an additional 30 min of the established enhanceosome indicates that renewal of STAT3 and GR bind

116 veral transcriptional components of the Ucp1 enhanceosome interact synergistically to achieve large d

117 For example, the Wnt enhanceosome is a multiprotein complex associated with W

118 emonstrate that once assembled, the IFN-beta enhanceosome is an unusually stable nucleoprotein struct

119 The enhanceosome is assembled in the nucleosome-free enhance

120 show that the stereospecific assembly of the enhanceosome is critical for the efficient recruitment o

121 Furthermore, the formation of this enhanceosome is dependent on inducer-specific helical ph

122 ce that recruitment of the holoenzyme by the enhanceosome is due, at least in part, to interactions b

123 cells by M. tuberculosis a unique TNF-alpha enhanceosome is formed, and it is distinct from the TNF-

124 n vitro assembled human interferon-beta gene enhanceosome is highly synergistic.

125 that the inducer-specific assembly of unique enhanceosomes is a general mechanism by which a single g

126 factors (TFs) at the composite DNA element (enhanceosome), is central for amplification of weak acti

127 complex, however, stimulates assembly of the enhanceosome itself such that the entire reaction can oc

128 onstrate NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of bfl-

129 olled during early mouse embryogenesis by an enhanceosome-like control region, termed the early enhan

130 dependent on one another and function in an enhanceosome-like manner.

131 00 assembles at the IL-2 promoter to form an enhanceosome-like signal transduction target that is cen

132 The Mif2p dimer seems to be part of an enhanceosome-like structure that nucleates kinetochore a

133 nowledge, this is the first demonstration of enhanceosome-mediated regulation of a cell death inhibit

134 p19 promoter, and propose a c-Rel-dependent enhanceosome model for p19 gene activation.

135 ected alveolar epithelial cells supports the enhanceosome model for RANTES gene transcription, which

136 r interaction with DNA that conforms to the 'enhanceosome' model, and furthermore identify associatio

137 HnRNP A2 associates with the enhanceosome, mostly through protein-protein interaction

138 Consistently, the HLA class I specific enhanceosome (NLRC5) and related transcription factors,

139 The time course of enhanceosome occupation by GR and tyrosine-phosphorylate

140 Run-on transcription shows a lag after full enhanceosome occupation that can be largely but not comp

141 lassical and nonclassical monocytes defining enhanceosomes of the 2 major subsets.

142 e how these factors interact to form the Wnt enhanceosome, primed for Wnt responses by Pygo.

143 between STAT3 and retinoid nuclear receptor enhanceosome proteins in pulmonary epithelial cells.

144 First, the enhanceosome recruits the SWI/SNF chromatin-remodeling c

145 We demonstrate that the IFN-beta enhanceosome region is not sufficient for maximal gene i

146 The enhanceosome remains assembled for approximately 90 min

147 Assembly of enhanceosomes requires architectural proteins to facilit

148 ate that this synergy, in the context of the enhanceosome, requires a new protein-protein interaction

149 anscription factors are key components of an enhanceosome responsible for activating SCL transcriptio

150 As a consequence, IRF-2 incorporation into enhanceosomes restricts the number of IFN-beta promoters

151 Analyses of the in vitro assembled enhanceosome revealed that the transcriptional synergy i

152 age and signal-responsive factors, including enhanceosome switch-off by Notch.

153 t for the assembly of an ER-stress-inducible enhanceosome that activates CHOP gene expression in resp

154 Ealpha is considered an archetypical enhanceosome that acts through the functional synergy an

155 ting that DEK is part of a tissue-restricted enhanceosome that contains BMP4-dependent and -independe

156 ormed, and it is distinct from the TNF-alpha enhanceosome that forms in T cells stimulated by antigen

157 refore function as part of a hypoxia-induced enhanceosome that helps to promote transcription of COX-

158 jun, are well-characterized components of an enhanceosome that mediates virus induction of the human

159 hypothesize that a multiprotein complex--an enhanceosome--that includes GABP, other transcription fa

160 Here we report that within the IFN-beta enhanceosome the ATF-2-c-jun heterodimer binds in a spec

161 on in B cells is known to involve the B cell enhanceosome, the molecular basis for high constitutive

162 require cooperative interactions between the enhanceosome; the general transcription factors TFID, TF

163 This enhanceosome then recruits transcription factor IIA (TFI

164 host immune system by disrupting the MHC-II enhanceosome through binding with RFX transcription fact

165 To examine the relative prevalence of the 'enhanceosome' versus the 'TF collective' model of combin

166 cruitment of the CBP/p300 coactivator to the enhanceosome, via a new activating surface assembled fro

167 A functional interferon-beta gene enhanceosome was assembled in vitro using the purified r

168 gher-order transcription enhancer complexes (enhanceosomes), which is dependent upon inducer-specific

169 LRC5 participates in an MHC class I-specific enhanceosome, which assembles on the conserved W/S-X-Y c

170 of a higher order nucleoprotein complex, the enhanceosome, which consists of the transcriptional acti

171 virus infection requires the assembly of an enhanceosome, which instructs a recruitment program of c

172 aB-interacting factors in the putative CXCL1 enhanceosome will provide key information in developing

173 Strikingly, preincubation of the enhanceosome with the CBP-RNA PolII holoenzyme complex r

174 rticoid receptor (GR) can associate with the enhanceosome without STAT3.