ライフサイエンスコーパス: enhancer activity

1 enomic region surrounding the Eya1 locus for enhancer activity.

2 down reduces ARID5B expression and rs7090445 enhancer activity.

3 s, and subtle changes in their spacing alter enhancer activity.

4 hancer orthologues show fetal-brain-specific enhancer activity.

5 and redistributes to open regions devoid of enhancer activity.

6 rring with RNAP2 were more likely to exhibit enhancer activity.

7 -seq demonstrates accurate quantification of enhancer activity.

8 riants for allelic differences in regulatory enhancer activity.

9 e effects, thereby buffering their impact on enhancer activity.

10 assify Drosophila cell-type-specific cardiac enhancer activity.

11 r NOG, we found that one, rs227727, disrupts enhancer activity.

12 how tightly coupled eRNA production is with enhancer activity.

13 variants that disrupt DNA binding and islet enhancer activity.

14 e generation of which is strongly related to enhancer activity.

15 Zld binding sites and the spatial domain of enhancer activity.

16 allelic differences in FOXA2-DNA binding and enhancer activity.

17 ssibility of an upstream genomic region with enhancer activity.

18 ncer of PTF1A and that the mutations abolish enhancer activity.

19 ets of features govern PPARgamma binding vs. enhancer activity.

20 ch TRFs target DNA regions with demonstrated enhancer activity.

21 to be upregulated by the NF-kappaB-mediated enhancer activity.

22 that denote open chromatin status and confer enhancer activity.

23 hat causes an approximately 80% reduction in enhancer activity.

24 mouse non-coding genomic DNA fragments with enhancer activity.

25 enome-wide binding profiles is predictive of enhancer activity.

26 re thereby both necessary and sufficient for enhancer activity.

27 ingless signal and apterous), and has nubbin enhancer activity.

28 site motifs accurately predicted mesodermal enhancer activity.

29 tionally measure the effect of divergence on enhancer activity.

30 ability of eRNAs and H3K27ac to discriminate enhancer activity.

31 t Tf1 increased gene expression by inserting enhancer activity.

32 chromatin modifications, eRNA production and enhancer activity.

33 results in loss or reduction of neural crest enhancer activity.

34 ts-1, TFAP2A and FoxD3, all are required for enhancer activity.

35 ated the mechanisms that regulate hsERVPRODH enhancer activity.

36 demonstrate that eRNA is more indicative of enhancer activity.

37 alternative approach to directly predicting enhancer activity.

38 ay, along with new candidates for ubiquitous enhancer activity.

39 gesting that TCF7L2 plays a critical role in enhancer activity.

40 binding and that demonstrated Tbx5-dependent enhancer activity.

41 uirement for Gli1 and Sox2 inputs for neural enhancer activity.

42 nd that the exonic sequence is necessary for enhancer activity.

43 of these TF binding sites in supporting full enhancer activity.

44 d repression through interfering with distal enhancer activity.

45 n this study that STAT5 can repress kappaE3' enhancer activity.

46 up contributing additively to the allosteric enhancer activity.

47 ogen receptor (AR) binding driving increased enhancer activity.

48 f every possible single-nucleotide change on enhancer activity.

49 e GATA binding site partially decreased CGRE enhancer activity.

50 l Myb binding site completely abrogated CGRE enhancer activity.

51 served Exd/Hox binding site is essential for enhancer activity.

52 inding sites is frequently not indicative of enhancer activity.

53 tor (TF) binding sites is important for BX-C enhancer activity.

54 r-binding events and markers associated with enhancer activity.

55 9, Ets1, and cMyb as direct inputs mediating enhancer activity.

56 e located at -44 bp) resulted in the loss of enhancer activity.

57 CRMs demonstrates that both have appropriate enhancer activity.

58 tion in vivo demonstrate its role in Neurog2 enhancer activity.

59 entations, only one of which is required for enhancer activity.

60 mentally validated as critical for forebrain enhancer activity.

61 The majority of the distal elements exhibit enhancer activity.

62 nied by massive and recurrent alterations in enhancer activity.

63 and some have been shown to be required for enhancer activity.

64 ikely to generally play a functional role in enhancer activity.

65 ARR-seq) to reliably obtain an assessment of enhancer activity.

66 atin is not sufficient for, nor specific to, enhancer activity.

67 igenetic markers of active transcription and enhancer activity.

68 SNPs within three COMs significantly altered enhancer activity.

69 f these activator sites were lost, weakening enhancer activity.

70 y establishing and simultaneously repressing enhancer activity.

71 ich only one specific group possesses active enhancer activity.

72 Lhx3 or Onecut1 binding sites into transient enhancer activity.

73 the most distal site displayed the greatest enhancer activity.

74 distal enhancers, despite generating similar enhancer activity.

75 senting an additional layer of regulation of enhancer activity.

76 ested conserved elements for transcriptional enhancer activity.

77 ring transcriptional mechanisms that control enhancer activity.

78 general association with cell-type-specific enhancer activity.

79 of transcription factor binding dynamics and enhancer activities.

80 of Hairless [Su(H)] discriminates PC from CC enhancer activities.

81 es, thereby controlling spatial and temporal enhancer activities.

82 vernight fasting had differential effects on enhancer activities.

83 hroughput technique to functionally quantify enhancer activities.

84 tium, and functional assays for differential enhancer activities.

85 selected candidate dsDMRs exhibit functional enhancer activities.

86 e silent or motif-improving changes maintain enhancer activity; (2) evolutionary conservation, nucleo

87 trength of the motif match are predictive of enhancer activity; (3) scrambling repressor motifs leads

88 sed on maintenance of endogenous OCT4 distal enhancer activity, a molecular signature of ground state

89 ted genome editing to demonstrate endogenous enhancer activity across 3 MFVs that predominantly affec

90 and in the antisense orientation to measure enhancer activities alone.

91 rs of active differentiation loci as well as enhancer activities and selective gene expression.

92 t genotypes are associated with differential enhancer activities and/or transcription factor binding

93 hancer RNAs (eRNAs) and were shown to impair enhancer activity and ACTRT1 expression.

94 350-bp region within DHS-35kb which has full enhancer activity and binds interferon regulatory factor

95 To determine the relationship between enhancer activity and biological outcomes in breast canc

96 The resulting data strongly confirm the enhancer activity and cell-type specificity of enhancer

97 antagonizing Polycomb silencing, stimulating enhancer activity and cellular memory.

98 ins a common base-pair change that decreases enhancer activity and colocalizes with peaks of positive

99 nstrated strong allele-specific promoter and enhancer activity and differential binding of HNF4alpha,

100 Moreover, BRD4 occupancy correlates with enhancer activity and enhancer RNA (eRNA) transcription.

101 factors are necessary for NOTCH1 and notch1b enhancer activity and for correct endogenous transcripti

102 that alleles of rs7090445 have differential enhancer activity and influence RUNX3 binding.

103 (Trr) branch of the COMPASS family regulates enhancer activity and is responsible for the implementat

104 found that Sox9-Brn2 and Isl1-Lhx3 regulate enhancer activity and NFIA expression in glial and neuro

105 vated c-MYC expression from increased distal enhancer activity and not from reorganization/creation o

106 Three regions exhibited enhancer activity and only rs1635852 displayed allelic d

107 ain development requires an understanding of enhancer activity and regulation.

108 scription factors that are essential for zli enhancer activity and Shh expression in the mouse embryo

109 The dynamic binding influences enhancer activity and shows enrichment for regulators li

110 d rs13294895 have allele-specific effects on enhancer activity and suggest chromatin interactions wit

111 MLL3 and MLL4 function in the regulation of enhancer activity and that mutations of MLL3 and MLL4 th

112 re highly conserved and enriched in marks of enhancer activity and transcription.

113 d transcripts does not influence measures of enhancer activity and we cannot detect evidence of purif

114 is of selected co-occupied elements verified enhancer activity, and also showed that the occurrence o

115 d by enhancer hypermethylation, reduction of enhancer activity, and delayed gene induction in the ear

116 thm determined that chromatin accessibility, enhancer activity, and distance to the transcription sta

117 ults reveal that DNA demethylation modulates enhancer activity, and its disruption influences the tim

118 Whether promoter and enhancer activities are encoded distinctly in DNA sequen

119 We found that enhancer activities are retained inside a genomic region

120 tinct underlying DNA sequences and divergent enhancer activity as marked by histone 3 containing the

121 represent the absolute expression limits of enhancer activity, as expression activity is lost stepwi

122 motifs that are predictive and required for enhancer activity, as we validate experimentally.

123 g protein-1 (AP-1) account for the increased enhancer activity ascribed to this PCa-risk LD block.

124 t we have employed a boundary trap assay, an enhancer activity assay, chromatin immunoprecipitations,

125 Further analysis revealed an enhancer activity at genomic region surrounding rs463183

126 d uncover widespread coordination of dynamic enhancer activity at preformed and acquired DNA loops.

127 revealed that RA-RARalpha directly regulated enhancer activity at Th1 lineage defining genes while re

128 t alter a SREBP-1 binding site and influence enhancer activity at the locus.

129 described FOX:ETS-dependent enhancers, ECE1 enhancer activity becomes restricted to arterial endothe

130 sue-specific or developmental-stage-specific enhancer activity, but our results indicate that some fe

131 nf32 gene lying within the Shh domain evades enhancer activities by a process that may be common amon

132 17226398, rs56038622, and rs2271338, reduced enhancer activity by 40% in neuroblastoma and astrocytom

133 We have demonstrated its virus-inducible enhancer activity by analyzing epigenomic profiles, tran

134 reporter constructs, which were analysed for enhancer activity by injection into Xenopus laevis embry

135 defects in SWI/SNF targeting and control of enhancer activity cause extensive dysregulation of gene

136 Insufficiency of enhancer activity causes variegated Cd8 expression in CD

137 Loss of UTX leads to attenuated enhancer activity, characterized by reduced levels of H3

138 he human PITX2 gene were identified; 11 have enhancer activities consistent with pitx2 expression.

139 The enhancer activity correlates with the binding of zinc fi

140 ided a quantitative metric of Tbx5-dependent enhancer activity, correlating with target gene expressi

141 Enhancer activity could not be recovered by T-cell activ

142 Two variations had a significant effect on enhancer activity, decreasing the activity to 0.6-fold,

143 , we show that KLK3e processes RNA-dependent enhancer activity depending on the integrity of core enh

144 Enhancer activity depends on the combination of bound tr

145 te epidermal-specific, developmental in vivo enhancer activities (DNaseI and transgenic mouse assays)

146 ions of chromatin modification in regulating enhancer activity during development.

147 Here, we evaluated regulation of enhancer activity during differentiation of embryonic st

148 ers, we find that DNA methylation status and enhancer activity during early zebrafish development dis

149 orm a repressive chromatin state that blocks enhancer activity during organogenesis.

150 of sequences examined display p53-dependent enhancer activity during the DNA damage response.

151 vides a quantitative readout of promoter and enhancer activity, during human, rhesus, and mouse limb

152 ulatory element 12 kb upstream of HLA-G with enhancer activity, Enhancer L Strikingly, clustered regu

153 active promoter showing nitrate and nitrite enhancer activity equivalent to that of the wild-type 18

154 nine autoimmune diseases and Brain-specific enhancer activities exclusively in Schizophrenia.

155 nsgenic reporter assays in zebrafish confirm enhancer activities for many HOXA1-bound regions and the

156 able to learn reliable statistical models of enhancer activity for over 70 expression domains and app

157 Here we examine the underlying basis of enhancer activity for the Ciona intestinalis betagamma-c

158 Two elements showed strong enhancer activity for the promoters of EHF and the 5' ad

159 r absence of tamoxifen, indicating divergent enhancer activity for tumors that develop in different e

160 Here, we perform a genome-scale analysis of enhancer activity from p53-bound sequences using a serie

161 Nep1 optic lobe enhancer overlaps with other enhancer activities, from which the novel activity was c

162 one mark H3K4me1 to analyze gain and loss of enhancer activity genome-wide in primary colon cancer li

163 reened 15 conserved non-coding sequences for enhancer activity, identifying three that regulate expre

164 s, characterisation of their spatio-temporal enhancer activities in a mammalian model system remains

165 nding and sequence features that distinguish enhancer activities in distinct subsets of heart cells.

166 demonstrate that this region shows specific enhancer activities in iridophores, a type of pigment ce

167 ere carried out to analyze iNOS promoter and enhancer activities in response to changes in methylatio

168 The DHS-35kb contains an element with enhancer activity in 16HBE14o- airway epithelial cells a

169 -dependent Myf5 epaxial somite-specific (ES) enhancer activity in 3T3 cells, and Zic1 activates endog

170 diabetes-associated variants were tested for enhancer activity in 832/13 and MIN6 insulinoma cells.

171 f multiple weak constituents can alter super-enhancer activity in a manner greatly exceeding repressi

172 leotide polymorphism, rs577676, which alters enhancer activity in a mouse atrial cell line and in emb

173 P3) contains a TATA-box and displays in vivo enhancer activity in a pattern that overlaps with the ze

174 hese, only rs5758550 demonstrated regulating enhancer activity in a reporter gene assay.

175 environmental stresses and disease, testing enhancer activity in animals remains tedious, with a min

176 d to functional assays, and all four exhibit enhancer activity in B but not in T lineage cells.

177 (CNS) at the mouse Ifng locus sufficient for enhancer activity in cell-based assays.

178 ion factor, reducing LEF1 responsiveness and enhancer activity in cultured human keratinocytes.

179 aberrant DNA methylation and cause perturbed enhancer activity in cytogenetically normal AML that con

180 bless snakes to reveal widespread sharing of enhancer activity in developing limbs and genitalia.

181 tterning and differentiation and analysis of enhancer activity in Dlx1/2 and Lhx6 mutants, we elucida

182 and Anolis lizards reveals that patterns of enhancer activity in embryonic limbs and genitalia overl

183 ject, as well as through in vivo analysis of enhancer activity in embryonic zebrafish.

184 Marco, a gene recently demonstrated to have enhancer activity in embryonic-derived but not postnatal

185 c neighboring cis elements, and preferential enhancer activity in GATA-2-expressing cells.

186 We show that one of these elements has enhancer activity in human keratinocytes and zebrafish p

187 n early T cells, and we show that it retains enhancer activity in immature T-lineage cells even where

188 sk allele for this SNP increases FOXA2-bound enhancer activity in islet- and liver-derived cells.

189 throughput strategy to quantitatively assess enhancer activity in mammals.

190 (77%) of the individual TEs tested exhibited enhancer activity in mouse ESCs.

191 g (CoupTFI, Pax6, and Pbx1), and analysis of enhancer activity in Pax6 mutants.

192 active and NF-kappaB binding site possesses enhancer activity in regulating Rgs4 transcription.

193 occupancy by p300, and a majority exhibited enhancer activity in reporter gene assays.

194 ents increased H3.3 enrichment and displayed enhancer activity in settings of injury- and/or Neuregul

195 We determine two key parameters of enhancer activity in single cells: their penetrance in a

196 lar mechanisms that regulate region-specific enhancer activity in the developing brain.

197 inding motifs within Sox10E2 greatly reduces enhancer activity in the ear.

198 Genome-wide quantification of enhancer activity in the human genome has proven to be a

199 conserved in therian mammals and capable of enhancer activity in the MBs.

200 tylation of histone 3 at lysine 27 (H3K27ac) enhancer activity in the regulatory regions of the assoc

201 n nearly all cases demonstrated reproducible enhancer activity in the tissues that were predicted by

202 ding sequences from the mouse Isl1 locus for enhancer activity in transgenic mouse embryos.

203 Furthermore, a subset of these sites shows enhancer activity in transient transfection assays.

204 system can also be used for the detection of enhancer activity in transient transgenesis.

205 P-DMRs located in INSR and CPT1A have enhancer activity in vitro and differential methylation

206 The 3' regulatory element exhibits enhancer activity in vitro and in transgenic mice, and i

207 highly risk-associated SNPs and tested their enhancer activity in vitro, identifying three SNPs with

208 rrounding rs1143679 exhibits transcriptional enhancer activity in vivo and binds to Ku70/80, NFKB1 an

209 at the cancer risk allele increases prostate enhancer activity in vivo relative to the non-risk allel

210 tify a sequence in the associated locus with enhancer activity in zebrafish somitic muscle and spinal

211 et FAIRE signals and that the variant alters enhancer activity, indicating that genetic variation at

212 vity-regulated TFs and predefined epigenetic enhancer activity influences the anatomical diversity of

213 The mechanism of hsERVPRODH enhancer activity involves the binding of the transcript

214 We also showed that HBE enhancer activity is critically dependent on its interac

215 HIF-1alpha dependent, whereas PHD3 promoter/enhancer activity is dependent on both HIF-1alpha and HI

216 This allele-specific enhancer activity is detectable during early prostate de

217 sis of reporter constructs reveals that this enhancer activity is evolutionarily conserved among jawe

218 ther tissues shows that species-specific ERV enhancer activity is generally restricted to hypomethyla

219 ells from mouse fetal liver, suggesting that enhancer activity is highly dynamic during early hematop

220 EPHB3 enhancer activity is highly variable in colorectal carci

221 Regulation of enhancer activity is important for controlling gene expr

222 functional impact of these modifications on enhancer activity is not well understood.

223 Our finding that enhancer activity is often deeply conserved and frequent

224 Enhancer activity is particularly diverse among individu

225 s physically interact with target genes, how enhancer activity is regulated during development, and t

226 s still largely unclear, but transcriptional enhancer activity is thought to play a central role.

227 factors and super-enhancers, while additive enhancer activity isolates key genes involved in cell id

228 mic characteristics that correlate well with enhancer activity, it remains onerous to comprehensively

229 essed in CHF via inhibition of AT2R intronic enhancer activity, leading to lowered muscle regeneratio

230 Tissue and temporal restriction of this enhancer activity may involve postnatal changes in prote

231 ss that loss of CTCF-mediated restriction of enhancer activity may well contribute to oncogenic activ

232 examined the effects on gene expression and enhancer activity measured by histone 3 lysine 27 (H3K27

233 -scale manipulation and provide quantitative enhancer activity measurements across thousands of const

234 Although CNS2 contains enhancer activity, methylated CpG sequences in this regi

235 onstructs of these BAC reporters to localize enhancer activity more precisely.

236 d transcription, transcriptional initiation, enhancer activity, non-methylated DNA, and transcription

237 genomic expanses, we have tested the in-vivo enhancer activity of 19 consecutive CSB clusters located

238 nsgenic mouse assay to compare the embryonic enhancer activity of 231 noncoding ultraconserved human

239 mong these candidates, motif-driven podocyte enhancer activity of CCNC and MEIS2 was functionally ana

240 The enhancer activity of hsERVPRODH is regulated by methylat

241 Using a systematic, whole-genome analysis of enhancer activity of human-specific endogenous retrovira

242 The risk allele T of 1:g.98515539A>T reduced enhancer activity of its flanking sequence by >50% in hu

243 e but serves as a repressor and inhibits the enhancer activity of Myc-Max.

244 Many experiments testing enhancer activity of neighboring cis-regulatory elements

245 In contrast, the enhancer activity of PPARgamma binding sites depends on

246 on, Western blot, and IFN-I bioassay; and 3) enhancer activity of predicted IFN regulatory factor 3/7

247 ESR1 is sufficient to mediate the E2-induced enhancer activity of RET -49.8 and RET +32.8.

248 Interestingly, the enhancer activity of Tf1 could be limited by Abp1, a hos

249 Baseline enhancer activity of the conserved region specifically o

250 and point mutations considerably reduced the enhancer activity of the intron 5 enhancer.

251 ragment near the insertion site and observed enhancer activity of this element in tissue culture cell

252 GAA motifs and thus the EWSR1-FLI1-dependent enhancer activity of this sequence, with epigenetic char

253 The ability to modulate enhancer activity offers an additional layer of complexi

254 KX2.2 in NPCs was sufficient to induce Sox10 enhancer activity, OPC mRNA, and protein expression cons

255 ained unclear how frequently mutations alter enhancer activity or create functional enhancers de novo

256 located upstream of critical genes and have enhancer activity, other sLTRs are located within intron

257 ive enhancer assay, to determine genome-wide enhancer activity profiles for five Drosophila species i

258 lated by multiple enhancers, coordination of enhancer activities remains poorly understood.

259 elationship between primary DNA sequence and enhancer activity remains obscure.

260 t on transcription factor (TF) occupancy and enhancer activity remains poorly understood.

261 The enhancer activity requires sustained Hh signaling.

262 egulatory PAX6 binding site, causing loss of enhancer activity, resulting in defective maintenance of

263 oes not affect other molecular indicators of enhancer activity, suggesting that eRNA production occur

264 , rosiglitazone paradoxically stimulates the enhancer activity, suggesting that the enhancer is not d

265 Importantly, Pro1 displays strong enhancer activity, suggesting that this may be its princ

266 Transcription is less predictive for enhancer activity than epigenetic modifications such as

267 and hypothyroidism has significantly greater enhancer activity than the allele associated with thyroi

268 also detect sequences with the potential for enhancer activity that are located in inaccessible, clos

269 se experiments also define a novel synthetic enhancer activity that has not been previously described

270 y rs1635852 displayed allelic differences in enhancer activity; the type 2 diabetes risk allele T sho

271 genetic predisposition that reinforces PEAR1 enhancer activity through allele-specific DNA methylatio

272 s provide new insight into how regulation of enhancer activity through DNA methylation can have drama

273 At the Igkappa 3' enhancer, BCL6 repressed enhancer activity through the PU.1 binding site.

274 Notably, we found that E93 controls enhancer activity through three different modalities, in

275 of nearby B-cell lineage genes by impairing enhancer activity, thus causing defects in B-cell differ

276 We have narrowed the enhancer activity to a 565 bp region and have identified

277 region localized a newly derived optic lobe enhancer activity to a region of an intron that has accu

278 scent 5' ends, we show that transfer of full enhancer activity to a target promoter requires both the

279 pression analysis in the mouse localizes the enhancer activity to craniofacial and limb structures.

280 erstanding of the relationship of long-range enhancer activity to enhancer-dependent noncoding transc

281 The dynamic enhancer activities uncovered in this study illuminate r

282 ted 4796 enhancer SNPs capable of disrupting enhancer activity upon allelic change.

283 rter assays, two new sites display decreased enhancer activity upon mutation.

284 Thus, interference between enhancer activities was a possible factor necessitating

285 fect of CpG methylation on iNOS promoter and enhancer activities was determined using a CpG-free luci

286 4E was cell-specific, as no enhancer activity was detected in a human lung cell line

287 also show, using the Gitr promoter, that the enhancer activity was further upregulated in conjunction

288 Enhancer activity was localized to a 180-bp fragment, an

289 Importantly, +286/+690 enhancer activity was suppressed in CHF mouse skeletal m

290 n sequence in mouse embryonic stem cells for enhancer activity we identified enhancers at pluripotenc

291 To explore the mechanism of allosteric enhancer activity, we examined their action on several A

292 To further validate their in vivo enhancer activity, we tested 65 of these human sequences

293 itors that induces and maintains OCT4 distal enhancer activity when applied directly to conventional

294 Intervening RNA was essential for the enhancer activity, which rules out the looping model.

295 with increased transcription elongation and enhancer activity, which together lead to exceptionally

296 as an enhancer "brake" to ensure appropriate enhancer activity, which, when compromised, could contri

297 595104, which displayed dramatically reduced enhancer activity with the AF risk allele.

298 s identified both prostate and mammary gland enhancer activities within the region.

299 n expression was mostly due to non-classical enhancer activity within the intron, and movement of put

300 lowed us to probe a large genomic region for enhancer activity without assumptions on sequence conser