ライフサイエンスコーパス: enhancer element

1 and recruitment of FOXA1 and ERalpha to the enhancer element.

2 (EF1alpha) promoter and a strong endothelial enhancer element.

3 e transcription factor activating this Wnt9a enhancer element.

4 1.54 x 10(-38)), and residing in a predicted enhancer element.

5 activator, CRM2 the repressor, and CRM3 the enhancer element.

6 and have excised an entire lincRNA gene and enhancer element.

7 the histone modifications associated with an enhancer element.

8 ns as a Pcdhalpha cluster-wide transcription enhancer element.

9 gulated by EWS/FLI via a GGAA microsatellite enhancer element.

10 clusion via binding to a downstream intronic enhancer element.

11 via the activity of an RBPJ-dependent Nodal enhancer element.

12 direct binding of PAL-1 in vivo to an hlh-1 enhancer element.

13 ontaining SOX9 binding sites from the COL2A1 enhancer element.

14 of the molecular events on a Hpo-responsive enhancer element.

15 1beta is mediated through a complex intronic enhancer element.

16 IF-2alpha through a consensus HIF-responsive enhancer element.

17 d tPA gene expression via a STAT1-responsive enhancer element.

18 DNA chemistry without activation by the Fis/enhancer element.

19 moters of PHLDB1 and DDX6, and in a putative enhancer element.

20 ing with stage-specific activity of multiple enhancer elements.

21 via dynamic regulation of its cis-regulatory enhancer elements.

22 eraction with the ETS-related ERG protein at enhancer elements.

23 activity depending on the integrity of core enhancer elements.

24 ng at erythroid genes and at known erythroid enhancer elements.

25 9 promoters and their shared tissue-specific enhancer elements.

26 growth, suggesting that these regions act as enhancer elements.

27 utative target genes for known and predicted enhancer elements.

28 istal promoter to identify the IMCD-specific enhancer elements.

29 of an inserted transgene cassette containing enhancer elements.

30 nteractions between gene promoters and their enhancer elements.

31 isplay many of the hallmarks associated with enhancer elements.

32 ranscriptional control of their own promoter/enhancer elements.

33 -2.4 kb, and the activation of two flanking enhancer elements.

34 nd nephron progenitors is driven by separate enhancer elements.

35 ng showed that Pcdh15 harbors suppressor and enhancer elements.

36 rotein marker directly driven by dfd and GMR enhancer elements.

37 nder the control of each of 15 different cis-enhancer elements.

38 acts], 3' splice sites (3'SS), and sometimes enhancer elements.

39 events occur predominantly within regulatory enhancer elements.

40 de new insight into the relationship between enhancer elements.

41 terations in DNA-methylation specifically in enhancer elements.

42 o be regulated by endogenous CD40LG promoter/enhancer elements.

43 sion of nearby genes via strong promoter and enhancer elements.

44 apped with GRO-cap signal over both TSSs and enhancer elements.

45 ene expression through spatial clustering of enhancer elements.

46 ability to bind gamma-activated sequence DNA-enhancer elements.

47 Here we demonstrate the utility of enhancer elements [422 (DlxI12b), Lhx6, 692, 1056, and 1

48 variant (P = 5.30 x 10(-25)), resides in an enhancer element 47 kb upstream of the transcription sta

49 expressing Lac-Z under the regulation of an enhancer element 9.7 kb upstream of the Irf6 start site,

50 Our results establish OL as a multifaceted enhancer element, able to activate transcription from lo

51 Finally, we show that E2A binds to enhancer elements across the FOXO1 locus to activate Fox

52 pstream regulators and segmental activity of enhancer elements across these distant species.

53 stinguished promoter elements from potential enhancer elements across this region.

54 Enhancer elements activate high levels of transcription

55 We provide evidence that small enhancer elements active in protodomains integrate broad

56 polymorphisms in LD that map to clusters of enhancer elements active in the same cell type.

57 In addition to mutations in genes, aberrant enhancer element activity at non-coding regions of the g

58 both RNA synthesis and stability as well as enhancer element activity following exposure to IR.

59 ne regulation in which spatial clustering of enhancer elements acts as a unified mechanism for both e

60 red homology, or presence of a recombination enhancer element adjacent to a donor.

61 de maps of histone modifications that reveal enhancer elements after 72 hr of in vitro polarization t

62 locator (ARNT) and binding to AHR-responsive enhancer elements (AHREs).

63 ncers, including the Nodal-proximal epiblast enhancer element and enhancer regions controlling Otx2 a

64 hat the change creates a new exonic splicing enhancer element and increases the amount of full-length

65 -mediated ALDH1A1 expression through a super-enhancer element and its associated enhancer RNA.

66 bition of ALDH1A1 expression through a super-enhancer element and other stem-related genes in promote

67 that Mysm1 directly associates with the Gfi1 enhancer element and promotes its transcription through

68 sults demonstrate robust effects of both the enhancer element and SNP rs5758550 on CYP2D6 expression,

69 TOR Y (NF-Y) binds a CCAAT box in the distal enhancer element and that CCAAT disruption dramatically

70 n Emu is a combination of both a 220-bp core enhancer element and two 310-350-bp flanking scaffold/ma

71 system is based on a sex-specific Drosophila enhancer element and validated through studies of inters

72 n-coding elements, many of which function as enhancer elements and are hypothesised to be under evolu

73 Also, DMSs were overrepresented in enhancer elements and enriched in enhancers that become

74 We further identify stage-specific distal enhancer elements and find enriched DNA binding motifs w

75 ed hCD79b promoter along with its associated enhancer elements and first exon could be deleted withou

76 locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop

77 ne under the control of human MnSOD promoter-enhancer elements and investigated the changes of MnSOD

78 The site lies close to Ubx enhancer elements and is also close to the locations of

79 c methods now range from the use of specific enhancer elements and large genomic regions assembled us

80 regulated network is activated when AR binds enhancer elements and modulates specific enhancer-promot

81 Accumulating evidence implicates both enhancer elements and noncoding RNAs in controlling this

82 ation, when in chromosomal translocations Ig enhancer elements and oncogenes appear in a novel genomi

83 Transcription factors bind to enhancer elements and recruit coactivators and chromatin

84 scription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much

85 methylation of specific NF-kappaB-responsive enhancer elements and the activation of iNOS transactiva

86 ranscription in the presence of the intronic-enhancer element, and this effect is dependent on nuclea

87 eling of neuronal processes, easy cloning of enhancer elements, and efficient and flexible generation

88 splicing inhibition were found to be exonic enhancer elements, and their inhibitory activity require

89 riants for ER(-) tumors lie in four separate enhancer elements, and their risk alleles reduce express

90 three-dimensional organization of the genes, enhancer elements, and transcription machinery plays an

91 Enhancer elements are essential for tissue-specific gene

92 Enhancer elements are genomic regulatory sequences that

93 Distal enhancer elements are key drivers of spatiotemporal spec

94 Although enhancer elements are known to be associated with certai

95 Here, we show that multiple enhancer elements are present within this region and tha

96 arget genes are activated or repressed, what enhancer elements are required for regulation, and how d

97 Gene enhancer elements are thought to exist in either active

98 These data highlight the role of enhancer elements as mediators of T2D risk in humans, st

99 represents a different class of translation enhancer element, as defined by its structure and abilit

100 xonic or intronic RNA regulatory silencer or enhancer elements, as well as in genes that encode splic

101 me conformation capture, we demonstrate that enhancer elements associate not just in linear sequence,

102 se studies have identified a cancer-specific enhancer element at the 8q24 gene desert that controls t

103 ding regions within evolutionarily conserved enhancer elements at +35 and +37 kb relative to the gene

104 We report here de novo formation of putative enhancer elements at CG hypomethylated sites that can be

105 s and exemplarily validated novel downstream enhancer elements at the CD14 locus.

106 sponsive region to the "osteoblast-specific" enhancer element between -420 and -350 bp that contains

107 d by the differential activity of ER AF1 and enhancer element binding.

108 We show that shuffling of existing enhancer elements both within and between species provid

109 Here, we have globally analyzed enhancer elements bound by IL-2-activated STAT5 and IL-2

110 modifications at both active and poised gene enhancer elements but also raise the possibility that en

111 s) are mediators of this defense with shared enhancer elements but display a spectrum of transcriptio

112 re correlated with transcriptionally engaged enhancer elements, but the functional impact of these mo

113 ne increased the occupancy of the identified enhancer element by RXRalpha, RARbeta, cJun, cFos, and p

114 s driven through a highly conserved intronic enhancer element by the transcription factors PAX3 and F

115 Thus, we defined thousands of candidate enhancer elements by incorporating these features, and f

116 dynamic regulation of specific cis Cd8 gene enhancer elements by positive selection signals in the t

117 for directly identifying active promoter and enhancer elements called FIREWACh (Functional Identifica

118 most retroviruses, in that introduced exonic enhancer elements can increase splicing efficiency.

119 taposed to active immunoglobulin heavy chain enhancer elements, chromosomal aneuploidy, somatic mutat

120 are regulated by clusters of Mediator-bound enhancer elements collectively referred to as super-enha

121 ugh the majority of our current knowledge of enhancer elements comes from detailed analyses of indivi

122 rpoS expression without an apparent upstream enhancer element commonly associated with other sigma(54

123 more than twice the number of hypomethylated enhancer elements compared with myoepithelial cells.

124 dentified a physical interaction between the enhancer element containing a functional SNP (rs73001406

125 at are regulated by a remote recombinational enhancer element containing two binding sites for the pr

126 uishes active enhancers from inactive/poised enhancer elements containing H3K4me1 alone.

127 modulates YY1 binding and the activity of an enhancer element controlling the autoimmune-associated I

128 Thus targeting intron 2 enhancer element could lead to the development of a nove

129 -seq and ChIP-seq, that specific Runx1-bound enhancer elements critically modulate lineage-dependent

130 KLK3e carries the core enhancer element derived from the androgen response elem

131 , the postsynaptic expression occurs through enhancer elements distinct from those responsible for re

132 xon 11 inclusion, which requires an intronic enhancer element downstream of exon 11.

133 RNA binding assays demonstrated that the enhancer element downstream of PKCdelta exon 10 is a SC3

134 nscription factors and deletion of a pivotal enhancer element dramatically decreases CFTR expression,

135 hat reproducible changes in the epigenome at enhancer elements drive a specific transcriptional progr

136 In eye, limb and kidney, multiple distinct enhancer elements drive Bmp7 expression within each orga

137 lele enables enhanced activities of upstream enhancer elements due to loss of Sp1 binding at the poly

138 he left (L) and right (R) ends of Mu, and an enhancer element (E), mediated by the transposase protei

139 to a more accessible chromatin structure at enhancer elements early during reprogramming.

140 ort of this hypothesis, we identify a distal enhancer element, ECR1, which is active in developing ur

141 sequence-specifically to ER stress response enhancer elements (ERSEs) in their promoter-regulatory r

142 gradation of RNA and monitor the activity of enhancer elements following exposure to IR, we used the

143 n-coding genomic region containing an active enhancer element for CTSB, resulting in upregulation of

144 The enhancer element for the apoB gene is located much farth

145 ) insertion site effects or (ii) deletion of enhancer elements for class switch recombination and tra

146 ly characterize previously described and new enhancer elements for their roles in the embryonic stem

147 nse element (ARE) is a cis-acting regulatory enhancer element found in the 5' flanking region of many

148 Here, we analyze an enhancer element from the even skipped (eve) gene, which

149 A transcriptional enhancer element from the Mason-Pfizer monkey virus can

150 ntified numerous such colocated boundary and enhancer elements from human CD4(+) T cells.

151 new approach for identifying TSSs and active enhancer elements genome-wide in intact cells.

152 o demonstrate the specific association of an enhancer element, H, on chromosome 14 with multiple OR g

153 nical gene therapy trials, although powerful enhancer elements have caused insertional mutagenesis an

154 where NF-Y complexes, bound at the FT distal enhancer element, help recruit CO to proximal cis-regula

155 of promoter activity via the human upstream enhancer element (hNUE).

156 inding sites was identified within a distant enhancer element (HS5-1), which is required for normal l

157 Here we show that two transcriptional enhancer elements, HS5-1 and HS7, play a critical role i

158 h-6, but mutagenesis of a short male gonadal enhancer element in egl-5 suggested that this regulation

159 on with restored occupancy of a sex-specific enhancer element in principal downstream gene Sox9, demo

160 recently evolved polymorphism within a super-enhancer element in the first intron of LMO1 influences

161 We show that evolution of an enhancer element in the homeobox gene REDUCED COMPLEXITY

162 th protein forms of PAX6 bind directly to an enhancer element in the MET promoter and activate the ex

163 the binding of T (Brachyury) and STAT3 to an enhancer element in the mouse Nanog gene.

164 in endothelial cells (ECs) by binding to an enhancer element in the Vegfr3 gene.

165 with primary T cells, we have identified an enhancer element in this gene.

166 We re-sequenced these enhancer elements in a cohort of non-syndromic patients

167 Our integrated analysis of enhancer elements in a large series of primary tumour sa

168 A genome-wide epigenetic analysis of enhancer elements in colon cancer has implicated distal

169 RNA turnover and did not address the role of enhancer elements in DDR-mediated transcriptional regula

170 e we interrogate the epigenetic landscape of enhancer elements in embryonic stem cells and several ad

171 Furthermore, we observe that p53 is bound to enhancer elements in healthy fibroblasts and poised for

172 Regulatory enhancer elements in solid tumours remain poorly charact

173 eER(T2) and GFP expression from 14 different enhancer elements in stable transgenic mice allowed us t

174 , mapping the activity of cell-type-specific enhancer elements in T helper 1 (Th1) and Th2 cells.

175 ce of the PCR products from the promoter and enhancer elements in the ChIP assay.

176 lls and those activated in vivo, Foxp3-bound enhancer elements in the DNA were poised for repression

177 ecognition, and is dependent on the scanning enhancer elements in the eIF1A CTT.

178 rative genome analysis to identify candidate enhancer elements in the human genome coupled with the e

179 Both the strong promoter/enhancer elements in the long terminal repeats (LTRs) of

180 ), which bind preferentially to promoter and enhancer elements in the mammalian genome.

181 ciation of the p65 subunit of NF-kappaB with enhancer elements in the Nos2 promoter but had little ef

182 sequence specifically to ER stress response enhancer elements in their promoters.

183 or GFI1B coding sequences proximal to active enhancer elements, including super-enhancers, instigatin

184 oter regions and instead localizes to distal enhancer elements, including those that regulate the act

185 Finally, BruUV-seq identified putative enhancer elements induced by tumor necrosis factor (TNF)

186 t long-distance chromatin loops bring distal enhancer elements into close association with the proxim

187 We found that promoter and enhancer elements invariably associate to form DNA loop

188 We find that the same enhancer element is also a target of HLH-1 positive auto

189 This enhancer element is consistently present in sortilin RNA

190 The crystal structure of a sex-specific enhancer element is described at a resolution of 1.6 A.

191 This distal enhancer element is observed in the homologous mouse gen

192 This enhancer element is unusually rich in general regulatory

193 Epigenetic regulation of gene enhancer elements is important for establishing and main

194 between signaling pathways and actively used enhancer elements is not clear.

195 the functional importance of these clustered enhancer elements is poorly understood, so it is not cle

196 he approximate locations of local cis-acting enhancer elements; it is therefore important to establis

197 Mutation of a TonE enhancer element located 489 bp upstream of the AQP2 tra

198 L2 neurons via internal promoters and remote enhancer elements located in introns of the daf-19 genom

199 and the retinoic acid (RA) receptor via two enhancer elements located upstream of the gene.

200 The recognition and activation of enhancer elements located within inaccessible chromatin

201 We identified a new regulatory enhancer element, located within the RUNX2 gene, which i

202 y generated global maps of poised and active enhancer elements marked by histone H3 lysine 4 monometh

203 ceptor choice in which a single trans-acting enhancer element may allow the stochastic activation of

204 These mutational enhancer elements (MEEs) are required over and above tra

205 e that common genetic variants in long-range enhancer elements modulate the immediate transcriptional

206 the presence of conserved ERG-bound putative enhancer elements near these target genes.

207 atin analysis showed that FoxP3 bound active enhancer elements, not repressed chromatin, around loci

208 Previous work identified the occludin enhancer element (OEE) as a GC-responsive cis-element in

209 GFP under the control of a cardiac-specific enhancer element of Nkx2-5, a transcription factor expre

210 This region, which comprises the distal enhancer element of P1-rr, is hypermethylated in P1-pr c

211 The CAR directly binds to the distal enhancer element of the CYP2B6 promoter, which is essent

212 or that interacts with an essential upstream enhancer element of the EKLF promoter and exerts a posit

213 es with the histone demethylase Jmjd3 at the enhancer element of the Eomes locus to allow enhancer-pr

214 es under the control of a 17-kb promoter and enhancer element of the gene encoding the alpha2 chain o

215 We identified a new enhancer element of this second class, ECR111, which is

216 exes was diminished by mutations of scanning enhancer elements of eIF1A that increase near-cognate re

217 part by recruiting to the ER stress response enhancer elements of ER stress response genes a collecti

218 so we have explored the potential of distal enhancer elements of non-coding RNAs in the prognosticat

219 We also identified promoter and enhancer elements of the human ITGAE gene, encoding CD10

220 Smad proteins, and we have mapped a putative enhancer element on the SIK1 gene.

221 eved and regulated, and suggests that distal enhancer elements, once appropriately positioned at the

222 We also demonstrate that one such enhancer element physically interacts with the Myc promo

223 ts reveal that the DHS-35kb airway-selective enhancer element plays a pivotal role in regulation of C

224 PR and NCoR each selectively localize to the enhancer element (PRE) of a transiently transfected PREt

225 poietic progenitors, multilineage priming of enhancer elements precedes commitment to the lymphoid or

226 we characterized an evolutionarily conserved enhancer element present in multiple zinc-inducible gene

227 tein interactions with splicing silencer and enhancer elements present in the pre-mRNA.

228 Our findings indicate that a downstream enhancer element provides the principal regulation of c-

229 nist-bound receptor was recruited to several enhancer elements proximal to the E2F1 transcript.

230 These features are similar to those of gene enhancer elements, raising the possibility that CHD7 fun

231 ovide experimental evidence of a replication enhancer element (REE) within the capsid gene of tick-bo

232 How distant enhancer elements regulate the assembly of a transcripti

233 Ps is that they would affect the activity of enhancer elements regulating critical target genes.

234 pings involving proximal promoter and distal enhancer elements regulating GABAergic gene expression,

235 ter deletion analysis further indicates that enhancer elements required for BP expression in the leaf

236 juxtapose the TERT coding sequence to strong enhancer elements, resulting in massive chromatin remode

237 DNA sequence analysis of this enhancer element revealed that it contained a consensus

238 and histone modification-based definition of enhancer elements revealed intragenic enhancer methylati

239 reporter under the control of the human IRF6 enhancer element showed high expression of IRF6 in major

240 31746 mapped to a long-range neuron-specific enhancer element shown previously to regulate PCDH-alpha

241 ritically, methylation treatment of the iNOS enhancer element significantly decreased its activity in

242 ells and the AC, based on the presence of an enhancer element similar to the one that transcribes lin

243 The HMPS duplication contains predicted enhancer elements; some of these interact with the GREM1

244 vity to distinctive gene subsets in a kappaB enhancer element-specific context.

245 The enhancer element-specific histone H3K4me1/2 mark is enri

246 lymorphisms are frequently positioned within enhancer elements specifically active in relevant cell t

247 Using epigenomic methods, we characterized enhancer elements specifically modified in differentiati

248 We describe three enhancer elements sufficient for endothelial gene expres

249 deregulated genes reside in the vicinity of enhancer elements, suggesting that cohesin regulates gen

250 g a luciferase reporter driven by c-fos gene enhancer elements, suggesting that PRL allowed markedly

251 -distal RNA polymerase II (RNAP2) binding at enhancer elements, suggesting that these interactions ma

252 of this long-range action, the annotation of enhancer element-target promoter pairs remains elusive.

253 nly one causal SNP in the region and several enhancer elements targeting STXBP4 are located within th

254 s noted above, the Total Functional Score of Enhancer Elements (TFSEE) identified key breast cancer s

255 78) maps to 15q21.3 and overlaps a noncoding enhancer element that contains multiple activator protei

256 In this work, we characterize an enhancer element that drives Myf5 expression in the bran

257 Therefore, we sought to identify an Otx2 enhancer element that functions in photoreceptor develop

258 factor 7-like 2-dependent (TCF7L2-dependent) enhancer element that functions to increase SHROOM3 tran

259 erlapping region of these duplications is an enhancer element that is active in epidermal keratinocyt

260 in chick Nkx2.5 binds directly to a genomic enhancer element that is required to maintain Nkx2.5 exp

261 demonstrated that SNP rs10941679 maps to an enhancer element that physically interacts with the FGF1

262 al coregulator, Hcf-1, to a highly conserved enhancer element that previously lacked a recognized bin

263 sociated risk variant in a non-coding distal enhancer element that regulates the expression of alpha-

264 We identified a specific splicing enhancer element that regulates the inclusion of a sorti

265 previously characterised Msx1 gene proximal enhancer element that supports the expression of the Msx

266 dicates that these SNPs localise to putative enhancer elements that bind known drivers of hormone-dep

267 ge cohort of preestablished, promoter-distal enhancer elements that demonstrates dynamic histone acet

268 adaptation defined by the activity of distal enhancer elements that drive expression of 5' Hoxd genes

269 atterning TFs regulate the activity of small enhancer elements that drive gene expression in pallial

270 n regulated by the action of transcriptional enhancer elements that function in an orientation-indepe

271 Here, we identified DNA enhancer elements that mediate intestine-specific transc

272 th this method, we isolated 100 bp synthetic enhancer elements that were as potent at activating tran

273 nstrate in this study that it is the four 3' enhancer elements themselves (a total of 4.7 kb) that ar

274 uclear factor 4alpha) with CAR at the distal enhancer element to activate the promoter.

275 ich sites within the nominal single-stranded enhancer element to form a high-affinity 2:1 protein:DNA

276 erapy field, which aim to incorporate weaker enhancer elements to avoid insertional mutagenesis.

277 CTCF was shown to restrict activity of kappa enhancer elements to the Ig kappa locus.

278 ctroporation together with Atoh1 and Neurog1 enhancer elements to visualize, and assess the consequen

279 lows distally located provirus, with its own enhancer elements, to access the 5' regulatory region of

280 gs provide evidence for 'tissue regeneration enhancer elements' (TREEs) that trigger gene expression

281 via switching of GATA-1 for GATA-2 at a key enhancer element upstream of the GATA-2 gene.

282 We identified a putative enhancer element upstream of the key lymphatic transcrip

283 We previously identified an enhancer element upstream of the mouse cd5 gene that was

284 An enhancer element upstream of the mouse Gata1 IE (1st exo

285 This enhancer element was transactivated by cotransfection wi

286 To characterize the CYP2D6 enhancer element, we applied chromatin conformation capt

287 V) were constructed in which strong promoter/enhancer elements were used to drive expression of simia

288 us GAC63 was recruited to TCF/LEF-responsive enhancer elements when beta-catenin levels were induced

289 , the H3K9me2 modification extends to active enhancer elements where it promotes developmentally-link

290 buted to transcription factors that bind DNA enhancer elements, which are often located far from gene

291 T inhibition to the association of Brd4 with enhancer elements, which tend to be involved in lineage-

292 The mutation is located in a long-range enhancer element whose ability to bind the transcription

293 express CreER(T2) and GFP from ten different enhancer elements with activity in distinct domains with

294 the PDZK1IP1 protein shared transcriptional enhancer elements with the blood stem cell regulator TAL

295 We find that differential DNA methylation at enhancer elements, with concurrent changes in histone mo

296 rough a Stat92E-modulated, injury-responsive enhancer element within the draper gene.

297 that beta-catenin/TCF4 complexes bind a DNA enhancer element within the first intron of the YAP gene

298 epeat, termed R0, that can function as a DNA enhancer element within the intronic sequences of Firre.

299 state and site specific DNA demethylation of enhancer elements within the proximal promoters of AREG

300 We have previously identified cis-acting enhancer elements within the proximal upstream genomic r