ライフサイエンスコーパス: enigma

1 e signaling hub(s) involved have remained an enigma.

2 sweet potato in the Pacific has long been an enigma.

3 ent pulses of technological innovation is an enigma.

4 s, peripartum cardiomyopathy has remained an enigma.

5 tization to food antigens largely remains an enigma.

6 lipids to benefit its infection is still an enigma.

7 ogical basis for Mn(II) oxidation remains an enigma.

8 Nevertheless, how they function remains an enigma.

9 affected, the etiology of flushes remains an enigma.

10 nisms that underlie their activity remain an enigma.

11 the earliest urban civilizations, remains an enigma.

12 hhK in pantothenate biosynthesis remained an enigma.

13 nsible for its biosynthesis have remained an enigma.

14 discern misfolded proteins has long been an enigma.

15 zed to a nascent RNA transcript, has been an enigma.

16 tes, but their occurrence in metazoans is an enigma.

17 nucleotides to ribosome activity is one such enigma.

18 ymphocyte responses has been a long-standing enigma.

19 proteins, their existence in RNA remains an enigma.

20 d substances, is a millennia-old nutritional enigma.

21 ver its function in hematopoiesis remains an enigma.

22 bodies, cilial function(s) long remained an enigma.

23 warming in the Northern Hemisphere remain an enigma.

24 on, and thus the pathogenesis of TRAPS is an enigma.

25 uninfected or HCMV-infected cells remains an enigma.

26 nd how transcription is initiated remains an enigma.

27 r precise role in membrane fusion remains an enigma.

28 For other disparities, they remain an enigma.

29 hibernation or similar behaviors remains an enigma.

30 isual fixation, can drive illusory motion in Enigma.

31 sects, yet the origin of the pupa remains an enigma.

32 e dynamic process of CE, however, remains an enigma.

33 or equilibrium can explain this evolutionary enigma.

34 d enzyme activity in NendoUs has remained an enigma.

35 ism for exercise hyperaemia is a century old enigma.

36 in a hitherto uncharacterized gene we named Enigma.

37 e unique human brain remains an evolutionary enigma.

38 iation therapy have elucidated parts of this enigma.

39 terium tuberculosis has been a long-standing enigma.

40 c position of the giant deer has remained an enigma.

41 tion of Hassall's corpuscles has remained an enigma.

42 e spongiform encephalopathy (BSE) remains an enigma.

43 protein to B-cell immortalization remains an enigma.

44 mus-independent type 2 Ags is an immunologic enigma.

45 LD) senses unfolded proteins has remained an enigma.

46 oosing what we look at, but has long been an enigma.

47 main of TFPI-alpha, however, has remained an enigma.

48 found in all PC-1 family members remains an enigma.

49 t in eukaryotic membranes remains largely an enigma.

50 GSH transferase superfamily has remained an enigma.

51 eted for ubiquitin conjugation is largely an enigma.

52 se mechanism of allelic exclusion remains an enigma.

53 of serum ferritin, its secretion remains an enigma.

54 pass membrane filter of the cell, remains an enigma.

55 ns and symbionts, has remained an unresolved enigma.

56 enrichment in prostate carcinoma remains an enigma.

57 esults from the imaging genomics consortium, ENIGMA.

58 how force might be generated has remained an enigma.

59 function of motor cortex continues to be an enigma.

60 resultant increase in firing rate remain an enigma.

61 nhibitory Mdm2 isoforms in tumors remains an enigma.

62 y photosynthetically produced O2 was once an enigma.

63 de biosynthesis, and its function remains an enigma.

64 able to sense and respond to heat remains an enigma.

65 , and yet its control and function remain an enigma.

66 ts nucleotide cleavage specificity remain an enigma.

67 is underlying the three Y(DOM) classes is an enigma.

68 enerate InsP3 after fertilization remains an enigma.

69 and natural history of desmoid tumors are an enigma.

70 ently been cloned, their function remains an enigma.

71 its progeny, and therefore, P10 presents an enigma.

72 tment of Shc and subcellular localization by Enigma.

73 n green plants is a long-standing biological enigma.

74 abetes syndrome, but the etiology remains an enigma.

75 The origin of the red algae has remained an enigma.

76 However, the pathogenesis remains an enigma.

77 DS, its biochemical function has remained an enigma.

78 nisms of this communication have remained an enigma.

79 tween rod and cone channels has long been an enigma.

80 Congenital heart disease (CHD) is an enigma.

81 ve effect on fitness remains an evolutionary enigma.

82 Indeed, in many regards, pRB remains an enigma.

83 our framework provides clues regarding this enigma.

84 n the interseismic period is a long-standing enigma.

85 es in the sub-RPE space, however, remains an enigma.

86 dimer of STING represents a physicochemical enigma.

87 nisms generating PC-containing EVs remain an enigma.

88 ecretion of these antibodies has remained an enigma.

89 that its functional significance remains an enigma.

90 strength, leaving the core dynamo process an enigma.

91 nomenology and mechanisms involved remain an enigma.

92 ed, these substances are mysteries within an enigma.

93 f the faculty of language largely remains an enigma.

94 lipping this giant substrate has remained an enigma.

95 he catalyzed chemical conversion is still an enigma.

96 s unusual structural feature has remained an enigma.

97 hanism of this allelic exclusion has been an enigma.

98 -catenin activity in these events remains an enigma.

99 ose of this remarkable structure has been an enigma.

100 within the cytoplasm remains somewhat of an enigma.

101 change in calcium gradient have remained an enigma.

102 mor angiogenesis and tumor growth remains an enigma.

103 heir poor splicing, has been a long-standing enigma.

104 al genetics, the T/t complex and its genetic enigmas.

105 Enigma, a 455-residue protein, was discovered based on i

106 However, many enigmas about the molecular mechanisms involved remain u

107 Through the formation of the international ENIGMA ADHD Working Group, we aimed to address weaknesse

108 ese organisms at a given vent site remain an enigma after 20 years of research.

109 nistic bases for this specificity/degeneracy enigma and also compare and contrast Ag recognition by A

110 protein kinases, whereas the PDZ domains of Enigma and family member actin-associated LIM protein bi

111 The LIM domains of Enigma and its most related family member, Enigma homolo

112 ion and the perception of illusory motion in Enigma and rule out the hypothesis that the origin of th

113 The interaction between Enigma and skeletal beta-TM was specific for the PDZ dom

114 ar complexes that are properly localized via Enigma and transmit mitogenic signals via Shc.

115 hropoietin (Epo) have been until recently an enigma, and abnormality in the hypoxia-sensing pathway h

116 Among possible resolutions of the enigma are: a substantial reduction from traditional est

117 ma with skeletal beta-TM suggests a role for Enigma as an adapter protein that directs LIM-binding pr

118 ti-loci interactions remains something of an enigma as beyond low-resolution DNA FISH we do not have

119 has been studied extensively, it remains an enigma as to how the observed composition arises and is

120 t to LIM3 of Enigma binding to InsR, LIM2 of Enigma associated specifically with the receptor tyrosin

121 chanism(s) enhancing its formation remain an enigma because abiotic dolomite has been challenging to

122 rangement of Ig H and L chain genes poses an enigma because both processes use the same recombinatori

123 acterial-specific CD8(+) T cells has been an enigma because few have been identified in any species.

124 ied whereas the function of AcpT has been an enigma because no carrier protein substrate could be fou

125 rents on brain oscillations have remained an enigma because of the inability to record them simultane

126 ated lactone moiety of PLMs has presented an enigma because the predicted dehydratase domain in modul

127 ls for renal transplant recipients remain an enigma because there are no adequate randomized controll

128 utility of these replacements represents an enigma because they yield no improvements in the affinit

129 ss to copper bioavailability has remained an enigma, because copper metalloproteins are prevalent and

130 f these receptors still remain a tantalizing enigma, because numerous previous attempts at the large-

131 to 347 in the C-terminal region, has been an enigma, because the basis for its transformation defect

132 utionary conservation of both isozymes is an enigma, because, in vitro, they have very similar enzyma

133 In contrast to LIM3 of Enigma binding to InsR, LIM2 of Enigma associated specif

134 n skeletal muscle and that the PDZ domain of Enigma binds to a skeletal muscle target, the actin-bind

135 hese systems not only explain a longstanding enigma but also provide guidelines for further studies t

136 The precise role of NPY has been an enigma, but a recent study provides a breakthrough, demo

137 The pathophysiology of fibrosis remains an enigma, but considerable research and debate surrounds t

138 has always been a suspect for this clinical enigma, but the exact mechanisms have been unclear.

139 We analyze this enigma by considering that amorphous silicas present two

140 Here we show that this enigma can be resolved by introducing a critical scaling

141 cale genetic and clinical resources from the ENIGMA, CIMBA and BCAC consortia to assess pathogenicity

142 While deciphering the Enigma code, Good and Turing derived an unintuitive, yet

143 summary statistics of putamen volume in the ENIGMA cohort, a total of 15 independent significant SNP

144 The ENIGMA consortium conducted genome-wide association stud

145 tely independent of a study performed by the ENIGMA consortium, we conducted a large-scale multisite

146 quality-control pipeline established by the ENIGMA consortium.

147 ric changes in schizophrenia reported by the ENIGMA consortium.

148 Neuroimaging Genetics through Meta-analysis (ENIGMA) Consortium is a global team science effort, now

149 sphingolipids for over a century because new enigmas continue to surface.

150 ul illusory motion perceived in the painting Enigma, created by op-artist Isia Leviant.

151 ce of well powered longitudinal studies, the ENIGMA cross-sectional sample across six decades of ages

152 ns in an ATN-1(alpha-actinin)- and ALP-1(ALP/Enigma)-dependent manner, where it contributes to the or

153 ular basis for biosynthesis of 1 had been an enigma despite the availability of the A. fumigatus geno

154 ructural mechanism of AGE recognition was an enigma due to the diversity of chemical structures found

155 ed Ca(2+)-selective channels has remained an enigma, due largely to the continued inability to convin

156 We show that Enigma encodes a mitochondrial protein with homology to

157 le brain research collaborations such as the ENIGMA (Enhancing Neuro Imaging Genetics through Meta An

158 sent the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-An

159 Enigma subfamily proteins (Enigma, Enigma homolog protein, and Cypher) of the PDZ-L

160 rt of water across epithelia has remained an enigma ever since it was discovered over 100 years ago t

161 Saturn's largest moon, Titan, remains an enigma, explored only by remote sensing from Earth, and

162 NeuroImaging Genetics through Meta-Analysis (ENIGMA) findings.

163 steep energy barrier is overcome has been an enigma for a long time.

164 of Galactic cosmic-ray ions has remained an enigma for almost a century.

165 esis of Crohn's disease (CD) has remained an enigma for at least a century.

166 er synthesis by two catalytic centers was an enigma for over three decades.

167 his reason that superconductivity remains an enigma for scientists for over a century after Kammerlin

168 re as on its leading hemisphere, has been an enigma for three centuries.

169 ow neurons instantiate conscious states), an enigma for various disciplines.

170 cterial order Bacillales, yet they remain an enigma from both functional and phylogenetic perspective

171 sent a molecular and genetic analysis of ALP-Enigma function in C. elegans.

172 ans provides an excellent model to study ALP-Enigma function.

173 Across the subcortical regions studied by ENIGMA, gene expression profiles for three pathways were

174 This enigma has been a major obstacle to a full understanding

175 A long-term enigma has been how injury leads to dedifferentiation.

176 This enigma has been overcome by constructing a poliovirus (P

177 A longstanding enigma has been the origin of maternal centrosomes that

178 re we show that the actin-associated protein enigma homolog (ENH) is a cytoplasmic retention factor f

179 Here we show that a PKC binding protein, enigma homolog (ENH), interacts specifically with both P

180 tion of striated muscle, whereas the role of Enigma homolog protein (ENH) in muscle remains largely u

181 We studied the role of Enigma homolog protein in the heart using global and car

182 Enigma subfamily proteins (Enigma, Enigma homolog protein, and Cypher) of the PDZ-LIM domai

183 f Enigma and its most related family member, Enigma homology protein, bind to protein kinases, wherea

184 It is a long-standing enigma how glycogen storage disease (GSD) type I patient

185 It has been an enigma how Na,K-ATPase discriminates between Na(+) and K

186 We are left with an enigma: how can the FtsZ protofilament, which appears to

187 r (501)NGR to iso-DGR possibly explains this enigma, i.e. ligation of iso-DGR by alphavbeta3 integrin

188 o previous study has directly correlated the Enigma illusion to any specific physiological mechanism,

189 r complexity of eukaryotes represent a major enigma in biology.

190 One celebrated enigma in cardiac evolution involves the transition from

191 gh-valent enzymatic intermediates remains an enigma in chemical catalysis.

192 Africa and Asia - represents a long-standing enigma in ecology.

193 A central enigma in epigenetics is how epigenetic factors are guid

194 A major enigma in evolutionary biology is that new forms or func

195 Revisiting this enigma in Saccharomyces cerevisiae, we found that the re

196 for deciphering the long-standing structural enigma in self-assembled monolayers (SAMs).

197 Here I review this enigma in some detail, identifying several evolutionary

198 Hemoglobin (Hb) E (beta-Glu26Lys) remains an enigma in terms of its contributions to red blood cell (

199 to occur in diverse viruses, SIE remains an enigma in terms of key molecular determinants and action

200 gammadelta T cells are an immunological enigma in that both their function in the immune respons

201 ssing heritability', which has emerged as an enigma in the post-genome-wide association studies (GWAS

202 One enigma in tumor immunology is why animals bearing malign

203 ric disorders are among the most intractable enigmas in medicine.

204 3, have both fueled new insights and exposed enigmas in our understanding of the iconic p53 tumor sup

205 wall extension endures as one of the central enigmas in plant cell morphogenesis.

206 eceptors (ORs) constitute one of the biggest enigmas in the field.

207 Because Shc and Enigma interact with the same site on a Ret/ptc2 monomer

208 Enigma interacted with isoforms of tropomyosin expressed

209 Most proposals for resolving this enigma invoke additional players, such as lipid rafts or

210 The enigma is epitomized by loggerhead sea turtles (Caretta

211 Solving this infection enigma is important clinically, for diagnosis, prognosis

212 We show that Enigma is present at the Z line in skeletal muscle and t

213 Enigma is representative of a family of proteins compose

214 A major mechanistic enigma is the huge disparity between the pKa values of t

215 Another enigma is the replacement of existing strains during a g

216 A necessary step toward resolving this enigma is to define the cell types in which mHTT express

217 ated species - however, for many genera this enigma is yet to be satisfactorily explained.

218 in primary biliary cirrhosis (PBC) remain an enigma, it has been suggested that the pathology is medi

219 Enigma localizes to actin filaments in fibroblasts via i

220 ring these times, this long-standing climate enigma may be solved.

221 The performance of the Enigma MiniLab assay for influenza A and B viruses and r

222 of shared epitope-RA association remains an enigma, observations made during the last year shed new

223 The enigma of carotenogenesis in the absence of light (e.g.

224 de important insights into the long-standing enigma of CCA regulation and complete the first descript

225 as a potential solution to the evolutionary enigma of co-existing host-specific races (or 'gentes')

226 of methodology and concepts for solving the enigma of CuA are emphasized and impediments, often root

227 nses, and may bear relevance to the clinical enigma of greater MS susceptibility in women but faster

228 sed whole-genome sequencing and resolved the enigma of how such complex phenotypic differences can ha

229 ility to produce normal eggs remains a great enigma of human biology.

230 tential possibilities to shed light into the enigma of Maurer's clefts.

231 An enigma of modern medicine has persisted for over 150 yea

232 e-like effector differentiation is a central enigma of NKT cell development.

233 ologies potentially aiding in clarifying the enigma of plant lignification.

234 A major enigma of primary biliary cirrhosis (PBC) is the selecti

235 Male infertility is a long-standing enigma of significant medical concern.

236 The enigma of Sizzled, a secreted Frizzled-related protein,

237 The model resolves the apparent enigma of the cofactor-dependent product distribution an

238 esent study provide a solution to address an enigma of the CRP system, namely, the 3 orders of magnit

239 A central enigma of the cytolytic mechanism of the CDCs is that th

240 The enigma of the varicocele, although a source of frustrati

241 entification of WFBV in part may resolve the enigma of these mass mortality events, the details of th

242 iTregs do not, our results suggest that the enigma of variable responses of different human diseases

243 proteases and provide an explanation to the enigma of why plasmin/tissue plasminogen activator (t-PA

244 se findings may help explain a long standing enigma of why, despite the DNA repair deficiency, patien

245 N reentry, remain one of the most intriguing enigmas of cardiac electrophysiology.

246 ng to local functionality remains one of the enigmas of condensed matter physics.

247 The enigmas of rangeomorph morphology, evolution, and extinc

248 The genus Neolecta defines an enigma: phylogenetically placed in a related group conta

249 he latter to escape the profound theological enigmas posed by notions of ID.

250 sical fungal pathogens to remain a taxonomic enigma, primarily because it has resisted cultivation an

251 In Caenorhabditis elegans, the ALP-Enigma protein family is encoded by a single gene, alp-1

252 ations that affect the Z-disk-associated ALP-Enigma proteins have been linked to human muscular and c

253 human health, the mechanism of action of ALP-Enigma proteins is largely unknown.

254 Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group.

255 We conclude that LIM domains of Enigma recognize tyrosine-containing motifs with specifi

256 the yeast deletion library, we addressed an enigma regarding the apparent prevalence of gene dispens

257 These findings may explain the enigma regarding why COX-2 inhibitors are palliative rat

258 This first ENIGMA Schizophrenia Working Group study validates that

259 ted circulating progesterone has remained an enigma since Csapo first theorized of a functional withd

260 otrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869.

261 richia coli has proved to be something of an enigma since its discovery.

262 ely used, this model has remained in part an enigma since mice that carry the Tg.AC transgene (consis

263 placental mammals have remained a scientific enigma since the discovery of MHC haplotype diversity an

264 nce of self-reactive Abs in these mice is an enigma, since it has been demonstrated that they have in

265 retinitis pigmentosa presents a fascinating enigma: some mutation carriers are blind, while others a

266 on in Bacillus subtilis, we stumbled upon an enigma: some strains used to describe pattern formation

267 Enigma subfamily proteins (Enigma, Enigma homolog protei

268 Among the Enigma subfamily, Cypher has been demonstrated to play a

269 tnessed the resolution of some long-standing enigmas surrounding the immunobiology of dendritic cells

270 These biochemical findings lead to an enigma that how PTPN11 mutations with opposite effects o

271 aining fundamental questions surrounding the enigma that is BV.

272 Either conclusion is an enigma that points to gaps in our fundamental understand

273 rting point for explaining the long standing enigma that the E2b core of the BCKDC binds E3 far more

274 It has been an enigma that Treg exhibit an anergic phenotype reflected

275 plicated by the early presence of an African enigma, the bottle gourd (Lagenaria siceraria).

276 lth used a novel approach to disentangle the enigma: The 116 cases of scarlet fever were compared wit

277 ession of the other has been a long-standing enigma, though we know RUNX transcription factors activa

278 Explanations for this enigma typically invoke the deposition in the corona of

279 ocalization was mediated by association with Enigma via the Ret/ptc2 sequence containing tyrosine 586

280 ENIGMA-Viewer is an open-source tool, the source code an

281 ENIGMA-Viewer supports presentations and communications

282 We present ENIGMA-Viewer, an interactive web-based visualization to

283 alization of the results is available at www.enigma-viewer.org.

284 The second of the three LIM domains in Enigma was also identified as a Ret/ptc2 binding domain.

285 The enigma was resolved by a kinetic model that allowed for

286 This enigma was resolved by the recent description of a metho

287 One remaining enigma was the basis for depolarization-induced weakness

288 l beta-TM was specific for the PDZ domain of Enigma, was abolished by mutations in the PDZ domain, an

289 In order to resolve this enigma, we have calculated the free energy landscape of

290 To address this enigma, we have developed two primary human cervical epi

291 To resolve this enigma, we have examined the ability of CTLs to recogniz

292 To unravel this enigma, we investigated transactivation response RNA bin

293 anoma, eumelanin photoprotection is still an enigma: What makes this pigment so efficient in dissipat

294 It has been an enigma whether the hormone interacts with the endodomain

295 It has long been an enigma whether the mechanism of P(4)-ATPases resembles t

296 up or slowed down during the observation of Enigma while we simultaneously recorded their eye moveme

297 The association of Enigma with skeletal beta-TM suggests a role for Enigma

298 sis, we used the data from the international ENIGMA Working Group collaboration, which in the present

299 Myc is an enigma wrapped in a mystery.

300 e even at large particle size, presenting an enigma yet to be understood.