ライフサイエンスコーパス: enteroendocrine cell

1 level of constitutive expression of NT/N in enteroendocrine cells.

2 and of preproglucagon, which is expressed in enteroendocrine cells.

3 signaling, specify their daughters to become enteroendocrine cells.

4 , including Paneth and goblet cells, but not enteroendocrine cells.

5 ge analysis to generate both enterocytes and enteroendocrine cells.

6 inal cell populations, including a subset of enteroendocrine cells.

7 y generalized malabsorption and a paucity of enteroendocrine cells.

8 lycan expression and a paucity of goblet and enteroendocrine cells.

9 , have fewer goblet cells, and supernumerary enteroendocrine cells.

10 quired to produce an appropriate fraction of enteroendocrine cells.

11 but are interspersed with hormone-producing enteroendocrine cells.

12 egulatory elements are not active in gastric enteroendocrine cells.

13 cosal T lymphocytes and serotonin-containing enteroendocrine cells.

14 or activator binding in islet beta-cells and enteroendocrine cells.

15 rminal differentiation of secretin-producing enteroendocrine cells.

16 receptors are expressed, at least partly, in enteroendocrine cells.

17 proteins are bioactive, nor their effects on enteroendocrine cells.

18 reprogram extant class I cells into class II enteroendocrine cells.

19 A2 and FFA3 were immunolocalised to duodenal enteroendocrine cells.

20 tty acids (LCFAs) and SCFAs are expressed in enteroendocrine cells.

21 certain other hormones in other types of the enteroendocrine cells.

22 d in the infection of mucosal nerves through enteroendocrine cells.

23 teria stimulate epithelial biosensors called enteroendocrine cells.

24 innervated sensory epithelial cells, such as enteroendocrine cells.

25 eages: intermediate-like (Paneth/goblet) and enteroendocrine cells.

26 iously unrecognized tissue-intrinsic role of enteroendocrine cells.

27 or the normal development of mouse and human enteroendocrine cells.

28 TRPA1 to excite primary sensory neurons and enteroendocrine cells.

29 g progeny that replace dying enterocytes and enteroendocrine cells.

30 he development of both pancreatic islets and enteroendocrine cells.

31 l enterocytes, as well as goblet, Paneth and enteroendocrine cells.

32 However, we recently uncovered in intestinal enteroendocrine cells a cytoplasmic process that we name

33 Here we report a novel function of enteroendocrine cells acting as local regulators of inte

34 s requires sensing of meal components by gut enteroendocrine cells, activation of neural and humoral

35 are incretins secreted by respective K and L enteroendocrine cells after eating and amplify glucose-s

36 focal immunohistochemistry with serotonin in enteroendocrine cells and also with endothelial nitric o

37 nd unexpected diversity in hormone-secreting enteroendocrine cells and constructed the taxonomy of ne

38 late GLP-1 and GIP secretion from intestinal enteroendocrine cells and increase GSIS from pancreatic

39 t T2R gene expression in both cultured mouse enteroendocrine cells and mouse intestine is regulated b

40 by biologic agents produced and released by enteroendocrine cells and neurons as well as by exogenou

41 europods provide a direct connection between enteroendocrine cells and neurons innervating the small

42 a small number of cell types, including gut enteroendocrine cells and sympathetic ganglia, where it

43 s on endogenous enteric hormones produced by enteroendocrine cells and the enteric nervous system.

44 Peptide YY(+) cells gave rise to all L-type enteroendocrine cells and to islet partial differential

45 FFA3 was immunolocalized to enteroendocrine cells and to the enteric neural plexuses

46 +) cells from Bmi1(GFP) mice are preterminal enteroendocrine cells and we identify CD69(+)CD274(+) ce

47 ocrine-cell progenitors differentiating into enteroendocrine cells, and (2) switching on the expressi

48 usion casein proteins are not detrimental to enteroendocrine cells, and alpha and beta casein are par

49 (NPS), is expressed by gastrointestinal (GI) enteroendocrine cells, and is involved in inflammation,

50 HRVs infect differentiated enterocytes and enteroendocrine cells, and viroplasms and lipid droplets

51 The abnormalities in the ileal enteroendocrine cells appear to be caused by two mechani

52 IBS), and whether any abnormalities in ileal enteroendocrine cells are correlated with abnormalities

53 Intestinal enteroendocrine cells are critical to central regulation

54 Despite being electrically excitable, enteroendocrine cells are generally thought to communica

55 5HT-containing enteroendocrine cells are most numerous in the duodenum

56 Enteroendocrine cells are one of the four major cell typ

57 although goblet cells resist E11 infection, enteroendocrine cells are permissive, suggesting that en

58 three secretory lineages, goblet, paneth, or enteroendocrine cells, are not fully understood.

59 r results indicate that all small intestinal enteroendocrine cells arise from ngn3-expressing cells a

60 ondin domain-containing protein expressed in enteroendocrine cells as well as in epithelial cells in

61 rminal differentiation of the pancreatic and enteroendocrine cells, as well as for the survival of ph

62 In the intestine, Pak3 is expressed in enteroendocrine cells but is not necessary for their dif

63 Transformation of secretin-producing enteroendocrine cells by SV40 requires functional cooper

64 We find that class I and class II enteroendocrine cells can be distinguished locally by co

65 me transcription factors as their intestinal enteroendocrine cell counterparts.

66 ssociated with reduced expression of PYY, an enteroendocrine cell-derived hormone that normally inhib

67 , is both necessary and sufficient for human enteroendocrine cell development in vitro.

68 To understand the molecular basis of enteroendocrine cell development, we have used gene targ

69 eurogenin 3 stimulated a program of terminal enteroendocrine cell development.

70 g that Arx is required in the progenitor for enteroendocrine cell development.

71 Neurogenin 3 is essential for enteroendocrine cell development; however, it is unknown

72 RB has relatively subtle effects on enteroendocrine cell differentiation and is not required

73 f the beta-catenin gene at an early stage of enteroendocrine cell differentiation induced small-intes

74 nin-3 overexpression induced goblet cell and enteroendocrine cell differentiation, respectively, cons

75 ed for intestinal secretory (goblet, Paneth, enteroendocrine) cell differentiation.

76 cellular and molecular mechanisms governing enteroendocrine cell diversity.

77 ngenital malabsorptive diarrhea secondary to enteroendocrine cell dysgenesis.

78 In obese patients, the total number of enteroendocrine cells (EEC) and EECs containing gut horm

79 nin (CCK) and secretin, peptides released by enteroendocrine cells (EECs) in the duodenum/jejunum, wh

80 urogenin3 (Neurog3)-expressing cells, unlike enteroendocrine cells elsewhere in the digestive tract.

81 Enteroendocrine cells engineered to secrete recombinant

82 ating glucagon-like peptide-1 secretion from enteroendocrine cells, enhancing glucose uptake in 3T3-L

83 pecialized elements of the mucosa (including enteroendocrine cells, enterocytes and immune cells) and

84 a cells, and for terminal differentiation of enteroendocrine cells expressing the hormone secretin.

85 ion, secretin- and cholecystokinin-producing enteroendocrine cells failed to develop in the absence o

86 NA from three unrelated patients with sparse enteroendocrine cells for mutations of NEUROG3.

87 mice to study neural circuits, we found that enteroendocrine cells have the necessary elements for ne

88 av1.8-expressing vagal afferents with select enteroendocrine cells (i.e., ghrelin, glucagon, GLP-1).

89 hat peptide profiles are a stable feature of enteroendocrine cell identity during homeostasis and fol

90 Intestinal enteroendocrine cells (IECs) secrete gut peptides in res

91 and molecular bridge between enteric nerves, enteroendocrine cells, immune cells, and epithelial cell

92 We describe a type of enteroendocrine cell in mouse duodenum that is defined b

93 xhibit greater than 90% decrease in tuft and enteroendocrine cells in both crypts and villi of the sm

94 We studied a subset of these enteroendocrine cells in duodenum that produce several p

95 We observed loss of Paneth, goblet, and enteroendocrine cells in Math1-null crypts.

96 stem cells that generate new enterocytes and enteroendocrine cells in response to tissue requirements

97 Enteroendocrine cells in the gastrointestinal tract play

98 redominantly in pancreatic beta-cells and in enteroendocrine cells in the gastrointestinal tract.

99 y participate in GABA-modulated functions of enteroendocrine cells in the GI lumen.

100 in-coupled receptor expressed by a subset of enteroendocrine cells in the gut epithelium.

101 e of regulating peptide hormone release from enteroendocrine cells in the gut.

102 otropic polypeptide (GIP)) are secreted from enteroendocrine cells in the intestinal epithelium, and

103 nsmembrane receptor that is expressed in the enteroendocrine cells in the intestine and in the islets

104 ause GABArho receptors are normally found in enteroendocrine cells in the lumen of the digestive trac

105 Secretin-producing enteroendocrine cells in the murine small intestine show

106 peptide-1 (GLP-1) and peptide YY (PYY), from enteroendocrine cells in the small intestine.

107 ngn3 is required for the differentiation of enteroendocrine cells in the stomach and the maintenance

108 l of the abnormal epithelium, the numbers of enteroendocrine cells in the villi are greatly reduced.

109 ween Nav1.8-expressing mucosal afferents and enteroendocrine cells, including apparent neuroendocrine

110 ng nutrient sensing and peptide secretion by enteroendocrine cells, including novel taste-like pathwa

111 ymphocytes and goblet cells reduced, and the enteroendocrine cells increased.

112 erizing the roles and functions of different enteroendocrine cells is an essential step in understand

113 absorptive diarrhea and a lack of intestinal enteroendocrine cells is caused by loss-of-function muta

114 tificial pancreas based on insulin-secreting enteroendocrine cells is insufficient as a standalone th

115 Expression of the hormone secretin in enteroendocrine cells is restricted to the nondividing v

116 kinin (CCK) secretion in humans and from the enteroendocrine cell line STC-1 depends critically on ac

117 Using the enteroendocrine cell line STC-1, the aim of this study w

118 Recently, we proposed that the murine enteroendocrine cell line, STC-1, responds to insoluble

119 ne, glucagon-like peptide (GLP-1), using the enteroendocrine cell line, STC-1.

120 eta and kappa casein) and hydrolysates on an enteroendocrine cell line.

121 receptors also was found in STC-1 cells, an enteroendocrine cell line.

122 cose homeostasis through a modulation of the enteroendocrine cell lineage.

123 s role in the development and maintenance of enteroendocrine cell lineages in the mouse duodenum and

124 cellular Ca2+ concentration ([Ca2+]i) in two enteroendocrine cell lines (STC-1 and GLUTag).

125 CK) secretion both in humans and from murine enteroendocrine cell lines.

126 The K cell is a specific sub-type of enteroendocrine cell located in the proximal small intes

127 s in a profound deficit in expression of the enteroendocrine cell markers CCK, secretin and glucagon

128 egatively regulating chromogranin A-positive enteroendocrine cell number.

129 These include the release from enteroendocrine cells of mediators including 5HT, CCK, G

130 Enteroendocrine cells of the gastrointestinal (GI) tract

131 ptide predominantly localized in specialized enteroendocrine cells of the small intestine and release

132 pancreatic beta-cells and incretin-producing enteroendocrine cells of the small intestine.

133 reting copper cells, interstitial cells, and enteroendocrine cells of the stomach.

134 The transgene was not expressed in goblet or enteroendocrine cells or in crypts.

135 canonical Notch signaling, was restricted to enteroendocrine cells or undetectable in the mucosa of t

136 Our results suggest that RB is required for enteroendocrine cells, particularly serotonin cells, to

137 controlling incretin secretion, we analyzed enteroendocrine cell pathways important for hormone bios

138 Stimulus-coupled incretin secretion from enteroendocrine cells plays a fundamental role in glucos

139 Enteroendocrine cells populate gastrointestinal tissues

140 Nkx2.2 null mice, several hormone-producing enteroendocrine cell populations are absent or reduced a

141 s the differentiation of progressively fewer enteroendocrine cell populations when deleted from Ngn3(

142 The patients had few intestinal enteroendocrine cells positive for chromogranin A, but t

143 , goblet cells, Paneth cells, tuft cells and enteroendocrine cells), presence of functional brush-bor

144 examined whether the densities of stem- and enteroendocrine cell progenitors are abnormal in the ile

145 related with abnormalities in stem cells and enteroendocrine cell progenitors.

146 Beta casein significantly stimulated enteroendocrine cell proliferation and all caseins were

147 Secretin-producing enteroendocrine cells represent a nondividing subpopulat

148 xis of the gastrointestinal system, discrete enteroendocrine cells respond to both mechanical and che

149 epithelium, enterochromaffin (EC) cells are enteroendocrine cells responsible for producing >90% of

150 mice, expression of NT in Drosophila midgut enteroendocrine cells results in increased lipid accumul

151 Loss of enteroendocrine cells reveals the critical need for ente

152 K) is a satiety hormone produced by discrete enteroendocrine cells scattered among absorptive cells o

153 Mechanistically, midgut enteroendocrine cells secrete the neuroendocrine hormone

154 Although Nkx2.2 regulates enteroendocrine cell specification in the duodenum at al

155 enterocytes, goblet cells, Paneth cells, and enteroendocrine cells, suggesting that the fusion partne

156 ntains a diffuse endocrine system comprising enteroendocrine cells that secrete peptides or biogenic

157 Enteroendocrine cells, the largest and most diverse popu

158 Enteroendocrine cells throughout the gut and pancreas se

159 cy caused by disruption of PCSK1, failure of enteroendocrine cells to produce functional hormones res

160 How fatty acids stimulate enteroendocrine cells to release cholecystokinin (CCK) i

161 that fatty acids can interact directly with enteroendocrine cells to stimulate CCK secretion via inc

162 e body, but remarkably little is known about enteroendocrine cell type specification in the embryo an

163 antral stomach and intestine, whereas other enteroendocrine cell types exhibited much lower cell cyc

164 developing endoderm results in a decrease of enteroendocrine cell types including gastrin-, glucagon/

165 continued in a significant fraction of most enteroendocrine cell types throughout fetal and postnata

166 Other enteroendocrine cell types were not ablated.

167 g embryonic development Nkx2.2 regulates all enteroendocrine cell types, except gastrin and preproglu

168 the taste G protein gustducin, expressed in enteroendocrine cells, underlie intestinal sugar sensing

169 cids directly influence peptide release from enteroendocrine cells using STC-1, a mouse intestinal en

170 tic of enterocytes, and a loss of goblet and enteroendocrine cells was observed.

171 ation, and altered proportions of goblet and enteroendocrine cells) was inhibited by AG1024.

172 chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 6

173 In keeping with this, no enteroendocrine cells were detected in intestinal biopsy

174 ght junctions and desmosomes, and goblet and enteroendocrine cells were present.

175 ction and transduction are also expressed in enteroendocrine cells where they underlie the chemosenso

176 T2Rs are also expressed in gut-derived enteroendocrine cells, where they have also been hypothe

177 reconstituted in vitro by coculturing single enteroendocrine cells with sensory neurons.