ライフサイエンスコーパス: enterohepatic

1 and sterol transporter that facilitates the enterohepatic and renal-hepatic circulation of bile acid

2 F15)/cholesterol-7alpha-hydroxylase (Cyp7a1) enterohepatic axis and eventually provide protection aga

3 Interruption of enterohepatic BA cycling after partial external biliary

4 nt mice maintained free of the Gram-negative enterohepatic bacteria Helicobacter spp. for up to 9 mon

5 We investigated the effect of the enterohepatic bacterial pathogen Helicobacter hepaticus

6 Disruption of the enterohepatic bile acid circulation during biliary tract

7 farnesoid X receptor dramatically increases enterohepatic bile acid levels and jet-lag-induced HCC,

8 rovide an important contributing role in the enterohepatic bile acid metabolism and cholesterol homeo

9 Replacing the enterohepatic bile acid pool with DCA restored FXR mRNA

10 FXR is the sensor of physiological levels of enterohepatic bile acids, the end products of cholestero

11 to 57% +/- 5% of paired controls with intact enterohepatic circulation (P < 0.0001).

12 nal selective FXR reactivation normalized BA enterohepatic circulation along with up-regulation of in

13 (11)C-cholylsarcosine underwent an enterohepatic circulation and reappeared in liver tissue

14 acid (BA) synthesis and transport within the enterohepatic circulation has revealed potential targets

15 Cholate feeding to rats with intact enterohepatic circulation increased mdr2 transcriptional

16 ects of bile acids on tissues outside of the enterohepatic circulation may be of major pathophysiolog

17 Thus, the enterohepatic circulation of all conjugated bile acids w

18 We analyzed expressions of factors mediating enterohepatic circulation of BA using ileal and colonic

19 r, they suggest a potential role for altered enterohepatic circulation of BAs in improving insulin se

20 tic BA uptake machinery maintains a (slower) enterohepatic circulation of BAs, although it is occasio

21 in the distal ileum plays a key role in the enterohepatic circulation of BAs.

22 defects in gallbladder emptying that disrupt enterohepatic circulation of BAs.

23 n of bile acids, a rate-limiting step in the enterohepatic circulation of bile acids and transactivat

24 The enterohepatic circulation of bile acids is maintained by

25 Interruption of the enterohepatic circulation of bile acids leads to increas

26 l diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced pla

27 hASBT, SLC10A2) plays a critical role in the enterohepatic circulation of bile acids, as well as in c

28 and intestine and controls the synthesis and enterohepatic circulation of bile acids.

29 ns (ILBPs) are involved in the transport and enterohepatic circulation of bile acids.

30 acid amidation, a critical component of the enterohepatic circulation of bile acids.

31 bile acid cotransporter participates in the enterohepatic circulation of bile acids.

32 y pump, a critical component involved in the enterohepatic circulation of bile acids.

33 otransporter superfamily and function in the enterohepatic circulation of bile acids.

34 oduct is likely to play an essential role in enterohepatic circulation of bile acids; further charact

35 transporter (ASBT, SLC10A2) facilitates the enterohepatic circulation of bile salts and plays a key

36 The enterohepatic circulation of bile salts is an important

37 nse of the transport process involved in the enterohepatic circulation of bile salts to obstructive c

38 g activity of FGF19 in organs engaged in the enterohepatic circulation of bile salts.

39 roteins and is thought to play a role in the enterohepatic circulation of bile salts.

40 function in the transcellular transport and enterohepatic circulation of bile salts.

41 We propose the existence of an enterohepatic circulation of lymphocytes, whereby some m

42 fecal excretion, suggests the possibility of enterohepatic circulation of this drug.

43 gation of bile acids entering liver from the enterohepatic circulation rather than in de novo bile ac

44 transformation enzyme activities, changes in enterohepatic circulation, altered bioavailability of en

45 terocyte, along with the contribution of the enterohepatic circulation, are considered.

46 results suggest that systemic alterations in enterohepatic circulation, as well as host and microbiot

47 bile salts, a critical determinant of their enterohepatic circulation, is mediated primarily by the

48 e quantity of bile salts fluxing through the enterohepatic circulation.

49 olate cotransporting polypeptide, within the enterohepatic circulation.

50 ossing biological membranes, and clearing by enterohepatic circulation.

51 ed rats and mice, and in mice with an intact enterohepatic circulation.

52 al CFTR(inh)-172 accumulation facilitated by enterohepatic circulation.

53 a measurement (one patient) is suggestive of enterohepatic circulation.

54 ll intestine and only in animals with intact enterohepatic circulation.

55 ted charcoal, to interrupt enterovascular or enterohepatic circulations, offers benefit compared with

56 xiliary transporters are able to sustain the enterohepatic cycle in its absence.

57 d X receptor (FXR) plays a major role in the enterohepatic cycling of bile acids, but the impact of n

58 salts in the circulation suggested residual enterohepatic cycling of bile salts.

59 ults are consistent with the hypothesis that enterohepatic cycling of bilirubin occurs with bile salt

60 ats), indices of bile salt malabsorption and enterohepatic cycling of bilirubin were measured, includ

61 Because ileectomy in rats induces enterohepatic cycling of bilirubin, the hypothesis that

62 o test the hypothesis that ileectomy induces enterohepatic cycling of bilirubin.

63 orption, dietary UDCA and cholesterol induce enterohepatic cycling of bilirubin.

64 xtrahepatic exposure and underwent extensive enterohepatic cycling.

65 us-associated tumors in woodchucks or causes enterohepatic disease in cats.

66 Clostridium piliforme induces enterohepatic disease in many domestic and laboratory an

67 liforme infection (Tyzzer's disease) induces enterohepatic disease in many domestic and laboratory an

68 ation of other Helicobacter spp. involved in enterohepatic disease.

69 a bona fide novel therapeutic agent to treat enterohepatic disorders such as cholestasis, NASH, and i

70 nductance regulator (CFTR) deficiency on the enterohepatic disposition of bile acids (BAs).

71 or PXR (pregnane X receptor), a regulator of enterohepatic drug metabolism and clearance, results in

72 nthesis is controlled, in part, by a complex enterohepatic feedback regulatory mechanism.

73 However, the activating ligand (DCA) in the enterohepatic flux is necessary for FXR-mediated transcr

74 We propose that the enhanced enterohepatic flux of bile acids during HF-LC consumptio

75 icobacter gastritis, we investigated whether enterohepatic Helicobacter bilis modulates Helicobacter

76 bacter cinaedi is the most commonly reported enterohepatic helicobacter in humans, there are no repor

77 Helicobacter hepaticus, an enterohepatic helicobacter in mice, is known to cause he

78 es of known virulence factors found in other enterohepatic helicobacter species (EHS) and H. pylori T

79 To investigate how different enterohepatic Helicobacter species (EHS) influence Helic

80 Discrimination of this organism from other enterohepatic Helicobacter species and Campylobacter spe

81 Enterohepatic Helicobacter species are associated with s

82 Helicobacter hepaticus is an enterohepatic Helicobacter species that induces lower bo

83 eptible to colitis induced by the pathogenic enterohepatic Helicobacter species, H. hepaticus.

84 Cdt with other enteric pathogens, including enterohepatic Helicobacter species.

85 sis of hepatitis and enterocolitis caused by enterohepatic Helicobacter species.

86 sults suggest a possible association between enterohepatic Helicobacter spp and cholesterol cholelith

87 7L mice were infected with several different enterohepatic Helicobacter spp or left uninfected and fe

88 Helicobacter bilis, an enterohepatic helicobacter, is associated with chronic h

89 Consistent with other murine enterohepatic helicobacters, WT(Hc) did not cause typhlo

90 ver to the gut as one branch of a postulated enterohepatic lymphocyte circulation.

91 g cells can induce gut tropism supporting an enterohepatic lymphocyte circulation.

92 ly susceptible to colitis induced by another enterohepatic microaerobe, Helicobacter hepaticus, which

93 Enterohepatic nuclear receptors including farnesoid X re

94 Helicobacter hepaticus, a widespread murine enterohepatic pathogen.

95 bt expression, fecal bile acid excretion, or enterohepatic pool size that might explain the phenotype

96 amage, breakdown of intercellular integrity, enterohepatic recirculation and neutrophil activation by

97 Enterohepatic recirculation most probably contributes to

98 hought to be critical for the maintenance of enterohepatic recirculation of bile acids and hepatocyte

99 Possible enterohepatic recirculation of flavan-3-ols is discussed

100 amage, breakdown of intercellular integrity, enterohepatic recirculation, and neutrophil activation b

101 Through a process known as enterohepatic recirculation, more than 90% of secreted b

102 dependent bile acid transporters involved in enterohepatic recirculation, the Na(+)-taurocholate co-t

103 from the intestinal lumen to preserve their enterohepatic recirculation.

104 stores, since progesterone does not undergo enterohepatic recirculation.

105 4%, elimination half-life of 4 hours, and an enterohepatic recirculation.

106 P5 in reconjugation of bile acids during the enterohepatic recirculation.

107 xperienced transaminitis, revealing enhanced enterohepatic recycling of deglucuronidated tacrine in t

108 or based oral delivery of GLP-1 gene through enterohepatic recycling pathways of bile acids.

109 intestinal microflora, are absorbed, undergo enterohepatic recycling, and reach circulating concentra

110 It is highly expressed in the enterohepatic system, where it senses bile acid levels t

111 ward, protective pathway operative in murine enterohepatic tissues wherein FXR induces AKR1B7 to deto

112 and inflammation by acting predominantly in enterohepatic tissues, but also in peripheral organs.

113 ed by bile acids and abundantly expressed in enterohepatic tissues, plays a crucial role in maintaini

114 d receptors that are highly expressed in the enterohepatic tissues.

115 ably, despite the broad knowledge of the FXR enterohepatic transcriptional activity, the molecular me

116 criptionally regulate their biosynthesis and enterohepatic transport.