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1 d aflibercept alone accounted for 95% of the entire $1.9 billion in drug reimbursements ophthalmologi
4 studied the effect of overexpression of the entire 4.8 kb miR-183 family cluster, including the inte
5 3 (SE = 0.017) survival probability over the entire 500 km study area compared to 0.199 (0.012) for t
8 on that is genetically more diverse than the entire A1/D1 East cluster caused the sudden emergence of
9 erstanding the structure and mechanism of an entire ABC transporter superfamily and the many diverse
10 tes, the model can successfully simulate the entire adsorption data set over all uranium loadings, pH
12 entify conformational changes throughout the entire AMPA receptor that accompany activation and desen
13 a) based on repeated measurements across the entire analytical procedure is 0.6 per thousand for delt
17 accharomyces species complex, and across the entire and diversified subphylum of Saccharomycotina.
18 n improvement, as breeders have selected for entire and lobed leaf morphs resulting from a single loc
19 major functional networks extend through the entire animal and are activated selectively during longi
20 en theory and experiment is achieved for the entire applied frequency range and the wide bipolar bias
26 to secure sufficient doses to vaccinate the entire at-risk population-approximately 1 million people
27 spectrotemporal-based representation of the entire auditory scene, with both attended and unattended
28 (0.305 diopter [D]) absolute error over the entire axial length range, and was comparable with the f
31 se resulted in hypoxic conditions across the entire Baltic sea as revealed by multiple sedimentary re
34 sels connect multiple systems throughout the entire body and allow organs to interact via circulating
35 sing the geometric coverage to encompass the entire body, sensitivity can be increased by a factor of
39 The 4D spectral function rho(EB; k) in the entire bulk Brillouin zone and 6 eV binding-energy (EB)
40 ntrast-enhanced US showed enhancement of the entire bulk of the tumor, whereas gadolinium-enhanced T1
42 s next generation sequencing (NGS), mean the entire cancer genome or parts of it can now be sequenced
47 ing pathways and effector systems across the entire cerebrovascular network in a highly orchestrated
48 edisposition gene, while the analysis of the entire coding region of the FANCM gene in familial index
49 cific survival after 5 years was 38% for the entire cohort (95% CI, 25%-51%); the disease-specific su
50 of breast cancer, representing 0.41% of the entire cohort and 7.56% of the subset with metastatic di
55 of overall and disease-free survival for the entire cohort, including patients with myeloid malignanc
62 convenient data resources widely used by the entire community and offer some lessons on what makes a
63 to annual oral azithromycin treatment of the entire community or biannual treatment of children aged
65 down of either RhopH2 or RhopH3 disrupts the entire complex, interfering with organellar targeting an
74 rwent vessel painting perfusion to label the entire cortex at 1 day post TBI followed by whole brain
75 eld suggests a boro rice yield loss over the entire country of 1.4-4.9 million tons annually, or 7-26
77 ing HIV-1 genomes and allows us to track the entire course of infection in macrophages, a key target
79 The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, inc
80 al tests, which compare the distributions of entire data sets, were used to determine if the ammonia
82 we performed hierarchical clustering on the entire dataset to investigate the underlying causal stru
86 n Gadoteridol was far less retained, and the entire detected gadolinium was intact soluble GBCA, whil
91 onide dry powder inhaler twice daily for the entire duration of the study using the approved dosages
92 o address this discrepancy, we expressed the entire ectodomain of mouse P-selectin as a monomer (sP-s
93 ness change for 14 endemic groups over their entire evolutionary histories without the need for fossi
94 at the RPE interdigitations extend along the entire external segment of the cones, we do not believe
95 of the SEC61G, yielding products lacking the entire extracellular ligand-binding domain of the recept
96 tional deletion of TGF-beta signaling in the entire eye, the retinal pigment epithelium (RPE), or the
100 equently provides an image in focus over the entire field of view without any beam scanning or imagin
115 ensive studies of genetic diversity over the entire genome of human cytomegalovirus (HCMV), a signifi
116 ere relatively evenly distributed across the entire genome, and covered 98.6% of the reference genome
117 rovides a comprehensive understanding of the entire genome, overcomes limitations of traditional QTL
119 ve Lgr5(-) cells that are able to repopulate entire glands, including the base, upon depletion of the
120 ed MUAC with WHZ.The mean +/- SD age for the entire group was 21 +/- 14 mo, WHZ was -1.18 +/- 1.23, h
121 d an overriding effect on risk-taking by the entire group, for reasons independent of their physiolog
123 cy to breathe air influence the behaviour of entire groups, and whether such influences vary in relat
128 langes, respectively, both contribute to the entire host autopod, indicating that the autopod positio
133 tantly, CRISPR/Cas9-mediated ablation of the entire Id (Id1-4) family in mouse embryos leads to failu
134 the same object detector which processes the entire image at homogeneous high spatial resolution.
140 portance of environmental filters during the entire invasion process for the facilitation or inhibiti
142 actin subunits typically diffuse across the entire lamellipodium before reassembling into the networ
144 r hair cells, whereas it was detected in the entire lateral wall of cochlear outer hair cells and had
146 resent such intimate ER-PM contact along the entire length of the pores that no intermembrane gap is
147 ragments (60-79 aa), which together span the entire length of tropomyosin, were weak secretagogues.
148 ight nanobeams with a complete LOS along the entire length to nanobeams in which the LOS ranges from
154 hich commonly involves the extraction of the entire list of chemicals mentioned in a document, includ
156 scripts, with increased transcription of the entire locus driving Flt1 upregulation in both EO-PE and
157 uced correlated atomic motion throughout the entire LRH-1 activation function surface, which was depe
160 ecedented in silico experiment-simulating an entire mammal red blood cell lipid bilayer and cytoskele
164 us, despite evolutionary conservation of the entire MeCP2 protein sequence, the DNA and co-repressor
167 esting that CSNK-1 prevents expulsion of the entire meiotic spindle into a polar body by negatively r
169 sagittal brain slices containing nearly the entire mesh electronics probe showed that the tissue int
172 tudies that evaluated microbial biofilms and entire microbiomes to establish their similarities and d
178 ropic dispersion of CN nanospheres along the entire NB head nanotubes lead to creating of abundant el
180 med "worm hospital" allows us to perform the entire nerve regeneration studies, including on-chip axo
182 PN) caused a rapid, global regression of the entire network, with some vessels regressing >10 mm with
183 models, enabling experimental access to the entire neuromechanical control loop of vocal motor contr
184 Such hitherto unknown patterns over the entire North American continent have the potential to si
189 Low-dose RCEM was efficient in digesting entire pancreases to obtain higher yield (5535 +/- 830 a
191 affords, after reductive elimination of the entire PCO group, the unprecedented [L2 Ge-GeL2 ] comple
193 gnostic biomarker that is present across the entire period of patient presentation, particularly in t
194 The failure-to-rescue rate was 4.4% for the entire period, but it significantly decreased after intr
197 yanin contents, antioxidant capacity and the entire phenolic profile were investigated for extracts f
198 ) to impose consistent associations with the entire phenotype paths in predicting phenotype-gene asso
199 nces 78 Recent decades have seen declines of entire plant clades while other clades persist despite c
200 binding, is not evenly distributed over the entire plasma membrane but instead is highly enriched on
201 Using a quantitative approach to profile the entire plasma membrane proteome, we find that CMTM6 disp
203 is the only method capable of exploring the entire population of free-floating planets down to Mars-
208 og/m3 increment in PM2.5 exposure during the entire pregnancy was associated with 8.8% (95% CI, -14.1
212 example of how a single miRNA can control an entire process by acting on a crucial mediator; however,
217 cell-penetrating peptides and that both the entire protein and the peptide corresponding to the N-te
218 ical response by being coupled to nearly the entire protein, responding to both stabilizing and desta
221 xtrapolated to account for the length of the entire pWH1266 plasmid, the qPCR rate constants were 2-7
222 ts required for Pxr function, we deleted the entire pxr gene from a developmentally defective strain
228 interact with almost equal facility over the entire range of pi systems studied, with the simple alke
229 nge of the physicochemical conditions in the entire reaction chamber can be reached in under 30 s.
230 nbiased alanine-scanning screen covering the entire region combined with quantitative electron micros
232 egy for reducing CRE transmissions across an entire region, particularly when implemented as early as
235 dity of TDA, D and Rh average values and the entire Rh distributions were obtained from the (poly)sac
238 ere, we present the cryo-EM structure of the entire SAGA complex where the major target of activator
239 sequencing of 97 samples collected along the entire salinity gradient at two-month intervals in 2014.
240 ween FRC use and severe periodontitis in the entire sample (odds ratio [OR]: 1.7, 95% confidence inte
245 foveated object detector that processes the entire scene with varying resolution, uses retino-specif
247 that modulate and augment key aspects of the entire secretory pathway, whereas maladaptive UPR output
248 rom AF after a single FIRM procedure for the entire series was 95% (PAF), 83% (PeAF), and 82% (LPeAF)
249 ructure to generate a continuum model of the entire sheath that also couples to a model of the viral
250 of high FGF and low BMP activity across the entire skin reveals a latent dermal capacity to undergo
252 challenge, we propose the utilization of the entire solar spectrum by redirecting solar photons to ma
256 the multipotent capacity to reconstitute the entire spectrum of memory and effector T cell subsets.
258 ly reconstitute the heterogeneity within the entire starting population, suggesting that GATA express
262 was 82 months (range, 6-329 months) for the entire study cohort; 363 patients (63%) underwent survei
263 butryn mass balance could be closed over the entire study period of 120 days and showed that relative
264 t differ between the treatment groups in the entire study population (HR 0.93, 95% CI 0.83-1.04; p=0.
265 and R(2)=0.32 for normalized TKEsys) in the entire study population including control subjects, whil
267 nts, investigators, other site staff and the entire study team including those assessing outcomes dat
270 rent from other contemporary approaches, the entire system is treated quantum mechanically and neithe
272 Unlike nonselective approaches targeting the entire T cell population, TRBC-targeted immunotherapy co
274 the fiber results in light emission from the entire taper surface, achieving broader and more efficie
275 all suppression of alpha activity across the entire task but also diminished the frequency of these m
277 s opportunity for systematic analyses of the entire TCGA NSCLC cohort, including comparisons and cont
278 gassing behavior with no-hysteresis over the entire temperature and water activity range considered h
279 etry index of the 95th percentile within the entire thalamus at 1 year was independently associated w
280 time derivative of force (dF/dt) predict the entire time course of transient IFRs in muscle spindle I
281 Organization recommends annual treatment of entire trachoma-endemic communities, although children t
283 ls and the hemodynamic properties across the entire tumor can be quantitatively evaluated with high s
288 d insurance claims for over one-third of the entire US population to create a subset of 128,989 famil
291 rsed RNA packaging signals mapping along the entire viral genome" play the critical role in polioviru
293 t high peak reflectivities (>96%) across the entire visible spectrum and wide spectral stop-band widt
294 r emission wavelength was tunable across the entire visible spectrum by tuning the excitation wavelen
297 A-t), were estimated and compared across the entire white matter skeleton between groups, and correla
298 cific and rescued by a fosmid containing the entire wild-type CaMKII locus, but only viability and Ca
299 e development of pipelines orchestrating the entire workflow and optimizing usage of available comput
300 in tropical canopies is near maximal for the entire year, implying that seasonal changes in LAI have
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