ライフサイエンスコーパス: enucleate

1 pical discoidal erythroid shape but they can enucleate.

2 Like their adult counterparts, EryP enucleate.

3 ar by what mechanism primitive erythroblasts enucleate.

4 er, express mostly fetal hemoglobin, and can enucleate.

5 death caused by failure of erythroblasts to enucleate.

6 On postnatal day 17, eyeballs were enucleated.

7 l culture medium, the uninoculated eyes were enucleated.

8 4.2%) required EBRT and 13 eyes (30.2%) were enucleated.

9 retinal lesions, even when the other eye was enucleated.

10 of nanoparticle carboplatin in the eye to be enucleated.

11 ndergoing salvage therapy that have not been enucleated.

12 Eyes were enucleated 1 day, 1 week, and 1 month after injection.

13 Eyes were enucleated 4 hours after antigen challenge, and inflamma

14 Both eyes in each animal were enucleated 6 hours after the final procedure, before eut

15 Two eyes were enucleated 6, 24 and 72 hours post injection.

16 Of the 28 treated eyes, 9 were enucleated, 6 for recurrent retinal disease, resulting i

17 ing the early subjective night using animals enucleated 60 days earlier, there were neither effects o

18 als, although robust reactivation similar to enucleated adults (P120) was not achieved yet.

19 into NU/NU or C57Bl/6 mouse eyes which were enucleated after 7 days.

20 er lymphatic vessels can be detected in eyes enucleated after an open globe injury.

21 vessels were detected in 15 of 21 eyes (71%) enucleated after an open globe injury.

22 Rhesus monkey eyes of different ages were enucleated after death, fixed in 4% paraformaldehyde for

23 ndothelial marker in 21 globes that had been enucleated after open globe injury.

24 All the eyes were enucleated after recurrence.

25 Given that phloem sieve elements are enucleate and lack translation machinery, RNA function r

26 Three and 24 hours after EIU, eyes were enucleated and aqueous humor (AqH) was collected.

27 A from left or right cortices of monocularly enucleated and control animals, the amplitudes of curren

28 The eyes were enucleated and embedded in paraffin, and sections were p

29 Both eyes were enucleated and examined by immunohistochemical analysis

30 by using magnetic resonance imaging (MRI) of enucleated and fellow orbits.

31 Eyes were enucleated and fixed, and the posterior eye cups were fl

32 A week later, the eyes were enucleated and high resolution maps of the retina vascul

33 anism by which Sph-1-P induces activation in enucleated and highly differentiated platelets.

34 d three eyes at 48 hours, respectively, were enucleated and immediately frozen and stored at -80 degr

35 Eyes were enucleated and immediately frozen.

36 Since erythrocytes are enucleated and lack DNA, genetic approaches to understan

37 Microtubule arrays in enucleated and nucleated cells are morphologically indis

38 rfused with glutaraldehyde and the eyes were enucleated and prepared for transmission electron micros

39 The eyes were enucleated and processed for immunohistochemistry and in

40 Their eyes were enucleated and processed for immunohistochemistry to det

41 ed clinically prior to euthanatization, then enucleated and processed for light microscopy and immuno

42 rs after AdL.11D injection and the eyes were enucleated and stored until assayed.

43 These cybrids were enucleated and the cytoplasts were electrofused to rhoda

44 ect to these parameters between the prenatal enucleates and normal monkeys of comparable age.

45 as been unknown whether human primitive RBCs enucleate, and what hematopoietic site might support thi

46 ter 24 hours the rats were killed, eyes were enucleated, and aqueous humor (AqH) was collected.

47 The eyes were enucleated, and both optic nerves were dissected and pro

48 e killed at regular time intervals, the eyes enucleated, and drug content quantified in the vitreous

49 72 hours post injection (pi), the eyes were enucleated, and frozen sections were stained with antibo

50 FITC high-molecular-weight dextran, the eyes enucleated, and neovascularization analyzed by confocal

51 s after injection, animals were killed, eyes enucleated, and retinal sections studied by histochemist

52 Eyes of animals in all groups were enucleated, and retinas were removed and stained with ad

53 Two weeks after treatment, the eyes were enucleated, and the ciliary body was exposed and submerg

54 The eyes were enucleated, and the neural retinas were separated from t

55 axotomy, the rats were killed, the eyes were enucleated, and the retinas were stained for OX42.

56 periment, animals were euthanized, eyes were enucleated, and the TM was dissected and stored in an aq

57 Rabbits were then killed, eyeballs enucleated, and their ocular volumes determined.

58 Eyes were enucleated, and tumor sections were analyzed.

59 mirror-symmetric map observed in neonatally enucleated animals, are present by P6-7, just as collate

60 s and induction occurred in both sighted and enucleated animals.

61 halan and topotecan in eyes not subsequently enucleated appears to be safe and effective for resistan

62 3 or 24 hours after LPS injection, eyes were enucleated, aqueous humor (AqH) was collected, and the n

63 ogic features in group D retinoblastoma eyes enucleated as primary or secondary treatment.

64 Eyes were enucleated at 1 or 24 hours after lesion placement.

65 of Bruch's membrane and were killed and eyes enucleated at 1, 2, 3, and 4 weeks after laser injury.

66 Eyes were enucleated at 20 weeks of age, snap frozen, and analyzed

67 Eyes were enucleated at 21 weeks of age and examined for residual

68 Eyes were enucleated at 5 to 25 hours after infection and CAP37 de

69 Two eyes were enucleated at 5.5 and 20 months after implantation and a

70 ning at 24 months, eyes from each group were enucleated at approximately 6-month intervals.

71 ed the mirror-symmetric pattern seen in rats enucleated at birth (P0).

72 ts, striate-extrastriate projections in rats enucleated at birth consisted of multiple, well-defined

73 c cortical loci, whereas in rats bilaterally enucleated at birth, callosal fibers connect topographic

74 ortical loci, whereas in animals bilaterally enucleated at birth, callosal fibers connect topographic

75 to measure the KLF6 transcript level in eyes enucleated at embryonic stages, and the corneas and lens

76 at the patterns of callosal linkages in rats enucleated at P12, P8, and P6 were nonmirror-symmetric,

77 n contrast, the patterns of linkages in rats enucleated at P4 closely resembled the mirror-symmetric

78 comparing cortical activity patterns of mice enucleated at postnatal day (P) 45, 90, or 120.

79 triate projections were not observed in rats enucleated at postnatal day (P)6, although the size of a

80 ection of either viral vector, and eyes were enucleated at specified times after injection for histop

81 ond protocol, activated in vivo oocytes were enucleated at the telophase II stage, electrofused with

82 Eyes were enucleated at various time points for quantitative funga

83 Photodisruption of the TM in enucleated baboon eyes and human donor eyes was performe

84 in normal ferrets and in ferrets bilaterally enucleated (BE) at postnatal day 7 (P7) or P20.

85 erythroblasts mature in the bloodstream and enucleate between embryonic day (E)14.5 and E16.5 of mou

86 Primitive erythroblasts progressively enucleate between embryonic days 12.5 and 16.5, generati

87 Enucleated bovine and porcine (n = 59 each) eyes were us

88 Fresh enucleated bovine eyes were obtained from a local abatto

89 Enucleated bovine eyes were perfused at 1 of 4 different

90 tudies indicate that primitive erythroblasts enucleate by nuclear extrusion to generate erythrocytes

91 While definitive erythroblasts enucleate by nuclear extrusion, generating reticulocytes

92 tream indicates that primitive erythroblasts enucleate by nuclear extrusion.

93 -tubulin to fluorescently label MTs and were enucleated by using a centrifugation procedure.

94 ic modulus was measured for nucleated cells, enucleated cells and nuclei (day 14) of 1.04 +/- 0.47 kP

95 rimental system to examine Ad trafficking in enucleated cells compared to Ad trafficking in intact, m

96 rated by fusing mtDNA-less rho(o) cells with enucleated cells from LHON patients carrying both m.1177

97 Ad localization to the MTOC in the enucleated cells was stable, as demonstrated by continui

98 Treatment of enucleated cells with arsenic followed by rescue fusion

99 Upon infection of enucleated cells with Cy3-labeled Ad, the majority of Ad

100 ) between the deformability of nucleated and enucleated cells, while they remain within the same size

101 cuole formation, increased the percentage of enucleated cells.

102 s compared to Ad trafficking in intact, mock-enucleated cells.

103 decreased, including reduced percentages of enucleated cells.

104 providing insight into previous studies with enucleated cells.

105 t are depleted in terminally differentiating/enucleating cells with decreasing transcriptional capaci

106 By artificially enucleating cells, we show that arrays can form de novo

107 r, area 17, but not area 18a, was smaller in enucleates compared to controls, resulting in an increas

108 Upon the completion of MRI, mouse eyes were enucleated, cryosectioned, and stained for assessing ret

109 g cell line devoid of mitochondrial DNA with enucleated cytoplasm from either a Large White pig or a

110 The enucleated definitive erythrocytes of mammals are unique

111 Eyes were enucleated, dissected, and assayed for changes in the ra

112 Eyes were enucleated, dissected, and snap-frozen, or they were fix

113 genomes from metaphase II (MII) oocytes into enucleated donor MII cytoplasm (PBNT).

114 transplantation of a somatic nucleus into an enucleated egg and most recently by introducing defined

115 nsplantation of a somatic cell nucleus to an enucleated egg results in a major reprogramming of gene

116 he transplantation of somatic cell nuclei to enucleated eggs has shown that genes can be reprogrammed

117 h inactive 5Sooc genes, were transplanted to enucleated eggs, the resulting nuclear-transplant embryo

118 otein (GFP), were transplanted into manually enucleated eggs.

119 ytes at the arrested metaphase II stage were enucleated, electrofused with donor somatic cells, and s

120 Compared with enucleated end-stage glaucoma eyes, this represents a 10

121 In intact and enucleated eosinophils, the PAF-induced increases in lip

122 as newly induced lipid bodies in intact and enucleated eosinophils.

123 reticulocyte and nucleus, in a population of enucleating erythroblasts.

124 Although the mature enucleated erythrocyte is no longer active in nuclear pr

125 tial, despite prolonged culture, to generate enucleated erythrocytes after 3-4 maturational cell divi

126 of the animals, with a dramatic reduction in enucleated erythrocytes and the presence of immature meg

127 This network dictates the genesis of enucleated erythrocytes by orchestrating the survival, p

128 w (BM) early stage erythroblasts and reduced enucleated erythrocytes compared to CMML patients with W

129 F-/- colonies were poorly hemoglobinized and enucleated erythrocytes in these colonies contained nume

130 finitive erythroid lineage generates smaller enucleated erythrocytes that become the predominant cell

131 ently die with failure to produce definitive enucleated erythrocytes.

132 s increases from early progenitors to mature enucleated erythrocytes.

133 Definitive erythroblasts mature and enucleate extravascularly and form a unique membrane ske

134 on biopsy [FNAB] compared with tumor from an enucleated eye), tumor basal diameter and height, and ci

135 conjunctiva in the socket of his previously enucleated eye, as well as lower eyelid ectropion, resul

136 erritories normally innervated by the other (enucleated) eye.

137 another animal onto the denuded stroma of an enucleated eyeball.

138 er mouse was placed on the bare stroma of an enucleated eyeball.

139 ing the denuded cornea before incubating the enucleated eyeball.

140 A retrospective case series of 12 enucleated eyes (11 patients) with retinoblastoma refrac

141 of-concept, laboratory-based study, 16 human enucleated eyes (8 with neovascular glaucoma and 8 as co

142 in live rabbit eyes (in vivo) and in freshly enucleated eyes (ex vivo).

143 g (d7-d13) and histopathologic evaluation of enucleated eyes after experimental termination.

144 Histologic tumor burden was quantified in enucleated eyes by image processing software, and microv

145 dividuals and biallelic BEST1 mutations, and enucleated eyes from 2 individuals with nonaffected reti

146 Subsequently analysis of the retinas of nine enucleated eyes from males with Coats' disease demonstra

147 Histology of the enucleated eyes injected with CD34(+) cells showed no in

148 lar meshwork from three sources was studied: enucleated eyes obtained at autopsy, trabeculectomy spec

149 the anterior segment, lens, and retina from enucleated eyes of C57BL/6, thrombospondin-1 knockout (T

150 Macroscopic photographs of the enucleated eyes of patients with retinoblastoma were ana

151 The enucleated eyes of the experimental mice were subjected

152 Enucleated eyes received at the pathology department of

153 The frequency of secondary enucleated eyes was 6.7% (n = 5).

154 The ocular shape of enucleated eyes was photographed during a 24-hour period

155 Animals were euthanized on day 14, and enucleated eyes were analyzed by light microscopy and im

156 Frozen sections of the enucleated eyes were analyzed for iNOS by the dual immun

157 of NF-1 associated with glaucoma, from which enucleated eyes were available, and 2 eye bank eyes used

158 Their enucleated eyes were examined for microglial expression

159 Enucleated eyes were processed for hematoxylin and eosin

160 The enucleated eyes were stained for OX42 and examined by co

161 Of 519 primarily enucleated eyes, 87 (17%) were classified as group D and

162 the grafts was determined in cryosections of enucleated eyes, and GFP expression in the grafts was vi

163 oblastoma was identified in 23% (117/519) of enucleated eyes, including 17% (15/87) group D and 24% (

164 In the 26 enucleated eyes, other features included retrolental neo

165 treous Gd-DTPA concentration occurred in the enucleated eyes, suggesting that there are significant b

166 ppressor pathways in 33 uveal melanomas from enucleated eyes.

167 y was then correlated with histopathology in enucleated eyes.

168 sed on centralized histologic examination of enucleated eyes.

169 which were also passively exposed to freshly enucleated eyes.

170 was the most prevalent seeding type of the 9 enucleated eyes.

171 imary RPE sheets were harvested from freshly enucleated female porcine eyes and embedded in a thin sl

172 Cybrids prepared from the fusion of enucleated fibroblasts homoplasmic for the A3460G mutati

173 d 1 to 7 days after injection, and eyes were enucleated for fluorescent or transmission electron micr

174 s at its peak, and the eyes were immediately enucleated for histologic and biochemical studies.

175 Both eyes were enucleated for histologic evaluation.

176 At P17, mice were killed and eyes enucleated for quantitation of retinal neovascularizatio

177 to categorize corneal inflammation and were enucleated for quantitative fungal cultures, analysis by

178 stopathologic risk factors in eyes primarily enucleated for retinoblastoma.

179 ion and no eye was treated with radiation or enucleated for seeding.

180 the embryo for several days before the first enucleated forms can be identified in the blood.

181 ogic correlation of consecutive group D eyes enucleated from 2002 to 2014.

182 odds ratio [OR], 0.49; 95% CI, 0.22-1.10) or enucleated glaucomatous eyes (OR, 0.66; 95% CI, 0.15-2.8

183 M eyes, 9 (1.7%) eye bank eyes, and 2 (1.3%) enucleated glaucomatous eyes.

184 ing 1985 UM eyes, 517 eye bank eyes, and 155 enucleated glaucomatous eyes.

185 Outflow facility was measured in enucleated glaucomatous human eyes.

186 Light microscopic examination of an enucleated globe as well as fibrous retroprosthetic memb

187 d one group of four age-matched, noninflamed enucleated globes (control samples) were used.

188 Two groups of four enucleated globes (total eight globes) from patients wit

189 All 5 enucleated globes displayed retinal detachment, fibrous

190 Enucleated globes from the 3 remaining untreated chimera

191 Clinical records and microscopic slides of 4 enucleated globes were reviewed.

192 Frozen sections of enucleated globes with intact EOMs and associated connec

193 Ten enucleated globes with the histopathologically and immun

194 rane formation and retinal detachment in all enucleated globes.

195 ion pTNM), and 5 eyes (21%) of the secondary enucleated group (pT2bNxM0, n = 2, pT3aNxM0, n = 2 and p

196 e entire cohort, 5 eyes (13%) of the primary enucleated group (pT3aNxM0, n = 2 and pT3bNxM0, n = 3, 8

197 A total of 64 enucleated group D eyes (62 patients), of which 40 (40 p

198 Secondary enucleated group D eyes with high-risk histopathologic f

199 Sixteen enucleated human eyes were perfused with PBS plus glucos

200 40 expression by infiltrating lymphocytes in enucleated human eyes with end-stage inflammation.

201 Outflow facility was measured in enucleated human eyes.

202 fusing an adult somatic cell to a previously enucleated human oocyte, in agreement with recent report

203 et of CSLT-detected ONH surface change) were enucleated immediately after death and immersion fixed a

204 24 hours after LPS injection, the eyes were enucleated immediately, and aqueous humor (AqH) was coll

205 BALB/c) were euthanatized, and the eyes were enucleated, immersed in 2% glutaraldehyde fixative, and

206 udies have shown that primitive RBCs in mice enucleate in the fetal liver.

207 r than the bloodstream, suggesting that they enucleate in the liver, a possibility supported by their

208 Late-stage primitive erythroblasts fail to enucleate in vitro unless cocultured with macrophage cel

209 ap reflection, a solid, rubbery specimen was enucleated in one piece leaving a wide moat-like intrabo

210 that the failure of Rb-null erythroblasts to enucleate is due to defects in associated macrophages.

211 re monitored by slit lamp biomicroscopy, and enucleated lenses were examined under a stereomicroscope

212 fective transport, sieve elements develop as enucleated living cells.

213 ne was selected, and the cells were fused to enucleated mature oocytes.

214 ng factors was documented in both intact and enucleated metaphase and interphase zygotes and two-cell

215 tion, a phenotype that was mimicked in adult enucleated mice when treated with indiplon, a GABAA rece

216 oid donor nuclei have been transplanted into enucleated MII oocytes that are activated on, or after t

217 omosomal complex transfer from one egg to an enucleated, mitochondrial-replete egg.

218 lateral geniculate nucleus of the prenatally enucleated monkey is due to the maintenance of a conting

219 lls that showed loss of IGF2 imprinting into enucleated mouse and human fibroblasts that had maintain

220 to measure conventional outflow facility in enucleated mouse eyes ex vivo.

221 Freshly enucleated mouse eyes were imaged using two nonlinear op

222 Freshly enucleated mouse eyes were incubated with human MMP-1, -

223 were detectable up to 24 hours postmortem in enucleated mouse eyes.

224 nd cumulus cells) taken from adult mice into enucleated mouse oocytes.

225 y or to increase membrane CD35 expression in enucleated neutrophil cytoplasts.

226 Sixteen freshly enucleated, New Zealand White rabbit eyes were investiga

227 d with complete Freund's adjuvant; eyes were enucleated on day 7 after immunization.

228 Both eyes of each mouse were enucleated on postinoculation day 15 and processed for h

229 Eleven eyes were enucleated: one at diagnosis, nine with progressive dise

230 is fused by electoporation with a recipient enucleated oocyte.

231 tomere nucleus from a four-cell embryo to an enucleated oocyte; however, no live offspring were obtai

232 tic cells of known phenotype introduced into enucleated oocytes are capable of supporting full develo

233 ion of embryonic or fetal somatic cells with enucleated oocytes have become steadily more successful

234 Enucleated oocytes have the distinctive ability to repro

235 ei of cultured LacZ-positive fibroblasts and enucleated oocytes of a different mouse strain.

236 s post coitum; however, a high percentage of enucleated oocytes receiving cumulus nuclei developed in

237 We found that some enucleated oocytes receiving Sertoli or neuronal nuclei

238 itum) and their nuclei were transferred into enucleated oocytes, 5.5% of the reconstructed oocytes de

239 ere used as nuclear donors for transfer into enucleated oocytes, and the resulting blastocysts were c

240 8.5, 9.5, and 10.5 dpc were transferred into enucleated oocytes, seven cloned embryos developed into

241 by injecting U2 RNA into isolated nuclei or enucleated oocytes, we observe that U2 internal modifica

242 sheep was derived exclusively from recipient enucleated oocytes, with no detectable contribution from

243 yonic development, we transplanted them into enucleated oocytes.

244 were used as donors for nuclear transfer to enucleated oocytes.

245 ys appear to retain their functional role in enucleated orbits.

246 by transfer of a donor cell nucleus into an enucleated ovum, and now we add the successful cloning o

247 stal to the inner wall Schlemm's canal in an enucleated perfused human eye.

248 uclear donors for embryos reconstructed with enucleated pig oocytes.

249 considered a nuclear receptor, we show that enucleate platelets highly express PPARgamma protein as

250 hat Sirt1, Sirt2, and Sirt3 are expressed in enucleate platelets.

251 Enucleated porcine (n = 140) and cadaver human eyes (n =

252 us humor outflow facility was measured using enucleated porcine eyes and a constant-pressure perfusio

253 corneal tissue through a gonioscopic lens in enucleated porcine eyes and of the trabecular meshwork (

254 us humor outflow facility were determined in enucleated porcine eyes by using a constant-pressure Gra

255 Perfusion of enucleated porcine eyes for 5 hours with 100 and 200 mic

256 umor outflow facility increased (40%-80%) in enucleated porcine eyes perfused with Y-27632 (10-100 mi

257 ion of LPA (50 microM) and S1P (5 microM) in enucleated porcine eyes produced a significant decrease

258 Enucleated porcine eyes were perfused in vitro under a c

259 Freshly enucleated porcine eyes were perfused using the constant

260 ons and penetrating keratoplasties (PKPs) in enucleated porcine eyes.

261 flow facility were evaluated by perfusion of enucleated porcine eyes.

262 queous humor (AH) outflow were determined in enucleated porcine eyes.

263 These enucleated primitive erythrocytes circulate as late as 5

264 uniplanar, 3-mm, clear corneal incisions in enucleated rabbit eyes (n = 18).

265 ) was applied to deepithelialized corneas of enucleated rabbit eyes for 2 minutes.

266 Moreover, our results from enucleated rats suggest that the cues that determine the

267 ion of the marker gene on the surface of the enucleated RBC progeny.

268 development, at which time the frequency of enucleated RBCs was higher in the villous stroma than in

269 Enucleated RBCs were then isolated to a pure population

270 ntiation of early erythroid progenitors into enucleated RBCs.

271 Chromosomes are then reintroduced into an enucleated recipient egg (cytoplast), derived from anoth

272 poiesis, characterized by anemia and lack of enucleated red blood cells in blood circulation.

273 ive erythropoiesis-the generation of mature, enucleated red cells.

274 sition from the proerythroblast stage to the enucleated reticulocyte.

275 It results in the release of 2 million new enucleate reticulocytes into your circulation and mine e

276 lls at the end of maturation, which includes enucleated reticulocytes in circulation.

277 ed for the human cells that generates normal enucleated reticulocytes.

278 ch proerythroblasts differentiate to produce enucleated reticulocytes.

279 A control porcine eye was enucleated, retina and RPE isolated, and specimens froze

280 the AH cfDNA and tumor-derived DNA from the enucleated samples was identified.

281 The experimental design was to fertilize enucleate sea urchin eggs with sperm of another species

282 rofusion of sheep mammary-derived cells with enucleated sheep oocytes.

283 lightly but not significantly greater on the enucleated side.

284 enriched cell fractions and the contents of enucleate sieve elements, in the form of phloem sap, wer

285 A in regulating protein synthesis within the enucleate sieve tube system of the angiosperms.

286 In angiosperms, the functional enucleate sieve tube system of the phloem appears to be

287 investigated to test the hypothesis that the enucleate sieve tube system utilizes a simplified signal

288 nificance with respect to functioning of the enucleate sieve tube system, as eIF5A was recently detec

289 ribution in higher plants takes place in the enucleate sieve-tube system of the phloem.

290 The enucleated specimen underwent histologic, immunohistoche

291 on, and viable tumor was present in 21 of 22 enucleated specimens (95%).

292 residual viable tumor was present in 95% of enucleated specimens.

293 ultimately sloughed from the skin surface as enucleated squames.

294 Notably, enucleating Tmod3(-/-) erythroblasts are still in the pr

295 us at a specific stage of development, to an enucleated unfertilized egg, provided an opportunity to

296 mined in adult animals that were bilaterally enucleated very early in life, before the retino-genicul

297 d precursors proliferate, differentiate, and enucleate, were first described 50 years ago by analysis

298 Axial length was measured on enucleated whole eyes, and ocular structural changes wer

299 EryP home to, complete their maturation, and enucleate within the FL, a tissue that is just developin

300 Eyes were enucleated within 13.5 hours after death.