ライフサイエンスコーパス: enucleation

1 nths after enucleation, 64.3% >3 years after enucleation).

2 eriod (42 (62 %) eviscerations and 26 (38 %) enucleations).

3 n and pain was achieved in all but 2 eyes (2 enucleations).

4 astoma who developed severe PVR and required enucleation.

5 ve more advanced disease and higher rates of enucleation.

6 uded local resection, radiation therapy, and enucleation.

7 atic disease, or death compared with primary enucleation.

8 observed after esophagectomy versus 0 after enucleation.

9 No eyes were managed with enucleation.

10 s to complications or local recurrence after enucleation.

11 ete nuclear condensation, and lower rates of enucleation.

12 Intravenous blood was collected during enucleation.

13 assembly and remodeling during erythroblast enucleation.

14 d cell maturation at a discrete stage before enucleation.

15 n, in erythroid proliferation, survival, and enucleation.

16 ologies and aberrant F-actin assembly during enucleation.

17 D groups did not differ for time to death or enucleation.

18 posterior segment toxic effects, or need for enucleation.

19 extensive cellular remodeling that precedes enucleation.

20 espectively, significantly increase prior to enucleation.

21 tive erythroblast cell-cycle progression and enucleation.

22 esenting the last four cell divisions before enucleation.

23 ng interphase and effectively removed during enucleation.

24 idase (CO) activity patterns after monocular enucleation.

25 undergo dramatic changes during erythroblast enucleation.

26 nhibiting cell size reduction and subsequent enucleation.

27 nce of external-beam radiotherapy (EBRT) and enucleation.

28 developed in 3 patients; 1 of them underwent enucleation.

29 esis, was shown to play an essential role in enucleation.

30 years of age and those treated with primary enucleation.

31 oses difficult management and often leads to enucleation.

32 unappreciated role for E2F-2 in erythroblast enucleation.

33 Cellular maturation was maintained including enucleation.

34 y partial lamellar sclerouvectomy (PLSU), or enucleation.

35 tachment, vitreous hemorrhage, and secondary enucleation.

36 t the need for external beam radiotherapy or enucleation.

37 cade 2) developed painful glaucoma requiring enucleation.

38 8 eyes (75%), and 2 of 8 eyes (25%) required enucleation.

39 cology center and are more likely to require enucleation.

40 elanomas that underwent primary treatment by enucleation.

41 with diffuse T3 disease, underwent secondary enucleation.

42 isual acuity, and 3 required evisceration or enucleation.

43 tribution of F-actin and pMRLC and inhibited enucleation.

44 because of trauma is a common indication for enucleation.

45 upture, and time interval between trauma and enucleation.

46 d infection was exceptionally uncommon after enucleation.

47 ere retained in the recipient cell following enucleation.

48 which matched the tumor sample postsecondary enucleation.

49 eradin, and nocodazole, and then assayed for enucleation.

50 icle trafficking contributes to erythroblast enucleation.

51 al of 110 (4.4%) patients required secondary enucleation.

52 ere managed by repeat brachytherapy, TTT, or enucleation.

53 keleton, which is ultimately formed prior to enucleation.

54 ates were comparable to those observed after enucleation.

55 ion; however, they display a near absence of enucleation.

56 ents within the critical first 2 years after enucleation.

57 valuated at the time of primary or secondary enucleation.

58 uced erythropoiesis and impaired erythrocyte enucleation.

59 ously published cases have been managed with enucleation.

60 ize, chromatin and nuclear condensation, and enucleation.

61 ocked terminal erythroid differentiation and enucleation.

62 layer 2/3 monocular visual cortex following enucleation.

63 quires intensive ocular-salvage treatment or enucleation.

64 All patients underwent enucleation.

65 urrences in the group primarily treated with enucleation.

66 anscriptome of erythroblasts, prior to their enucleation.

67 symptoms and possibly reduces the number of enucleations.

68 ces requiring additional treatment and fewer enucleations.

69 l melanoma, 99 (19%) of which were secondary enucleations.

70 83), central pancreatectomy (13), pancreatic enucleation (10), total pancreatectomy (5), Appleby rese

71 bital enhancement was a common finding after enucleation (100% in the first 3 months after enucleatio

72 outcomes of local recurrence (14% vs. 15%), enucleation (14% vs. 11%), or metastasis (2% vs. 0%) com

73 itreous hemorrhage, 35% (42%); and secondary enucleation, 16% (26%).

74 ned with teletherapy or brachytherapy (14%), enucleation (3%), or observation (21%).

75 med during follow-up (median follow-up after enucleation, 45 months; range, 8-126).

76 nucleation (100% in the first 3 months after enucleation, 64.3% >3 years after enucleation).

77 partial/wedge nephrectomies in 27 patients, enucleations 8 in 8 patients.

78 stages of postnatal development by binocular enucleation, a significant proportion of layer 4 spiny n

79 hstanding the morphological heterogeneity of enucleation across species.

80 ting of neoadjuvant chemotherapy followed by enucleation, adjuvant radiotherapy, and chemotherapy.

81 Newer implants following enucleation allow excellent cosmetic and motility outcom

82 th eye-preserving radiotherapy compared with enucleation alone, and adding chemotherapy aggravated th

83 children with Rb, including 2 after primary enucleation and 1 undergoing multiple intravitreous inje

84 tients (63 eyes) were primarily treated with enucleation and 72 patients (77 eyes) were primarily tre

85 ound dehiscence in 11.5 % of patients in the enucleation and 9.5 % in the evisceration groups.

86 edure involving retro-orbital puncture after enucleation and biopsied the frontal lobes and optic ner

87 identify an erythroid-specific regulator of enucleation and elucidate a previously unrecognized mech

88 d surgical outcomes of anophthalmic surgery (enucleation and evisceration) at Jordan University Hospi

89 More efficient enucleation and induction of maturation to an adult phen

90 ormed to analyze associations with secondary enucleation and metastases and Kaplan-Meier estimates to

91 his study suggests that in larger tumors the enucleation and neovascular glaucoma rates might be redu

92 RIK activity promotes efficient erythroblast enucleation and nuclear condensation.

93 However, studies comparing enucleation and partial nephrectomy to date have reveale

94 present a shift in the paradigm of erythroid enucleation and provide novel tools to further study and

95 In reticulocytes, this includes enucleation and the elimination of all membrane-bound or

96 asis by promoting keratinocyte apoptosis and enucleation and thereby influencing skin immune response

97 rapeutic biopsy on the feasibility of E-GIST enucleation, and (iii) the impact of mucosal ulceration

98 d scrotal US, contrast-enhanced US, surgical enucleation, and at least 18 months of follow-up.

99 r Kaplan-Meier rates of local tumor relapse, enucleation, and distant metastasis were 3.9%, 3.7%, and

100 Knockdown of either Riok3 or Mxi1 blocks enucleation, and either physiological overexpression of

101 Treatment included FNAB, enucleation, and histopathologic analysis.

102 even patients (58%) required evisceration or enucleation, and only 1 patient regained pre-injection v

103 Some authorities advocated prompt enucleation, and others proposed that enucleation promot

104 large symptomatic melanoma that necessitated enucleation, and the systemic prognosis was poor.

105 Twenty-two of 28 patients underwent enucleation, and viable tumor was present in 21 of 22 en

106 rates of radiation complications, secondary enucleation, and visual acuity outcomes.

107 feasibility and impact on outcomes of tumor enucleation are unknown.

108 There has been a greater acceptance of tumor enucleation as a safe alternative for renal masses which

109 included 10 patients who were scheduled for enucleation as primary treatment for uveal melanoma.

110 as well as increased apoptosis) and terminal enucleation as well as the accumulation of hemoglobin.

111 and in terminal erythroblast maturation and enucleation, as master regulators of the cytoskeleton an

112 esponded, but 3 of them ultimately underwent enucleation at a median of 8 months (range, 7.9-9.1 mont

113 In contrast, enucleation at P20 had no significant effect on the call

114 One patient underwent enucleation because of a presumed local tumor recurrence

115 currence and 4 additional patients underwent enucleation because of complications (9.3%).

116 local recurrence, and 16% (n = 21) underwent enucleation because of complications.

117 Three patients (33%) subsequently underwent enucleation because of recurrent tumor and persistent an

118 l melanoma (28 males, 22 females) treated by enucleation between 2004 and 2010 were analyzed.

119 f patients who had undergone evisceration or enucleation between August 2006 and June 2011.

120 ereye competition is eliminated by monocular enucleation, blocking cholinergic stage II retinal waves

121 ion were 16.6 and 18.0 mm, respectively; for enucleation, both were 20 mm.

122 c overexpression of miR-191 blocks erythroid enucleation but has minor effects on proliferation and d

123 ere inhibition of chromatin condensation and enucleation but otherwise had little effect on erythroid

124 ythoblasts late in terminal differentiation (enucleation), but the mechanism is largely unexplained.

125 ormal late erythroblasts prior to and during enucleation, but not in Xpo7-knockdown cells.

126 pective study of patients with UM treated by enucleation by a single ocular oncologist between Novemb

127 ial for erythroid chromatin condensation and enucleation by allowing up-regulation of Riok3 and Mxi1.

128 use of systemic chemotherapy, and diminished enucleations by 90% without evidence of compromising pat

129 scopy, and with the introduction of surgical enucleation, chemotherapy, and radiation therapy.

130 bles the role played by Hb in erythroid cell enucleation, cytoskeleton maturation, and heme and iron

131 tro and found that absence of Tmod1 leads to enucleation defects in mouse fetal liver erythroblasts,

132 Surprisingly, both cell cycle and enucleation deficits are rescued by epistatic reintroduc

133 Finally, enucleation did not change the time course and definitio

134 Consequently, enucleation did not provide a likely explanation for the

135 otony in 1 eye in the PPV group (that led to enucleation due to phthisis bulbi), and elevated intraoc

136 show significant enhancement of erythroblast enucleation during definitive erythropoiesis.

137 Global nuclear condensation, culminating in enucleation during terminal erythropoiesis, is poorly un

138 assembly, respectively, exhibited decreased enucleation efficiency, as quantified by flow cytometry.

139 ular prognosis with higher need for extended enucleation, exenteration, or both.

140 achieved in 10 cases, as 1 patient required enucleation for chronic ocular irritation.

141 in 80 patients (97.6%); 2 patients underwent enucleation for local recurrence.

142 rides over the past century from the days of enucleation for massive, fatal tumor to early detection

143 s, controversy erupted regarding the role of enucleation for PUM.

144 No patients have required secondary enucleation for recurrence or neovascular glaucoma.

145 an alternative to external beam radiation or enucleation for recurrent or refractory vitreous seeds.

146 feasibility of a modified ESD technique with enucleation for removal of gastric subepithelial tumors

147 of 6 days can be an effective alternative to enucleation for residual scleral-invasive conjunctival S

148 ndings in 266 patients who underwent primary enucleation for retinoblastoma were reviewed.

149 Of 403 patients who underwent primary enucleation for the treatment of retinoblastoma, 145 (36

150 of 16 patients received a modified ESD with enucleation for their subepithelial tumors.

151 Using a modified ESD with enucleation for treatment of gastric subepithelial tumor

152 Data of patients who underwent secondary enucleation for uveal melanoma in the London Ocular Onco

153 Patients undergoing enucleation for uveal melanoma need to be informed of th

154 Indications for secondary enucleations for uveal melanoma were tumor recurrence, n

155 The 5-year enucleation-free survival rate was 94.8% in the endorese

156 ent baseline MR imaging, followed by primary enucleation from 1993 through 2014.

157 ore eyes with iris neovascularization in the enucleation group (25.4%) than in the OAC group (5.2%) a

158 more eyes with group E retinoblastoma in the enucleation group (87.3%) than in the OAC group (29.9%),

159 l recurrence-free survival was worse for the enucleation group (92.1%; 95% CI, 82.0-96.7) than for th

160 risk histopathologic features in the primary enucleation group (P = 0.042), whereas none were found i

161 recurrences (incidence, 7.9%) in the primary enucleation group and 1 orbital recurrence (incidence, 1

162 nful eye secondary to glaucoma (19 %) in the enucleation group and endophthalmitis (28.6 %) in the ev

163 The enucleation group had 5 cases of metastatic disease (7.9

164 In the enucleation group, median tumoral diameter was 40 mm (18

165 es were 50% and 25% in the esophagectomy and enucleation groups, respectively, with 2 postoperative d

166 However, the process of erythroblast enucleation has remained provocative and poorly understo

167 evacizumab, plaque radiotherapy, and primary enucleation in 1 patient because of painful neovascular

168 cluded plaque radiotherapy in 4 patients and enucleation in 1 patient; 1 patient refused therapy.

169 or control in 87%, poor visual acuity in 9%, enucleation in 13% (for reasons of tumor recurrence [n =

170 developed in 17% of patients and resulted in enucleation in 4% of patients.

171 patch graft in 14% of patients (10/73), and enucleation in 5% of patients (4/73).

172 glaucoma was the leading cause of secondary enucleation in 78 of the 2499 patients (3.1%).

173 treatment was surgical for 16 patients, with enucleation in 8 and esophagectomy in 8.

174 ars), scheduled to undergo planned uniocular enucleation in an institutional setting, were randomly d

175 l to evaluate orbital tumor recurrence after enucleation in children with retinoblastoma.

176 l in 87% of patients at 6 years and avoiding enucleation in most cases.

177 comycin or levofloxacin eye drops leading to enucleation in one case.

178 mon predisposing factor for evisceration and enucleation in our tertiary care center followed by blin

179 dered as a safe and efficient alternative to enucleation in patients with large choroidal melanoma, a

180 at I-125 EPBT offers a viable alternative to enucleation in patients with local recurrence of PUM, yi

181 e of erythroblasts and a reduced erythrocyte enucleation in their BM compared to littermate controls.

182 d completion of mouse and human erythroblast enucleation in vivo.

183 that sieve element differentiation involves enucleation, in which the nuclear contents are released

184 Factors related to enucleation included diabetes mellitus, poor initial vis

185 After unilateral enucleation, increased GCC and pRNFL thicknesses were de

186 d expanded in the last year, suggesting that enucleation is a form of asymmetric cell division.

187 dis et al provide evidence that erythroblast enucleation is a more complex and multistep process than

188 In conclusion, enucleation is a multistep process that resembles cytoki

189 scleral invasion or intraocular involvement, enucleation is advised.

190 In addition, enucleation is an acceptable method for management, part

191 Enucleation is caused by the coalescence of vesicles at

192 Enucleation is frequently the only management option for

193 ical techniques, however, the indication for enucleation is no longer determined by posttrauma NLP vi

194 Enucleation is performed by following the natural plane

195 reatment with recent surveys indicating that enucleation is preferred in the USA and evisceration in

196 poorly to local resection and in most cases enucleation is required.

197 Enucleation is the culmination of terminal erythroid dif

198 ar management including plaque radiotherapy, enucleation, local resection, or laser therapy.

199 Rates of neovascular glaucoma (NVG) and enucleation (mainly for local recurrence or NVG) were 27

200 Enucleation may be required due to poor vision and inabi

201 Monocular enucleation (ME) drastically affects the contralateral v

202 In adult mice, monocular enucleation (ME) results in an immediate deactivation of

203 During erythroblast enucleation, membrane proteins distribute between extrud

204 been no recurrence, extrascleral extension, enucleation, metastasis, or death.

205 of 5 months postradiotherapy, necessitating enucleation (n = 2) or orbital exenteration (n = 2).

206 Primary tumor treatment included enucleation (n = 21, 60%), tumor removal by PLSU (n = 8,

207 adiotherapy (n = 1) for localized disease or enucleation (n =3) for extensive tumor hemorrhage (n = 1

208 (n=60) or proton beam radiation (n=2), with enucleation necessary in 26 patients.

209 oskeletal mechanisms underlying erythroblast enucleation, notwithstanding the morphological heterogen

210 poiesis, Trim58 expression, dynein loss, and enucleation occur concomitantly, and all are inhibited b

211 chnique can save eyes otherwise destined for enucleation, ocular salvage may be accompanied by local

212 pact of macrophages on the proliferation and enucleation of erythroblasts from healthy individuals an

213 f differentiation is inherently critical for enucleation of erythroid precursors, thereby demonstrati

214 was to evaluate the feasibility of surgical enucleation of esophageal gastrointestinal stromal tumor

215 were killed after 3 and 24 hours followed by enucleation of eyes and collection of the aqueous humor

216 ta indicate that the terminal maturation and enucleation of human primitive RBCs occurs in first trim

217 reover, knock-down of clathrin inhibited the enucleation of late erythroblasts.

218 ic kinases have specialized roles supporting enucleation of maturing erythroblasts.

219 The distribution, maturation, and enucleation of primitive erythroblasts were also impaire

220 Therapy consisted of a simple surgical enucleation of the cyst.

221 stage glaucoma in patient 2 resulted in the enucleation of the eye, which on histology demonstrated

222 Holmium laser enucleation of the prostate is an endoscopic alternative

223 ion of the prostate, laser vaporization, and enucleation of the prostate to provide superior hemostat

224 vaporization of the prostate, Holmium laser enucleation of the prostate, and vaporization of the pro

225 ng-term efficacy and safety of holmium laser enucleation of the prostate.

226 objectives evaluated (i) the impact of tumor enucleation on oncological outcomes, (ii) the effect of

227 We also estimated the effect of enucleation on the surface areas of striate and extrastr

228 Patients treated with enucleation only evidenced the greatest decline in cogni

229 pected, as was the poorer performance of the enucleation-only group.

230 fused sequentially, either immediately after enucleation or after 3 hours storage at 4 degrees C.

231 Patients who underwent either enucleation or esophagectomy were compared.

232 NLP should not be an indication for primary enucleation or evisceration for severely traumatized eye

233 There is no consensus as to whether enucleation or evisceration is the best treatment for ir

234 Enucleation or evisceration was performed in 15 of 49 pa

235 le devastating globe injuries require either enucleation or evisceration.

236 019) invasion and a higher need for extended enucleation or exenteration (27% vs. 11%; P < 0.001).

237 atients received radical resection by either enucleation or hepatic resection, while the remaining 8

238 Radiotherapy, chemotherapy, enucleation, or observation.

239 r HIV, conjuntival excision biopsy, extended enucleation, orbital exenteration.

240 odal protocol with neoadjuvant chemotherapy, enucleation, orbital external-beam radiotherapy, and adj

241 manageable complications and fewer secondary enucleations over time for these large melanomas.

242 detected significantly more after secondary enucleation (P = 0.048).

243 0.303), and time interval between trauma and enucleation (P = 0.145).

244 We analyzed the effects of bilateral enucleation performed at different ages on both the dist

245 Enucleation, plaque radiotherapy, local resection, or th

246 prompt enucleation, and others proposed that enucleation promoted metastasis, known as the "Zimmerman

247 added early in culture, they failed to block enucleation proper when added to postmitotic cells.

248 me to distant failure, local failure, death, enucleation, radiation retinopathy, optic neuropathy, an

249 eceived neoadjuvant chemotherapy followed by enucleation, radiotherapy, and adjuvant chemotherapy.

250 and involves strategically chosen methods of enucleation, radiotherapy, chemotherapy, laser photocoag

251 Enucleation rates decreased over time.

252 mor recurrence, visual acuity, and secondary enucleation rates were analyzed and compared between gro

253 rculation and with their late maturation and enucleation, respectively.

254 en (6.3%) who underwent primary or secondary enucleation, respectively.

255 After enucleation, retinal arterioles were isolated and pressu

256 E-GIST enucleation seems safe for tumors of less than 65 mm in

257 Patients who had undergone unilateral enucleation showed cortical dominance corresponding to t

258 No enucleation specimen contained tumor cells within sclera

259 shed between 2003 and 2017 on outcomes after enucleation surgeries in which a variety implants were u

260 mplants resulted in excellent motility after enucleation surgery, although many studies did not asses

261 of the studies did not assess motility after enucleation surgery, and the 7 that did evaluate this me

262 rates of porous and nonporous implants after enucleation surgery.

263 scenarios have led to the development of the enucleation technique.

264 Once enucleation techniques were perfected, the majority of c

265 we identified a family of genes required for enucleation that encode proteins with nuclease domains.

266 ic mice, and Hb Null erythroid cells undergo enucleation to form reticulocytes.

267 patients with a lag time >1 month and no pre-enucleation treatment (P = 0.007 and P = 0.010, respecti

268 characteristics, including lag time and pre-enucleation treatment status.

269 ocular pain improved with sildenafil, making enucleation unnecessary.

270 ured retinoblastoma patients and, also after enucleation using spectral domain optical coherence tomo

271 Opinions remain variable when considering enucleation versus evisceration and primary versus secon

272 Mean follow-up after enucleation was 20.4 months (range 9.9-31.7).

273 Enucleation was carried out in 14 patients (9.5%) becaus

274 the early stage of terminal erythropoiesis, enucleation was decreased.

275 RBC enucleation was further evidenced by the presence of pri

276 ee groups; 15 unilateral RB patients in whom enucleation was indicated as a sole treatment performed

277 Enucleation was necessary in 3 of 20 eyes (15%).

278 Enucleation was necessary in 9 (24%) cases for recurrenc

279 Primary enucleation was performed and histopathologic features n

280 Evisceration or enucleation was performed in 16 (25%) patients.

281 Primary enucleation was performed in 33.3% of patients and was m

282 An enucleation was performed, and an intraocular tumor comp

283 Dia2, a Rho effector known to play a role in enucleation, was also found essential for erythroblast c

284 membrane signaling molecules in erythroblast enucleation, we developed a novel analysis protocol of m

285 Higher rates of enucleation were associated with low educational attainm

286 reated for a retinoblastoma or who underwent enucleation were excluded.

287 Younger patients at enucleation were more likely to report pain (t = 4.13; d

288 Patients studied sooner after enucleation were more likely to report seeing (Mann-Whit

289 CAR formation and subsequent enucleation were not affected in murine erythroblasts wi

290 ients with primary uveal melanoma treated by enucleation were reviewed.

291 Indications for secondary enucleation were tumor recurrence in 60 (61%), neovascul

292 Enucleations were indicated only in case of re-recurrenc

293 During the study period 515 enucleations were performed for uveal melanoma, 99 (19%)

294 ibited cell-cycle progression and subsequent enucleation when added early in culture, they failed to

295 acquire a dumbbell-shaped morphology during enucleation, whereas human bone marrow erythroblast nucl

296 microtubules during the preparatory stage of enucleation, whereas NSC23766 led to absence of lipid ra

297 r distal pancreatic resections or gastrinoma enucleation with lymphadenectomy, 2 patients also had sy

298 ixty consecutive patients undergoing primary enucleation with no adjuvant chemotherapy or radiation w

299 (Reese-Ellsworth group V) treated by primary enucleation with or without adjuvant therapy depending o

300 l and signaling requirements of erythroblast enucleation with the cytokinesis process have been confi