ライフサイエンスコーパス: env gene

1 cates that interferon resistance maps to the env gene.

2 probes complementary to the V1 region of the env gene.

3 s mediated by the gp120 coding region of the env gene.

4 ial sequence of the gp41 region of the HIV-1 env gene.

5 cine using a deduced ancestral state for the env gene.

6 mbination event may have occurred within the env gene.

7 tution (S84A) in the VRA region of the viral env gene.

8 des 752 to 2818 which encompasses the entire env gene.

9 es, and an internal promoter (IP) within the env gene.

10 murine B cells transfected with the HERV-K18 env gene.

11 ent paradigm is based on the BG505 subtype A env gene.

12 ines revealed second-site changes within the env gene.

13 HIV-gpt proviruses, which lack a functional env gene.

14 ion of the transmembrane (TM) protein of the env gene.

15 resence of unique sequences within the viral env gene.

16 utant containing a point mutation within the env gene.

17 ions and cells transfected with the complete env gene.

18 covered internal promoter located within the env gene.

19 ve-like SOSIP.664 trimers based on the BG505 env gene.

20 ase in splicing at a cryptic 5'ss within the env gene.

21 ions, and recombination events involving the env gene.

22 of soluble trimers based on the clade B B41 env gene.

23 d polymerase chain reaction specific for the env gene.

24 less stringent negative selection within the env gene.

25 RF13_cpx, each of which contains a subtype A env gene.

26 transmembrane domain, similar to retroviral env genes.

27 d PI and TCLA viruses and molecularly cloned env genes.

28 ed by DNA sequence analysis of pol, gag, and env genes.

29 al fluid (CSF)-derived, R5 macrophage-tropic env genes.

30 t-generation sequencing of the viral gag and env genes.

31 make recombinant trimers from many different env genes.

32 most of them directed against the envelope (env) gene.

33 pression of an interfering MCF MLV envelope (Env) gene.

34 e sheep retrovirus (JSRV) encodes within the env gene a trans-acting factor (Rej) necessary for the s

35 gammaretroviruses with concentration in the env gene across the GALV strains that were particularly

36 ssing retroviral gag-pol (AdGagPol) and 10A1 env genes (Ad10A1).

37 icate that a vaccine expressing a mismatched Env gene alone can prevent SIV infection in NHPs and ide

38 encoding a murine leukemia virus amphotropic env gene and a green fluorescent protein (GFP) reporter

39 d a large pool of insertion mutations in the env gene and analyzed the fitness of each mutant in comp

40 and tissue tropisms controlled by the HIV-1 env gene and for the analysis of mechanisms of viral imm

41 dependent on sequences at the 3' end of the env gene and not on the polytropic regions or on the 585

42 e evolution of the C2-V5 region of the HIV-1 env gene and of T-cell subsets in nine men with a modera

43 ctivation element [CTE]) located between the env gene and the 3' long terminal repeat of simian retro

44 ptible, full-length, biologically functional env genes and characterized viruses pseudotyped with the

45 human immunodeficiency virus type 1 (HIV-1) env genes and exhibit distinct phenotypes.

46 We transfected various combinations of these Env genes and investigated Env-mediated cell fusion and

47 eficiency virus type 1 (HIV-1) pol, vif, and env genes and the 3' long terminal repeat (LTR) sequence

48 a sequence was also found in analysis of the env gene, and linkage by long-distance reverse transcrip

49 minor HIV-1 variants in the V3 region of the env gene, and to identify minor drug-resistant variants

50 ced by a ribozyme directed against the HIV-1 env gene, and whether the antiviral activity was affecte

51 inant multimeric proteins based on the HIV-1 env gene are current candidate immunogens for vaccine tr

52 Recombinant trimeric proteins based on HIV-1 env genes are being developed for future vaccine trials

53 Thus, the computer-generated "consensus" env genes are capable of expressing envelope glycoprotei

54 e C17.2 was engineered to express the CasBrE env gene as either gp70/p15E (CasE) or gp70 alone (CasES

55 be an experimental approach to analyze HIV-1 env genes as intact genetic units amplified from plasma

56 ct open reading frames for the gag, pol, and env genes, as well as nearly identical flanking long ter

57 ew SOSIP.664 trimer derived from a subtype B env gene, B41, including how to make this protein in low

58 mpared the pattern of evolution of the HIV-1 env gene between individuals with recent HIV infection w

59 V-A, PERV-B, and PERV-C) which have distinct env genes but have highly homologous sequences in the re

60 on values were similar for the gag, pol, and env genes but these genes differed significantly from th

61 mapped to specific regions in the envelope (env) gene by using a cloning-hybridization technique and

62 one, HIV-Du151.2env-NLuc, which expresses an env gene (C.Du151.2) cloned from an acute heterosexually

63 t, substitution of both the FeLV-945 LTR and env gene changed the disease outcome entirely.

64 ess of the primary B5 HIV-1 isolates and its env gene cloned into the NL4-3 laboratory strain had sim

65 able to that seen with several primary HIV-1 env genes cloned from individuals with disease progressi

66 Primary env genes cloned from sequential isolates from two seroc

67 ested and was exclusively R5 tropic, and its env gene clustered with HIV-C by phylogenetic analysis;

68 synthesized an artificial group M consensus env gene (CON6 gene) to be equidistant from contemporary

69 have generated a synthetic group M consensus env gene (CON6) for induction of cross-subtype immune re

70 the numerous copies of endogenous retroviral env genes conserved within mammalian genomes act as rest

71 and gp41 was demonstrated in that a chimeric env gene consisting of a gp120 coding sequence from an N

72 All three env genes contained 3' regions identical to that of SFFV

73 n resulting in acquisition of a heterologous env gene could in theory facilitate cross-species transm

74 ent study, we investigated whether envelope (env) genes could be amplified from proviral DNA or RNA d

75 constructing mutants with either the pol or env gene deleted.

76 Cloning of this endogenous retroviral env gene demonstrated fusogenicity in an ex vivo cell-ce

77 he HERV-W env gene represents the first HERV env gene demonstrated to encode the functional propertie

78 enesis of multiple primary and prototypic R5 env genes demonstrated that the GPG motif was necessary

79 vaccination with a mismatched SIV envelope (Env) gene, derived from simian immunodeficiency virus SI

80 antiretroviral env, we argue that many more env gene-derived restriction factors await discovery in

81 leukosis virus (ALV) that includes a unique env gene, designated J, was identified recently in Engla

82 with selective deletion of the gag, pol, and env genes developed extensive vasculopathy.

83 To determine if changes in env gene diversification occur with NNRTI therapy, we us

84 sign is designated SOSIP.664, but many HIV-1 env genes do not yield fully native-like trimers efficie

85 -tropic proteins, while the remaining cloned env genes encoded R5 T cell-tropic proteins.

86 The Friend spleen focus-forming virus (SFFV) env gene encodes a 409-amino-acid glycoprotein with an a

87 The Friend spleen focus-forming virus (SFFV) env gene encodes a glycoprotein with apparent Mr of 55,0

88 The env gene encodes a protein that is over 40% identical in

89 al might be an artifact of the region of the env gene evaluated and that regions other than V3 might

90 Viral env genes evolving from individual transmitted or founde

91 unodeficiency virus type 1 (HIV-1) envelope (env) gene exhibits a high level of genetic heterogeneity

92 ormation following transfection with primary env gene expression vectors.

93 To study the properties of these env genes, expression plasmids for the three env genes w

94 erythropoietin receptor (EpoR) by the virus env gene (F-gp55), aberrant over-expression of the trans

95 ino acids of the N-terminal mature SU of FRA env gene, followed by eight amino acids from the framesh

96 n be adapted for use with multiple different env genes for both vaccine and structural studies.

97 ve paired blood-derived, T cell-tropic HIV-1 env genes, four of which are CCR5-using (R5) and one of

98 -R) activation, such as interaction with the env gene Friend virus envelope glycoprotein (F-gp55) of

99 ction with a eukaryotic vector expressing an env gene from a cell culture-adapted strain of virus cor

100 n with HIV-1 env DNA plus HIV-1 Env protein (env gene from HXBc2 clone of HIV IIIB; Env protein from

101 In the analysis of full env genes from 22 early seroconverters, the Trinidad iso

102 uencing (UDS) of partial HIV-1 gag, pol, and env genes from 32 recently infected individuals.

103 inant vaccinia vectors (vv) expressing HIV-1 env genes from early isolates of four vertically infecte

104 gh frequency of G-to-A hypermutations in the env genes from HIV-1BaL-infected MDDCs treated with low

105 HIV-1 env genes from macaque m584 (env(m584)) and from inocula

106 mined the functional properties of the HIV-1 env genes from six long-term survivors.

107 ed phenotypic and genetic variation in HIV-1 env genes from subjects in acute/early infection and sub

108 We cloned genetically divergent env genes from the plasma of two wild-infected sabaeus A

109 We have now cloned the env genes from the the parental and escape mutant isolat

110 Furthermore, evaluation of env genes from three chimpanzees infected with the same

111 In this study, we analyzed 37 full-length env genes from uncultured brain biopsy and blood samples

112 ing sequences derived from the viral gag and env genes fused to the myb coding region.

113 ency virus type 1 (HIV-1) tat, rev, vpu, and env genes generated pathogenic viruses (SHIV-89.6P) indu

114 n of specific long terminal repeat (LTR) and env gene genomic sequences with the initiation of infect

115 Although the product of the env gene, gp160/gp120, is known to play a role in cell d

116 was shown that almost the entire retroviral env gene had been replaced by a sequence of cellular ori

117 Notably, proteins produced from envelope (env) genes have been shown to act as restriction factors

118 We found that HIV-1 lacking the env gene (HIVDeltaenv) still induced apoptosis in T-cell

119 s responsible have been mapped to within the env gene; however, it has remained unclear how env media

120 RV-T provirus in hominid genomes includes an env gene (hsaHTenv) that has been uniquely preserved.

121 t range, and sequence analysis of the CasE#1 env gene identifies segments related to PMVs and XMVs.

122 of the viruses, including the Vif, OrfA, and Env genes; (ii) the 5' end extending from the 5' long te

123 in the V1/V2 and C2/V3 regions of the HIV-1 env gene in 30 late-stage and 6 early-stage subjects.

124 evolution in the C2V3C3 region of the viral env gene in 8 HIV-2-infected individuals from Dakar, Sen

125 cation-competent MLV by replacing the native env gene in a full-length viral genome with that of anot

126 ly variable V3 or V4-V5 regions of the HIV-1 env gene in eight subjects, we found that all detectable

127 cellular receptor CD21, induces the HERV-K18 env gene in resting B lymphocytes.

128 inal repeat (LTR), a region that harbors the env gene in retroviral genomes.

129 as inserted after the last nucleotide of the env gene in the ecotropic FeLV-A Rickard (FRA) provirus.

130 es showed that the gp70-coding region of the env gene in the HM DNA was minus-sense single-stranded D

131 Conversely, inactivation of the HIV-2 env gene in the original ROD10 clone resulted in a decre

132 Evolution of the env gene in transmitted R5-tropic human immunodeficiency

133 virus, we constructed chimeras encoding 81T env genes in a 61E background.

134 phenotype was transferable by expressing the env genes in an isogenic proviral DNA backbone, indicati

135 Moreover, clonally amplified virus env genes in milk produced functional virus Envs that we

136 nd new clonal amplification of evolved virus env genes in milk.

137 virus type I (HTLV-I) proviral pX, pol, and env genes in the lesional skin of 42 American patients w

138 e that was homologous with other feral SIVsm env genes in the troop but having a gag gene from anothe

139 del for analyzing the functions of subtype-E env genes in viral transmission and pathogenesis and for

140 id resistance gene gpt in place of the viral env gene) in permissive cells, and we used them to gener

141 man cells in SCID-hu mice to a region of the env gene including the three most amino-terminal variabl

142 on of rev) open reading frames, the complete env gene (including the first exon of rev), and the 3' l

143 us vectors (Ad5 or Ad35) and HIV-1 envelope (Env) gene inserts (clade A or B) in a prime-boost regime

144 Transfer of the entire SHIV(DH12R-CL-7) env gene into the genetic background of nonpathogenic SH

145 One such env gene is CZA97.012 from a neutralization-resistant (t

146 ous studies of men have shown that the HIV-1 env gene is homogeneous early in infection, leading to t

147 The EnvD gene is carried on the P. noertemanii genome but co

148 opic SHIV carrying a primary pediatric HIV-C env gene isolated from a 2-month-old Zambian infant, who

149 se data led to the suggestion that the ALV-J env gene might have arisen by multiple recombination eve

150 HIV CCR5 antagonists select for env gene mutations that enable virus entry via drug-boun

151 ts expressing molecularly cloned full-length env genes obtained from patient-derived HIV-1 isolates b

152 HIV-1 env genes obtained from seven mothers and their perinata

153 genetic events that led to truncation in the env gene occurred de novo in FeLV lymphomagenesis and th

154 These represent the only cases in which the env gene of a retrovirus has been traced back to its ori

155 ty and myeloid leukosis induction map to the env gene of ALV-J.

156 Interestingly, we find that the env gene of an anemic strain of Friend virus, Rauscher v

157 nt data show that this MAA is encoded by the env gene of an ecotropic retrovirus produced by B16 mela

158 virus (EBV) transcriptionally activates the env gene of an endogenous retrovirus, HERV-K18, that pos

159 Analysis of the env gene of eight other HERV families indicated that rei

160 e gag/pol genes and the other expressing the env gene of FeLV-A/Glasgow-1.

161 The env gene of gammaretroviruses encodes a glycoprotein con

162 s in hypervariable regions (V1 to V3) of the env gene of HIV type 1 (HIV-1) 89.6.

163 A naturally arising point mutation in the env gene of HIV-1 activates the aberrant inclusion of th

164 s begun with a chimeric virus containing the env gene of HIV-1 HXBc2 and the gag and pol genes of sim

165 n vitro or in vivo, were introduced into the env gene of HIV-1(NL4-3) by site-directed mutagenesis an

166 d the complete variable region 3 (V3) of the env gene of HIV-1(YU2) or HIV-1(Ccon) to yield the chime

167 chimeric simian-human virus that encodes the env gene of HIV-IIIB.

168 x RNA stem-loop structure located within the env gene of HIV.

169 The env gene of human immunodeficiency virus type 1 (HIV-1)

170 cted by PCR a 660-bp sequence similar to the env gene of MMTV but not to the known endogenous viruses

171 an ITAM signaling domain encoded within the env gene of murine mammary tumor virus (MMTV).

172 tutions accumulated over time throughout the env gene of SHIVSF33A; some of them coincided with the a

173 the Rev responsive element (RRE) within the env gene of the HIV-1 RNA genome and is involved in tran

174 the Rev responsive element (RRE) within the env gene of the HIV-1 RNA genome, activating the switch

175 The env gene of the KU-1 virus was used to create a molecula

176 n expression levels of plasmid clones of the env gene of the MCF13 and noncytopathic NZB-9 MLV strain

177 gle transmembrane helix that is coded by the env gene of the polycythemic strain of the spleen focus

178 ied and sequenced the full-length RNA of the env gene of the type 1 and 2 HERV-K (HML-2) viruses coll

179 ng an SI phenotype and was restricted by the env gene of the virus.

180 he internal promoter (IP) located within the env gene of these viruses.

181 Thus, the env gene of transmitted HIV-1 confers resistance to a la

182 ted by recombination of ecotropic MuLVs with env genes of a family of endogenous proviruses in mice,

183 When the recombinant trimers based on the env genes of isolates 92UG037.8 and CZA97.012 were made

184 The sites of recombination between the env genes of M-MuLV and endogenous proviruses were confi

185 egulatory regions are located in the pol and env genes of MMTV.

186 2 cell line L5178Y and closely resembles the env genes of modified polytropic proviruses.

187 These results indicate that the env genes of primary HIV-1 isolates collected worldwide

188 In the present study, the gag, pol, and env genes of SIV(K6W) were expressed in the NYVAC vector

189 Furthermore, genetic sequencing of the env genes of strains infecting the vaccinees did not rev

190 Our study aimed to analyze env genes of subtype-E viral strains, prevalent in Asia

191 e regions that are related to those found in env genes of the A to E subgroups, the majority of the s

192 uences of a simple retrovirus and gag-pol or env genes of the complex BLV.

193 (SHIV) that contained the tat, rev, vpu, and env genes of the HXBc2 strain of HIV-1 in a genetic back

194 e common laboratory strains contain proviral env genes of the xenotropic/polytropic subgroup of mouse

195 ke soluble, recombinant trimers based on the env genes of two isolates of human immunodeficiency viru

196 env genes of viruses transmitted to infants IP, but not

197 We used the HIV-1 env genes of well-defined, subject-matched M-tropic and

198 mbinant FeLVs in which the LTR and envelope (env) gene of FeLV-945, or the LTR only, was substituted

199 Here we show that the envelope (env) gene of JSRV has the unusual property that it can i

200 ncytin genes are fusogenic envelope protein (env) genes of retroviral origin that have been captured

201 Syncytins are fusogenic envelope (env) genes of retroviral origin that have been captured

202 ults suggest that the alteration maps in the env gene or in a gene whose product affects the maturati

203 These findings indicate that HIV-1 env genes, other viral genes, and even full-length viral

204 unodeficiency virus genome where the rev and env genes overlap, resulting in changes in the predicted

205 nv gene sequence was expressed in 66% of the env gene-positive human breast cancers.

206 ic MuLV with two distinct sets of polytropic env genes present in the genomes of inbred mouse strains

207 ) in addition to the canonical gag, pol, and env genes, presumably reflecting its limited tropism to

208 sition 427 in the C4 region of the HIV-2/vcp env gene product (VCP) gp120 as a key determinant for th

209 iple SRV antigens representing gag, pol, and env gene products by Western immunoblotting.

210 In CV-1 cells, palmitate was added to env gene products containing single mutations but was ab

211 ing target cells infected with vv-expressing env gene products from early isolates and HIV-1 IIIB wer

212 of target cells expressing laboratory strain env gene products might limit the detection of HIV-1 env

213 The env gene products, gp52 and gp36, have been positioned o

214 d with those stimulated with the full-length env gene products.

215 l as in the gag, pol, and rex but not tax or env gene products.

216 nant vaccinia virus (rVV) delivering the BLV env gene ranged from 30 to 65%.

217 late, higher fitness mapped to the subtype B env gene rather than the subtype C gag and pol genes.

218 leukemogenesis in mice is the appearance of env gene recombinants known as mink cell focus-inducing

219 itional 31 sexually transmitted Kenyan HIV-1 env genes, representing several recent infections with s

220 Thus, the HERV-W env gene represents the first HERV env gene demonstrated

221 ypical retroviruses, whereas others lack the env gene required for virions to enter cells and thus be

222 xpressing SIVmac239 or SIVmac251 gag/pol and env genes, respectively.

223 e subunit (TM) of the envelope glycoprotein (env) gene result in a different topology for some retrov

224 Our data showed that exchange of the env gene resulted in altered T-cell transformation tropi

225 CR analyses of plasma viral RNA indicated an env gene segment containing the V3 region from the inocu

226 of plasma HIV-1 RNA > 50 copies/ml and virus env gene sequence changes.

227 660-bp mouse mammary tumor virus (MMTV)-like env gene sequence in approximately 38% of human breast c

228 viral-experienced patients and that based on env gene sequence of the viruses in the patients.

229 This MMTV-like env gene sequence was expressed in 66% of the env gene-p

230 Phylogenetic analysis of C2-V3 env gene sequences confirmed that 94CY032.3 was closely

231 However, the three env gene sequences did not contain any polytropic sequen

232 exogenous ecotropic MuLVs are replaced with env gene sequences from an endogenous polytropic retrovi

233 In this study, env gene sequences from SHIV(SF162-p3)-infected rhesus m

234 cular, is limited since only about 400 bp of env gene sequences have been determined for just two epi

235 In these recombinants the env gene sequences of exogenous ecotropic MuLVs are repl

236 proviruses that are potential donors of the env gene sequences of polytropic MuLVs; however, the pre

237 gical studies, the HIV-1 tat and part of the env gene sequences of the longitudinal isolates at four

238 HIV gag, pol, and env gene sequences were consistent with a clonal relatio

239 vestigate their validity for HIV, samples of env gene sequences were tested for departure from neutra

240 ant branching orders for "subtype E" gag and env gene sequences, thus excluding selection-driven evol

241 the pol gene and various amounts of gag and env gene sequences.

242 sociated with the central region of the Fr98 env gene showed no upregulation of cytokines or chemokin

243 thern China, where partial sequencing of the env gene showed subtype C and circulating recombinant fo

244 affinity for IgG1b12, and sequencing of its env gene showed that amino acid substitutions had occurr

245 iruses and their acquisition of an envelope (env) gene, similar independent events may have occurred

246 ogenous feline leukemia virus (FeLV)-related env gene species from lymphosarcomas induced by intrader

247 verse an imbalance in splicing caused by the env gene substitution.

248 Phylogenetic analyses of gag and env genes suggest that chains of transmission frequently

249 rmined for the gag and pol genes but not the env gene, suggesting that a recombination event may have

250 rs: the LTR and a second promoter within the env gene termed the internal promoter (IP).

251 nt, SIV/17E-Cl, contained the portion of the env gene that encodes the surface glycoprotein and a sho

252 ha secretion mapped to a region of the HIV-1 env gene that includes the third hypervariable domain.

253 enotypic and phenotypic changes in the viral env gene that occur in the viral populations of DKO-hu-H

254 ved SIV showed a mosaic genome containing an env gene that was homologous with other feral SIVsm env

255 Escape virus contained mutations in the env gene that were unexpectedly sparse, did not map gene

256 tribution of V3 sequence variation, chimeric Env genes that contained consensus V3 sequences from sev

257 promoter, located towards the 3' end of the env gene, that directs expression of the viral auxiliary

258 e virulence of these viruses maps within the env gene, the mechanism of fusion enhancement is not ful

259 RV lineages, we show that when ERVs lose the env gene their proliferation within that genome is boost

260 the methods may have wider utility for other env genes, thereby further guiding immunogen design.

261 /V2) and variable region 3 (V3) of the HIV-1 env gene to analyze the effect of a genetic bottleneck c

262 in order to deliver the neurovirulent CasBrE env gene to endogenous CNS cells.

263 ion and sequence analysis of the full-length env gene to identify CSF-compartmentalized variants and

264 ate the evolutionary potential of retroviral env genes to alter receptor usage in response to appropr

265 Here, we used the CZA97.012 and 92UG037.8 env genes to compare some of these designs and determine

266 endpoint dilution PCR followed by cloning of env genes to create pseudotyped virus to explore the lin

267 region of the surface envelope glycoprotein (env) gene to investigate the replication and cellular tr

268 cine candidate vector expressing HIV gag and env genes, vCP205, was modified by the introduction of a

269 roteins (gp140UNC-Fd-His), based on the same env genes, very rarely form native-like trimers, a findi

270 A full-length ancestral subtype B HIV-1 env gene was constructed and shown to produce a glycopro

271 specific sequence in the C2-V3 region of the env gene was found in 46 HIV-1-infected women.

272 ated with the N-terminal portion of the Fr98 env gene was preceded by upregulation of cytokines and c

273 the United States and a 620 nt region of the env gene was sequenced for each sample.

274 A series of chimeras from NS and NR env genes was constructed, and each was presented on pse

275 immunodeficiency virus sm (SIVsm) envelope (env) gene was analyzed in relation to route of virus cha

276 To characterize this env gene, we examined resistance in crosses between Rmcf

277 e phosphoribosyl transferase in place of the env gene, we generated cell lines resistant to mycopheno

278 contains multiple copies of xenotropic MuLV env genes, we suggest that these resistance genes contro

279 eterogeneity in protection, fragments of the env gene were amplified from peripheral blood mononuclea

280 on, the V1/V2 and V3 variable regions of the env gene were examined by using a heteroduplex tracking

281 and secondary protease cleavage sites of the env gene were identified that resulted in the stable sec

282 fact that the endogenous subgroup J-related env genes were associated with long terminal repeats (LT

283 kine receptor utilization, full-length HIV-1 env genes were cloned from latently infected cells and a

284 Full-length functional env genes were cloned longitudinally from these subjects

285 env genes, expression plasmids for the three env genes were constructed and used to generate retrovir

286 Full-length gag and env genes were recovered directly from peripheral blood

287 A series of 22 chimeric envelope (env) genes were generated between the ecotropic Moloney

288 In this study, HIV envelope (env) genes were sequenced from virus variants amplified

289 g-pol coding region and/or the viral nef and env genes, were designed.

290 We constructed a series of mutant MuLV env genes which express Env proteins with serial truncat

291 me indicates that neurovirulence maps to the env gene, which encodes the surface glycoprotein respons

292 Our results suggest that the env gene, which is linked to a myriad of viral character

293 We show that all genes, including the env gene, which is necessary only for movement between c

294 ovirus genome and entirely overlapped by the env gene with reading frame -2.

295 and screened for the presence of retroviral env genes with a full-length ORF.

296 In silico search for env genes with full coding capacity identified several c

297 An in silico search for env genes with full coding capacity within a Tenrecidae

298 rvivors, indicating the presence of proviral env genes with intact open reading frames.

299 rent factor-independent cell clones revealed env genes with open reading frames encoding 644, 449, an

300 can be recovered in vivo by mutations in the env gene, without an associated pathogenic phenotype, an