ライフサイエンスコーパス: enzyme

1 cost of the biological recognition element (enzyme).

2 affects access of the NADPH substrate to the enzyme.

3 a Ni-centered hydride intermediate like the enzyme.

4 le factor prolylhydroxylase domain-1 (PHD-1) enzyme.

5 whereby at least one step is catalyzed by an enzyme.

6 ubsequent generation of catalytically active enzyme.

7 idal neurons in this layer also express this enzyme.

8 zymatic kinetics similar to the olive native enzyme.

9 other sugars were used as substrate by this enzyme.

10 ase-off cobalamin in the active site of this enzyme.

11 ound 19, IC50 = 2.9 muM) in complex with the enzyme.

12 transglutaminase (hTG2) is a multifunctional enzyme.

13 affling substrate-inhibition behavior of the enzyme.

14 cellular concentration are governed by this enzyme.

15 en there is a large excess of substrate over enzyme.

16 ine (TIH) as an allosteric activator of this enzyme.

17 a rate-controlling tricarboxylic acid cycle enzyme.

18 site located on an inner chamber wall of the enzyme.

19 the canonical pairing expected for class III enzymes.

20 mmunoblotting or gene expression of relevant enzymes.

21 d systems featuring heterologously expressed enzymes.

22 redox partner for most human cytochrome P450 enzymes.

23 and genetic variants in alcohol-metabolizing enzymes.

24 etyl-CoA activation, in contrast to other PC enzymes.

25 nce of disorder in several functional native enzymes.

26 ate activities of many important melanogenic enzymes.

27 can competitively inhibit alphaKG-dependent enzymes.

28 modified bases prior to cDNA synthesis using enzymes.

29 trate specificity with those of fungal Icp55 enzymes.

30 bin/SVBP complexes represent long-sought TCP enzymes.

31 id compositions and angiotensin I-converting enzyme (ACE) inhibitory potentials.

32 Angiotensin-I converting enzyme (ACE) is a zinc metalloprotease consisting of two

33 We aimed to identify the role of the enzyme acid sphingomyelinase in the aging of stored unit

34 nctional stress protein acting as a Phase II enzyme, activating cancer pro-drugs and stabilizing p53

35 The enzyme activation rates by two most active compounds at

36 d were evaluated for in vitro binding to the enzyme active site and for inhibition constants.

37 ofactor with respect to the substrate in the enzyme active site.

38 similar mechanism of cyclization within the enzyme active site; however, there is evidence that conf

39 The redesign of enzyme active sites to alter their function or specifici

40 DNA copy number as well as respiratory chain enzyme activities and levels.

41 Direct measurements of circadian enzyme activities in mouse skeletal muscle confirmed tha

42 The contribution of various enzyme activities that collectively lead to the formatio

43 echanisms for coupling droplet morphology to enzyme activity (host-guest interactions with uncaging a

44 l pH, which leads to impairment of lysosomal enzyme activity and disruption of autophagic processes.

45 ated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydr

46 The in situ enzyme activity evaluation was based on the ability of N

47 is validated by quantitative measurements of enzyme activity for three different classes of enzymes (

48 zymes enables quantification of differential enzyme activity resulting from endogenous changes in loc

49 evere G6PD deficiency were analyzed for G6PD enzyme activity, cellular oxidized nicotinamide adenine

50 tential role for the juxtamembrane region in enzyme activity.

51 O2 at the level of transcripts, proteins and enzyme activity.

52 x with the HSA binding capacity and retained enzyme activity.

53 These enzymes allow proteasomes to remove ubiquitin from subst

54 phosphorylation and activate desired protein enzymes allowing the control of phagocytosis in macropha

55 y identified from a focused library of three enzymes, allowing for completion of the synthesis withou

56 methyl acids in Escherichia coli using these enzymes allows the construction of microbial strains tha

57 amples towards metabolic syndrome-associated enzymes (alpha-amylase, alpha-glucosidase and lipase) wa

58 zyme activity for three different classes of enzymes (amylase, lipase, and sulfatase), relying on two

59 profound effect on domain orientation in the enzyme and we analyse the data in terms of a two-state e

60 e overall activity of a cocktail of multiple enzymes and achieve optimal organ/tissue digestion, whil

61 Additionally, assay of liver enzymes and histology analysis of local tissues identifi

62 acid selectivity profiles of cellular zDHHC enzymes and mapped molecular determinants governing this

63 ption factors, neurotransmitter-synthesizing enzymes and neuropeptides, were selected according to th

64 ise from specialized fatty acid biosynthetic enzymes and specialized acyltransferases.

65 ing has enabled the optimization of existing enzymes and the invention of entirely new biocatalytic r

66 This approach may be amenable to numerous enzymes and to engineering and screening approaches to i

67 Here we review specific ubiquitin-modifying enzymes and ubiquitination events that orchestrate infla

68 d reverse prenylations catalyzed by a single enzyme, and it offers novel insight into the engineered

69 including ABC transporters, cytochrome P450 enzymes, and an acyltransferase.

70 pime, are poorly hydrolyzed by specific ESBL enzymes, and certain strains demonstrate in vitro suscep

71 AP2 transcription factors, histone-modifying enzymes, and regulators of nucleosome positioning.

72 y gene deaminase AID and the RNA/DNA editing enzyme APOBEC1 (A1).

73 ome analysis reveals that lipid biosynthetic enzymes are among the downstream targets of mTORC1-SRPK2

74 Bacterial enzymes are an important target for antibacterial compou

75 itochondrial processing, we found that these enzymes are genuine Xaa-Pro aminopeptidases, which hydro

76 The sequences of all of these enzymes are highly divergent from sequences found in oth

77 ilisation of NEIL1, demonstrating that these enzymes are important in regulating cellular NEIL1 stead

78 Crystal structures of enzymes are indispensable to understanding their mechani

79 Biomethylation of As is catalyzed by the enzyme arsenite (As[III]) S-adenosylmethionine methyltra

80 nce of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myelo

81 nthesis of, among others, eicosanoid-forming enzymes as well as relevant transcription factors, allow

82 method for a universal fluorescence turn-on enzyme assay, which relies on the target enzyme-triggere

83 Validation through enzyme assays and customized (13) C metabolite profiling

84 The in vitro enzyme assays indicate that these distinct metabolic phe

85 Although early in vitro enzyme assays showed that recombinant BAR and PAT exhibi

86 oxide (SFE-CO2) pressurised liquid (PLE) and enzyme-assisted extractions (EAE).

87 host lipid catabolism by an M. tuberculosis enzyme, augmenting our current understanding of how M. t

88 vels of amyloid precursor protein processing enzymes (BACE1 and presenilin 2) and are accompanied by

89 Two different formats of an enzyme-based high-throughput screen yielded two attracti

90 Here, we report an enzyme-based method for the synthesis of a library of 15

91 ietary beta-carotene to retinaldehyde by the enzyme BCO1.

92 h the milk proteins and the main proteolytic enzymes becomes important in determining the quality of

93 sengers Ins(1,3,4,5)P4 and Ins(1,4,5)P3 Both enzymes bound these less-phosphorylated IPs in a catalyt

94 t the two isomers bind simultaneously to the enzyme but within different domains.

95 report the engineering of a cytochrome P450 enzyme by directed evolution to catalyze metal-oxo-media

96 Beyond its CBP activity, this enzyme can use cellobiose and long-chain cellodextrins w

97 The discovery of PhnH demonstrates that enzymes can be used to promote the enantioselective hydr

98 is protein EgtB, a mononuclear non-haem iron enzyme capable of catalysing the C-S bond formation and

99 ses of DNA modifications rely on restriction enzymes capable of digesting genomic DNA at defined sequ

100 The latter include examples of remarkable enzyme catalysis including an unusual cytidilation react

101 It is believed that enzyme catalysis is facilitated by conformational dynami

102 The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like APOBEC3A and APOBEC3B

103 ,6-bisphosphate (FBP) aldolase, a glycolytic enzyme, catalyzes the reversible and stereospecific aldo

104 zDHHC S-acyltransferases are enzymes catalyzing protein S-acylation, a common post-tr

105 ne, engage electrostatic interactions in the enzyme cavity, and with the haem.

106 romising source of novel carbohydrate active enzymes (CAZymes) that modify plant cell wall polysaccha

107 Sensitivity differed among tests across enzyme classes.

108 are good systems for studying how metabolic enzymes communicate via substrate channeling.

109 teins increased with decreased pH and higher enzyme concentrations of young child gastric digestion c

110 rases (cis-PTs) constitute a large family of enzymes conserved during evolution and present in all do

111 ubstrate scope that is broader than those of enzymes containing iron porphyrins.

112 owever, very little is known about how zDHHC enzymes contribute to acyl chain heterogeneity.

113 rstanding the substrate specificity of these enzymes could create opportunities for their biocatalyti

114 27B1 (produces 1,25(OH)2D3) and inactivating enzyme CYP24A1 (produces 24R,25(OH)2D3).

115 , migration, and on the vitamin D activating enzyme CYP27B1 (produces 1,25(OH)2D3) and inactivating e

116 nt inhibitor of the mRNA decapping scavenger enzyme (DcpS), but the mechanism whereby DcpS inhibition

117 Mitochondrial and enzyme defects predominate as disease-related etiologies

118 he identification of a cDNA for a DGAT1-type enzyme, designated CpuDGAT1, from the transcriptome of C

119 nsfer proteins; or (iii) mediator-generating enzymes detached from cells.

120 revented by inhibiting the 2-AG-synthesizing enzyme diacylglycerol lipase alpha.

121 knockout of the microRNA (miRNA)-processing enzyme Dicer (ADicerKO), as well as humans with lipodyst

122 We demonstrate that, while free enzymes display weak activities for only a short duratio

123 sponse to graded transcription of glycolytic enzymes downstream of fibroblast growth factor (FGF) sig

124 olism of arachidonic acid by cytochrome P450 enzymes emerged.

125 This gigantic redox-driven enzyme employs the energy from quinone reduction to pump

126 ), to serine hydrolase and cysteine protease enzymes enables quantification of differential enzyme ac

127 -tetrahydrofolate reductase (MTHFR) gene, an enzyme essential in DNA synthesis and methylation, have

128 s a bispecific antibody recognizing both the enzyme factor IXa and the substrate factor X.

129 reaction pathway of a bacterial homodimeric enzyme, fluoroacetate dehalogenase (FAcD).

130 This enzyme's potential for the use as the enzyme for blood glucose monitor enzyme sensor strips wa

131 carboxylase appeared to be the rate-limiting enzyme for polyamine production.

132 aling leads to up-regulation of lipase 3 and enzymes for mitochondrial beta-oxidation.

133 Flavin-dependent halogenases are useful enzymes for providing halogenated molecules with improve

134 on exists on the quinate/shikimate catabolic enzymes found in these organisms.

135 A new enzyme-free sensor based on iron oxide (Fe3O4) nanodots

136 The structure of a QuiC1 enzyme from P. putida reveals that the protein is a fusi

137 The object of this study was the HDH enzyme from the model legume plant, Medicago truncatula

138 es the way for correctly classifying similar enzymes from other organisms.

139 by which pathogenic mutations interfere with enzyme function, and a compelling explanation for severe

140 in women whose CYP2D6 genotypes confer poor enzyme function.

141 ryptic site at the dimerization interface to enzyme function.

142 opens new avenues for optically controlling enzyme function.

143 nd modulate TLR responses, but whether these enzymes function in TLR4 responses of hepatocytes is unk

144 at bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase.

145 The enzyme had optimum temperaturet 35 degrees C and was rel

146 and ECs through the inhibition of degrading enzymes has been considered to be a viable therapeutic a

147 LTB4 synthesis and hence inhibitors of this enzyme have been actively pursued.

148 Cytochrome P450 enzymes have been engineered to catalyze abiological C-H

149 een the model NiAz system and the native ACS enzyme, highlighting the potential for related reactivit

150 ing mouse development, the histone-modifying enzyme histone deacetylase 3 (Hdac3) regulates the forma

151 t assays may be easily developed for certain enzymes, HTS assays designed to identify ligands that bl

152 s are consistent with the morpheein model of enzyme hysteresis, in which substrate binding induces co

153 nvolved enhanced activity of defence related enzymes, i.e. chitinase, beta-1,3-glucanase and PAL, and

154 VB radiation with biphasic expression of the enzyme immediately and then after a several-hour delay.

155 trix, amino groups in HKCN were used for the enzyme immobilization.

156 s was tested for lactose hydrolysis, and the enzyme immobilized in SiQT10 and SiQT20 composites showe

157 Enzyme immunoassay determined LTB4, and enzyme-linked im

158 Histamine and leptin levels were measured by enzyme immunoassay.

159 nd sera for antirotavirus immunoglobulins by enzyme immunoassays.

160 Despite the broad cellular impact of SCF enzymes, important questions remain about the architectu

161 beta-1,3 galactosyltransferase, an essential enzyme in forming plant-specific Le(a) structure, were p

162 deletion in mice of glutaminase, the initial enzyme in glutamine catabolism, markedly blunts angiogen

163 Uracil DNA Glycosylase (UNG2) is the primary enzyme in humans that prevents the stable incorporation

164 d Re-citrate synthase (Ccar_06155) was a key enzyme in its tricarboxylic acid cycle (TCA) pathway.

165 role of acetate kinase (AK), which is a key enzyme in methane production.

166 identification and characterization of this enzyme in P. fluorescens strain A506.

167 62% and 47%, respectively) compared with the enzyme in SiO2aptms.

168 rized C. neoformans GMP synthase, the second enzyme in the guanylate branch of de novo purine biosynt

169 Indoleamine 2,3 dioxygenase-1 (IDO-1) is an enzyme in the kynurenine pathway which augments tumor-in

170 ne encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan

171 acking gcd1 and zwf1, which encode the first enzyme in the pentose phosphate pathway, have a more sev

172 nhibitor to cyclooxygenase-2, the initiating enzyme in the RvT pathway, reversed the protective actio

173 ) is one of the largest and most complicated enzymes in mammalian cells.

174 EN, and identifies an important role for ACC enzymes in redox regulation and cell survival.

175 Encapsulation of specific enzymes in self-assembling protein cages is a hallmark o

176 More intense processing conditions led to enzyme inactivation.

177 ction also carried out in biology by oxidase enzymes, includes the critical O-O bond reductive cleava

178 as PARPs, but it can also be added by other enzymes, including sirtuins or bacterial toxins.

179 We show that each enzyme independently follows its own specific substrate

180 inhibitors of the tryptophan (Trp) catabolic enzyme indoleamine 2,3-dioxygenase (IDO) represent a van

181 ave identified key in vivo functions of ADAR enzymes, informing our understanding of the biological i

182 s, compartmentalization minimizes inevitable enzyme inhibition and alleviates constraints that self-i

183 The enzyme interconverts d- and l-lactic acid, which is impo

184 racteristic thioether cross-links, tailoring enzymes introduce additional post-translational modifica

185 /apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expression of ge

186 Mutations in an enzyme involved in protein degradation affect a signalin

187 substrate flux from the isoprenoid pathway, enzymes involved in late biosynthetic steps remain uncha

188 ctive tyrosines (Ys) play essential roles in enzymes involved in primary metabolism including energy

189 As this enzyme is not restricted to pyoverdine-producing bacteri

190 f the L. major phosphatase revealed that the enzyme is redox sensitive.

191 Import of peroxisomal enzymes is facilitated by peroxins including PEX5, a rec

192 f the mammalian SWI/SNF chromatin-remodeling enzymes, is required for both myoblast proliferation and

193 (Fabs) that can modulate the activity of the enzyme isocitrate dehydrogenase 1 (IDH1).

194 gh detailed kinetic analyses and suggests an enzyme isomerization model of inhibition.

195 Consistent with Fic acting as a deAMPylation enzyme, its activity was both time- and concentration-de

196 Enzyme kinetic analysis revealed that BA inhibited tyros

197 tal structure of a monocot CAD combined with enzyme kinetic data and a catalytic model supported by s

198 e mechanism of Prp activity, we analyzed Prp enzyme kinetics and substrate preference using a fluorog

199 e discover that NAD(P)H oxidase 4 (NOX4), an enzyme known to catalyse the oxidation of NAD(P)H, is up

200 However, the mycobacterial enzyme lacks this reverse activity, but the reason for t

201 an E3 ubiquitin ligase to an E2-conjugating enzyme, leading to prolonged inflammatory signaling.

202 tile S-adenosyl-l-methionine (SAM)-dependent enzyme, LepI, that can catalyse stereoselective dehydrat

203 The enzyme leukotriene A4 hydrolase (LTA4H) catalyses the di

204 might be involved in the regulation of liver enzyme level.

205 ormational changes with catalysis in modular enzymes, like the PMT, provides new insights on interdom

206 narene capsule represents the first man-made enzyme-like catalyst that is capable of catalyzing this

207 of the fac-C,N,S-iron(II) motif in promoting enzyme-like reactivity.

208 C), purified and the quality was assessed by enzyme linked immuno sorbet assay.

209 this work, we describe an electronics-based Enzyme-Linked ImmunoSorbent Assay (eELISA), using a Lab-

210 Here, we developed a sensitive sandwich enzyme-linked immunosorbent assay (ELISA) for PEG by tet

211 Chlamydia trachomatis elementary body enzyme-linked immunosorbent assay (ELISA) was used to in

212 , osmotic shock increased cBIN1 detection by enzyme-linked immunosorbent assay (ELISA), and cBIN1 lev

213 Using enzyme-linked immunosorbent assay (ELISA), we obtain ser

214 ion sensitivity is as good as or better than enzyme-linked immunosorbent assay (ELISA).

215 d and analyzed for NE using a single-analyte enzyme-linked immunosorbent assay (ELISA).

216 asma samples collected in 211 patients using enzyme-linked immunosorbent assay (Tac/Sir = 104, Tac/Mt

217 and demonstrated a high correlation with an enzyme-linked immunosorbent assay for sample detection i

218 mples) when combined with the IgG anti-BP180 enzyme-linked immunosorbent assay.

219 sm or Alzheimer's disease were quantified by enzyme-linked immunosorbent assays (ELISA) or theoretica

220 derived Lb8E and Lb6H, and evaluated both in enzyme-linked immunosorbent assays (ELISA).

221 Enzyme immunoassay determined LTB4, and enzyme-linked immunosorbent assays quantified tumor necr

222 Comparative enzyme-linked immunosorbent assays with monoclonal antib

223 2Delta30 and used them in a gamma interferon enzyme-linked immunosorbent spot assay to interrogate CD

224 Enzyme-linked immunospots, cytotoxicity assays as well a

225 Many chromatin- and DNA-modifying enzymes make use of substrates and cofactors that are in

226 We investigated the enzyme-mimicking activity of the CoOxH-GO nanohybrid in

227 own primase, DNA ligase, DNA polymerase, and enzymes necessary to synthesize and incorporate dG(+).

228 ine (NPY), and the nitric oxide synthesizing enzyme neuronal nitric oxide synthase (nNOS) in nerve fi

229 vels of the iron-sulfur cluster biosynthetic enzyme NFS1.

230 cluster, we also characterized a homologous enzyme of Corynebacterium glutamicum (NCgl2339) and obse

231 lycerol lipase (MAGL), the major degradative enzyme of the endocannabinoid 2-arachidonoylglycerol.

232 enylalanine ammonia-lyase (PAL) is the first enzyme of the general phenylpropanoid pathway catalyzing

233 Recent work, however, showed that the first enzyme of the glyoxylate shunt, isocitrate lyase (ICL),

234 Enzymes of amino acid biosynthesis were higher in cocult

235 that BDV infection induces expression of key enzymes of the kynurenine pathway in brains of newborn a

236 and we provide an overview of one of the key enzymes of the pathway, PHGDH.

237 ens against an amino-sugar acetyltransferase enzyme, PglD, involved in biosynthesis of UDP-diNAcBac i

238 the expression of two critical gluconeogenic enzymes, phosphoenolpyruvate carboxykinase and glucose-6

239 aling (RGS1) protein and a lipid-hydrolyzing enzyme, phospholipase Dalpha1 (PLDalpha1), both act as G

240 eased soil cellulolytic and hemicellulolytic enzyme potential and higher foraging intensity reduced c

241 rt the discovery of a hitherto unprecedented enzyme-promoted alpha-hydroxyketone rearrangement cataly

242 phenotypes reflect the divergence of UGT89A2 enzyme properties in the Col-0 and C24 accessions.

243 ed two distinct conformational states of the enzyme, providing a first glimpse of what an active TAM

244 tify reversible aggregation of the metabolic enzyme pyruvate kinase under environmental stress and pr

245 re hydrolyzed with both free and immobilized enzyme, reaching a similar degree of hydrolysis of appro

246 ments that lack this nutrient; thus, unusual enzyme reactions have also evolved to cleave the C-P bon

247 e been an area of interest since intravenous enzyme replacement therapy was successfully introduced f

248 plex with three substrates revealed that the enzyme represents a new class of zinc-binding flavin-dep

249 vant to liquid laundry formulations, whereby enzymes require protection to prevent their deactivation

250 is an oncogene-encoded chromatin-remodeling enzyme required for DNA repair that possesses a poly(ADP

251 ed that CYP450 is not the sole intracellular enzyme responsible for intracellular transformation.

252 exist for structural characterization of the enzymes responsible for biomineralization.

253 E (RS), and STACHYOSE SYNTHASE (STS) are the enzymes responsible for RFO biosynthesis in plants.

254 ck the desmosterol-to-cholesterol conversion enzyme, resulted in the generation of infectious extrace

255 ling and in silico analysis of the GmSACPD-C enzyme revealed that most of these mutations were locali

256 This enzyme reversibly converts AMP, pyrophosphate, and phosp

257 The di-iron enzyme ribonucleotide reductase (RNR) uses a diferric-ty

258 wer than the KM of the primary carboxylating enzyme Rubisco, and in order to photosynthesize efficien

259 This enzyme's potential for the use as the enzyme for blood g

260 ncreased active gamma-glutamyltranspeptidase enzyme secretion.

261 use as the enzyme for blood glucose monitor enzyme sensor strips was evaluated, especially by invest

262 pyrazolopyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed

263 xidative phosphorylation and a substrate for enzymes signaling energy stress and oxidative stress res

264 Deletion of the genes encoding these enzymes significantly reduced phage replication and the

265 ent resembling the constraints in pockets of enzymes stabilizing active sites.

266 evels of the gibberellic acid (GA) catabolic enzyme StGA2ox1.

267 Thus, the crosslinking enzymes studied caused significantly different end produ

268 ion of citrate synthase, but not down-stream enzymes suppressed DeltadacA phenotypes.

269 The SNAP system consists of a self-labelling enzyme tag, which catalyses the covalent linking of exog

270 epair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic acids in the cytosol, preven

271 However, carbonic anhydrase (CA), the enzyme that hydrolyses COS, is expected to be light inde

272 II diglyceride acyltransferases (DGATs), the enzymes that catalyze TAG production.

273 The enzymes that catalyze the oxygenation of AA begin by abs

274 85 subunit of PI3K and phospholipase Cgamma, enzymes that deplete plasma membrane phosphatidylinosito

275 h-PPO mechanism is reminiscent of DNA repair enzymes that displace mismatched bases, and is different

276 cycle, as well as RNA- and protein-modifying enzymes that functionally diversify mammalian ribosomes.

277 Metabolites can inhibit the enzymes that generate them.

278 tinguishing active-site residues to generate enzymes that had a common Zn(2+) bimetallo core but litt

279 ) represent an important class of epigenetic enzymes that play essential roles in regulation of gene

280 NA replication fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities o

281 eIF4E stimulates production of enzymes that synthesize the building blocks of HA, UDP-G

282 iptomic and biochemical data to identify two enzymes that, in tandem, convert strictosidine to akuamm

283 Unlike other GMC enzymes, the conserved His447 is not the catalytic base

284 rectional activity reminiscent of the native enzyme: the complex activates H2 under mild conditions,

285 DMATS enzymes thus contribute significantly to the biological

286 Dihydrofolate reductase (DHFR) is a key enzyme to regulate folate metabolism, however folate/DHF

287 at recruit septal peptidoglycan-synthesizing enzymes to the division site.

288 condensin MukB and the cellular decatenating enzyme topoisomerase IV interact.

289 -on enzyme assay, which relies on the target enzyme-triggered DNA polymerase activity.

290 on partners, with a focus on the melanogenic enzyme tyrosinase.

291 dergoes activation by its cognate activating enzyme, UBA5.

292 The enzyme variant was readily identified from a focused lib

293 The enzyme was stable in the pH range of 3.0-8.0.

294 When both enzymes were administered in a prophylactic or therapeut

295 was performed by partial gene synthesis, and enzymes were overproduced from the cold-inducible cspD2

296 Consistently, liver enzymes were significantly increased in cholestatic WT m

297 the deficiency of glucose-6-phosphatase, an enzyme which catalyses the final step of gluconeogenesis

298 ation and its elevation of the levels of TET enzyme, which is responsible for DNA demethylation in UV

299 rstanding of the mechanism of this efficient enzyme will facilitate the development of synthetic mole

300 The interaction of these enzymes with the milk proteins and the main proteolytic

301 fforts to design and engineer stable, active enzymes without laborious high-throughput activity scree