ライフサイエンスコーパス: enzyme activity

1 tential role for the juxtamembrane region in enzyme activity.

2 O2 at the level of transcripts, proteins and enzyme activity.

3 he life essential topoisomerase II (Topo II) enzyme activity.

4 lacing the CYP126A1 distal water but inhibit enzyme activity.

5 sed glucose-6-phosphate dehydrogenase (G6PD) enzyme activity.

6 sperm eliminated detectable PPDK protein and enzyme activity.

7 pose that dimerization is a predictor of A3C enzyme activity.

8 of lysine residues in MDH could enhance its enzyme activity.

9 of EPC have an important role in maintaining enzyme activity.

10 olism by analysing their effect on biomarker enzyme activity.

11 mRNA-cap depends on its cytoplasmic capping-enzyme activity.

12 n plasma and abolished the increase in liver enzyme activity.

13 on the basis of characteristic symptoms and enzyme activity.

14 ulfur cluster of primase has a redox role in enzyme activity.

15 e of NADH production to assess dehydrogenase enzyme activity.

16 n-inhibitory phenolics that permits enhanced enzyme activity.

17 bit ASXH binding, thereby leading to loss of enzyme activity.

18 sides of the membrane that are important for enzyme activity.

19 this ligand has a role in regulation of the enzyme activity.

20 on depletion of PADI1 or inhibition of PADI1 enzyme activity.

21 d allow strange but yet unexplained membrane enzyme activity.

22 increase with increasing hydrogenase (H2ase) enzyme activity.

23 x with the HSA binding capacity and retained enzyme activity.

24 M-binding domain, lacks both SAM binding and enzyme activity.

25 TgDHODH activity were designed to ablate the enzyme activity.

26 opsis demonstrate that AtPAT14 possesses PAT enzyme activity.

27 inexpensive, and it provides information on enzyme activity.

28 at the ferrous heme negatively modulates the enzyme activity.

29 but also an allosteric ligand that increases enzyme activity.

30 spectroscopy and compared with the change in enzyme activity.

31 analysed, and these correlated with reduced enzyme activity.

32 in a NAD(+)-dependent manner that increases enzyme activity.

33 on was confirmed by RT-PCR, Western blot and enzyme activity.

34 ls, which rendered intra- and trans-cellular enzyme activity.

35 pt ATP binding reduce FAD binding and reduce enzyme activity.

36 own TPMT mutations associated with deficient enzyme activity.

37 asma membrane localization and inhibition of enzyme activity.

38 of phosphate ion produced is proportional to enzyme activity.

39 ass of analgesics by inhibition of oxidative enzyme activity.

40 ed human neutrophils, accompanied by reduced enzyme activity.

41 t dimerization interface in topo II to block enzyme activity.

42 by higher pressures (450MPa), which reduced enzyme activity.

43 aphic peak and identify those inhibiting the enzyme activity.

44 helix domain and plays an important role in enzyme activity.

45 te reductase, restoring its nitrate-reducing enzyme activity.

46 evels and a decreased pyruvate dehydrogenase enzyme activity.

47 nt within the SPASM domain, are critical for enzyme activity.

48 mation of phospholipid domains that regulate enzyme activity.

49 y structure and diversity, and extracellular enzyme activity.

50 ed in reduced or absent SGPL1 protein and/or enzyme activity.

51 mplex displaying a large number of different enzyme activities.

52 ns in the liver, thereby impairing lysosomal enzyme activities.

53 cell activation, and normalization of liver enzyme activities.

54 thaliana We detected strong cis-QTL for five enzyme activities.

55 unity succession and increased extracellular enzyme activities.

56 ased on relative growth of plants and stress enzyme activities.

57 d antagonistic effects on host mortality and enzyme activities.

58 levels of various amino acids or individual enzyme activities.

59 saprotrophic fungi directly influenced soil enzyme activities.

60 linized lysosomal pH and decreased lysosomal enzyme activities.

61 se genes are important for the regulation of enzyme activities.

62 analysis of substrates, protein content and enzyme activities.

63 y have an opposite effect via suppression of enzyme activities.

64 ed levels of lysosomal proteins and lysosome enzyme activities.

65 e glutathione reductase and thioltransferase enzyme activities.

66 distorted leaf development and decreased FeS enzyme activities.

67 eased mRNA accumulation 24-fold and reporter enzyme activity 40-fold relative to the intronless contr

68 (enzyme/protein ratio 0.04 U/mg of protein, enzyme activity 6.5 U/mg protein, hydrolysis conditions

69 We observed different trends in enzymes activities according to cultivar and storage tem

70 of NgBR that is conserved and essential for enzyme activity across phyla.

71 es restores focal adhesions, implicating its enzyme activity acts on targets in the focal adhesion co

72 The SDL retained over 90% of the initial enzyme activity after 25 days storage at room temperatur

73 Thus, we hypothesize that nonA lost enzyme activity allowing the preservation of an effectiv

74 mitochondrial hexokinase 2 (HK2) levels and enzyme activities also were observed in androgen-deprive

75 s heteroannulation is entirely contingent on enzyme activity, although the mechanism of the requisite

76 organic matter concentrations or degradative enzyme activities among treatments.

77 analysis, as well as pharmacokinetic and DPD enzyme activity analyses.

78 metabolic pathways by direct measurement of enzyme activities, analysis of transcriptome data, and d

79 We found metabolites, enzyme activities and enzyme transcript abundances vary

80 previously known quantitative trait loci for enzyme activities and hypothesise that these genes are i

81 borated the experimentally proven functional enzyme activities and indicated the order of the metabol

82 DNA copy number as well as respiratory chain enzyme activities and levels.

83 Cellular metabolic fluxes are determined by enzyme activities and metabolite abundances.

84 mour cells, causing changes in mitochondrial enzyme activities and redox status that lead to apoptosi

85 la melanogaster core 1 galactosyltransferase enzyme activity and a predominant inhibitory effect on i

86 n of the variant by using assays of in vitro enzyme activity and by quantifying metabolites in patien

87 would be helpful to efficiently improve the enzyme activity and catalytic efficiency.

88 eacetylation of ceramide synthases increased enzyme activity and ceramide accumulation after IR.

89 direction of fluid pumping (i) depend on the enzyme activity and coverage, (ii) vary with the distanc

90 l pH, which leads to impairment of lysosomal enzyme activity and disruption of autophagic processes.

91 ested two phiNM1 mutant phages that had null enzyme activity and found that they could still mobilize

92 is a tumor suppressor with de-ubiquitinating enzyme activity and has been implicated in chromatin reg

93 ins a polymorphism (Val(158)Met) that alters enzyme activity and influences PFC function.

94 On the basis of tissue-specific enzyme activity and inhibition by catalytic products, Ha

95 WARS2(L53F) has low enzyme activity and inhibition of WARS2 in endothelial c

96 ften unclear but in some cases they regulate enzyme activity and metabolic homeostasis.

97 tanding of how climate influences N-fixation enzyme activity and physiology, comparatively little is

98 compound-dependent, suggesting dependency on enzyme activity and specificity.

99 Tracing the evolution of enzyme activity and stability from the hot-start toward

100 nctionally interacts with TH to regulate the enzyme activity and synaptic vesicle targeting.

101 letely inhibit glycogen phosphorylase kinase enzyme activity and that this interferes with glycogenol

102 sphorylation, where Ser-20/Thr-240 influence enzyme activity and Thr-309 endorses its cell wall local

103 These MPs exhibited angiotensin-converting enzyme activity and upregulated AT1 receptors and angiot

104 Both enzyme activity and wine flavour were clearly influenced

105 as inhibited, due to possible suppression of enzyme activity and/or gene expression linked to ester s

106 glutarate, inhibits the AlkB homolog (ALKBH) enzymes activity and induces DNA alkylation damage.

107 ls of malondialdehyde, glutathione reductase enzyme activity, and calcium levels, which were reduced

108 asma metabolome, liver histopathology, liver enzyme activity, and gene expression were analyzed.

109 ffector-induced oligomerization required for enzyme activity, and oligomerization was rescued in the

110 es for structural stability, ligand binding, enzyme activity, and protein interactions, suggesting th

111 es Asp251 in the absence of Pdx retains good enzyme activity, and the crystal structure shows that pr

112 rotein content, proline content, antioxidant enzymes activities, and antioxidant enzymes related gene

113 This study aims to determine whether enzyme activities are correlated with protein amounts an

114 Of the many protein families in which these enzyme activities are found, only a subset have been emp

115 Polymerization and enzyme activity are regulated in part by binding of puri

116 hanges in lipid composition due to different enzyme activity are seemingly independent of oxygen avai

117 codes proteins with the following sequential enzyme activities as determined by mass spectrometry and

118 level, hypoglycemic MPCCs upregulated CYP3A4 enzyme activity as compared to other glycemic states.

119 Metabolic analysis and enzyme activity assay on native gel showed that Arabidop

120 Based on enzyme activity assays and metabolic responses to waterl

121 nic techniques with fitness measurements and enzyme activity assays, a new study demonstrates a habit

122 mics, qRT-PCR mRNA transcripts analysis, and enzyme activities assessment in rodents, and protein det

123 gh-throughput, single cell measurement of an enzyme activity associated with the biosynthesis of quor

124 To address this problem, we measured soil enzyme activity at 12 sites across a broad climate gradi

125 This technique enables rapid imaging of enzyme activity at cellular resolution, and it can be co

126 N mineralization and microbial extracellular enzyme activity at multiple locations within 18 permanen

127 paper, we describe an approach to measuring enzyme activity based on the reconfiguration of complex

128 ical scavenging activity), polyphenoloxidase enzyme activity, browning degree and microbial load were

129 s PsXEG1-like protein, PsXLP1, that has lost enzyme activity but binds to GmGIP1 more tightly than do

130 ulation, M2 macrophages and the anti-oxidant enzyme activity but reduced protein oxidation (carbonyls

131 and katA(Y339A)) containing catalase without enzyme activity but that retain all Met residues were cr

132 his depends on the discovery not only of new enzyme activities, but also of reagents that are both su

133 linoleic acid with DHA lowers select cardiac enzyme activities by potentially targeting domain organi

134 ith potential implications for modulation of enzyme activity by drug molecules.

135 was used to compare general cytochrome P450 enzyme activity by monitoring the transformation of a 7-

136 /NDBD and CYP3A4/CYP3A5, partial recovery of enzyme activity by potassium ferricyanide illuminated an

137 High-affinity cdN binding inhibited RECON enzyme activity by simultaneously blocking the substrate

138 we obtained a approximately 3-fold change in enzyme activity by the photocontrolled modulation of the

139 elmo et al. describe how reduction of PFKFB3 enzyme activity can promote vascular normalization.

140 biotic resistance is due to a decline in the enzyme activity caused by a marginal loss of its thermal

141 evere G6PD deficiency were analyzed for G6PD enzyme activity, cellular oxidized nicotinamide adenine

142 we show this reaction can be used to detect enzyme activity changes caused by mutations in fumarate

143 assessed against biochemically measured TPMT enzyme activity, clinical response and adverse effects.

144 at relies on an unexpectedly small number of enzyme activities comprising the glycosyltransferase act

145 ated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydr

146 ated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydr

147 Importantly, inhibition of enzyme activity correlated with the binding affinity, sh

148 eduction in DAG kinase activity; the reduced enzyme activity could be increased 5.5-fold by treatment

149 ition, membrane-bound angiotensin-converting enzyme activity decreased.

150 atal aperture due to its cell wall-modifying enzyme activity during the HS response.

151 spacer (ITS) copy numbers and extracellular enzyme activity (EEA) potentials were one to two orders

152 The in situ enzyme activity evaluation was based on the ability of N

153 confirmed that 2-PMPA inhibited FOLH1/GCPII enzyme activity ex vivo.

154 ng Pt electrodes and was also used to detect enzyme activity for the reaction of beta-galactosidase w

155 is validated by quantitative measurements of enzyme activity for three different classes of enzymes (

156 ease specific and can be applied to quantify enzyme activities from different microbes.

157 tions to estimate each individual's level of enzyme activity from their genotype.

158 mechanism by which the compounds inhibit the enzyme activity has been determined as competitive mode.

159 echanisms for coupling droplet morphology to enzyme activity (host-guest interactions with uncaging a

160 This monovalent cation site controls enzyme activity: (i) PFL-AE in the absence of any simple

161 Therefore, methods to detect specific enzyme activities in biological samples can provide info

162 ored OXPHOS protein levels and mitochondrial enzyme activities in C1qbp(-/-) MEFs.

163 Direct measurements of circadian enzyme activities in mouse skeletal muscle confirmed tha

164 to the high kernel to kernel variability in enzyme activity in a batch of sprouted wheat, the potent

165 measured erythrocyte FN3K concentrations and enzyme activity in a population dichotomized for a large

166 how the presence of CSE genes and associated enzyme activity in barrel medic (Medicago truncatula, di

167 ical ventilated rats, angiotensin-converting enzyme activity in bronchoalveolar lavage fluid increase

168 t contribute to increased levels of residual enzyme activity in cultured fibroblasts of individuals w

169 nhibitors of MTH1, and we use it to quantify enzyme activity in eight cell lines and in colorectal tu

170 o adults may be due to lower cytochrome P450 enzyme activity in fat bodies.

171 of the inhibitors effectively reduced their enzyme activity in liver (GABA-T for vigabatrin; GABA-T

172 is relies on the spectrophotometric assay of enzyme activity in mitochondrially-enriched tissue homog

173 eotide amplification and imaging to quantify enzyme activity in native contexts with high spatial res

174 correlated with both DPYD expression and DPD enzyme activity in peripheral blood specimens from healt

175 The higher enzyme activity in plasma-treated brown rice likely trig

176 w this platform is suitable for detection of enzyme activity in relevant biological samples, the cult

177 ns in gene expression, protein function, and enzyme activity in response to diverse stimuli.

178 of phosphate in vegetation, and phosphatase enzyme activity in soil to shed light on potential effec

179 might be related to postharvest increase in enzyme activity in the biosynthesis.

180 e general applicability of EOPPP to studying enzyme activity in the ECS, and grants a simple approach

181 cted with SMS1 (HepG2-SMS1) exhibit elevated enzyme activity in vitro and increased sphingomyelin con

182 fering with the other conformations, blocked enzyme activity in vitro, and blocked autophagy inductio

183 tion sensitively and selectively to quantify enzyme activity in vitro, and can be used to measure the

184 he difficulty associated with reconstituting enzyme activity in vitro.

185 pable of capturing natural variations of the enzyme activity in vivo.

186 ary structure was substantially affected and enzyme activity increased.

187 by different mechanisms, including increased enzyme activity, increased polypeptide accumulation, and

188 h proinflammatory burden, collagen-degrading enzyme activity, infarct resorption, and adverse structu

189 e activation loop, in the stimulation of the enzyme activity, inhibitor recognition and the potential

190 tation of the RING domain that abolishes the enzyme activity inhibits rapsyn- as well as agrin-induce

191 ynthesis adjusts to low-N conditions and the enzymes/activities integral to these adjustments have no

192 disease network intervention, up-regulating enzyme activities is equally as important as down-regula

193 Control of enzyme activity is fundamental to biology and represents

194 The enzyme activity is pH dependent, within a range of 6.8 t

195 Enzyme activity is potently and reversibly inhibited by

196 on between the intrinsic specificity and the enzyme activity kcat/Km.

197 ith higher phenylalanine ammonia lyase (PAL) enzyme activity leading to higher total phenols and anth

198 DBS from the PNPO-deficient samples showed enzyme activity levels lower than all samples from these

199 re group (7.5%) indicated elevated metabolic enzyme activity, likely through the aryl hydrocarbon rec

200 nonuclear cell arginase 1 mRNA, protein, and enzyme activity; lower NOS2 mRNA; lower plasma arginine;

201 Enzyme activities measured conventionally with currently

202 could be fast-tracked by availability of an enzyme activity measurement method that is fast, label-f

203 iated with transport, metabolic process, and enzyme activity might play important roles in the format

204 wberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionali

205 de association studies, we mapped QTL for 24 enzyme activities, nine metabolites, three structural co

206 Plasma ADA2 enzyme activity normalized in those tested post-HSCT (7/

207 When the enzyme activities of 7 different 2A(pro) were measured c

208 By screening enzyme activities of extracts derived from a yeast knock

209 Moreover, DHA lowered enzyme activities of respiratory complexes I, IV, V, and

210 to as surface display laccase (SDL), had an enzyme activity of 104 +/- 3 mU/g dry cell (with 2,2-azi

211 The residual enzyme activity of cheeses averaged 67.7, 43.7 and 8.4%

212 emical estimation of dipeptidyl-peptidase IV enzyme activity of donor cells in the negative host live

213 of the crystal structures and the effect on enzyme activity of mutations in the SA binding site, we

214 An increased enzyme activity of protein variant H163A in the presence

215 The enzyme activity of S36E increased linearly with increasi

216 of WT enzyme (95 mumol/min/mg), whereas the enzyme activity of T40E was not significantly affected.

217 -600MPa, 30-60 degrees C, 3-10min) influence enzyme activity of the myrosinase-glucosinolate system.

218 DA) concentration and increasing antioxidant enzymes activities of retina induced by HFD.

219 Enzyme activity (often quantified by kcat/Km) is the mai

220 measurement of thiopurine methyltransferase enzyme activity or genotype before starting thiopurine t

221 ty and glucose uptake by D5A and not loss of enzyme activity or mixing issues, thereby demonstrating

222 on the cell wall, inhibit protein folding or enzyme activity, or act intracellularly.

223 te inhibition of matrix-bound collagenolytic enzyme activities over time in the HL.

224 dies revealed delayed generation of fIIa(MZ) enzyme activity, platelet aggregation by fII(MZ) is simi

225 Thiol-dependent redox regulation of enzyme activity plays a central role in the rapid acclim

226 e found between some key-aroma compounds and enzyme activities/precursor FAA.

227 to obtain accurate measurements of specific enzyme activity preference toward alpha-2,3-sialyllactos

228 ofile was characterized, where corresponding enzyme activity profile led to similar protein recovery

229 Their enzyme activity profile was characterized, where corresp

230 ied gene sets which were correlated with the enzyme activity profiles, including seven genes located

231 In turn, increasing enzyme activities promoted ecosystem respiration.

232 A more direct approach is to identify enzyme activity QTL, which distinguishes between cis-QTL

233 ransfected with mutated OTULIN had decreased enzyme activity relative to cells transfected with WT OT

234 lular level, shifting community composition, enzyme activity, respiration rates, and residual organic

235 zymes enables quantification of differential enzyme activity resulting from endogenous changes in loc

236 ecific oxygen uptake rates and dehydrogenase enzyme activity results indicated that CAPB markedly imp

237 In vitro enzyme activity revealed that CsBGlu12 catalyzes the hyd

238 High-throughput enzyme activity screens are essential for target charact

239 Determining the level of G6PD enzyme activity should be followed by analysis of reacti

240 This enhanced TNF-alpha-converting enzyme activity significantly increases the release of T

241 Pharmacological inhibition of AAT1 enzyme activity significantly reduced biofilm formation

242 Pharmacological inhibition of ATGL enzyme activity similarly reduced triglyceride-hydrolyti

243 limited in their ability to measure multiple enzyme activities simultaneously in single cells.

244 al : bacterial (F : B) ratios, extracellular enzyme activities, soil carbon : nitrogen ratio, and soi

245 ct timing separation constraints on rhythmic enzyme activities that allow for substantial rhythms in

246 Just as p53 impacts epigenetic change, the enzyme activities that carry out epigenetic protein modi

247 The contribution of various enzyme activities that collectively lead to the formatio

248 Enzyme activities that improve digestion of recalcitrant

249 ber of human cancers and confer a neomorphic enzyme activity that catalyzes the conversion of alpha-k

250 like other allergens, contains trypsin-like enzyme activity that contributes to allergenicity and ai

251 is ratio reflects an elovl6-encoded elongase enzyme activity that has been found to be associated wit

252 n gliomagenesis, probably through neomorphic enzyme activity that produces D-2-hydroxyglutarate.

253 titrait QTL on chromosome 4 that affects six enzyme activities, three metabolites, protein, and bioma

254 tion ("hierarchical control") and changes of enzyme activities through metabolite-enzyme interactions

255 enced fungal functional composition and soil enzyme activities through their direct effect on dissolv

256 dependence on CaM, but also limited maximal enzyme activity through persistence of LAVP-mediated aut

257 bstrate (azocasein) was used to quantify the enzyme activity through the release of a chromogenic pro

258 We then fit saturating functions of enzyme activity to soil moisture and extracted half satu

259 ngs represent the first use of mitochondrial enzyme activity to unmask agents for mitochondrial fluor

260 in parallel, of butyrylcholinesterase (BChE) enzyme activity towards butyrylthiocholine with and with

261 and sublethal (respiration rate, antioxidant enzyme activity) toxicity in acute (96 h) copper and cad

262 measured enzymes and found that, unlike the enzyme activities, transcript levels of the correspondin

263 est in designing spatiotemporal control over enzyme activities using noninvasive stimuli such as ligh

264 predictive method for reversibly controlling enzyme activity using covalently attached photoresponsiv

265 re associated with enhanced beta-glucosidase enzyme activities (V max ) but short-term drying and wat

266 of the dimer interface, and we show that the enzyme activity varies by more than four orders of magni

267 n camelid inhibitory antibodies, which block enzyme activities via their unusually long, convex-shape

268 The pH optimum for enzyme activity was 4.98 for isoenzymes A1 and A2, and 5

269 In the present study, tunneling of enzyme activity was achieved using redox cofactors namel

270 The inhibition of enzyme activity was alleviated when SWCNTs were pre-coat

271 Maximal enzyme activity was detected at 5h of reaction using 0.0

272 No CHDH enzyme activity was detected in GV oocyte lysate, but CH

273 Enzyme activity was evaluated by halo-assays and microca

274 We found that FOLH1/GCPII enzyme activity was increased in the colorectal tissues

275 Leukocyte alpha-galactosidase A enzyme activity was mildly reduced in 19 subjects and ly

276 ere up-regulated in crd1Delta cells, but PDH enzyme activity was not increased, indicating that PDH u

277 proteins and nanoparticles), where enhanced enzyme activity was observed.

278 PAH enzyme activity was reduced in the presence of DNAJC12 m

279 Madin-Darby canine kidney (MDCK) cells, but enzyme activity was severely diminished when assayed at

280 The enzyme activity was stabilized by Ca(+2) (2mM) up to 7h

281 Most of the enzymes' activity was promptly affected by the red light

282 mechanism linking Atox1-MBD interactions and enzyme activity, we have determined the MBD1-3 conformat

283 patic steatosis (HS) on ultrasound and liver enzyme activities were associated with increased liver d

284 The enzyme activities were induced in the cells by lactate.

285 Soil pH and enzyme activities were negatively correlated with the ab

286 esidue substitutions that increased BnaDGAT1 enzyme activity were introduced into recombinant Camelin

287 [fV ]), metabolic rate (M O2), and cellular enzyme activity were measured.

288 xidase (POX), and superoxide dismutase (SOD) enzymes activities were measured during storage.

289 s was obviously decreased with weakened soil enzyme activities when compared to the healthy soils.

290 bably by inhibiting carbohydrate hydrolyzing enzyme activity which could be attributed to naringin.

291 amma-aminobutyric acid transaminase (GABA-T) enzyme activity which ensured sufficient ATP supplying l

292 se findings contrast with simply promiscuous enzyme activities, which have been described numerous ti

293 may be an evolutionary vestige of ancestral enzyme activities, which have been eliminated over time.

294 e in the plasma membrane, anchorage requires enzyme activity, which suggests co-synthesis of chitin a

295 nstrated excellent potency (inhibiting PARP1 enzyme activity with IC50 = 0.079 muM), as well as inhib

296 sing rapid kinetic techniques to monitor the enzyme activity with its substrate dicyclotyrosine (cYY)

297 xcellent potency, inhibiting PARP1 and PARP2 enzyme activity with Ki = 1.2 and 0.87 nM, respectively.

298 t potent compounds were found to inhibit the enzyme activity with Ki values ranging from 3 to 24 mum

299 ater-soluble payloads, and can be coupled to enzyme activity within the MPE droplets.

300 ogen atom of the alkaloid acceptor decreased enzyme activity without disrupting the structure of the