ライフサイエンスコーパス: enzyme cofactor

1 centrations and converts 5-formylTHF into an enzyme cofactor.

2 tion of modulators of enzyme activity and of enzyme cofactors.

3 rs; in each case, a single ionic form of the enzyme/cofactor accounts for the pH dependence.

4 Magnesium (Mg) is an essential enzyme cofactor and a key structural component of biolog

5 ntracellularly to enhance its function as an enzyme cofactor and antioxidant.

6 enine dinucleotide (NAD(+)) is an endogenous enzyme cofactor and cosubstrate that has effects on dive

7 tical micronutrient for cells, serving as an enzyme cofactor and protecting against oxidative stress.

8 Metal ions serve as essential enzyme cofactors and perform both structural and signali

9 vents and the simultaneous solubilization of enzymes, cofactors and substrates.

10 nts or by facilitating the interface between enzymes/cofactors and electrode surfaces.

11 cob(III)alamin is the probable physiological enzyme cofactor, and cob(II)alamin rather than cob(I)ala

12 to explain the connections among B vitamins, enzyme cofactors, and stress conditions in plants.

13 sic fluorophores, like aromatic amino acids, enzyme cofactors, and vitamins.

14 Organic enzyme cofactors are involved in many enzyme reactions.

15 The enzyme cofactor biotin (vitamin H or B7) is an energetic

16 acillus anthracis protective antigen and the enzyme cofactor biotin.

17 that in addition to its catalytic role as an enzyme cofactor, biotin has multiple roles in regulating

18 itamin supplementation supports the need for enzyme cofactors but cannot provide substrate in the for

19 e directly demonstrate the competence of the enzyme cofactor complex.

20 peptide bond to the catalytic cleft of this enzyme-cofactor complex does not significantly contribut

21 el we conclude that the resting state of the enzyme-cofactor complex is such that the cofactor is alr

22 at the pool of exchangeable hydrogens in the enzyme-cofactor complex is two-a finding consistent with

23 th previous NMR studies of the apoenzyme and enzyme-cofactor complex provide snapshots of the pathway

24 urface tissue factor (TF) to form the active enzyme-cofactor complex.

25 otein substrate sequences recognized by this enzyme-cofactor complex.

26 st dramatically, activation of the assembled enzyme-cofactor complex.

27 ctivation of factor X by this membrane-bound enzyme/cofactor complex.

28 signed ternary complex, data for the binary (enzyme-cofactor) complex were collected, providing chemi

29 molecular substrate docking with coagulation enzyme-cofactor complexes involves multiple contacts dis

30 serine proteases that typically function in enzyme-cofactor complexes, exemplified by coagulation fa

31 Redox-active enzyme cofactors derived from ribonucleotides have been

32 chemical activity was investigated using the enzyme cofactor dihydronicotinamide adenine dinucleotide

33 The structure of the mixed, enzyme-cofactor disulfide intermediate of ketopropyl-coe

34 the amounts of tetrahydrobiopterin (BH4), an enzyme cofactor essential for the synthesis of several n

35 es a reaction in two parts: reduction of the enzyme cofactor FAD by NADPH in response to binding p-hy

36 es a reaction in two parts: reduction of the enzyme cofactor, FAD, by NADPH in response to binding p-

37 voltammetric peaks were due to the redox of enzyme cofactor flavin adenine dinucleotide (FAD), which

38 le structure and function via its role as an enzyme cofactor for collagen and carnitine biosynthesis.

39 Iron-sulfur (Fe-S) clusters are ancient enzyme cofactors found in virtually all life forms.

40 form of vitamin B12 that is best known as an enzyme cofactor, has expanded the number of known photor

41 Tissue factor (TF), a rate-limiting enzyme cofactor in activating coagulation, is highly exp

42 (vitamin C) is an essential antioxidant and enzyme cofactor in both plants and animals.

43 Water-soluble vitamins are required as enzyme cofactors in a wide variety of metabolic reaction

44 ata extracted from the literature on organic enzyme cofactors in biocatalysis, as well as automatical

45 ically important ternary structures, such as enzyme-cofactor-inhibitor complexes.

46 urface amino acid residues, so understanding enzyme-cofactor interactions is important for the design

47 Enzyme cofactors involved in this chemistry can be large

48 m to better understand the way in which this enzyme cofactor is built and the role of these metalloen

49 ts in complex mixtures containing metal ion, enzyme cofactor, metabolite, and drug analytes.

50 lex with a substrate-based inhibitor and the enzyme cofactors NAD(+) and inorganic phosphate.

51 assay was invalidated by honey oxidising the enzyme cofactor NADH.

52 rial, of novel, bioactive derivatives of the enzyme cofactor nicotinamide adenine dinucleotide (NAD).

53 Initially recognized as an enzyme cofactor of a few enzymes, recent studies have re

54 tinamide adenine dinucleotide (NAD(+)) is an enzyme cofactor or cosubstrate in many essential biologi

55 Furthermore, the evolved orthogonal enzyme/cofactor pair is active in non-natural carbenoid-

56 The enzyme/cofactor pair is spatially separated in the open

57 DNA nanodevice to actuate the activity of an enzyme/cofactor pair.

58 d SAM analogs that can render the orthogonal enzyme-cofactor pairs for efficient catalysis.

59 methodology for the generation of orthogonal enzyme/cofactor pairs promises to expand cofactor divers

60 Thiamin pyrophosphate (TPP) is an essential enzyme cofactor required for the viability of all organi

61 Biotin (vitamin H) is a key enzyme cofactor required in all three domains of life.

62 nucleosome complex and only compete with the enzyme cofactor SAM (S-adenosyl-L-methionine) but not th

63 availability of desired cofactor, changes in enzyme cofactor specificity, and introduction of novel r

64 The dimeric structure, mimicking an enzyme/cofactor/substrate complex, yields the structural

65 duced at a 1:1 ratio; and 3) the addition of enzyme cofactors such as NADP(H) was not necessary.

66 Lipoic acid is an essential enzyme cofactor that requires covalent attachment to its

67 Transition metals are essential enzyme cofactors that are required for a wide range of c

68 In addition to functioning as enzyme cofactors, these reducing agents have a critical

69 nal repurposing of adenosylcobalamin from an enzyme cofactor to a light sensor, we find that nature a

70 on of monoamine degradation, and addition of enzyme cofactors to promote monoamine production.

71 de novo derived thiamin is converted to the enzyme cofactor TPP.

72 hate (PLP) is a fundamental, multifunctional enzyme cofactor used to catalyze a wide variety of chemi