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1 25-hydroxyvitamin D 1alpha-hydroxylase, the enzyme required for 1,25-dihydroxyvitamin D3 (1,25(OH)2D
2 pacer regions, but the identities of several enzymes required for 18S rRNA release remain unknown.
3 ion, inactivation of Hs2st (which encodes an enzyme required for 2-O-sulfation of uronic acids in hep
5 These efforts notwithstanding, APP and the enzymes required for Abeta production are synthesized by
6 e: mutants identical to WS, but defective in enzymes required for acetylation produced biofilms with
7 rized carboxymuconolactone decarboxylase, an enzyme required for aerobic growth with aromatic compoun
8 NO in susceptible larval stages may involve enzymes required for aerobic energy metabolism, since si
10 uggest that M. lepromatosis has lost several enzymes required for amino acid synthesis whereas M. lep
12 sulfide (CoB-S-S-CoM) reductase (Hdr), a key enzyme required for anaerobic respiration in methane-pro
14 e conclude that srtA and srtB encode sortase enzymes required for anchoring different subsets of prot
15 ctive antiandrogens, inhibitors of CYP17, an enzyme required for androgen synthesis, inhibitors of 5a
18 atients with AML are deficient in a critical enzyme required for arginine synthesis, argininosuccinat
20 t disrupts phosphoglycerate kinase (PGK), an enzyme required for ATP generation in the terminal stage
21 motif constitutes the catalytic core of the enzyme required for autopalmitoylation and palmitoyl tra
22 Dihydrodipicolinate synthase (DHDPS), an enzyme required for bacterial peptidoglycan biosynthesis
24 ndance of DNA polymerase beta (beta-pol), an enzyme required for BER, which was almost absent in p53
25 ne-6-phosphate isomerase (Gln6PI), the first enzyme required for biosynthesis of N-acetylgalactosamin
26 pha-demethylase (CYP51) is a cytochrome P450 enzyme required for biosynthesis of sterols in eukaryoti
27 t GIBBERELLIN 20 OXIDASE 2, which encodes an enzyme required for biosynthesis of the growth regulator
28 en attributed to mutations in genes encoding enzymes required for biosynthesis of pigments and to ABC
31 Ilv5p is a bifunctional yeast mitochondrial enzyme required for branched chain amino acid biosynthes
34 crophages genetically deficient in Dicer, an enzyme required for canonical microRNA (miRNA) biogenesi
36 t TXNIP deficiency causes marked deficits in enzymes required for catabolism of branched chain amino
37 ritance of defects in the genes encoding the enzymes required for catabolism of GSLs within lysosomes
40 monstrate that keratinocytes express two key enzymes required for catecholamine (beta-AR agonist) syn
42 ules for the pathogen resistance pathway and enzymes required for cell wall modification and secondar
43 ollowing exposure to antibiotics that target enzymes required for cell wall synthesis, bacteria typic
44 bes exposed to saturated fats, inhibitors of enzymes required for ceramide synthesis enhance insulin
45 ulfur allele (su) of magnesium chelatase, an enzyme required for chlorophyll formation; and (2) the f
46 BPs) are transcription factors that regulate enzymes required for cholesterol and fatty acid synthesi
47 , we found that the fly genome lacks several enzymes required for cholesterol biosynthesis, ruling ou
48 luding the low-density lipoprotein receptor, enzymes required for cholesterol synthesis (3-hydroxy-3-
49 s, Sqle, Cyp51, Sc4mol and Ebp, which encode enzymes required for cholesterol synthesis, were highly
51 el increase in epidermal mRNA levels for the enzymes required for cholesterol, fatty acid, and cerami
54 tribute to telomerase, a medically important enzyme required for chromosome stability and long-term c
55 Activation-induced deaminase (AID) is an enzyme required for class switch recombination (CSR) and
56 xpression for lysyl oxidase, the determining enzyme required for collagen cross-linking, is down-regu
57 T is an inhibitor of the HIV proteinase, the enzyme required for correct processing of retroviral pre
58 dly, levels of mRNA for cyclooxygenase 2, an enzyme required for cumulus expansion, are increased.
60 dihydroorotate dehydrogenase (DHODH), a host enzyme required for de novo pyrimidine biosynthesis, and
61 e [dihydroorotate dehydrogenase (DHODH)], an enzyme required for de novo pyrimidine biosynthesis, hav
62 transcarbamylase/dihydroorotase (CAD) is an enzyme required for de novo pyrimidine nucleotide synthe
64 s) that encode mitochondrial and peroxisomal enzymes required for de novo amino acid biosynthesis.
67 rgdorferi has a reduced genome and lacks the enzymes required for de novo synthesis of purines for sy
68 phils deficient in glutaredoxin 1 (Grx1), an enzyme required for deglutathionylation of actin and tub
69 R controls bleach-mediated expression of two enzymes required for detoxification of reactive electrop
70 own of lipid biosynthetic enzymes identified enzymes required for division, which highly correlated w
71 e rhp6 gene product, a ubiquitin-conjugating enzyme required for DNA damage repair, promotes entry to
72 is an oncogene-encoded chromatin-remodeling enzyme required for DNA repair that possesses a poly(ADP
73 ses is that it is through an increase in the enzymes required for DNA synthesis, which include nucleo
77 the dsbA locus, which encodes a periplasmic enzyme required for efficient disulfide bond formation i
78 hylenetetrahydrofolate reductase (MTHFR), an enzyme required for efficient homocysteine metabolism, c
79 at mice lacking the Tec kinases Itk and Rlk, enzymes required for efficient activation of phospholipa
80 se is one of several recombination or repair enzymes required for efficient levels of pilin Av, and R
82 ted levels of fatty acid synthase, the major enzyme required for endogenous fatty acid biosynthesis,
83 he efficacy of inhibitors targeting FabY, an enzyme required for FAS initiation in the absence of exo
87 plant feedstocks could reduce the amount of enzymes required for feedstock pretreatment and hydrolys
88 cs gene, which encodes an acetate-scavenging enzyme required for fitness during periods of carbon sta
90 cine alpha-amidating monooxygenase (PAM), an enzyme required for generating amidated bioactive signal
91 aving enzyme 1 (BACE1) is the beta-secretase enzyme required for generating pathogenic beta-amyloid (
92 is a specialized chromosome end-replicating enzyme required for genome duplication in many eukaryote
93 illomaviruses lack most of the rate-limiting enzymes required for genome synthesis, they need to unco
94 teins act as phosphatidate phosphatase (PAP) enzymes required for glycerolipid biosynthesis, and also
95 ciated with loss of T-synthase but not other enzymes required for glycoprotein biosynthesis, demonstr
96 that affect individual proteoglycans or the enzymes required for glycosaminoglycan synthesis regulat
98 onine sulfoximine (BSO), an inhibitor of the enzyme required for GSH synthesis, or when cells were de
99 ansferase (GPRTase) from Giardia lamblia, an enzyme required for guanine salvage and necessary for th
101 targets in this assay are viral and cellular enzymes required for HCV replication, which are monitore
102 pothesis, we created mice that lack Ext1, an enzyme required for heparan sulfate biosynthesis, in hep
103 e proteoglycan protein cores or biosynthetic enzymes required for heparan sulfate (HS) assembly.
104 Its effect is attributed to induction of the enzyme required for hepatic bilirubin elimination, UDP-g
107 , although the has operon, which encodes the enzymes required for hyaluronic acid synthesis, is highl
108 The yfcYX operon (renamed fadIJ) encodes enzymes required for hydration, oxidation, and thiolytic
110 usine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the transla
113 gulation of the catalase KatG, an activating enzyme required for isoniazid sensitivity, and upregulat
114 Activation-induced cytidine deaminase, an enzyme required for isotype switching and somatic hyperm
115 compartments contains acid lipase (AL), the enzyme required for liberating cholesterol from choleste
116 w "PCP" genes we identified several kinases, enzymes required for lipid modification, scaffolding pro
118 prolipoprotein signal peptidase A (lspA), an enzyme required for lipoprotein synthesis, to demonstrat
119 iciency in lysosomal acid lipase (Lipa), the enzyme required for lysosome lipid catabolism, leads to
120 G6PD is an essential myocardial antioxidant enzyme, required for maintaining cellular glutathione le
125 e effect of knocking out Dicer, an RNase III enzyme required for miRNA and small interfering RNA biog
126 conditional knock-out of Dicer, an RNase III enzyme required for miRNA maturation, previous studies h
127 miRNAs to pancreatic development, Dicer1, an enzyme required for miRNA processing, was conditionally
128 f mitochondrial Ribonuclease P (RNase P), an enzyme required for mitochondrial tRNA processing, but l
130 E235K) and pronounced activity of E214K, an enzyme required for "N-end rule" proteolysis; (iii) ATP-
131 molecule inhibitor of NAMPT, a rate-limiting enzyme required for NAD generation, to probe the pathway
132 s of protein-arginine deiminase 4 (PAD4), an enzyme required for NET formation, should enable clinica
138 e of this screening was 2-fold: to implicate enzymes required for Nod factor-induced calcium spiking
139 ependent protein kinase (DNA-PK), a critical enzyme required for nonhomologous end-joining (NHEJ).
140 ding to cyclin-dependent kinase-2 (cdk2), an enzyme required for normal cell cycle progression; these
143 encoding protein O-fucosyltransferase 1, an enzyme required for Notch ligand binding and thus activa
145 NtdB, and NtdC, constitute a complete set of enzymes required for NTD synthesis, although their funct
146 ate expression of the transport proteins and enzymes required for nucleoside catabolism but also prov
148 iochemically delineates the functions of the enzymes required for OCN modification and demonstrates t
150 teracting protein, p135), a deubiquitinating enzyme required for p97/p47-mediated postmitotic Golgi m
151 ila Fat facets protein is a deubiquitinating enzyme required for patterning the developing compound e
152 ident sequestering of both Ipk1 and Mss4 (an enzyme required for phosphatidylinositol 4,5-bisphosphat
153 ssion of the pebAB operon, which encodes the enzymes required for phycoerythrobilin synthesis in the
154 s cerevisiae encodes a ubiquitin-conjugating enzyme required for postreplicational repair of UV-damag
155 f the mammalian SWI/SNF chromatin remodeling enzyme required for PPARgamma2 activation and adipogenic
158 yrosyl protein sulfotransferase (TPST) is an enzyme required for production of the mature sulfated PS
159 at blocking either beta- or gamma-secretase, enzymes required for production of Abeta from amyloid pr
160 none of the copper protein lysyl oxidase, an enzyme required for proper cross-linking of collagen and
163 by elevated expression of PC-PLC or Mpl, the enzyme required for proteolytic activation of PC-PLC.
165 dihydropteridine reductase (LmQDPR), the key enzyme required for regeneration and maintenance of H(4)
166 , an inhibitor of cathepsin K, an osteoclast enzyme required for resorption of bone matrix, is underw
168 se H2 as a key mammalian genome surveillance enzyme required for ribonucleotide removal and demonstra
169 ation and results in increased expression of enzymes required for serine synthesis from the accumulat
170 vation of ytpB, encoding a C35 -PP utilizing enzyme required for sesquarterpenoid synthesis, leads to
171 haracterize the forms of selection acting on enzymes required for sialic acid scavenging and cataboli
172 polymerase IVb/Pol V, a multisubunit nuclear enzyme required for siRNA-mediated gene silencing of tra
174 protein tyrosine kinase ZAP-70 is a critical enzyme required for successful T lymphocyte activation.
176 iscovered as were genes encoding the various enzymes required for SUMO processing, ligation, and rele
178 double-mutant mice lacking both NPC1 and an enzyme required for synthesis of all complex ganglioside
179 gmhA encodes phosphoheptose isomerase, an enzyme required for synthesis of heptose, a conserved co
180 ne-beta-hydroxylase (DBH) is the penultimate enzyme required for synthesis of norepinephrine and is t
181 n of glutamate decarboxylase 65 (GAD65), the enzyme required for synthesis of the major inhibitory ne
182 ed reduction in the levels of mRNAs encoding enzymes required for synthesis of cholesterol, fatty aci
183 e include genes encoding myelin proteins and enzymes required for synthesis of normal myelin lipids.
184 accharomyces cerevisiae mitochondria contain enzymes required for synthesis of the phospholipids card
185 nowledge of the radical S-adenosylmethionine enzymes required for synthesis of these remarkable metal
186 termined whether the mRNA levels for the key enzymes required for synthesis of these three classes of
188 rgets in the pathway, FadD32 is an essential enzyme required for the activation of the long meromycol
192 tearoyl-CoA desaturase (SCD) is a microsomal enzyme required for the biosynthesis of oleate and palmi
193 polyketide synthase gene (SpPks) encodes an enzyme required for the biosynthesis of the larval pigme
194 -1,4-galacturonosyltransferase (GalAT) is an enzyme required for the biosynthesis of the plant cell w
196 ate dehydrogenase (IMPDH) is a rate-limiting enzyme required for the de novo synthesis of guanine nuc
197 Thioredoxin reductase (TrxR) is an essential enzyme required for the efficient maintenance of the cel
198 synthase (ALAS2; also known as ALAS-E), the enzyme required for the first step in haem biosynthesis.
199 lated, and expression of 5-lipoxygenase, the enzyme required for the first step in leukotriene synthe
200 in an X-linked gene, PIG-A, that encodes an enzyme required for the first step in the biosynthesis o
201 protein level of pyruvate oxidase(PoxL), an enzyme required for the generation of hydrogen peroxide
202 , expression of stearoyl-CoA desaturase, the enzyme required for the generation of mono-unsaturated f
203 -mannosyl transferase 1 (POMT1) is the first enzyme required for the glycosylation of alpha-dystrogly
204 ase epsilon (Pol epsilon) is a multi-subunit enzyme required for the initiation of chromosomal DNA re
205 ndiabetic mice expressed 5-lipoxygenase, the enzyme required for the initiation of leukotriene synthe
207 nt formaldehyde dehydrogenase (FLD) is a key enzyme required for the metabolism of methanol as a carb
210 defensin gene (DEFA5) and in mice lacking an enzyme required for the processing of mouse alpha-defens
211 ed that ecto-5'-nucleotidase (CD73) is a key enzyme required for the production of elevated adenosine
212 ate dehydrogenase (IMPDH), the rate-limiting enzyme required for the production of guanylyl metabolit
213 ough podocyte-specific knockout of Dicer, an enzyme required for the production of mature miRNAs (Nph
214 e phosphoribosyltransferase, a rate-limiting enzyme required for the regeneration of NAD(+) from nico
215 ylase Lsd1 (also known as Aof2 or Kdm1a), an enzyme required for the removal of the repressive histon
216 ion of T. brucei pyridoxal kinase (PdxK), an enzyme required for the salvage of vitamin B6, an essent
217 benzoate polyprenyl transferase) encodes the enzyme required for the second step of the final reactio
218 tes that JGT is the only glucosyltransferase enzyme required for the second step of the pathway.
219 g alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan
220 ine-6-sulfate sulfatase (GALNS), a lysosomal enzyme required for the stepwise degradation of keratan
221 Salmonella enterica, ThiI is a bifunctional enzyme required for the synthesis of both the 4-thiourid
222 Polyphosphate kinase (PPK), the principal enzyme required for the synthesis of inorganic polyphosp
223 Myoinositol monophosphatase (IMP) is a major enzyme required for the synthesis of myoinositol and the
224 ncoding UDP-glucose dehydrogenase (Ugdh), an enzyme required for the synthesis of the glycosaminoglyc
225 rt, and the nature and regulation of several enzymes required for the absorption, storage, activation
226 ospholipase C (PLC)-gamma were the signaling enzymes required for the alphaPDGFR to mediate PVR.
228 -CoA reductase (DCR) is one of the auxiliary enzymes required for the beta-oxidation of unsaturated f
229 perm storage parameters in females mutant in enzymes required for the biochemical synthesis of tyrosi
230 es of Listeria spp. encode all but one of 25 enzymes required for the biosynthesis of adenosylcobalam
231 ion and reconstitution of the minimum set of enzymes required for the biosynthesis of anhydrotetracyc
232 phila sugarless and sulfateless genes encode enzymes required for the biosynthesis of heparan sulfate
233 functional operon allows coregulation of two enzymes required for the biosynthesis of L-serine, pyrid
234 ilar to Escherichia coli lpx genes (encoding enzymes required for the biosynthesis of lipid A) have b
236 example by the expression of genes encoding enzymes required for the biosynthesis of phytochemicals
237 ooxygenases (COXs) are crucial rate-limiting enzymes required for the biosynthesis of prostaglandins.
238 hree unlinked gene clusters that encode five enzymes required for the conversion of 4-hydroxybenzoate
241 ted to cholesterol, implying that all of the enzymes required for the conversion of mevalonate to far
242 medaka eggs revealed selective deposition of enzymes required for the degradation of N-linked glycans
243 tyrosine kinase and phospholipase C-gamma2, enzymes required for the development of FoB from T2 B ce
244 an 16 carbons in length, suggesting that the enzymes required for the elongation of palmitic to stear
245 (TS) and ribonucleotide reductase (RR), two enzymes required for the entire de novo deoxyribonucleot
246 ectrometry, were shown to contain all of the enzymes required for the extension of a 2-carbon precurs
251 ehydrogenase 6 (17beta-HSD6), one of several enzymes required for the interconversion of androstanedi
252 of alpha-N-acetylglucosaminidase, one of the enzymes required for the lysosomal degradation of hepara
253 e structures and enzymatic mechanisms of the enzymes required for the production of dTDP-Fucp3NAc.
255 was to determine the mechanism and specific enzymes required for the retroconversion step in human s
256 conserved core of SahR regulons includes all enzymes required for the SAM cycle: the SAH hydrolase Ah
257 ology and identify at least one new class of enzymes required for the suppression of cell shape defec
258 ng tissue was found to express steroidogenic enzymes required for the synthesis of corticosterone fro
259 rferon gamma decreases the expression of the enzymes required for the synthesis of these ultra long-c
260 se in interferon gamma by decreasing the key enzymes required for the synthesis of ultra long-chain c
261 tisera against octopamine, tyramine, and the enzymes required for their synthesis, tyrosine decarboxy
262 the Rv1079 gene showed it to encode the key enzyme required for this conversion, cystathionine gamma
263 e synthesized, indicating that the necessary enzymes required for this pathway are present in Arabido
265 ases are essential ATP-dependent homodimeric enzymes required for transcription, replication, and chr
268 genes encoding matrix-degrading proteinases, enzymes required for tumor cell migration and invasion.
269 reductase activity of the elongase system of enzymes required for very long-chain fatty acid (VLCFA)
271 IV-1 integrase is one of the three essential enzymes required for viral replication and has great pot
272 mydomonas reinhardtii genome encodes all the enzymes required for vitamin C biosynthesis via the L-ga
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