ライフサイエンスコーパス: eosinophil peroxidase

1 ated by levels of the specific enzyme marker eosinophil peroxidase.

2 that is dependent on the presence of active eosinophil peroxidase.

3 g and internalizing both myeloperoxidase and eosinophil peroxidase.

4 g the presence of DNA traps colocalized with eosinophil peroxidase.

5 d significant enrichments in eosinophils and eosinophil peroxidase.

6 10 secretory tissues stained only weakly for eosinophil peroxidase.

7 Western blotting to evaluate the presence of eosinophil peroxidase (a marker of eosinophil degranulat

8 in vitro and in vivo led to degranulation of eosinophil peroxidase, a granule protein whose enzymatic

9 Eosinophil peroxidase, a heme enzyme released by eosinop

10 d fsp-1) and bronchial alveolar lavage fluid eosinophil peroxidase activity differentially increased

11 s the synthesis of OVA-specific IgE and skin eosinophil peroxidase activity in mice with ongoing skin

12 Moreover, eosinophil peroxidase activity in the skin and productio

13 e endometrium and smaller effects on uterine eosinophil peroxidase activity than nafoxidine, tamoxife

14 Eosinophil peroxidase activity was also elevated in lung

15 l lowering, uterine weight gain, and uterine eosinophil peroxidase activity.

16 n peroxidases, including myeloperoxidase and eosinophil peroxidase, all of which exhibit strong seque

17 the reactive brominating species produced by eosinophil peroxidase and by activated eosinophils, resu

18 ctivated eosinophils degranulate and release eosinophil peroxidase and leukotriene C(4) in a dose-dep

19 9 likewise reduced extracellular deposits of eosinophil peroxidase and tenascin C, the effects not se

20 ressed eosinophil-related genes, such as the eosinophil peroxidase and the major basic protein, but d

21 orrelated with lower mRNA expression of Epx (eosinophil peroxidase) and Prg2 (major basic protein) as

22 Bromide was the preferred substrate for eosinophil peroxidase, and chloride was not appreciably

23 nd transcripts encoding major basic protein, eosinophil peroxidase, and GATA-1, -2, and -3 to an exte

24 Myeloperoxidase (MPO), eosinophil peroxidase, and lactoperoxidase all catalytic

25 eptides, neuropeptides, major basic protein, eosinophil peroxidase, and many US Food and Drug Adminis

26 unts, and indices of subepithelial fibrosis, eosinophil peroxidase, and TGF-beta immunostaining.

27 Myeloperoxidase and eosinophil peroxidase are heme-containing enzymes often

28 They also reveal eosinophil peroxidase as a potential therapeutic target

29 Eosinophil adhesion was measured with an eosinophil peroxidase assay.

30 d in the release of comparable quantities of eosinophil peroxidase at 48 hours post-ligation.

31 Reactive brominating species produced by eosinophil peroxidase attacked the plasmalogen vinyl eth

32 l surface markers, as well as the release of eosinophil peroxidase by eosinophils in the bronchial mu

33 halogenating activity of myeloperoxidase and eosinophil peroxidase by using APF.

34 cificity studies show that only MPO, but not eosinophil peroxidase, can highly activate these agents,

35 alpha-chain, and transcripts encoding mouse eosinophil peroxidase, CCR3, the IL-3/IL-5/GM-CSF recept

36 ls, bronchoalveolar lavage eosinophilia, and eosinophil peroxidase deposition in bronchial mucosa.

37 3 receptors, whereas airway eosinophilia and eosinophil peroxidase deposition were blunted but not el

38 Furthermore, 2-BrHDA production elicited by eosinophil peroxidase-derived reactive brominating speci

39 s and activated eosinophils, indicating that eosinophil peroxidase did not contribute to luminol-BLI

40 peroxidase, a naturally dimeric protein, and eosinophil peroxidase do not undergo H(2)O(2)-dependent

41 double knock-out mice (major basic protein-1/eosinophil peroxidase dual gene deletion) show that eosi

42 Further, eosinophil peroxidase enhanced responses to ovalbumin se

43 hiocyanate (SCN(-)) compete for oxidation by eosinophil peroxidase (EPO) and H(2)O(2), yielding, resp

44 We now show that eosinophil peroxidase (EPO) and lactoperoxidase (LPO), p

45 Both eosinophil peroxidase (EPO) and neutrophil myeloperoxida

46 the discovery that myeloperoxidase (MPO) and eosinophil peroxidase (EPO) can generate nitrotyrosine v

47 Eosinophil peroxidase (EPO) has been implicated in promo

48 nate (SCN(-)) is the preferred substrate for eosinophil peroxidase (EPO) in fluids of physiologic hal

49 Eosinophil peroxidase (EPO) is an abundant heme protein

50 ncrease in the number of eosinophils and the eosinophil peroxidase (EPO) level in the animals.

51 Eosinophil peroxidase (EPO) levels in BALF were elevated

52 otection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MB

53 dy, we generated knockout mice deficient for eosinophil peroxidase (EPO) to assess the role(s) of thi

54 idase superfamily (lactoperoxidase (LPO) and eosinophil peroxidase (EPO)).

55 Eosinophil peroxidase (EPO), a highly cationic hemoprote

56 tic infections and many forms of cancer, and eosinophil peroxidase (EPO), a secreted hemoprotein, pla

57 Here we show eosinophil peroxidase (EPO), an abundant granule protein

58 Eosinophil peroxidase (EPO), an abundant protein secrete

59 Myeloperoxidase (MPO), eosinophil peroxidase (EPO), and chloroperoxidase can ox

60 in (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO), and eosinophil-derived neur

61 dies demonstrate that myeloperoxidase (MPO), eosinophil peroxidase (EPO), and lactoperoxidase (LPO),

62 inophil-derived neurotoxin (EDN or RNase 2), eosinophil peroxidase (EPO), and major basic protein-1 (

63 anule products major basic protein (MBP) and eosinophil peroxidase (EPO), it was determined that eosi

64 ith either isolated myeloperoxidase (MPO) or eosinophil peroxidase (EPO), plasma levels of halides (C

65 3-chlorotyrosine (ClY), selective markers of eosinophil peroxidase (EPO)- and myeloperoxidase-catalyz

66 ing a monoclonal antibody specific for human eosinophil peroxidase (EPO).

67 roxidases, such as myeloperoxidase (MPO) and eosinophil peroxidase (EPO).

68 The presence of autoantibodies against eosinophil peroxidase (EPX) and anti-nuclear antibodies

69 s were quantified for levels of eosinophils, eosinophil peroxidase (EPX) immunohistochemical staining

70 was to validate a novel ELISA-based assay of eosinophil peroxidase (EPX) in sputum as a rapid and rel

71 ranule genes, major basic protein (MBP), and eosinophil peroxidase (EPX) is absent.

72 was to compare nasal, pharyngeal, and sputum eosinophil peroxidase (EPX) levels with induced sputum e

73 mass) are major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX).

74 ty that halogenated nucleobases generated by eosinophil peroxidase exert cytotoxic and mutagenic effe

75 Zn-SOD to physiologically relevant levels of eosinophil peroxidase-generated reactive brominating spe

76 oxin (DT) receptor (DTR) into the endogenous eosinophil peroxidase genomic locus.

77 ngerprint" for proteins modified through the eosinophil peroxidase-H(2)O(2) system in the presence of

78 The eosinophil peroxidase-H(2)O(2)-Br(-) system also convert

79 Human eosinophils used the eosinophil peroxidase-H(2)O(2)-Br(-) system to oxidize u

80 Here we demonstrate that eosinophil peroxidase/H(2)O(2) is able to oxidize bisulf

81 dase-H2O2-Cl(-)- Br(-) system but not by the eosinophil peroxidase-H2O2-Cl(-)-Br(-) system, indicatin

82 Eosinophils use eosinophil peroxidase, hydrogen peroxide (H(2)O(2)), and

83 , MPO, Neutrophil elastase, Cathepsin G, and Eosinophil peroxidase in Cited2-/- fetal livers.

84 ed their granule proteins, including EAR and eosinophil peroxidase in response to CCL11.

85 y release of eosinophil cationic protein and eosinophil peroxidase in response to eotaxin.

86 However, neither cytokines nor eosinophil peroxidase in the bronchoalveolar lavage of D

87 There was focally intense deposition of eosinophil peroxidase in the fibrotic connective tissue

88 The mammalian peroxidases eosinophil peroxidase, lactoperoxidase (LPO), and myelop

89 ing the classic eosinophil granule proteins (eosinophil peroxidase, major basic protein, the ribonucl

90 oxidase enzymes, such as myeloperoxidase and eosinophil peroxidase, may play a fundamental role in re

91 plore the possibility that HOBr generated by eosinophil peroxidase might oxidize nucleic acids.

92 was accompanied by an increase in lung Epx (eosinophil peroxidase) mRNA levels.

93 egulation of immunity was not dependent upon eosinophil peroxidase or major basic protein 1 and did n

94 t 5-bromouracil could be generated by either eosinophil peroxidase or myeloperoxidase, which preferen

95 hese results indicate that HOBr generated by eosinophil peroxidase oxidizes uracil to 5-bromouracil.

96 In contrast, eosinophil peroxidase preferentially converts Br(-) to H

97 In addition to TNF secretion, release of eosinophil peroxidase promoted colitis identifying direc

98 correlated to eosinophil counts (r = 0.691), eosinophil peroxidase (r = 0.738), and TGF-beta (r = 0.5

99 bstrate specificities of myeloperoxidase and eosinophil peroxidase regarding chloride and bromide.

100 Eosinophil peroxidase required H(2)O(2) and Br(-) to pro

101 reactive brominating species produced by the eosinophil peroxidase system of activated eosinophils at

102 nal modification of proteins produced by the eosinophil peroxidase system of eosinophils.

103 lves halogenation by the myeloperoxidase and eosinophil peroxidase systems of phagocytes.

104 Reactive brominating species produced by eosinophil peroxidase target the vinyl ether bond of pla

105 We show that human eosinophils use eosinophil peroxidase to produce 5-bromodeoxycytidine.

106 (lysoPAF) promote degranulation (release of eosinophil peroxidase) via a mechanism that is independe

107 rated that 5-bromodeoxycytidine generated by eosinophil peroxidase was taken up by cultured cells and

108 Remarkably, both myeloperoxidase and eosinophil peroxidase were able to brominate deoxycytidi

109 hil granule proteins major basic protein and eosinophil peroxidase were more frequently detected in t

110 ophils and contain extracellular deposits of eosinophil peroxidase, which uses hydrogen peroxide as a