ライフサイエンスコーパス: ependymal

1 nt of Mnb/Dyrk1A in neurons, astrocytes, and ependymal and endothelial cells appear to reflect cell t

2 OCT3-like immunoreactivity was observed in ependymal and glial-like cells in the DMH.

3 ints, we observed extensive proliferation of ependymal and periependymal cells that immunohistochemic

4 s, glia, and myelinated axon tracts but even ependymal and pial membranes.

5 Although the densities of mutant ependymal and respiratory cilia were largely normal, the

6 nal populations of the brain, in ventricular ependymal and subependymal cells and in peripheral tissu

7 ponents of ciliary rootlets of multiciliated ependymal and tracheal cells.

8 xcess brain water through glial limitans and ependymal barriers.

9 nent hub genes of the gene network unique to ependymal CD133(+)/GFAP(-) quiescent cells were enriched

10 y, separate studies have implicated ciliated ependymal (CE) cells, and special subependymal zone (SEZ

11 RV produces specific and easily identifiable ependymal cell as well as neuronal labeling following ve

12 evelopmental model of IS, exhibit defects in ependymal cell cilia development and cerebrospinal fluid

13 Ultrastructural examination of the ependymal cell cilia that line the enlarged third ventri

14 r was also observed in young mice after mild ependymal cell denudation with low dosages of neuraminid

15 whether this organization is acquired during ependymal cell development or is already present in radi

16 Dystroglycan is furthermore required for ependymal cell differentiation and assembly of niche pin

17 Foxj1, a transcription factor that promotes ependymal cell differentiation.

18 ax is required for hypothalamic tanycyte and ependymal cell differentiation.

19 ependymal ciliary beat frequency and caused ependymal cell disruption.

20 involved in the regulation of EC stability, ependymal cell function, and periventricular permeabilit

21 eased expression of DIO2 in the hypothalamic ependymal cell layer containing tanycytes.

22 a role supported by the loss of cilia on the ependymal cell layer in ventricles of Tg737(orpk) brains

23 Hydin expression is confined to the ciliated ependymal cell layer lining the lateral, third and fourt

24 Before their migration through the ependymal cell layer, a subset of these infected myeloid

25 larged ventricles, partial denudation of the ependymal cell layer, altered subcommissural organ morph

26 ells infected with CVB3 migrated through the ependymal cell layer, they revealed distinct morphologic

27 Here, we show that Six3 is necessary for ependymal cell maturation during postnatal stages of bra

28 endothelium, as well as the disappearance of ependymal cell microvilli and the development of periven

29 Hypothalamic tanycytes, a radial glial-like ependymal cell population that expresses numerous genes

30 ccess to the CSF through a specialized glial/ependymal cell type, the tanycyte.

31 infant and adult human spinal cord contains ependymal cell types that resemble those present in the

32 ic genes while also inhibiting expression of ependymal cell-specific genes.

33 Aging-associated ependymal-cell pathologies can manifest as ventricular g

34 contacts between 5HT axons and NSCs (B1) or ependymal cells (E1) and these cells were labeled by a t

35 the lateral ventricular wall: a monolayer of ependymal cells (Layer I), a hypocellular gap (Layer II)

36 expression of thyroid hormone deiodinases in ependymal cells (tanycytes) of the fetal hypothalamus, a

37 between cells in both radial progenitors and ependymal cells (tissue polarity).

38 tein (BMP) antagonist Noggin is expressed by ependymal cells adjacent to the SVZ.

39 n endothelial cells, inflammatory cells, and ependymal cells after intracerebral inoculation of NSV.

40 Timely generation and normal maturation of ependymal cells along the aqueduct are critical for prev

41 or for generating developmentally controlled ependymal cells along the ventricular lining of the aque

42 It has been suggested that ependymal cells also function as stem cells.

43 get genes to regulate the differentiation of ependymal cells and a small subset of astrocytes in the

44 in mice is required for differentiation into ependymal cells and a small subset of FoxJ1(+) astrocyte

45 icular zones of the brain differentiate into ependymal cells and astrocytes.

46 In conclusion, loss of ependymal cells and ciliary function exposes the underly

47 birth and early stages in the maturation of ependymal cells and demonstrates that these cells are de

48 patch clamp single motile cilia of mammalian ependymal cells and examine their potential function as

49 by astrocytes in the adult brain except for ependymal cells and in the neurogenic regions, where SOX

50 ments reveal that they also make astrocytes, ependymal cells and interneurons.

51 e, in animal tissues, (ii) that infection of ependymal cells and neuroblasts provides a route by whic

52 The fused gene is expressed highly in ependymal cells and the choroid plexus, tissues involved

53 terestingly, we found that the maturation of ependymal cells and the formation of cilia occur signifi

54 Our results indicate that ependymal cells are born in the embryonic and early post

55 Most ependymal cells are born prenatally and are derived from

56 localized to the ependyma, although not all ependymal cells are CD133(+).

57 Ependymal cells are generated from radial glia cells dur

58 Ependymal cells are LeX(-), and purified ependymal cells

59 ells in the alpha2 tanycytic zone, where few ependymal cells are normally found, suggesting that Rax

60 Ependymal cells are part of the neurogenic niche in the

61 , and a late phase, in which only additional ependymal cells are produced.

62 results suggest that PCNA and late dividing ependymal cells are required for normal CNS development

63 erneurons in laminae I and II, as well as in ependymal cells around the central canal.

64 types of astrocytes and a group of displaced ependymal cells between Layers II and III.

65 icate that, unlike cuboidal ependymal cells, ependymal cells bordering the CVOs possess long processe

66 ephalus or prevent the formation of ciliated ependymal cells but caused defects in their differentiat

67 the developmental origin of postnatal spinal ependymal cells by studying the dynamic expression of se

68 in the hypothalamus is formed by specialized ependymal cells called the tanycytes.

69 Our data show that ependymal cells can serve as a source of enzyme secretio

70 ing approaches, we demonstrate that CD133(+) ependymal cells continuously produce new neurons destine

71 with increased KLF4 in NSCs and NSCs-derived ependymal cells developed hydrocephalus-like characteris

72 l ventricles, and uniciliated and biciliated ependymal cells display cilia with large, star-shaped ba

73 Ependymal cells are LeX(-), and purified ependymal cells do not make neurospheres, resolving the

74 o the ventricular surface of differentiating ependymal cells during FoxJ1-dependent ciliogenesis.

75 CC lining serves as a source of cells beyond ependymal cells during the first postnatal weeks of the

76 The homeobox gene Six3 is expressed in ependymal cells during the formation of the lateral wall

77 trocytes, Iba-1(+) microglia and S100beta(+) ependymal cells expressed PLIN in the aging brain.

78 In its absence, ependymal cells fail to suppress radial glia characteris

79 ntricle-contacting NSCs, which together with ependymal cells form regenerative units (pinwheels) alon

80 S100B+/PV+ ependymal cells found in younger mice diminished in the

81 cal characteristics similar to multiciliated ependymal cells from the lateral ventricles, and unicili

82 Ependymal cells have a remarkable planar polarization th

83 In addition, we suggested that the Nkx6.1+ ependymal cells in adult mouse spinal cords may retain t

84 This suggests an involvement of PV+ ependymal cells in aging-associated ventricle stenosis.

85 PV and display phenotype shift to "reactive" ependymal cells in aging-related ventricle stenosis; mor

86 ia of respiratory epithelial cells and brain ependymal cells in both mice and humans.

87 Application of 5-HT to ependymal cells in cultured rat brainstem slices caused

88 esulted in CBF responses similar to those of ependymal cells in cultured slices suggesting that these

89 transgene, defines neurons, subependymal, or ependymal cells in discrete locations throughout the neu

90 mRNA to determine the role of late dividing ependymal cells in embryos of the ascidian Styela clava.

91 also observed in some endothelial cells and ependymal cells in HIVE CNS.

92 ver, GFP expression persisted in a subset of ependymal cells in the adult spinal cord, suggesting tha

93 ncy also resulted in the ectopic presence of ependymal cells in the alpha2 tanycytic zone, where few

94 n inflammatory cells, endothelial cells, and ependymal cells in the central nervous system of infecte

95 d choroid epithelial cells diminished, while ependymal cells in the lateral and fourth ventricles sho

96 Here we show that basal bodies in ependymal cells in the lateral ventricle walls of adult

97 16 is required for the formation of ciliated ependymal cells in the lateral ventricle.

98 However, PV+ ependymal cells in the LV-wall adhesions, unlike injury-

99 sion in the cortex and striatum, and in most ependymal cells in the ventricular and subventricular zo

100 stin immunoreactivity in glial, neuronal and ependymal cells is suggestive of a protein expression pa

101 Ciliated ependymal cells line the ventricular surfaces and aquedu

102 Ependymal cells lining the brain ventricles also carry m

103 Recent studies have suggested that the ependymal cells lining the central canal of postnatal sp

104 , which contains glucosensing neurons, or in ependymal cells lining the third ventricle, where others

105 qually distributed within microglia, and the ependymal cells lining the ventricles of the brain expre

106 Ciliated ependymal cells loaded with caged cAMP exhibited a 54.3

107 Sox2 and Sm-Sox19 were strongly expressed in ependymal cells located in neurogenic niches revealed by

108 brains of adult C57BL/6 mice and found that ependymal cells located in the adhesions of the medial a

109 We found that PrPSc was present in the ependymal cells of both 263K- and 139H-infected hamsters

110 (Sm-Sox2) and Sm-Sox19 mRNAs was detected in ependymal cells of different regions of the telencephalo

111 fects in the motile cilia of the ventricular ependymal cells of mutants, suggesting a role for Katnal

112 Our findings implicate that compromised ependymal cells of the adhering ependymal layers upregul

113 These biciliated ependymal cells of the central canal (Ecc) resembled E2

114 retinoic acid (RA) within the tanycytes and ependymal cells of the hypothalamus have been implicated

115 cause Noggin expression is restricted to the ependymal cells of the lateral ventricles, where FXR2 is

116 form the secondary tail muscle, the lateral ependymal cells of the spinal cord, and the dorsal cells

117 GLUT2 immunoreactivity was seen in the ependymal cells of the third ventricle and in scattered

118 d, with Na,K-ATPase, in certain tanycytes or ependymal cells of the ventricle wall.

119 gene expression in circumventricular organs; ependymal cells of the ventricles, meninges, and choroid

120 Ependymal cells of wild-type ventricles strongly express

121 Ependymal cells on the walls of brain ventricles play es

122 for several weeks, we found no evidence that ependymal cells proliferate.

123 ental potential of the postnatal spinal cord ependymal cells remain to be defined.

124 lational polarity) in radial progenitors and ependymal cells remain unclear.

125 owever, the proliferative capacity of mature ependymal cells remains controversial, and the developme

126 expressing adult neural stem cells, CD133(+) ependymal cells represent an additional-perhaps more qui

127 e (ATP-gamma-S) to acutely isolated ciliated ependymal cells resulted in CBF responses similar to tho

128 Multiciliated ependymal cells show morphological characteristics simil

129 The postmitotic nature of ependymal cells strongly suggests that these cells do no

130 Finally, many ependymal cells surrounding the central canal were inten

131 epithelium of the choroid plexus and in the ependymal cells surrounding the lateral ventricles.

132 Tanycytes are highly specialized ependymal cells that form a blood-cerebrospinal fluid (C

133 HSD2 immunoreactivity was also found in the ependymal cells that form the subcommissural organ.

134 ymal cells, proliferate and give rise to new ependymal cells that presumably remain in the macaque ce

135 .1 progenitor gene is constantly detected in ependymal cells throughout chick and mouse development.

136 n the labeling intensity observed in regular ependymal cells throughout the ventricular system.

137 The opposite response of ciliated ependymal cells to 5-HT and ATP provides a novel mechani

138 In addition, loss of SOX9 led ependymal cells to adopt a neuroblast identity.

139 Exposure of ependymal cells to forskolin caused a decrease in CBF.

140 Some fourth-ventricle ependymal cells were also labeled.

141 lls lacked NET immunoreactivity, whereas CNS ependymal cells were an unexpected site of labeling.

142 In contrast, ependymal cells were labeled by BrdU administration duri

143 ved in circumventricular organs, and OCT3-ir ependymal cells were observed in the linings of all cere

144 Although, ependymal cells were once suggested to have stem cell ch

145 calization restored by incubation of fro/fro ependymal cells with exogenous C24:1 ceramide, which dir

146 Here we show that ependymal cells with one or two cilia, but not multicili

147 ible roles for ASPM in sperm flagellar or in ependymal cells' cilia.

148 , osteocytes, glandular myoepithelial cells, ependymal cells, and by stromal reticular cells and foll

149 s, including neurons, glial cells, meninges, ependymal cells, and cells of cerebral vessels.

150 ected in a subset of GFAP+ astroglial cells, ependymal cells, and Dlx2+ precursors in the SVZ.

151 ain gene Mdnah5 is specifically expressed in ependymal cells, and is essential for ultrastructural an

152 and patterning of hypothalamic tanycytes and ependymal cells, as well as for maintenance of the cereb

153 f uniciliated, biciliated, and multiciliated ependymal cells, astrocytes, and neurons.

154 uring the acute phase of infection including ependymal cells, astrocytes, microglia, oligodendroglia,

155 TrkB-TR is expressed in SVZ astrocytes and ependymal cells, but not in neuroblasts.

156 n ventricular progenitors destined to become ependymal cells, but not in NSCs, and is required for SV

157 sured CaV1 voltage-gated calcium channels in ependymal cells, but these channels are not specifically

158 rd ventricle, which is formed by specialized ependymal cells, called tanycytes.

159 using Nestin-Cre prevented the formation of ependymal cells, disrupting cerebrospinal fluid flow and

160 Our data indicate that, unlike cuboidal ependymal cells, ependymal cells bordering the CVOs poss

161 share the "shoreline" on the ventricles with ependymal cells, forming a unique adult ventricular zone

162 the murine brain stem and subsequently brain ependymal cells, leading to enlargement of the cerebral

163 Multiciliated epithelial cells, called ependymal cells, line the ventricles in the adult brain.

164 , endothelial cells, tanycytes, radial glia, ependymal cells, microglia, and cells from the meninges

165 Spinal cord ependymal cells, previously reported to be multipotent,

166 with one or two cilia, but not multiciliated ependymal cells, proliferate and give rise to new ependy

167 Here we show that SVZ astrocytes, and not ependymal cells, remain labeled with proliferation marke

168 for ciliogenesis in Chlamydomonas and murine ependymal cells, respectively.

169 ity and promoted aberrant growth of aqueduct ependymal cells, resulting in aqueduct stenosis and the

170 ern of expression to markers of hypothalamic ependymal cells, such as Rarres2 (retinoic acid receptor

171 topic expression of genes specific to cuboid ependymal cells, such as Rarres2.

172 antigenic and morphologic characteristics of ependymal cells, suggesting a novel form of SVZ-supporte

173 ighly concentrated in a group of specialized ependymal cells, tanycytes, lining the wall and floor of

174 strocytes in the glial scar are generated by ependymal cells, the neural stem cells in the spinal cor

175 On the ependymal cells, these defects lead to disorganized beat

176 rectly test whether radial glia give rise to ependymal cells, we used a Cre-lox recombination strateg

177 ventricle resulted in stable transduction of ependymal cells, with approximately 10-fold more positiv

178 tors were localised within the tanycytes and ependymal cells, with higher expression under long (LD)

179 of adult male mice--albeit with NSCs nearer ependymal cells--and that distance from the ventricle is

180 cyte progenitor cells (OPCs), astrocytes and ependymal cells-during multiple sclerosis and other CNS

181 y confined to large ventral horn neurons and ependymal cells.

182 pical endfeet in the center of a pinwheel of ependymal cells.

183 aintenance of choroid plexus vasculature and ependymal cells.

184 rity that predicts the orientation of mature ependymal cells.

185 ial glia and then refined by motile cilia in ependymal cells.

186 ly in and induce cellular damage in infected ependymal cells.

187 hat share cellular adherens with neighboring ependymal cells.

188 eta were detected in adult CP, as well as on ependymal cells.

189 rogenesis from postnatal SVZ progenitors and ependymal cells.

190 lia in various stages of transformation into ependymal cells.

191 icular wall transform to give rise to mature ependymal cells.

192 ytes, astrocytes, and the choroid plexus and ependymal cells.

193 ere was positive staining in the ventricular ependymal cells.

194 racic spinal cord is located on neurones and ependymal cells.

195 ian brain ventricles are lined with ciliated ependymal cells.

196 ion and spread caudally without infection of ependymal cells.

197 days postinfection, with no apparent loss of ependymal cells.

198 blasts, immature precursors, astrocytes, and ependymal cells.

199 rally similar to the mammalian multiciliated ependymal cells.

200 and neurogenesis as well as the formation of ependymal cells.

201 tive phenotype, similarly to injury-reactive ependymal cells.

202 is expressed in the astrocytic end feet and ependymal cells.

203 f Chlamydomonas flagella and motile cilia in ependymal cells.

204 stricted to Purkinje neurons and a subset of ependymal cells.

205 microglial activation when PV is absent from ependymal cells.

206 two distinct cell populations: tanycytes and ependymal cells.

207 mylation and glycylation in developing mouse ependymal cilia and the expression of the corresponding

208 Ependymal cilia dysfunction can hinder the movement of C

209 ring brain development, namely impairment of ependymal cilia formation.

210 before, the effects of ethanol ingestion on ependymal cilia function have not been investigated in v

211 Here, we show that ependymal cilia generate a laminar flow of cerebrospinal

212 the beating frequency of all three types of ependymal cilia in both the third and the lateral rat br

213 ies reinforce the presence of three types of ependymal cilia in the brain ventricles and demonstrate

214 Beating of ependymal cilia is required for normal CSF flow, concent

215 hanol as a risk factor for the impairment of ependymal cilia motility in the brain.

216 Ependymal cilia protrude into the central canal of the b

217 argely normal, the planar polarity of mutant ependymal cilia was disrupted, resulting in uncoordinate

218 mal denudation by apoptosis and reduction of ependymal cilia were already evident in young mice, with

219 f3a and Ift88 genetic ablation also disrupts ependymal cilia, resulting in hydrocephalus by postnatal

220 Here, we report three distinct types of ependymal cilia, type-I, type-II and type-III classified

221 of the TTLL family for specific functions in ependymal cilia, we demonstrate that the glycylating enz

222 re required for stability and maintenance of ependymal cilia, whereas the polyglutamylase TTLL6 was n

223 articipates in specifying planar polarity of ependymal cilia.

224 ylating and glycylating enzymes in mammalian ependymal cilia.

225 ed with hydrocephalus are colocalized to the ependymal cilia.

226 ultrastructural and functional integrity of ependymal cilia.

227 ice also implicates Spag6 in the motility of ependymal cilia.

228 , pneumolysin caused rapid inhibition of the ependymal ciliary beat frequency and caused ependymal ce

229 zed loss of cilia, a decrease of the overall ependymal ciliary beat frequency, and damage to the epen

230 Disruption of ependymal ciliary beating, by injury or disease, results

231 Ependymal ciliary stasis by purified pneumolysin was als

232 aB-induced neuroinflammation interferes with ependymal ciliogenesis.

233 Our findings show that ependymal contribution of progeny after SCI is minimal,

234 Ependymal denudation by apoptosis and reduction of epend

235 red molecular properties of CD133(+)/GFAP(-) ependymal (E) cells in the adult mouse forebrain neuroge

236 Defects in ependymal (E) cells, which line the ventricle and genera

237 Multiciliated ependymal (E1) cells line the brain ventricles and are e

238 Multiciliated ependymal (E1) cells line the walls of the ventricles an

239 y or completely blocked by the overgrowth of ependymal epithelia.

240 sion is detectable in the choroid plexus and ependymal epithelium by immunohistochemistry or by nonin

241 ch cells of mixed neuronal and non-neuronal (ependymal) fates are formed, and a late phase, in which

242 In Mdnah5-mutant mice, lack of ependymal flow causes closure of the aqueduct and subseq

243 ugh the cerebral aqueduct, which we term as 'ependymal flow'.

244 The intraventricular delivery of, and ependymal infection by, viral vectors encoding neurotrop

245 CI is minimal, local and dependent on direct ependymal injury, indicating that ependyma are not a maj

246 ricular white matter gliosis, and axonal and ependymal injury.

247 vations, permeability studies show that this ependymal layer acts as a diffusion barrier.

248 eases (TIMPs) 1, 2, and 3 are present in the ependymal layer but not in the SVZ and RMS.

249 -chase experiment and found that a subset of ependymal layer cells (ELCs) were label-retaining after

250 Some precursor cells in the ependymal layer displayed similar transients.

251 This ependymal layer harbors well-organized tight junctions,

252 surements with origin defined by the remnant ependymal layer in the center of the granule cell layer

253 t model of meningitis to examine whether the ependymal layer is affected by S. pneumoniae.

254 bventricular zone of lateral ventricles, and ependymal layer of 3rd ventricle of adult brains.

255 adult brain of both rodents and humans, the ependymal layer of the lateral ventricle contains cells

256 We hypothesized that cells within the ependymal layer of the original spinal cord include popu

257 ur results demonstrate that cells within the ependymal layer of the original, regenerating and fully

258 d interneurons, but do not contribute to the ependymal layer of the postnatal spinal cord.

259 -positive terminals were seen contacting the ependymal layer of the third and fourth ventricles.

260 We show that primarily Th1 cells cross the ependymal layer of the ventricle and migrate within the

261 ted spinal cord with a simple morphology: an ependymal layer surrounded by nerve tracts.

262 ls were observed adjacent to the ventricular ependymal layer.

263 compromised ependymal cells of the adhering ependymal layers upregulate PV and display phenotype shi

264 ains a hypocellular gap layer separating the ependymal lining from a periventricular ribbon of astroc

265 found a strong PRL-RLB immunostaining in the ependymal lining of the 3rd ventricle and in the process

266 the choroid plexus, a specialization of the ependymal lining of the brain ventricles.

267 PDGF-C-deficient mice displayed a distorted ependymal lining of the lateral ventricles, and we found

268 ft in cellular tropism from 2,3-linked SA(+) ependymal lining to 2,8-linked PSA(+) migrating progenit

269 of astrocytes interposed within the adjacent ependymal lining.

270 ular wall and reduction of both tanycyte and ependymal markers.

271 be consistent with a cerebrospinal fluid or ependymal mediated pathogenesis.

272 We conclude that beating of ependymal motile cilia is not tightly regulated by volta

273 r and intercellular rotational alignments of ependymal motile cilia were disrupted.

274 ular rotational alignment and positioning of ependymal motile cilia.

275 tein (GFAP), excluding the possibility of an ependymal nature.

276 lial growth factor (VEGF) activated CD133(+) ependymal neural stem cells (NSCs), lining not only the

277 We thus propose that ependymal Noggin production creates a neurogenic environ

278 This study revealed the existence of dormant ependymal NSCs throughout the ventricular surface of the

279 Targeting a pathway regulating ependymal organization/assembly and showing its requirem

280 Ependymal overexpression of brain-derived neurotrophic f

281 These results suggest that ependymal planar cell polarity is a multistep process in

282 little is known about the mechanisms guiding ependymal planar polarity and whether this organization

283 aporin-4 pool but retain the non-endfoot and ependymal pools.

284 tion of progenitors and apical attachment of ependymal precursor cells.

285 ealed a remarkable network of astrocytic and ependymal processes.

286 al spinal fluid, TNF-alpha expression in the ependymal region, and the influx of neutrophils of encep

287 idge-forming astrocytes are not derived from ependymal stem cells within the spinal cord, suggesting

288 identified in the lateral ventricles a rare ependymal subpopulation (E2) with only two cilia and uni

289 s, IHC staining was seen in association with ependymal surfaces and periventricular regions of formal

290 ercentage of BrdU labeling was higher in the ependymal than in nonependymal regions.

291 Ependymal tumors across age groups are currently classif

292 al ciliary beat frequency, and damage to the ependymal ultrastructure during meningitis.

293 shRNA into the third ventricle, transducing ependymal wall cells and tanycytes.

294 tified roles for Numb/Numblike in regulating ependymal wall integrity and SVZ neuroblast survival.

295 Injections that involved the ependymal wall of the lateral ventricle resulted in prom

296 we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma.

297 rocytes generated after SCI are derived from ependymal zone stem cells (EZCs).

298 is required for the proper formation of the ependymal zone, the epithelial cell lining of the centra

299 ever, the new neurons were restricted to the ependymal zone, were never labeled by antineurofilament

300 divide in situ rather than migrate from the ependymal zone.