ライフサイエンスコーパス: ependymal cell

1 hat share cellular adherens with neighboring ependymal cells.

2 eta were detected in adult CP, as well as on ependymal cells.

3 rogenesis from postnatal SVZ progenitors and ependymal cells.

4 lia in various stages of transformation into ependymal cells.

5 and neurogenesis as well as the formation of ependymal cells.

6 icular wall transform to give rise to mature ependymal cells.

7 ytes, astrocytes, and the choroid plexus and ependymal cells.

8 ere was positive staining in the ventricular ependymal cells.

9 racic spinal cord is located on neurones and ependymal cells.

10 ian brain ventricles are lined with ciliated ependymal cells.

11 tive phenotype, similarly to injury-reactive ependymal cells.

12 ion and spread caudally without infection of ependymal cells.

13 days postinfection, with no apparent loss of ependymal cells.

14 blasts, immature precursors, astrocytes, and ependymal cells.

15 rally similar to the mammalian multiciliated ependymal cells.

16 microglial activation when PV is absent from ependymal cells.

17 is expressed in the astrocytic end feet and ependymal cells.

18 f Chlamydomonas flagella and motile cilia in ependymal cells.

19 stricted to Purkinje neurons and a subset of ependymal cells.

20 two distinct cell populations: tanycytes and ependymal cells.

21 y confined to large ventral horn neurons and ependymal cells.

22 pical endfeet in the center of a pinwheel of ependymal cells.

23 aintenance of choroid plexus vasculature and ependymal cells.

24 rity that predicts the orientation of mature ependymal cells.

25 ial glia and then refined by motile cilia in ependymal cells.

26 ly in and induce cellular damage in infected ependymal cells.

27 tein (BMP) antagonist Noggin is expressed by ependymal cells adjacent to the SVZ.

28 n endothelial cells, inflammatory cells, and ependymal cells after intracerebral inoculation of NSV.

29 Timely generation and normal maturation of ependymal cells along the aqueduct are critical for prev

30 or for generating developmentally controlled ependymal cells along the ventricular lining of the aque

31 It has been suggested that ependymal cells also function as stem cells.

32 get genes to regulate the differentiation of ependymal cells and a small subset of astrocytes in the

33 in mice is required for differentiation into ependymal cells and a small subset of FoxJ1(+) astrocyte

34 icular zones of the brain differentiate into ependymal cells and astrocytes.

35 t to the SC, where it is expressed mainly by ependymal cells and by small-diameter axons located in t

36 In conclusion, loss of ependymal cells and ciliary function exposes the underly

37 birth and early stages in the maturation of ependymal cells and demonstrates that these cells are de

38 patch clamp single motile cilia of mammalian ependymal cells and examine their potential function as

39 d neurons, astrocytes, oligodendrocytes, and ependymal cells and hence did not discriminate among CNS

40 by astrocytes in the adult brain except for ependymal cells and in the neurogenic regions, where SOX

41 ments reveal that they also make astrocytes, ependymal cells and interneurons.

42 e, in animal tissues, (ii) that infection of ependymal cells and neuroblasts provides a route by whic

43 The fused gene is expressed highly in ependymal cells and the choroid plexus, tissues involved

44 terestingly, we found that the maturation of ependymal cells and the formation of cilia occur signifi

45 , osteocytes, glandular myoepithelial cells, ependymal cells, and by stromal reticular cells and foll

46 s, including neurons, glial cells, meninges, ependymal cells, and cells of cerebral vessels.

47 ected in a subset of GFAP+ astroglial cells, ependymal cells, and Dlx2+ precursors in the SVZ.

48 ain gene Mdnah5 is specifically expressed in ependymal cells, and is essential for ultrastructural an

49 of adult male mice--albeit with NSCs nearer ependymal cells--and that distance from the ventricle is

50 Our results indicate that ependymal cells are born in the embryonic and early post

51 Most ependymal cells are born prenatally and are derived from

52 localized to the ependyma, although not all ependymal cells are CD133(+).

53 Ependymal cells are generated from radial glia cells dur

54 Ependymal cells are LeX(-), and purified ependymal cells

55 ells in the alpha2 tanycytic zone, where few ependymal cells are normally found, suggesting that Rax

56 Ependymal cells are part of the neurogenic niche in the

57 , and a late phase, in which only additional ependymal cells are produced.

58 results suggest that PCNA and late dividing ependymal cells are required for normal CNS development

59 erneurons in laminae I and II, as well as in ependymal cells around the central canal.

60 RV produces specific and easily identifiable ependymal cell as well as neuronal labeling following ve

61 , these antibodies also labeled rat pial and ependymal cells as well as reactive astrocytes adjacent

62 and patterning of hypothalamic tanycytes and ependymal cells, as well as for maintenance of the cereb

63 f uniciliated, biciliated, and multiciliated ependymal cells, astrocytes, and neurons.

64 uring the acute phase of infection including ependymal cells, astrocytes, microglia, oligodendroglia,

65 types of astrocytes and a group of displaced ependymal cells between Layers II and III.

66 icate that, unlike cuboidal ependymal cells, ependymal cells bordering the CVOs possess long processe

67 ephalus or prevent the formation of ciliated ependymal cells but caused defects in their differentiat

68 TrkB-TR is expressed in SVZ astrocytes and ependymal cells, but not in neuroblasts.

69 n ventricular progenitors destined to become ependymal cells, but not in NSCs, and is required for SV

70 sured CaV1 voltage-gated calcium channels in ependymal cells, but these channels are not specifically

71 neuronal cell nuclei at distant sites and to ependymal cells by cerebrospinal fluid, (iii) the virus

72 the developmental origin of postnatal spinal ependymal cells by studying the dynamic expression of se

73 in the hypothalamus is formed by specialized ependymal cells called the tanycytes.

74 rd ventricle, which is formed by specialized ependymal cells, called tanycytes.

75 Our data show that ependymal cells can serve as a source of enzyme secretio

76 evelopmental model of IS, exhibit defects in ependymal cell cilia development and cerebrospinal fluid

77 Ultrastructural examination of the ependymal cell cilia that line the enlarged third ventri

78 ible roles for ASPM in sperm flagellar or in ependymal cells' cilia.

79 ing approaches, we demonstrate that CD133(+) ependymal cells continuously produce new neurons destine

80 r was also observed in young mice after mild ependymal cell denudation with low dosages of neuraminid

81 with increased KLF4 in NSCs and NSCs-derived ependymal cells developed hydrocephalus-like characteris

82 whether this organization is acquired during ependymal cell development or is already present in radi

83 Dystroglycan is furthermore required for ependymal cell differentiation and assembly of niche pin

84 Foxj1, a transcription factor that promotes ependymal cell differentiation.

85 ax is required for hypothalamic tanycyte and ependymal cell differentiation.

86 l ventricles, and uniciliated and biciliated ependymal cells display cilia with large, star-shaped ba

87 using Nestin-Cre prevented the formation of ependymal cells, disrupting cerebrospinal fluid flow and

88 ependymal ciliary beat frequency and caused ependymal cell disruption.

89 Ependymal cells are LeX(-), and purified ependymal cells do not make neurospheres, resolving the

90 o the ventricular surface of differentiating ependymal cells during FoxJ1-dependent ciliogenesis.

91 CC lining serves as a source of cells beyond ependymal cells during the first postnatal weeks of the

92 The homeobox gene Six3 is expressed in ependymal cells during the formation of the lateral wall

93 cyte progenitor cells (OPCs), astrocytes and ependymal cells-during multiple sclerosis and other CNS

94 contacts between 5HT axons and NSCs (B1) or ependymal cells (E1) and these cells were labeled by a t

95 Our data indicate that, unlike cuboidal ependymal cells, ependymal cells bordering the CVOs poss

96 trocytes, Iba-1(+) microglia and S100beta(+) ependymal cells expressed PLIN in the aging brain.

97 In its absence, ependymal cells fail to suppress radial glia characteris

98 ntricle-contacting NSCs, which together with ependymal cells form regenerative units (pinwheels) alon

99 share the "shoreline" on the ventricles with ependymal cells, forming a unique adult ventricular zone

100 S100B+/PV+ ependymal cells found in younger mice diminished in the

101 cal characteristics similar to multiciliated ependymal cells from the lateral ventricles, and unicili

102 involved in the regulation of EC stability, ependymal cell function, and periventricular permeabilit

103 Ependymal cells have a remarkable planar polarization th

104 In addition, we suggested that the Nkx6.1+ ependymal cells in adult mouse spinal cords may retain t

105 This suggests an involvement of PV+ ependymal cells in aging-associated ventricle stenosis.

106 PV and display phenotype shift to "reactive" ependymal cells in aging-related ventricle stenosis; mor

107 ia of respiratory epithelial cells and brain ependymal cells in both mice and humans.

108 Application of 5-HT to ependymal cells in cultured rat brainstem slices caused

109 esulted in CBF responses similar to those of ependymal cells in cultured slices suggesting that these

110 transgene, defines neurons, subependymal, or ependymal cells in discrete locations throughout the neu

111 mRNA to determine the role of late dividing ependymal cells in embryos of the ascidian Styela clava.

112 also observed in some endothelial cells and ependymal cells in HIVE CNS.

113 ried out by astrocytes, oligodendrocytes and ependymal cells in other CNS regions.

114 ver, GFP expression persisted in a subset of ependymal cells in the adult spinal cord, suggesting tha

115 ncy also resulted in the ectopic presence of ependymal cells in the alpha2 tanycytic zone, where few

116 n inflammatory cells, endothelial cells, and ependymal cells in the central nervous system of infecte

117 certain nonneuronal cell populations such as ependymal cells in the choroid plexus.

118 d choroid epithelial cells diminished, while ependymal cells in the lateral and fourth ventricles sho

119 Here we show that basal bodies in ependymal cells in the lateral ventricle walls of adult

120 16 is required for the formation of ciliated ependymal cells in the lateral ventricle.

121 However, PV+ ependymal cells in the LV-wall adhesions, unlike injury-

122 sion in the cortex and striatum, and in most ependymal cells in the ventricular and subventricular zo

123 stin immunoreactivity in glial, neuronal and ependymal cells is suggestive of a protein expression pa

124 eased expression of DIO2 in the hypothalamic ependymal cell layer containing tanycytes.

125 a role supported by the loss of cilia on the ependymal cell layer in ventricles of Tg737(orpk) brains

126 Hydin expression is confined to the ciliated ependymal cell layer lining the lateral, third and fourt

127 Before their migration through the ependymal cell layer, a subset of these infected myeloid

128 larged ventricles, partial denudation of the ependymal cell layer, altered subcommissural organ morph

129 ells infected with CVB3 migrated through the ependymal cell layer, they revealed distinct morphologic

130 injection site, possibly associated with the ependymal cell layer.

131 the lateral ventricular wall: a monolayer of ependymal cells (Layer I), a hypocellular gap (Layer II)

132 the murine brain stem and subsequently brain ependymal cells, leading to enlargement of the cerebral

133 Ciliated ependymal cells line the ventricular surfaces and aquedu

134 Multiciliated epithelial cells, called ependymal cells, line the ventricles in the adult brain.

135 Ependymal cells lining the brain ventricles also carry m

136 s expressed by choroid plexus epithelium and ependymal cells lining the brain ventricles and neural t

137 Recent studies have suggested that the ependymal cells lining the central canal of postnatal sp

138 f the DRG, by most neurons of the SC, and by ependymal cells lining the central canal.

139 ved in the pia matter, on a subpopulation of ependymal cells lining the cerebral ventricle wall, and

140 ese other cells included patches of ciliated ependymal cells lining the lateral ventricles and many i

141 , which contains glucosensing neurons, or in ependymal cells lining the third ventricle, where others

142 qually distributed within microglia, and the ependymal cells lining the ventricles of the brain expre

143 Ciliated ependymal cells loaded with caged cAMP exhibited a 54.3

144 Sox2 and Sm-Sox19 were strongly expressed in ependymal cells located in neurogenic niches revealed by

145 brains of adult C57BL/6 mice and found that ependymal cells located in the adhesions of the medial a

146 Here, we show that Six3 is necessary for ependymal cell maturation during postnatal stages of bra

147 , endothelial cells, tanycytes, radial glia, ependymal cells, microglia, and cells from the meninges

148 endothelium, as well as the disappearance of ependymal cell microvilli and the development of periven

149 We found that PrPSc was present in the ependymal cells of both 263K- and 139H-infected hamsters

150 (Sm-Sox2) and Sm-Sox19 mRNAs was detected in ependymal cells of different regions of the telencephalo

151 fects in the motile cilia of the ventricular ependymal cells of mutants, suggesting a role for Katnal

152 Our findings implicate that compromised ependymal cells of the adhering ependymal layers upregul

153 These biciliated ependymal cells of the central canal (Ecc) resembled E2

154 Staining was most prominent in the ependymal cells of the choroid plexus, Purkinje cells of

155 retinoic acid (RA) within the tanycytes and ependymal cells of the hypothalamus have been implicated

156 cause Noggin expression is restricted to the ependymal cells of the lateral ventricles, where FXR2 is

157 ta homologue is expressed in the ventralmost ependymal cells of the neural tube, while the Ciona snai

158 form the secondary tail muscle, the lateral ependymal cells of the spinal cord, and the dorsal cells

159 GLUT2 immunoreactivity was seen in the ependymal cells of the third ventricle and in scattered

160 d, with Na,K-ATPase, in certain tanycytes or ependymal cells of the ventricle wall.

161 gene expression in circumventricular organs; ependymal cells of the ventricles, meninges, and choroid

162 Ependymal cells of wild-type ventricles strongly express

163 Ependymal cells on the walls of brain ventricles play es

164 Aging-associated ependymal-cell pathologies can manifest as ventricular g

165 Hypothalamic tanycytes, a radial glial-like ependymal cell population that expresses numerous genes

166 Spinal cord ependymal cells, previously reported to be multipotent,

167 for several weeks, we found no evidence that ependymal cells proliferate.

168 with one or two cilia, but not multiciliated ependymal cells, proliferate and give rise to new ependy

169 ental potential of the postnatal spinal cord ependymal cells remain to be defined.

170 lational polarity) in radial progenitors and ependymal cells remain unclear.

171 Here we show that SVZ astrocytes, and not ependymal cells, remain labeled with proliferation marke

172 owever, the proliferative capacity of mature ependymal cells remains controversial, and the developme

173 expressing adult neural stem cells, CD133(+) ependymal cells represent an additional-perhaps more qui

174 for ciliogenesis in Chlamydomonas and murine ependymal cells, respectively.

175 e (ATP-gamma-S) to acutely isolated ciliated ependymal cells resulted in CBF responses similar to tho

176 ity and promoted aberrant growth of aqueduct ependymal cells, resulting in aqueduct stenosis and the

177 Multiciliated ependymal cells show morphological characteristics simil

178 ic genes while also inhibiting expression of ependymal cell-specific genes.

179 The postmitotic nature of ependymal cells strongly suggests that these cells do no

180 ern of expression to markers of hypothalamic ependymal cells, such as Rarres2 (retinoic acid receptor

181 topic expression of genes specific to cuboid ependymal cells, such as Rarres2.

182 antigenic and morphologic characteristics of ependymal cells, suggesting a novel form of SVZ-supporte

183 Finally, many ependymal cells surrounding the central canal were inten

184 epithelium of the choroid plexus and in the ependymal cells surrounding the lateral ventricles.

185 expression of thyroid hormone deiodinases in ependymal cells (tanycytes) of the fetal hypothalamus, a

186 ighly concentrated in a group of specialized ependymal cells, tanycytes, lining the wall and floor of

187 Tanycytes are highly specialized ependymal cells that form a blood-cerebrospinal fluid (C

188 HSD2 immunoreactivity was also found in the ependymal cells that form the subcommissural organ.

189 ymal cells, proliferate and give rise to new ependymal cells that presumably remain in the macaque ce

190 strocytes in the glial scar are generated by ependymal cells, the neural stem cells in the spinal cor

191 On the ependymal cells, these defects lead to disorganized beat

192 .1 progenitor gene is constantly detected in ependymal cells throughout chick and mouse development.

193 n the labeling intensity observed in regular ependymal cells throughout the ventricular system.

194 between cells in both radial progenitors and ependymal cells (tissue polarity).

195 The opposite response of ciliated ependymal cells to 5-HT and ATP provides a novel mechani

196 In addition, loss of SOX9 led ependymal cells to adopt a neuroblast identity.

197 Exposure of ependymal cells to forskolin caused a decrease in CBF.

198 ccess to the CSF through a specialized glial/ependymal cell type, the tanycyte.

199 infant and adult human spinal cord contains ependymal cell types that resemble those present in the

200 rectly test whether radial glia give rise to ependymal cells, we used a Cre-lox recombination strateg

201 Some fourth-ventricle ependymal cells were also labeled.

202 lls lacked NET immunoreactivity, whereas CNS ependymal cells were an unexpected site of labeling.

203 In contrast, ependymal cells were labeled by BrdU administration duri

204 ved in circumventricular organs, and OCT3-ir ependymal cells were observed in the linings of all cere

205 Although, ependymal cells were once suggested to have stem cell ch

206 calization restored by incubation of fro/fro ependymal cells with exogenous C24:1 ceramide, which dir

207 Here we show that ependymal cells with one or two cilia, but not multicili

208 ventricle resulted in stable transduction of ependymal cells, with approximately 10-fold more positiv

209 tors were localised within the tanycytes and ependymal cells, with higher expression under long (LD)