ライフサイエンスコーパス: epibranchial

1 lacodes, with emphasis on the trigeminal and epibranchial.

2 y occupy within the embryo, dorsolateral and epibranchial.

3 ified as being respectively equivalent to an epibranchial and ceratobranchial.

4 ons largely derive from neurogenic placodes (epibranchial and dorsolateral), which are ectodermal thi

5 ganglia in the dogfish, with a focus on the epibranchial and lateral line placodes.

6 x2 is a conserved pan-gnathostome marker for epibranchial and otic placodes, and confirm that Phox2b

7 contributions to cranial ganglia, including epibranchial and trigeminal ganglia, and sensory structu

8 Knockdown of fgf24 or sox3 causes severe epibranchial deficiencies but has little effect on otic

9 Epibranchial (EB) placodes generate neurons of the dista

10 vate otic expression of fgf24, which induces epibranchial expression of sox3.

11 ted that Fgf initially induces a common otic/epibranchial field, which later subdivides in response t

12 A common feature of chick trigeminal and epibranchial ganglia is the expression of N-cadherin and

13 nings that contribute sensory neurons to the epibranchial ganglia.

14 whereas low levels increase cell numbers in epibranchial ganglia.

15 we show that the pharyngeal endoderm induces epibranchial neurogenesis in zebrafish, and that BMP sig

16 onents of the endodermal signals that induce epibranchial neurogenesis.

17 it can modulate the BMP signals that induce epibranchial neurogenesis: a gain of PRDC function resul

18 rons in the nodose ganglion that express the epibranchial neuron marker Phox2a on the same schedule a

19 e neuroglial hindbrain crest cells guide the epibranchial neuronal cells inward to establish their ce

20 m explants, it will promote the formation of epibranchial neuronal cells.

21 essary for the number and positioning of the epibranchial neurons.

22 centrate particles near the entrances of the epibranchial organs.

23 ensory neuron development in the trigeminal, epibranchial, otic, and olfactory placodes coincides wit

24 ix regulatory hierarchy also operates in the epibranchial placodal development.

25 nderlying the delamination of cells from the epibranchial placodal ectoderm.

26 xi1 is an important determination factor for epibranchial placodal progenitor cells to acquire both n

27 onal fate and neuronal subtype identity from epibranchial placodal progenitors.

28 al crest cell migration and ectoderm-derived epibranchial placode development are affected, leading t

29 ed on these findings, we propose a model for epibranchial placode development in which Fgf3 is a majo

30 factor, Foxi1, is required for both otic and epibranchial placode development.

31 expressed correctly and pharyngeal pouch and epibranchial placode formation are unaffected.

32 etween the cranial neural crest (NC) and the epibranchial placode is critical for the formation of pa

33 grafted ectoderm are induced to express the epibranchial placode marker Pax2 and form neurons in the

34 a major endodermal determinant required for epibranchial placode neurogenesis.

35 Initially, a subset of epibranchial placode precursors lie lateral to otic prec

36 ctodermal foxi1 expression, a marker for the epibranchial placode precursors, is present in both endo

37 During the development of epibranchial placode-derived distal cranial sensory gang

38 2b is a conserved pan-gnathostome marker for epibranchial placode-derived neurons.

39 ectoderm is grafted in place of the nodose (epibranchial) placode, Pax3-expressing cells form Pax3-p

40 that innervate the face and jaws, while the epibranchial placodes (geniculate, petrosal and nodose)

41 Mis-expression of Pax3 in the Pax2+ otic and epibranchial placodes also downregulates Pax2 and disrup

42 We identify specific defects in the epibranchial placodes and neural crest, which contribute

43 t in the chick head, integration between the epibranchial placodes and the hindbrain is achieved as t

44 The epibranchial placodes are cranial, ectodermal thickening

45 hat the zebrafish mutation no soul, in which epibranchial placodes are defective, disrupts the fork h

46 ngside the central nervous system, while the epibranchial placodes are located close to the top of th

47 govern the induction and neurogenesis of the epibranchial placodes are only now being elucidated.

48 In vertebrates, epibranchial placodes are transient ectodermal thickenin

49 We find that epibranchial placodes do not require neural crest for th

50 actor Pax3 from very early stages, while the epibranchial placodes express Pax2.

51 However, we find that otic and epibranchial placodes form at different times and by dis

52 Thus, both the otic and epibranchial placodes form in a common region of ectoder

53 The epibranchial placodes generate the neurons of the genicu

54 mapping approach to test the hypothesis that epibranchial placodes give rise to gustatory neurons, wh

55 Vertebrate epibranchial placodes give rise to visceral sensory neur

56 The trigeminal and epibranchial placodes of vertebrate embryos form differe

57 c placode forms the inner ear whereas nearby epibranchial placodes produce sensory ganglia within bra

58 eby the otic placode forms first and induces epibranchial placodes through an Fgf-relay.

59 We find that Bmp4 is expressed in the epibranchial placodes while Bmp7 and PRDC are expressed

60 on in directing the later development of the epibranchial placodes, and how this signalling is regula

61 ding question regarding the induction of the epibranchial placodes, and represents the first elucidat

62 statory neurons were generated from cultured epibranchial placodes, and when cultured alone, axon out

63 e signals that trigger neurogenesis from the epibranchial placodes, this represents the first demonst

64 of the nodose ganglion are derived from the epibranchial placodes, whereas jugular ganglion neurons

65 specifically, gustatory neurons derive from epibranchial placodes, whereas neural crest-derived neur

66 s derived from both cranial neural crest and epibranchial placodes.

67 pment is required for the development of the epibranchial placodes.

68 ventually contribute to the otic vesicle and epibranchial placodes.

69 coincides with the onset of neurogenesis in epibranchial placodes.

70 s required for neurogenesis of the zebrafish epibranchial placodes.

71 des, including trigeminal, lateral line, and epibranchial placodes.

72 ctive signal underlying the formation of the epibranchial placodes.

73 ordia and posterior (otic, lateral line, and epibranchial) placodes of vertebrates probably evolved f

74 The mutant epibranchial progenitor cells fail to express Neurog2 th

75 for the segregation of the otic lineage from epibranchial progenitors.

76 We further show that epibranchial sox3 expression is unaffected in mutants in