ライフサイエンスコーパス: epicardial

1 odies, 756 [12%] outflow tract, and 162 [3%] epicardial).

2 acoronary, intramyocardial, intravenous, and epicardial.

3 ation attempts from multiple endocardial and epicardial (1 patient) sites.

4 and 5 controls) with atrial fibrillation, an epicardial 8x6 electrode grid (interelectrode distance 1

5 A combined endocardial-epicardial ablation approach for initial VT ablation was

6 Failure of endo/epicardial ablation attempts was because of VT of intram

7 when conventional endocardial or transvenous epicardial ablation fails in the elimination of the acce

8 Reasons for epicardial ablation failure and the effect on outcome ha

9 al mitral isthmus blockade were the need for epicardial ablation from within the coronary sinus (P<0.

10 ocardial ablation only with minimal need for epicardial ablation from within the coronary sinus.

11 Epicardial ablation has shown improvement in clinical ou

12 Patients were randomized 1:1 to additional epicardial ablation of the 4 major GPs and Marshall's li

13 Percutaneous epicardial ablation of ventricular arrhythmias arising f

14 hen the distance between the endocardial and epicardial ablation sites was >8 mm and the earliest loc

15 m was to compare the efficacy of endocardial+epicardial ablation versus only endocardial ablation in

16 ablation was possible in 22 cases (7%), and epicardial ablation was deemed not feasible in 88 cases

17 Adjuvant epicardial ablation was performed for recurrent VT or pe

18 Epicardial ablation was performed in 90 (32%) patients.

19 be challenging and often requires additional epicardial ablation within the coronary sinus.

20 nstrated that the majority of patients after epicardial ablation, using bipolar radiofrequency instru

21 hythmic drugs after unsuccessful endocardial/epicardial ablation.

22 ial-only ablation, whereas 3 had endocardial-epicardial ablation.

23 V1 help identify appropriate candidates for epicardial ablation.

24 Although the majority of epicardial abnormal electrograms are associated with tra

25 accuracy resulting in identification of all epicardial abnormal electrograms at sites with <1.0 mm f

26 A dry epicardial access (EA) is increasingly used for advanced

27 grafts, is thought to preclude percutaneous epicardial access (EpiAcc) and, therefore, mapping and a

28 nts), nonendocardial origin with prohibitive epicardial access because of pericardial adhesions (16),

29 However, usually epicardial access is only performed when endocardial abl

30 Epicardial access was associated with significantly high

31 Epicardial access was attempted during 309 ablation proc

32 hemic VT and depending on the presence of an epicardial access.

33 atients (14 males) referred for percutaneous epicardial accessory pathway ablation.

34 se patients, we observed abnormal and varied epicardial activation breakthrough locations and regions

35 valuated that estimates both endocardial and epicardial activation from body surface potential maps.

36 isecond temporal resolution allowing precise epicardial activation of Channelrhodopsin2 (ChR2).

37 Asynchronous endo-epicardial activation ranged between 0.9 and 55.9% witho

38 p transmurally, leading to an endocardial to epicardial activation rate gradient as LDVF progressed.

39 LV endocardial and epicardial activation recovery intervals significantly d

40 determine the incidence of asynchronous endo-epicardial activation times (>/=15 ms) of opposite elect

41 dedifferentiation, overt muscle hyperplasia, epicardial activation, increased vascularization, and ca

42 52 versus 42 ms; P=0.007) and prolonged mean epicardial activation-recovery intervals (a surrogate fo

43 ight gain but increased glucose intolerance, epicardial adipose tissue (EAT) inflammation, and polari

44 The abundance of epicardial adipose tissue (EAT) is associated with atria

45 rrounded by an extensive layer of fat called epicardial adipose tissue (EAT).

46 Classic concepts about the role of epicardial adipose tissue (EpAT) in heart physiology inc

47 Although adiponectin is released from epicardial adipose tissue (EpAT), it is unclear whether

48 ncludes epicardial cells, differentiate into epicardial adipose tissue after myocardial infarction.

49 GF1R signaling as a key pathway that governs epicardial adipose tissue formation in the context of my

50 Epicardial adipose tissue located close to the atrial wa

51 ertheless, recent evidence has revealed that epicardial adipose tissue regulates multiple aspects of

52 Epicardial adipose tissue volume and coronary artery dis

53 d paracrine signaling pathways that regulate epicardial adipose tissue's formation and expansion are

54 A total of 8494 epicardial and 6331 endocardial voltage signals and 314

55 The relationship between epicardial and body surface potentials defines the forwa

56 Langendorff-perfused hearts, the calculated epicardial and endocardial activation patterns showed go

57 The novel noninvasive epicardial and endocardial electrophysiology system (NEE

58 ineteen patients with CC undergoing detailed epicardial and endocardial LV tachycardia mapping and ab

59 egment in the BrS-ECG with data from various epicardial and endocardial right ventricular activation

60 ed-chest pigs (n=5) during sinus rhythm, and epicardial and endocardial ventricular pacing (65 record

61 Bipolar epicardial and endocardial voltages within scar were low

62 We validated many new pan-epicardial and epicardial markers by alternative express

63 mine toxicity, adrenoceptor-mediated damage, epicardial and microvascular coronary vasoconstriction a

64 ic ultrasound (DUS) transducer might restore epicardial and microvascular flow in acute ST-segment el

65 issue (VAT) and subcutaneous adipose tissue, epicardial and pericardial fat by MRI in 75 nondiabetic

66 Myocardial triglyceride, epicardial and pericardial fat, VAT, and subcutaneous ad

67 stability of phase singularities between the epicardial and the endocardial planes was significantly

68 ures with a range of discordance between the epicardial and the endocardial tissue.

69 h the interaction with multiple myocardial-, epicardial-, and neural crest-derived signals.

70 Furthermore, chronic ablation of CSAR by epicardial application of a selective afferent neurotoxi

71 In sham rats, acute CSAR activation by epicardial application of bradykinin (BK) increased hear

72 Chronic ablation of the CSAR by epicardial application of the afferent neurotoxin, RTX,

73 Percutaneous epicardial approach is an alternative when conventional

74 f the pericardium using a minimally invasive epicardial approach would mitigate the increase in LV en

75 and help choosing between an endocardial or epicardial approach.

76 symptomatic cases refractory to endocardial-epicardial approach.

77 ssed via transseptal, retrograde aortic, and epicardial approaches in 87%, 33%, and 37% of patients,

78 Although MBs can be found in any epicardial artery, most of them involve the left anterio

79 Endo-epicardial asynchrony may play a major role in the patho

80 nderlie EBW and that a slight degree of endo-epicardial asynchrony required for EBW to occur is alrea

81 To provide direct proof of endo-epicardial asynchrony, we performed simultaneous high-re

82 rrhythmogenic substrate and result from endo-epicardial asynchrony, which also occurs to some degree

83 We identified larger B-cell clusters in epicardial AT of human patients with coronary artery dis

84 Lymphoid clusters were examined in epicardial AT of humans with or without coronary artery

85 cutoff) predicted the presence and extent of epicardial bipolar scar (P<0.001).

86 as calculated from the distances between the epicardial border of the LV apex and the midpoint of a l

87 Epicardial breakthrough waves (EBW) during atrial fibril

88 endocardial UV cutoff for identification of epicardial BV <1.50 mV was 3.9 mV (area under the curve,

89 ng-term outcomes of endocardial and adjuvant epicardial CA in nonischemic dilated cardiomyopathy.

90 diomyopathy and VT, endocardial and adjuvant epicardial CA is effective in achieving long-term VT fre

91 nts with HFpEF had more cardiac hypertrophy, epicardial CAD, coronary microvascular rarefaction, and

92 , is mediated by two phenotypically distinct epicardial cell subpopulations.

93 sis suggested the presence of at least three epicardial cell subsets defined by expression signatures

94 Unbalancing epicardial cell-cycle dynamics with chemical modulators

95 quantitative expression and localization of epicardial cell-specific proteins.

96 s allows long-term expansion of hPSC-derived epicardial cells (for at least 25 population doublings).

97 echanisms underlying the dissociation of pro-epicardial cells (PECs) from the pro-epicardium (PE) and

98 However, the differentiation steps between epicardial cells and caSMCs are unknown as are the final

99 o nuclear shape maintenance and migration of epicardial cells and highlights the use of these cells f

100 es drove strong expression in ostensibly all epicardial cells and in coronary vascular endothelial ce

101 dial cells, and immortalized mouse embryonic epicardial cells as model systems to identify signaling

102 riate transgenic lines, dynamic behaviors of epicardial cells can be monitored by live imaging using

103 Here we found that epicardial cells contain a potent cardiogenic activity i

104 Functional human epicardial cells differentiated via this protocol may co

105 ly) are enriched in the perinuclear space of epicardial cells during development.

106 during embryogenesis, we show that Lb1-null epicardial cells exhibit in vivo and in vitro migratory

107 We use outgrowth of epicardial cells from E9.5 isolated mouse proepicardium

108 Further, we found that Lb1-null epicardial cells have a delayed nuclear morphology chang

109 s (hPSCs) differentiation into self-renewing epicardial cells in a completely defined, xeno-free syst

110 matrices, procedures described here maintain epicardial cells on an intact cardiac surface, thereby b

111 g protocols for culturing isolated zebrafish epicardial cells on matrices, procedures described here

112 Epicardial cells on the heart's surface give rise to cor

113 The in vitro-derived epicardial cells underwent an epithelial-to-mesenchymal

114 Here, we found that adult human atrial epicardial cells were highly adipogenic through an epith

115 1 null E12.5 mouse heart explants, adult rat epicardial cells, and immortalized mouse embryonic epica

116 e Wt1(+) mesothelial lineage, which includes epicardial cells, differentiate into epicardial adipose

117 ls, side population cells, cardiospheres and epicardial cells.

118 resent a method to simultaneously map Vm and epicardial contraction in the beating heart.

119 irculation in combination with nonobstructed epicardial coronary arteries is the prerequisite of norm

120 categorized according to the number of major epicardial coronary arteries with 50% or more lumen diam

121 overlying the intramyocardial segment of the epicardial coronary artery (referred to as a tunneled ar

122 the absence of known history for obstructive epicardial coronary artery disease, is associated with r

123 exist in MFR in patients with HFpEF without epicardial coronary artery disease.

124 clearer normal value, and is independent of epicardial coronary artery stenosis.

125 ow recognize ACS that occur without apparent epicardial coronary artery thrombus or stenosis.

126 physiological assessment has focused on the epicardial coronary artery.

127 changes, and balanced ischemia from diffuse epicardial coronary atherosclerosis and microvascular dy

128 These epicardial defects are consistent with incomplete develo

129 From these data, epicardial deformation during the cardiac cycle was quan

130 The expansion of epicardial-derived CFs follows BMC infiltration into the

131 t can increase EMB sensitivity in diagnosing epicardial diseases.

132 is study was to characterize endocardial and epicardial dispersion of repolarization (DOR) and its ef

133 nificantly decreased, and LV endocardial and epicardial DOR increased during sympathetic nerve stimul

134 %) and cutoff for identification of abnormal epicardial electrogram was 3.7 mV (area under the curve,

135 Eighty-six percent of abnormal epicardial electrograms had corresponding endocardial si

136 erall amount, apex-to-base, circumferential, epicardial-endocardial distribution, pattern, and type o

137 Epicardial-endocardial distributions were as follows: tr

138 and 6331 endocardial voltage signals and 314 epicardial/endocardial matched pairs of points were anal

139 Systematic characterization of the LV epicardial/endocardial scar distribution and density in

140 decrease in LATs for endocardial (en) versus epicardial (ep) LV pacing (defined as %dLV=100x(LVLATep-

141 Patch-clamp studies revealed epicardial (EPI)-predominant prolongation of the action

142 brillation waves could be attributed to endo-epicardial excitation.

143 cT1 correlated with hepatic and epicardial fat (p < 0.001 and p = 0.01, respectively).

144 rgetics were similar between the T2D groups, epicardial fat (p = 0.04), hepatic triglyceride (p = 0.0

145 Such complex interactions as well as epicardial fat accumulation as a consequence of cardiac

146 ssociations were observed between increasing epicardial fat and AF.

147 rize and compare the associations of AF with epicardial fat and measures of abdominal and overall adi

148 atrial fibrillation (AF), the importance of epicardial fat compared with other adipose tissue depots

149 Epicardial fat infiltrated the posterior LA in the obese

150 toff values are based on studies that lacked epicardial fat information.

151 ver, the strength of associations of AF with epicardial fat is greater than for measures of abdominal

152 , 1 mL at each fat pad; n=30) injection into epicardial fat pads during surgery.

153 and safety of botulinum toxin injection into epicardial fat pads for preventing atrial tachyarrhythmi

154 ation over coronary arteries and surrounding epicardial fat resulted in deep lesions with normal angi

155 ore right ventricular dysfunction, increased epicardial fat thickness (10+/-2 versus 7+/-2 and 6+/-2

156 Likewise, a 1-SD higher epicardial fat volume was associated with 2.2-fold highe

157 A 1-SD higher epicardial fat volume was associated with a 2.6-fold hig

158 Epicardial fat, hepatic triglyceride, and insulin resist

159 tration of contiguous posterior LA muscle by epicardial fat, representing a unique substrate for AF.

160 als, comparing AF risk for 1-SD increases in epicardial fat, waist circumference, waist/hip ratio, an

161 ess the mechanisms and clinical relevance of epicardial fat.

162 ronary arteries or poor energy delivery over epicardial fat.

163 y the presence of major coronary vessels and epicardial fat.

164 ent implantation after restoration of normal epicardial flow by a minimalist immediate mechanical int

165 thway in proepicardial organ positioning and epicardial formation.

166 ST-segment elevation and epicardial fractionation/conduction delay in BrS patient

167 Epicardial Fstl1 declines following myocardial infarctio

168 The mechanism for epicardial gene (re-)activation remains elusive.

169 suggesting SWI/SNF activity across the fetal epicardial gene programme.

170 harboring a transgenic reporter for the pan-epicardial gene tcf21.

171 d for covariables, midwall, endocardial, and epicardial GLS were significant predictors of fatal and

172 hazard ratios for midwall, endocardial, and epicardial GLS, while accounting for family cluster and

173 2 and 6+/-2 mm; P<0.0001), and greater total epicardial heart volume (945 mL [831-1105 mL] versus 797

174 Collectively, these results suggest that epicardial Hippo signaling plays a key role in adaptive

175 r cells spontaneously differentiate and lose epicardial identity, whereas atrial-derived cells remain

176 Epicardial illumination effectively terminated ventricul

177 electrode-tissue contact, but sensitivity of epicardial imaging was 92%.

178 patients had failed RFA attempts (including epicardial in 3).

179 ft ventricular summit underwent percutaneous epicardial instrumentation for mapping and ablation beca

180 on, VT was inducible in 75%, and endocardial/epicardial LAVA were present in 88%/75%.

181 Epicardial LAVAs could not be eliminated because of the

182 Epicardial LAVAs were observed in 44 of 49 patients (15

183 nchronous activation of the atrial endo- and epicardial layer and transmurally propagating fibrillati

184 While NPs were mostly confined to epicardial layers, BODIPY was capable of penetrating int

185 premature failure and fractures with earlier epicardial leads led our unit to undertake transvenous p

186 er safely delivers contiguous endocardial or epicardial lesions without gaps in a single ablation.

187 CSAR inhibition by epicardial lidocaine decreased cardiac contractility to

188 Furthermore, we also found that epicardial lidocaine paradoxically decreased left ventri

189 Furthermore, we found that epicardial lidocaine paradoxically decreased LV end-dias

190 tion in peripheral vascular resistance since epicardial lidocaine significantly lowered peripheral (r

191 Following CSAR inhibition by epicardial lidocaine, blood pressure, HR, LVSP, dp/dt, L

192 en limited to ventricular defibrillation via epicardial light application.

193 The LM was robustly differentiated to an epicardial lineage by activation of WNT, BMP and retinoi

194 erformed transcriptome analysis on dozens of epicardial lineage cells purified from zebrafish harbori

195 defines a new platform for the discovery of epicardial lineage markers, genetic tools, and mechanism

196 Healthy swine underwent endocardial and epicardial linear ablation using a novel linear irrigate

197 picardial lines were longer than focal (n=8) epicardial lines (3.3+/-0.7 versus 2.1+/-0.9 cm; P<0.000

198 At gross pathology, linear (n=18) epicardial lines were longer than focal (n=8) epicardial

199 nary tree with color-coded FFR values at any epicardial location.

200 Endo-epicardial LPs were recorded in 2/3 patients, more frequ

201 ween those of the idiopathic endocardial and epicardial LVOT VAs, and more similar to those of the id

202 ardial LVOT VAs than those of the idiopathic epicardial LVOT VAs.

203 compared with the idiopathic endocardial and epicardial LVOT VAs.

204 High-resolution epicardial mapping (192 unipolar electrodes, interelectr

205 METHODS AND Intraoperative epicardial mapping (interelectrode distances 2 mm) of th

206 Epicardial mapping and ablation of accessory pathways th

207 We report the outcomes of percutaneous epicardial mapping and ablation of ventricular arrhythmi

208 Of 6889 endocardial-epicardial mapping point pairs, 547 (8%) pairs with dist

209 Patients with BrS underwent epicardial mapping to identify areas of abnormal electro

210 ated endocardial mapping, and ablation after epicardial mapping yielded no early activation site.

211 In 49 patients undergoing epicardial mapping, real-time multidetector computed tom

212 i) is sufficient to produce cells expressing epicardial markers and exhibiting epicardial phenotypes

213 We validated many new pan-epicardial and epicardial markers by alternative expression assays.

214 ocardium performing better than those in the epicardial myocardium (areas under the receiver-operatin

215 Replenishment of epicardial NADH fluorescence was then imaged using low i

216 n of high intensity UV pulses to photobleach epicardial NADH.

217 to increase coronary blood flow by relieving epicardial obstruction.

218 s underwent endocardial-only ablation, 2 had epicardial-only ablation, whereas 3 had endocardial-epic

219 atomically opposite side (endocardial versus epicardial or above versus below the aortic valve) may b

220 vast majority of infarct fibroblasts were of epicardial origin and not derived from bone marrow linea

221 activation and discriminate endocardial from epicardial origin of activation with clinically relevant

222 ts within the infarcted area were largely of epicardial origin.

223 Epicardial pacemaker implantation is the favored approac

224 acute hemodynamic response compared with LV epicardial pacing (EPI-CRT).

225 Epicardial pacing of the injection site identified match

226 the transition that occurred from the use of epicardial pacing systems to the familiar transvenous sy

227 ge-tracing analyses, we demonstrate that sub-epicardial pericytes arise from EPDCs in a process that

228 expressing epicardial markers and exhibiting epicardial phenotypes with a high yield and purity from

229 Ramipril does not slow development of epicardial plaque volume but does stabilize levels of en

230 tal to solving the inverse problem, in which epicardial potentials are computed from known body surfa

231 Body surface and epicardial potentials were recorded simultaneously in an

232 ary lymphangiogenesis, adverse remodeling of epicardial precollector and collector lymphatics occurre

233 ntrated to the basal lateral LV, with marked epicardial predominance.

234 density predict scar transmurality and endo-epicardial presence of LPs, although DS is not always id

235 rate that RhoA activity is suppressed in the epicardial progenitor state, that the cAMP-dependent Rap

236 that regulate RhoA activity to maintain the epicardial progenitor state.

237 he effect of individual paracrine factors on epicardial progenitors in the adult heart.

238 cytes of atrial EAT derived from a subset of epicardial progenitors.

239 Initial epicardial recanalization rates prior to emergent PCI an

240 Body surface potentials were simulated from epicardial recordings using experiment-specific volume c

241 arteriosus by tissue recombination initiates epicardial regeneration and can govern its direction.

242 By reconstituting epicardial regeneration ex vivo, we show that extirpatio

243 tributes outflow from the ventricle-prevents epicardial regeneration.

244 reasing both cardiomyocyte proliferation and epicardial responses.

245 We assessed reasons for epicardial RFA failure relative to the anatomic target a

246 Epicardial RFA for ventricular arrhythmias is often limi

247 rt disease and assessed the effect of failed epicardial RFA on outcome after ablation procedures for

248 Intraoperative mapping of the endo- and epicardial right atrial wall was performed during (induc

249 ars; 79% men) underwent combined endocardial-epicardial right ventricular electroanatomical mapping a

250 ination of abnormal electric activity in the epicardial right ventricular outflow tract may be benefi

251 Epicardial right ventricular scar overlay and exceeded t

252 For identification of epicardial right ventricular scar, an endocardial UV cut

253 In 2 other BrS patients, endocardial, epicardial RV (CARTO), and body surface mapping was perf

254 ocardial electroanatomic mapping to identify epicardial scar has not been assessed in this setting.

255 polar voltage mapping serves to characterize epicardial scar in this setting.

256 ith normal bipolar voltage (BV) may indicate epicardial scar.

257 xercise-induced vasoconstriction of stenosed epicardial segments and dilatation of normal segments, w

258 The epicardial sheet covering the heart is activated by inju

259 The first ablation was performed on the epicardial side in 9 VAs and endocardial side in 5 VAs.

260 tion and best pace map on the endocardial or epicardial side.

261 heter ablation from both the endocardial and epicardial sides for their elimination, suggesting the p

262 e catheter ablation from the endocardial and epicardial sides for their elimination, suggesting the p

263 neous ablation from both the endocardial and epicardial sides.

264 of fluorescence emitted by a motion-tracked epicardial site in adjacent frames removes artifacts, le

265 er tracking enabled the pixel(s) imaging any epicardial site within the marked region to be identifie

266 tricular stimulation from 27 endocardial and epicardial sites.

267 equent migration of these cells into the sub-epicardial space.

268 Epicardial-specific Cdc42 deletion disrupted epicardium

269 sinus rhythm and localizing endocardial and epicardial stimulation sites.

270 caveolin 1 (cav1), which was present in each epicardial subset.

271 abnormal ECG pattern, the extent of abnormal epicardial substrate, and ventricular tachycardia/ventri

272 Brugada syndrome (BrS) depends on functional epicardial substrates, which may be definitively elimina

273 ication consisted in mapping right ventricle epicardial surface before and after flecainide (2 mg/kg

274 Transpericardial RFCA was successful on the epicardial surface in the A-LV summit in 6 patients and

275 ietic lineages were observed attached to the epicardial surface of infarcted and sham-operated hearts

276 ixed multielectrode plaque was placed on the epicardial surface of the left atrium in dogs.

277 The tissue thermocouples were placed on the epicardial surface of the left atrium-PV junction, as we

278 ence of collagen-producing fibrocytes on the epicardial surface that resulted at least in part from t

279 Bipolar voltage mapping demonstrated larger epicardial than endocardial scar and core-dense (</=0.5

280 ith persistent atrial fibrillation underwent epicardial thoracoscopic radiofrequency pulmonary vein i

281 ts as explants and study the regeneration of epicardial tissue ex vivo, as a means to identify therap

282 the extent of cellular heterogeneity within epicardial tissue is largely unexplored.

283 velocities and mechanical tension within the epicardial tissue sheet, and experimentally induced tens

284 (LATs) for LV endocardial and biventricular epicardial tissue were calculated (LVLAT and TLAT), as w

285 gitudinal strain showed a similar trend from epicardial to endocardial layers (epiwall: -16.0 +/- 2.9

286 cle that showed universal increment from the epicardial to endocardial myocardial wall (epiwall: -15.

287 ch can be an alternative when endocardial or epicardial transvenous mapping has failed.

288 m electrocardiographic imaging-reconstructed epicardial unipolar electrograms.

289 nt with a female-male odds ratio for CMD and epicardial vasospasm of 4.2 (95% confidence interval: 3.

290 ructed coronaries and ACH test performed for epicardial vasospasm or coronary microvascular dysfuncti

291 thological ACH test, 33% for CMD and 26% for epicardial vasospasm.

292 ogy might be of value to treat intramural or epicardial ventricular tachycardia substrates resistant

293 There were no LV epicardial versus endocardial differences in activation

294 e or two de-novo native lesions in different epicardial vessels.

295 e or two de-novo native lesions in different epicardial vessels.

296 to minimize risks of PN and CA injury during epicardial VT ablation.

297 ence for asynchronous activation of the endo-epicardial wall during AF in humans.

298 lution mapping of the right atrial endo- and epicardial wall during AF in humans.

299 Mice deficient in epicardial YAP and TAZ, two core Hippo pathway effectors

300 ytes, respectively, from the endocardial and epicardial zones of the ventricular wall postnatally.