ライフサイエンスコーパス: epidermal differentiation

1 ted ETS-family transcription factor, EHF, in epidermal differentiation.

2 s into the potent role of miR-203 during the epidermal differentiation.

3 lso be targets of KLF4, a known activator of epidermal differentiation.

4 , a transcription factor that activates late epidermal differentiation.

5 exhibit ectopic proliferation and defective epidermal differentiation.

6 Myc and an essential mediator of Myc-induced epidermal differentiation.

7 defined a requirement for ZNF750 in terminal epidermal differentiation.

8 he hair follicle and epidermis and decreased epidermal differentiation.

9 are recruited to the cell cortex by DP upon epidermal differentiation.

10 phoproteomic changes occur and contribute to epidermal differentiation.

11 o the structural genes that are required for epidermal differentiation.

12 the epidermis, and Smad2/3 are required for epidermal differentiation.

13 unctions as a molecular switch that controls epidermal differentiation.

14 tic derepression by JMJD3 controls mammalian epidermal differentiation.

15 nteract some of the effects of cytokinins on epidermal differentiation.

16 e regional influence of GA and cytokinins on epidermal differentiation.

17 to cysts of cells undergoing interfollicular epidermal differentiation.

18 iate a zymogen cascade that is essential for epidermal differentiation.

19 nteracting serine-threonine kinase 4) during epidermal differentiation.

20 te that class II PI3Ks are not essential for epidermal differentiation.

21 s, suggesting a potential role for C2beta in epidermal differentiation.

22 ein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation.

23 andidate to be involved in the regulation of epidermal differentiation.

24 cial tissue-specific regulator of vertebrate epidermal differentiation.

25 ession of target genes to specific stages of epidermal differentiation.

26 ethylene is known to act at later stages of epidermal differentiation.

27 gesting an important role for this enzyme in epidermal differentiation.

28 ng involucrin, one of the genes required for epidermal differentiation.

29 ap-junctional intercellular communication in epidermal differentiation.

30 main by RIPK4 is essential for their role in epidermal differentiation.

31 type mice, but gene disruption did not alter epidermal differentiation.

32 odermal derivatives and inhibited neural and epidermal differentiation.

33 iated by both Cx31 and Cx30.3 is crucial for epidermal differentiation.

34 sing pathway and a key regulator of terminal epidermal differentiation.

35 n potentially plays a role in the process of epidermal differentiation.

36 llicle morphogenesis and cycling, as well as epidermal differentiation.

37 dermis, indicating that oxysterols stimulate epidermal differentiation.

38 perinatal lethality associated with abnormal epidermal differentiation.

39 yer of the skin, which is the end-product of epidermal differentiation.

40 g into filaggrin monomers and ultimately the epidermal differentiation.

41 ave defects in the brain, immune system, and epidermal differentiation.

42 y with skin abnormalities including aberrant epidermal differentiation.

43 maintenance in epidermis and contributes to epidermal differentiation.

44 l hyperproliferation and a possible delay in epidermal differentiation.

45 granular layer during the late stages of the epidermal differentiation.

46 r of the regenerative hyperplasia pathway of epidermal differentiation.

47 to spatially regulate Notch signaling during epidermal differentiation.

48 ) and IV (FLG/FLG) HEEs showed impaired late epidermal differentiation.

49 were maintained at centrosomes upon initial epidermal differentiation.

50 y of transglutaminases (TGs) during terminal epidermal differentiation.

51 ocalization, Notch signaling, and subsequent epidermal differentiation.

52 hondrial proteins is therefore essential for epidermal differentiation.

53 ed Fra-2/AP-1 as a key regulator of terminal epidermal differentiation.

54 A lncRNA-TF network is thus essential for epidermal differentiation.

55 ription factor, egr-5, that is essential for epidermal differentiation.

56 and were enriched for genes associated with epidermal differentiation.

57 NCR-CALML5-SFN network is thus essential for epidermal differentiation.

58 of differentially expressed genes linked to epidermal differentiation.

59 eased reactive oxygen species (ROS) to drive epidermal differentiation.

60 er capture Hi-C (CHi-C) was performed during epidermal differentiation.

61 ulate developmental processes, such as human epidermal differentiation.

62 ntaining 11.6 % of open chromatin regions in epidermal differentiation.

63 onnected hub that is strongly induced during epidermal differentiation.

64 esting the emergence of organizing themes in epidermal differentiation.

65 on receptor (AHR), resulting in induction of epidermal differentiation.

66 e population, are characterized by disrupted epidermal differentiation.

67 lts suggest that Hoxb13 functions to promote epidermal differentiation, a critical process for skin r

68 ategy for reversing UV-induced impairment of epidermal differentiation after acute sun exposure.

69 nulosum, we studied the regulation of murine epidermal differentiation after loss of calcium accompan

70 otein is a key regulator of keratinocyte and epidermal differentiation and a critical suppressor of s

71 hemical alterations associated with abnormal epidermal differentiation and barrier formation in HI ep

72 ible factors are central to the processes of epidermal differentiation and barrier formation, in part

73 BCA12 will lead to a better understanding of epidermal differentiation and barrier formation.

74 ed serine protease, plays essential roles in epidermal differentiation and barrier function, largely

75 To study the role of c-myc in epidermal differentiation and carcinogenesis, a transgen

76 isk human papillomaviruses (HPVs) deregulate epidermal differentiation and cause anogenital and head

77 c-MYC, a transcription factor that controls epidermal differentiation and cell proliferation and who

78 explain the mechanism of retinoid action in epidermal differentiation and chemoprevention.

79 3/Get1); Grhl3-deleted mice exhibit impaired epidermal differentiation and decreased expression of mu

80 ivators of liver X receptors (LXR) stimulate epidermal differentiation and development, but inhibit k

81 X receptor are involved in the regulation of epidermal differentiation and development.

82 , beta-catenin signaling actively suppresses epidermal differentiation and directs pigmentation and n

83 ical skin conditions, including disorders of epidermal differentiation and epidermal tumors.

84 thick, it expresses the classical markers of epidermal differentiation and establishes a functional b

85 e expressed in NHEK-HPV cells and changes in epidermal differentiation and gene expression examined.

86 osing effects in shared pathways influencing epidermal differentiation and immune response.

87 shown to inhibit neural development, promote epidermal differentiation and influence the specificatio

88 he role of aberrant connexin hemichannels in epidermal differentiation and inherited connexin disorde

89 imerizes with retinoid X receptor, stimulate epidermal differentiation and inhibit proliferation.

90 ulation of PPARalpha stimulates keratinocyte/epidermal differentiation and inhibits proliferation.

91 ing protein kinase 4 (RIPK4) is required for epidermal differentiation and is mutated in Bartsocas-Pa

92 hat the protein plays an independent role in epidermal differentiation and is required for epidermal

93 n activation cascade that regulates terminal epidermal differentiation and is required for prostasin

94 ubset of genes encoding proteins involved in epidermal differentiation and lipid metabolism.

95 s for HA-CD44 interaction in regulating both epidermal differentiation and lipid synthesis/secretion,

96 TIVE KERNEL1 (DEK1) is a master regulator of epidermal differentiation and maintenance, acting upstre

97 They have been implicated in epidermal differentiation and may therefore play an impo

98 The impairment in epidermal differentiation and permeability barrier in (E

99 Delta NLef1 does not suppress epidermal differentiation and promote ORS/bulge differen

100 deficiency in psoriatic skin interferes with epidermal differentiation and promotes a sustained and l

101 ciency accelerated wound closure, increasing epidermal differentiation and reepithelialization, despi

102 asal epidermal keratinocytes, exhibit normal epidermal differentiation and skeletal morphology.

103 ptor (AHR) by xenobiotics is known to affect epidermal differentiation and skin barrier formation.

104 The role of hypoxia in epidermal differentiation and skin barrier function is i

105 channels may play an important part in both epidermal differentiation and skin development, presumab

106 aPKC-lambda has recently been implicated in epidermal differentiation and stem cell fate; however, w

107 Epidermal differentiation and stratification, crucial fo

108 ures or in 3D skin equivalents have impaired epidermal differentiation and stratification.

109 ether PPAR-alpha plays a physiologic role in epidermal differentiation and stratum corneum formation

110 Furthermore, we have reported that both epidermal differentiation and stratum corneum formation

111 -p53 interplay as a major regulatory axis in epidermal differentiation and suggest that DLX3 is a mod

112 expression coincident with normalization of epidermal differentiation and suppression of inflammator

113 rinciple tight junction components, and that epidermal differentiation and thickness were increased.

114 m by which IkappaB kinase 1 (IKK1) regulates epidermal differentiation and tumor suppression in the s

115 Notch signalling regulates epidermal differentiation and tumour formation via non-c

116 , and ulceration, without obvious effects on epidermal differentiation and wound healing.

117 n profile characterized by genes involved in epidermal differentiation and wound repair, which were d

118 ows the presence of abnormal keratinization (epidermal differentiation) and acantholysis (loss of coh

119 acterized by epidermal hyperplasia, impaired epidermal differentiation, and accumulation of dermal CD

120 lacode and hair shaft fate at the expense of epidermal differentiation, and activates signals directi

121 r is expressed in defined cell layers during epidermal differentiation, and because AP1 factors regul

122 in lipid metabolism, antimicrobial defenses, epidermal differentiation, and control of cutaneous vasc

123 eased epidermal cell proliferation, impaired epidermal differentiation, and decreased the density and

124 normal skin barrier function, alterations in epidermal differentiation, and developmental anomalies o

125 GCN2 thwarted translational control, normal epidermal differentiation, and differentiation gene expr

126 f phosphoproteomic changes that occur during epidermal differentiation, and identifies RIPK-PKP1 sign

127 se results indicate that CaR is important in epidermal differentiation, and that the alternatively sp

128 vealed that Glis1DeltaC promoted PMA-induced epidermal differentiation, as indicated by increased exp

129 that a specific mutation in Cx26 can impair epidermal differentiation, as well as inner ear function

130 olatum robustly modulates antimicrobials and epidermal differentiation barrier measures.

131 3 ablation in epidermis is linked to altered epidermal differentiation, barrier development, and IL-1

132 mitochondrial uncoupling drove keratinocyte/epidermal differentiation both in vitro and in vivo.

133 iation-induced ncRNA (TINCR), controls human epidermal differentiation by a post-transcriptional mech

134 trolling the open chromatin landscape during epidermal differentiation by cooperating with the master

135 Thus, the induction of epidermal differentiation by Fra-2 is controlled by a du

136 ssion in vivo, we show that miR-203 promotes epidermal differentiation by restricting proliferative p

137 re p63 include epidermal lineage commitment, epidermal differentiation, cell adhesion, and basement m

138 Disrupted epidermal differentiation characterizes numerous disease

139 Altered epidermal differentiation characterizes numerous skin di

140 independent disease-specific loci within the epidermal differentiation complex (chromosome 1q21.3), t

141 The TDRKH gene was mapped to the Epidermal Differentiation Complex (EDC) at chromosome 1q

142 Recent studies suggest additional epidermal differentiation complex (EDC) gene association

143 40 integration at 1q21.1, in the vicinity of epidermal differentiation complex (EDC) genes, resulted

144 Numerous epidermal differentiation complex (EDC) genes, such as f

145 The epidermal differentiation complex (EDC) locus comprises

146 The epidermal differentiation complex (EDC) locus consists o

147 iasis, share distinct genetic linkage to the Epidermal Differentiation Complex (EDC) locus on 1q21.

148 with innate defense, including genes in the epidermal differentiation complex (EDC) that regulate ep

149 the higher-order chromatin structure of the epidermal differentiation complex (EDC), a keratinocyte

150 The SMCP gene is located in the epidermal differentiation complex (EDC), a large gene cl

151 contains a number of genes, constituting the Epidermal differentiation complex (EDC), most of which a

152 This region contains the epidermal differentiation complex (EDC), which consists

153 human gene maps at the telomeric end of the epidermal differentiation complex (EDC), within chromoso

154 mal differentiation genes located within the epidermal differentiation complex (EDC).

155 9 transcripts, particularly genes within the epidermal differentiation complex and antimicrobial mole

156 cells regulate the homeostatic expression of epidermal differentiation complex and other skin genes.

157 Decreased epidermal differentiation complex gene expression in mic

158 epidermal maturation, expression of >80% of epidermal differentiation complex genes, and formation o

159 ull epidermis, chromatin architecture of the epidermal differentiation complex locus containing genes

160 racterized an AP-1-dependent enhancer at the epidermal differentiation complex locus that establishes

161 used to screen candidate loci including the epidermal differentiation complex on 1q, the desmoplakin

162 kers to screen candidate loci, including the epidermal differentiation complex on 1q, the keratin gen

163 rnified envelope (LCE) genes, located in the epidermal differentiation complex on chromosome 1, encod

164 ion to atopic dermatitis (AD), including the epidermal differentiation complex on chromosome 1q21.

165 S100 multigene family that is encoded in the epidermal differentiation complex on chromosome 1q21.

166 en S100 protein genes are located within the epidermal differentiation complex on human chromosome 1q

167 ified envelope (LCE) gene cluster within the epidermal differentiation complex on human chromosome on

168 e Sprr genes are clustered within the larger epidermal differentiation complex on mouse chromosome 3,

169 alpha and PglyrpIbeta are encoded within the epidermal differentiation complex on mouse chromosome 3F

170 A similar result has been seen for the epidermal differentiation complex region of chromosome 1

171 required for red feathers resides within the epidermal differentiation complex, a cluster of genes in

172 f mouse chromosome 3, in the vicinity of the epidermal differentiation complex, a gene locus that inc

173 the same co-expression module, mapped to the epidermal differentiation complex, and exhibited differe

174 s all of the 27 genes so far assigned to the epidermal differentiation complex, and integrates the ph

175 al regulation, function and evolution of the epidermal differentiation complex, as well as the identi

176 This DNA segment, termed the epidermal differentiation complex, contains 27 genes, 14

177 S100A7/psoriasin, a member of the epidermal differentiation complex, is widely overexpress

178 transcripts including several members of the epidermal differentiation complex, molecules with antimi

179 Twelve mapped to the epidermal differentiation complex, upstream or within ge

180 arrier function, including most genes of the epidermal differentiation complex.

181 genes in 1q21 loci and corresponding to the epidermal differentiation complex.

182 expression of JunB and Ras induced premature epidermal differentiation concomitant with upregulation

183 s normalizes cell proliferation and promotes epidermal differentiation, correcting the cutaneous path

184 This increase in epidermal differentiation corresponded to the loss of ma

185 se zymogen activation during early stages of epidermal differentiation, coupled with a loss of matrip

186 st to wild type, this mutant fails to rescue epidermal differentiation defects seen upon Psen1 and 2

187 RIP4(-/-) mice die at birth with epidermal differentiation defects, causing fusions of al

188 ts in EPB defects accompanied by compromised epidermal differentiation, drastic reduction in profilag

189 vators of nuclear hormone receptors regulate epidermal differentiation during fetal development, affe

190 Abnormal epidermal differentiation-evidenced by positive expressi

191 results suggest that progenitors capable of epidermal differentiation exist in the mesenchymal compa

192 crucial and previously unrecognized role in epidermal differentiation, functioning both to repress p

193 s to hair follicle placodes and can suppress epidermal differentiation gene expression.

194 ive DNA demethylation, are required for full epidermal differentiation gene induction.

195 nalysis showed that a significant portion of epidermal differentiation gene promoters were methylated

196 upregulated in lesional skin and binds known epidermal differentiation gene targets.

197 s suggest that Eig3 is homologous to a human epidermal differentiation gene, XP5, and belongs to a fa

198 istically, Dnmt3a promotes the expression of epidermal differentiation genes by interacting with thei

199 tly or indirectly regulates a broad array of epidermal differentiation genes encoding structural prot

200 ic expression of Fra-2 induced expression of epidermal differentiation genes located within the epide

201 d multiple modules of coordinately expressed epidermal differentiation genes, overlapping significant

202 vealed delayed expression of additional late epidermal differentiation genes: filaggrin, repetin and

203 ontrols epithelial homeostasis by regulating epidermal-differentiation genes, a role underscored by i

204 vels of a transcription factor necessary for epidermal differentiation, GRHL3, at low levels through

205 orting the central role of these pathways in epidermal differentiation, highlighting the integration

206 tinoic acid (RA) signalling is essential for epidermal differentiation; however, the mechanisms by wh

207 In addition to failed epidermal differentiation, IKK-alpha-deficient mice exhi

208 ne trigger of inflammation and impaired late epidermal differentiation in AD.

209 As Dsg1 promotes epidermal differentiation in addition to participating i

210 sm and gene expression of protein markers of epidermal differentiation in fetal rat skin explants gro

211 pically applied PPARalpha activators promote epidermal differentiation in intact adult mouse skin.

212 otein products may play an important role in epidermal differentiation in normal and diseased state.

213 opical clofibrate treatment did not increase epidermal differentiation in PPARalpha-/- mice.

214 rtant second messenger involved in signaling epidermal differentiation in skin.

215 ntal and spatiotemporal cues at the onset of epidermal differentiation in the mouse embryo.

216 ting adult HF-SC maintenance and suppressing epidermal differentiation in the niche.

217 ce, the K14-RIP4 transgene failed to promote epidermal differentiation in these mutant backgrounds.

218 es in vitro induces virtually all aspects of epidermal differentiation in vivo: transcription of corn

219 ic acid (RA) signaling is essential for skin epidermal differentiation including the eyelids.

220 ed with suppression of the genes involved in epidermal differentiation, including genes in 1q21 loci

221 required for induction of mRNAs involved in epidermal differentiation induced by O-tetradecanoylphor

222 ved in a variety of biological functions as, epidermal differentiation, intracellular signal function

223 As disturbed epidermal differentiation is a main feature of many skin

224 mplex locus containing genes associated with epidermal differentiation is altered primarily at its ce

225 Although commitment to epidermal differentiation is generally considered to be

226 that, in response to KGF and EGF signalling, epidermal differentiation is promoted at the expense of

227 These studies demonstrate that epidermal differentiation is regulated by liver X recept

228 Thus, epidermal differentiation is required for proper morphog

229 nd differentiation, and KLF4, a regulator of epidermal differentiation, is sufficient to convert derm

230 is characterized by inflammation and altered epidermal differentiation leading to redness and scaling

231 in caused defects in spindle orientation and epidermal differentiation, leading to neonatal lethality

232 the following mechanisms: (i) stimulation of epidermal differentiation, leading to thickened cornifie

233 downstream of Rho GTPases that contribute to epidermal differentiation, little is known about which u

234 Both tumor sets showed downregulation of epidermal differentiation markers (e.g., profilaggrin, k

235 mors negatively correlate with expression of epidermal differentiation markers and components of the

236 ts have been compared with the expression of epidermal differentiation markers and of the "hyperproli

237 All EFNAs induce epidermal differentiation markers and suppress cell adhe

238 follicular hyperplasia and the expression of epidermal differentiation markers in the follicular epit

239 did not modify the expression profile of the epidermal differentiation markers involucrin, keratin 10

240 also induced mRNA and protein expression of epidermal differentiation markers such as keratin 1, ker

241 suppressed the expression of the "classical" epidermal differentiation markers, but strongly and spec

242 Epidermal differentiation markers, including involucrin,

243 Epidermal differentiation markers, including small proli

244 idermal KCs, and increased the expression of epidermal differentiation markers.

245 ermis, are similar to each other, expressing epidermal differentiation markers.

246 nstituted human epidermis, a model system of epidermal differentiation, members of the IL-20 subfamil

247 us, the 25OHD 1OHase is essential for normal epidermal differentiation, most likely by producing the

248 During epidermal differentiation, ninein, which is a centrosoma

249 skin phenotypes and expression of markers of epidermal differentiation of their transgenic or knockou

250 2+) signaling-dependent systems, such as the epidermal differentiation process, must effectively resp

251 nd by the end of the first growth phase, the epidermal differentiation program is activated in outer

252 The interfollicular epidermal differentiation program was largely unaffected

253 transgene exhibited a striking arrest in the epidermal differentiation program, perishing within 2 we

254 e withdrawal, and proteins that regulate the epidermal differentiation program.

255 l genes encoding important components of the epidermal differentiation program.

256 ole in regulating one or more aspects of the epidermal differentiation program.

257 h due to deficits primarily during the early epidermal differentiation programme and lack of a protec

258 lysis indicated that disrupted expression of epidermal differentiation programs under the control of

259 The dysregulated expression of epidermal differentiation proteins becomes evident 2 d a

260 We showed further that stimulation of epidermal differentiation provides one mechanism that co

261 es the transcription of a striking number of epidermal differentiation-related genes.

262 EGFR signalling maintains TG activity during epidermal differentiation remains elusive.

263 KLF4 accounted for the majority of disrupted epidermal differentiation resulting from AEC mutant TP63

264 eus appears to interfere with late stages of epidermal differentiation, resulting in a VS-like phenot

265 Epidermal differentiation seems to be affected in nkt sk

266 ceptor activator, markedly accelerated fetal epidermal differentiation, stimulating both profilaggrin

267 gene expression programs in the disorders of epidermal differentiation, such as psoriasis and epiderm

268 ates ionic signaling for specific aspects of epidermal differentiation, such as synthesis or processi

269 DC and the transcriptional activation during epidermal differentiation suggested a cis-regulatory mec

270 hypertrophic sebaceous glands, and increased epidermal differentiation, suggesting aberrant cell fate

271 lysis demonstrated MAF:MAFB binding to known epidermal differentiation TF genes whose expression they

272 appaB activity but instead are due to failed epidermal differentiation that disrupts proper epidermal

273 calcium coordinately regulate events late in epidermal differentiation that together form the barrier

274 tor-alpha-/- mice revealed no alterations in epidermal differentiation, the epidermis was thinner in

275 These data suggest that, during epidermal differentiation, the matriptase-prostasin prot

276 d just before birth and at the last stage of epidermal differentiation, the skin's proteinaceous/lipi

277 ly eliminated from the skin through terminal epidermal differentiation, thereby causing hair follicle

278 domains suggest a role in the regulation of epidermal differentiation through the control of Ca2+-me

279 Although much has been learned about epidermal differentiation through the deciphering of the

280 tly suppress the immune response and enhance epidermal differentiation to restore the barrier.

281 These data suggest that disrupting epidermal differentiation via different pathways can inc

282 y a new role for SIRT3 in the suppression of epidermal differentiation via lowering oxidative stress.

283 in, KLKs are involved in desquamation during epidermal differentiation via proteolytic cleavage of th

284 However, restoration of epidermal differentiation was non-cell autonomous and re

285 on of keratin 1 and keratin 5 indicated that epidermal differentiation was not affected.

286 However, loricrin, a late marker of epidermal differentiation, was not significantly altered

287 the role of the epithelial sodium channel in epidermal differentiation, we examined skin of mice in w

288 role of the vitamin D receptor in mediating epidermal differentiation, we examined the histomorpholo

289 model system to monitor the course of human epidermal differentiation, we found elevated matriptase

290 calcium-sensing receptor in calcium induced epidermal differentiation, we investigated the ability o

291 nctions of matriptase in normal and aberrant epidermal differentiation, we used enzymatic gene trappi

292 While most of E7's effects on epidermal differentiation were found to require pRb inac

293 he ectoderm has effects on specific steps of epidermal differentiation, which may be amenable to trea

294 Finally, GCs promote terminal epidermal differentiation while simultaneously inhibitin

295 fected by TRAF3IP2 silencing are involved in epidermal differentiation, with early differentiation ge

296 vivo results in a severe defect in terminal epidermal differentiation, with inhibition of XK81A1 epi

297 aspin expression to be closely associated to epidermal differentiation, with low levels in proliferat

298 he p38 inhibitor SB203580 abolished abnormal epidermal differentiation without affecting limbal epith

299 tes p38 MAPK signaling coupled with abnormal epidermal differentiation without intrinsic alteration o

300 ndication of its relevance to skin adhesion, epidermal differentiation, wound healing, scarring, angi