ライフサイエンスコーパス: epidermal growth factor-like

1 NELL1 and NELL2 (neural epidermal growth factor-like 1 and 2) are recently descr

2 SK9) is a secreted protein that binds to the epidermal growth factor-like-A domain of the low density

3 as tomoregulin or transmembrane protein with epidermal growth factor-like and 2 follistatin-like doma

4 , epidermal growth factor-like, laminin-type epidermal growth factor-like, and link domain-containing

5 e N-terminal end, proline-rich C region, and epidermal growth factor-like calcium-binding (EGF-cb) do

6 o repeated module types: the calcium binding epidermal growth factor-like (cbEGF) domain and the tran

7 We have used recombinant calcium binding epidermal growth factor-like (cbEGF) domain fragments fr

8 rganisation that includes 43 calcium binding epidermal growth factor-like (cbEGF) domains and seven t

9 rganisation that includes 43 calcium-binding epidermal growth factor-like (cbEGF) domains arranged as

10 The calcium-binding epidermal growth factor-like (cbEGF) module and the tran

11 conformation of fibrillin-1 calcium-binding epidermal growth factor-like (cbEGF-like) domains within

12 with subsequent release of its extracellular epidermal growth factor-like-containing domain and autoc

13 cysteine-rich domain instead of the expected epidermal growth factor-like disulfide structure.

14 FVII with an in-frame deletion of the first epidermal growth factor-like domain (EGF 1).

15 The first epidermal growth factor-like domain (EGF-1) from blood c

16 The functional importance of the N-terminal epidermal growth factor-like domain (EGF-N) of factor X/

17 rombin-sensitive region (TSR), and the first epidermal growth factor-like domain (EGF1) of protein S,

18 polypeptides in which residues in the third epidermal growth factor-like domain (EGF3) are mutated d

19 g the single transmembrane receptor multiple epidermal growth factor-like domain 10 (MEGF10) cause an

20 Epidermal growth factor-like domain 7 (Egfl7) is importa

21 this method, we developed an assay for human epidermal growth factor-like domain 7 (EGFL7), an extrac

22 cally, we show that CASZ1 directly regulates Epidermal Growth Factor-Like Domain 7 (Egfl7).

23 ammalian uPA by lacking two cysteines of the epidermal growth factor-like domain and a uPAR-binding s

24 ctor VIII allows the factor IXa protease and epidermal growth factor-like domain binding sites (local

25 2 (HER2) receptor tyrosine kinase through an epidermal growth factor-like domain in its extracellular

26 Neuregulins contain an epidermal growth factor-like domain located C-terminally

27 We have cloned, expressed, and purified the epidermal growth factor-like domain of murine uPA alone

28 oneoplastic potential in comparison with the epidermal growth factor-like domain of neuregulin-1beta

29 amino-acid residue within the fifth laminin-epidermal growth factor-like domain of the USH2A gene an

30 ats 1-2 and 6-8 of tenascin-R but not to the epidermal growth factor-like domain or the fibrinogen-li

31 mmation, but the function of the recombinant epidermal growth factor-like domain plus serine/threonin

32 a chimeric Factor IX by replacing the first epidermal growth factor-like domain with that of Factor

33 motif, (iii) a cysteine-rich domain, (iv) an epidermal growth factor-like domain, (v) a hydrophobic t

34 Upon deletion of its C-terminal epidermal growth factor-like domain, BAD-1 resisted aggr

35 arginine at a highly conserved residue of an epidermal growth factor-like domain, impairs Wnt signali

36 Deletion of the C-terminal epidermal growth factor-like domain, in which Asn(350) i

37 ipocyte factor-1 (Pref-1) is a transmembrane epidermal growth factor-like domain-containing protein h

38 Pref-1 is an epidermal growth factor-like domain-containing transmemb

39 e region that is N-terminal of the bioactive epidermal growth factor-like domain.

40 N-terminal fragment containing the bioactive epidermal growth factor-like domain.

41 y lacking the exon encoding the uPAR-binding epidermal growth factor-like domain; zfuPA-b differs fro

42 alloendopeptidase isolated from crayfish, an epidermal growth-factor-like domain, and three regions o

43 /kexin type 9 (PCSK9) through the first EGF (epidermal growth factor-like) domain [EGF(A)].

44 Calcium binding epidermal growth factor-like domains (cbEGFs) are presen

45 Epidermal growth factor-like domains 1-4 comprise the co

46 egion of fibrillin-1 between calcium-binding epidermal growth factor-like domains 11 and 21.

47 ne-rich tandem repeats encompassing integrin-epidermal growth factor-like domains 2, 3, and 4 of the

48 ntiation-related protein, cysteine-rich with epidermal growth factor-like domains 2, nuclear protein

49 al structure of thrombin in complex with the epidermal growth factor-like domains 4, 5, and 6 of TM (

50 The epidermal growth factor-like domains 4-6 of thrombomodul

51 vation of alpha-thrombin in complex with the epidermal growth factor-like domains 4-6 of TM (TM4-6) w

52 Thrombomodulin (TM), or its epidermal growth factor-like domains 456 (TM456), enhanc

53 in, suggesting that this region contains the epidermal growth factor-like domains 5 and 6.

54 d specifically with ErbB2 through one of its epidermal growth factor-like domains and that the co-exp

55 d soluble EMR2, containing highly homologous epidermal growth factor-like domains but a different sta

56 Notch is modified in its epidermal growth factor-like domains by the addition of

57 portions encompassing the N-terminal CUB and epidermal growth factor-like domains have been expressed

58 a highly conserved enzyme that hydroxylates epidermal growth factor-like domains in transformation-a

59 atistically significant sequence homology to epidermal growth factor-like domains is found, and a dis

60 plex with a naphthyl inhibitor DX-9065a, two epidermal growth factor-like domains of factor Xa are we

61 to position 274 is highly conserved in other epidermal growth factor-like domains of jagged1 and in t

62 erase 1 (OFUT1), an enzyme that glycosylates epidermal growth factor-like domains of Notch, also has

63 e residues at a strict consensus site within epidermal growth factor-like domains of several serum pr

64 n variants of tenascin-C containing only the epidermal growth factor-like domains or the fibronectin

65 In contrast, no binding was observed to the epidermal growth factor-like domains or to the activatio

66 The structure reveals two tightly packed epidermal growth factor-like domains oriented head to ta

67 181 aa long N-terminal domain containing two epidermal growth factor-like domains, a follistatin moti

68 gamma-carboxyglutamic acid (Gla) domain, two epidermal growth factor-like domains, and a protease dom

69 d stronger blocking compared with mAb to its epidermal growth factor-like domains, and binding was ca

70 The latter, which contains two epidermal growth factor-like domains, binds the receptor

71 domains of BMP1 and mTLL1, devoid of CUB or epidermal growth factor-like domains, have procollagen C

72 ve activity and a transmembrane subunit with epidermal growth factor-like domains, one of which acts

73 ith human fibrillin-2 and had Ca(2+) binding epidermal growth factor-like domains, transforming growt

74 few helical hydrophobic residues and the two epidermal growth factor-like domains, whereas the heavy

75 ed conformation of the N-terminal lectin and epidermal growth factor-like domains.

76 ne-binding globulin, with three interspersed epidermal growth factor-like domains.

77 ormed by the disintegrin, cysteine-rich, and epidermal growth factor-like domains.

78 samine in a beta1,3 linkage onto O-fucose on epidermal growth factor-like domains.

79 e a disorder caused by mutations in multiple epidermal-growth-factor-like-domains 8 (MEGF8), which ex

80 , C6PS binds to two sites on FXa, one in the epidermal growth factor-like (EGF) domain and one in the

81 Epidermal growth factor-like (EGF) domain Ca2+ binding s

82 sists of 11 exons with an Ig-like domain, an epidermal growth factor-like (EGF) domain, a beta-stalk,

83 O-Linked fucose modifications on Notch1 epidermal growth factor-like (EGF) domains 8 and 12 enga

84 Calcium binding (cb) epidermal growth factor-like (EGF) domains are found in

85 ual forms of O-linked glycosylation found on epidermal growth factor-like (EGF) modules.

86 des a secreted molecule containing a variant epidermal growth factor-like (EGF) motif.

87 s studies suggest that O-fucosylation of the epidermal growth factor-like (EGF) repeat in Cripto is e

88 is an unusual form of glycosylation found on epidermal growth factor-like (EGF) repeats and thrombosp

89 Epidermal growth factor-like (EGF) repeats are also smal

90 st-translational modification that occurs on epidermal growth factor-like (EGF) repeats harboring the

91 O-Glucosylation of epidermal growth factor-like (EGF) repeats in the extrac

92 O-Fucose has been identified on epidermal growth factor-like (EGF) repeats of Notch, and

93 erase that modifies O-fucose moieties on the epidermal growth factor-like (EGF) repeats of Notch.

94 h activity by modifying O-fucose residues on epidermal growth factor-like (EGF) repeats of Notch.

95 receptors require modification by fucose on epidermal growth factor-like (EGF) repeats of their extr

96 ar domain of mouse Notch1 contains 36 tandem epidermal growth factor-like (EGF) repeats, many of whic

97 hway and transfers O-GlcNAc to proteins with epidermal growth factor-like (EGF) repeats.

98 ase that modifies O-fucose in the context of epidermal growth factor-like (EGF) repeats.

99 comprises multiple copies of ligand binding, epidermal growth factor-like (EGF), and YWTD-type domain

100 Ca2+ binding epidermal growth factor-like (EGF-like) domains are foun

101 The receptor also contains 7 epidermal growth factor-like (Egf-like) motifs at the am

102 nning activity was also inhibited by another epidermal growth factor-like (EGF-like) peptide, neuregu

103 DASIL mutations described to date affect the epidermal growth factor-like (EGF-like) repeats located

104 uregulins (NRGs) are a family of multipotent epidermal-growth-factor-like (EGF-like) factors that ari

105 We previously reported that the first epidermal growth factor-like (EGF1) domain in factor X (

106 We investigated factor VIIa's first epidermal growth factor-like (egf1) domain's role in the

107 vulation by regulating the expression of the epidermal growth factor-like family of growth factors.

108 ransmembrane receptor member of the homeotic epidermal growth factor-like family of proteins, partici

109 Heparin-binding epidermal growth factor -like growth factor (HB-EGF) exp

110 pport a critical role for heparin-bound EGF (epidermal growth factor)-like growth factor (HB-EGF) and

111 the increased expression of heparin-binding epidermal growth factor-like growth factor (EGFR ligand)

112 Furthermore, heparin-binding epidermal growth factor-like growth factor (HB- EGF), a

113 n the ectodomain cleavage of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and

114 ite can activate cleavage of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and

115 rray analysis and identified heparin-binding epidermal growth factor-like growth factor (HB-EGF) as b

116 wth factor was identified as heparin-binding epidermal growth factor-like growth factor (HB-EGF) base

117 growth factor-2 (FGF-2) and heparin-binding epidermal growth factor-like growth factor (HB-EGF) bind

118 igated the effect of VEGF on heparin-binding epidermal growth factor-like growth factor (HB-EGF) expr

119 Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has

120 Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has

121 Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a

122 Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a

123 Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a

124 Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a

125 Heparin binding epidermal growth factor-like growth factor (HB-EGF) is a

126 Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a

127 Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a

128 Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is e

129 Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is p

130 Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is s

131 have recently reported that heparin-binding epidermal growth factor-like growth factor (HB-EGF) mRNA

132 tomy mice, the expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF) prec

133 phtheria toxin (DT) receptor/heparin-binding epidermal growth factor-like growth factor (HB-EGF) prec

134 We have shown that heparin-binding epidermal growth factor-like growth factor (HB-EGF) prot

135 Heparin-binding epidermal growth factor-like growth factor (HB-EGF), a m

136 Heparin-binding epidermal growth factor-like growth factor (HB-EGF), a m

137 Heparin-binding epidermal growth factor-like growth factor (HB-EGF), a m

138 s study, we demonstrate that heparin-binding epidermal growth factor-like growth factor (HB-EGF), a p

139 We examined whether, heparin binding-epidermal growth factor-like growth factor (HB-EGF), a r

140 The expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF), an

141 Heparin-binding epidermal growth factor-like growth factor (HB-EGF), an

142 duction of the growth factor heparin-binding epidermal growth factor-like growth factor (HB-EGF), are

143 that block signaling by the heparin-binding epidermal growth factor-like growth factor (HB-EGF).

144 d v-Jun target, a homolog of heparin-binding epidermal growth factor-like growth factor (HB-EGF).

145 Here we identify heparin-binding epidermal growth factor-like growth factor (HBEGF) as a

146 recursor of the monkey (Mk) heparin-binding, epidermal growth factor-like growth factor (proHB-EGF) f

147 arin-binding growth factors, heparin-binding epidermal growth factor-like growth factor and fibroblas

148 ibroblast growth factor-2 or heparin-binding epidermal growth factor-like growth factor increases neu

149 ly, in the remodeling phase, heparin-binding epidermal growth factor-like growth factor limits mesenc

150 Heparin-binding epidermal growth factor-like growth factor promotes neur

151 ouse gene (mHB-EGF) encoding heparin-binding epidermal growth factor-like growth factor was isolated

152 the ADAM17 substrate HB-EGF (heparin-binding epidermal growth factor-like growth factor).

153 An epidermal growth factor-like growth factor, amphiregulin

154 factor-alpha, amphiregulin, heparin-binding epidermal growth factor-like growth factor, and sonic he

155 forming growth factor alpha, heparin-binding epidermal growth factor-like growth factor, and Tie-2.

156 d transcripts (amphiregulin, heparin-binding epidermal growth factor-like growth factor, and transfor

157 mphiregulin and its homolog, heparin-binding epidermal growth factor-like growth factor, to the recep

158 ation of membrane content of heparin binding-epidermal growth factor-like growth factor, which serves

159 ng to the putative receptor, heparin-binding epidermal growth factor-like growth factor.

160 he heparin-binding domain of heparin-binding epidermal growth factor-like growth factor.

161 ese studies demonstrate that LH induction of epidermal growth factor-like growth factors and EGFR tra

162 Betacellulin belongs to the family of epidermal growth factor-like growth factors that are exp

163 Heparin-binding epidermal-growth-factor-like growth factor (HB-EGF) has

164 e receptor, the precursor of heparin-binding epidermal-growth-factor-like growth factor (HBEGF).

165 a transmembrane and secreted protein in the epidermal growth factor-like homeotic family.

166 the alpha subunit genu and between integrin epidermal growth factor-like (I-EGF) domains 1 and 2.

167 w density lipoprotein receptor 1; fasciclin, epidermal growth factor-like, laminin-type epidermal gro

168 rminal (LN) domain followed by three laminin epidermal growth factor-like (LE) domains and a C' regio

169 propeller domain in nidogen bound to laminin epidermal-growth-factor-like (LE) modules III3-5 in lami

170 domain followed by a tandem of laminin-type epidermal growth factor-like (LEa) domains.

171 or the first time that signaling through the epidermal growth factor-like ligand LIN-3 and the LET-23

172 not through the release of an extracellular epidermal growth factor-like ligand.

173 (SFKs), which induce proteolytic shedding of epidermal growth factor-like ligands from the cell surfa

174 y identified a secreted glycoprotein, neural epidermal growth factor-like like 2 (NELL2), in a subtra

175 e identified a secreted Robo3 ligand, neural epidermal growth factor-like-like 2 (NELL2), which repel

176 binding repeats alone (Ca) or with the third epidermal growth factor-like module (E3Ca), without (Asn

177 ke module compared with folding of the first epidermal growth factor-like module alone.

178 sis of constructs comprised of the adjoining epidermal growth factor-like module and the Ca2+ -bindin

179 dly facilitated correct folding of the first epidermal growth factor-like module compared with foldin

180 ial of the human eosinophil surface receptor epidermal growth factor-like module containing mucin-lik

181 the thrombin-sensitive module, and the first epidermal growth factor-like module of human plasma prot

182 ow the human-restricted adhesion-GPCR, EMR2 (epidermal growth factor-like module-containing mucin-lik

183 nus of ECM1 interacted specifically with the epidermal growth factor-like modules flanking the LG2 su

184 domain of thrombospondins consists of tandem epidermal growth factor-like modules, 13 calcium-binding

185 our disulfides from a previous prediction of epidermal growth factor-like modules.

186 We have studied whether dlk, an epidermal growth factor-like molecule that intervenes in

187 n, containing two follistatin domains and an epidermal growth factor-like motif that is mainly expres

188 A common feature of proteins that include epidermal growth factor-like motifs is their involvement

189 terminal leucine-rich repeats and C-terminal epidermal growth factor-like motifs, and in Drosophila S

190 containing tandem arrays of calcium-binding epidermal growth factor-like motifs, is present in the b

191 with four additional tandem calcium-binding epidermal growth factor-like motifs.

192 their 5' ends that have some similarity with epidermal growth factor-like motifs.

193 ringe proteins and solutions from docking an epidermal growth factor-like O-fucose acceptor substrate

194 fy the endothelial cell (EC)-secreted factor epidermal growth factor-like protein 7 (EGFL7) as a nove

195 G protein-coupled CC chemokine receptor, and epidermal growth factor-like protein which are found in

196 domain, followed by a fixed order of CUB and epidermal growth factor-like protein-protein interaction

197 hich have tertiary structures resembling the epidermal growth factor-like proteins.

198 The epidermal growth factor-like receptor tyrosine kinase (E

199 is a proto-oncogene product that encodes an epidermal growth factor-like receptor tyrosine kinase.

200 uterine pi lineage respond via their LET-23 epidermal growth factor-like receptors to a vulval-deriv

201 l injections of a small peptide encoding the epidermal growth factor-like region of heregulin ectodom

202 ur versions of recombinant C-terminal 19-kDa epidermal growth factor-like region of the major surface

203 The C-terminal 19-kDa, epidermal growth factor-like region of the merozoite sur

204 in, containing two follisatin domains and an epidermal growth factor-like region.

205 in a sequence-specific manner with the first epidermal growth factor-like repeat (EGF-A) in the EGF h

206 pairing similar to the laminin gamma1 chain epidermal growth factor-like repeat 11, suggests conform

207 receptors (LDLRs) in liver by binding to the epidermal growth factor-like repeat A (EGF-A) domain of

208 ding site of PCSK9 has been localized to the epidermal growth factor-like repeat A (EGF-A) domain of

209 ADAMTS-12 selectively binds to only the epidermal growth factor-like repeat domain of COMP of th

210 The third epidermal growth factor-like repeat dramatically altered

211 s, and 1 exon sequence had similarity to the epidermal growth factor-like repeat from several protein

212 he missplicing of exon 34, a calcium-binding epidermal growth factor-like repeat in fibrillin-2 in a

213 a Crumbs isoform that contains an additional epidermal growth factor-like repeat in the extracellular

214 The gamma chain is cleaved within the second epidermal growth factor-like repeat of domain Ill.

215 Clone H411 encodes a protein in the epidermal growth factor-like repeat protein family.

216 pref-1 is an epidermal growth factor-like repeat protein present on t

217 arated by eight YWTD spacer regions, and one epidermal growth factor-like repeat.

218 t for binding to Notch, the integrity of the epidermal-growth-factor-like repeat (ELR) 2 is also requ

219 Notch1 epidermal growth factor-like repeats 11 and 12 interact

220 an NH2-terminal Gla domain followed by four epidermal growth factor-like repeats and tandem globular

221 By contrast, the region bearing epidermal growth factor-like repeats can be deleted with

222 A domain of alpha2delta-1 interacts with the epidermal growth factor-like repeats common to all throm

223 vasculature and the presence of Ca2+ binding epidermal growth factor-like repeats contained in the pr

224 icted to occur at consensus sites within the epidermal growth factor-like repeats in the extracellula

225 e thyrotropin receptor (TSHR) ectodomain and epidermal growth factor-like repeats in the laminin gamm

226 The O-fucose modification is found on epidermal growth factor-like repeats of a number of cell

227 nant protein of domain VI and the first four epidermal growth factor-like repeats of domain V, genera

228 tion between Jagged1 and MAGP-2 requires the epidermal growth factor-like repeats of Jagged1.

229 lcNAcT) that transfers GlcNAc to O-fucose in epidermal growth factor-like repeats of Notch.

230 ain of Cripto-1 and the C-terminal region of epidermal growth factor-like repeats of Notch1.

231 a recombinant protein consisting of only the epidermal growth factor-like repeats showed no cell bind

232 s delta-like/preadipocyte factor-1, contains epidermal growth factor-like repeats that are related to

233 The Gla domain and epidermal growth factor-like repeats were not required f

234 sites for glycosaminoglycan attachment, two epidermal growth factor-like repeats, a putative hyaluro

235 Its extracellular domain includes epidermal growth factor-like repeats, a von Willebrand f

236 a type-1 membrane protein, 15 extracellular epidermal growth factor-like repeats, and multiple cytop

237 dicted 1713 amino acid protein containing 18 epidermal growth factor-like repeats, four 8-cysteine do

238 The enzyme that adds O-fucose to epidermal growth factor-like repeats, GDP-fucose protein

239 er of cysteine residues in the extracellular epidermal growth factor-like repeats, important for liga

240 , a region related to fibrinogen beta/gamma, epidermal growth factor-like repeats, neurexin motifs as

241 act that O-FucT-1 recognizes properly folded epidermal growth factor-like repeats, together with this

242 omain and an extracellular region containing epidermal growth factor-like repeats.

243 domain V involved the first two laminin- and epidermal growth factor-like repeats.

244 th an extracellular domain that contains ten epidermal growth factor-like repeats.

245 which is responsible for adding O-fucose to epidermal growth factor-like repeats.

246 tion of O-linked fucose residues attached to epidermal growth factor-like sequence repeats of Notch.

247 ghlighting the importance of heparin-binding epidermal growth factor-like signaling in blastocyst-ute

248 Neuregulin 4 (NRG4), an epidermal growth factor-like signaling molecule, plays a

249 is believed to be mediated by neuregulin, an epidermal growth factor-like trophic factor released by

250 shares a similar organization of Fasciclin, epidermal growth factor-like, Xlink, and transmembrane d

251 binding domains with a laminin alpha 4 chain epidermal-growth-factor-like/ zinc-finger-like motif.