ライフサイエンスコーパス: epigenetic

1 ientists in advancing the field of synthetic epigenetics.

2 N) in broccoli sprouts (BSp) on neutralizing epigenetic aberrations in estrogen receptor-alpha (ERalp

3 However, the molecular mechanisms driving epigenetic accessibility are still unknown.

4 Thus identifying the epigenetic activator of ERalpha that can be targeted to

5 arly life dietary cues that lead to lifelong epigenetic adaptations to a perceived nutritional enviro

6 We discuss a model in which an "epigenetic addiction" to the HJURP chaperone represents

7 typic and genetic interrelationships between epigenetic age acceleration and white matter integrity i

8 In the current study we examined epigenetic age acceleration using saliva samples collect

9 We examined the association of epigenetic age and immune cell aging with sleep in the W

10 s of insomnia were associated with increased epigenetic age of blood tissue and were associated with

11 nd heritable biomarker, with acceleration in epigenetic age predicting a number of age-related phenot

12 s or less; long sleep greater than 8 hours), epigenetic age, naive T cell (CD8+CD45RA+CCR7+), and lat

13 gnificantly associated (P=2.2 x 10(-8)) with epigenetic ageing of the prefrontal cortex, independent

14 sample, we are also able to demonstrate that epigenetic aging and white matter tract integrity also s

15 targeted methylated or unmethylated minority-epigenetic-alleles.

16 thogenesis of neurodegenerative diseases, to epigenetic alterations and to cell signaling and redox r

17 Further analysis of tumoral epigenetic alterations in hematopoietic CDRs points to s

18 ocampus specifically, which co-occurred with epigenetic alterations in histone H3 N-terminal lysine 4

19 lopment indicates that additional genetic or epigenetic alterations may account for neoplastic progre

20 ys is a hallmark of cancer and can be due to epigenetic alterations.

21 Cancer is characterized by both genetic and epigenetic alterations.

22 s, and to disentangling reverse causation in epigenetic analyses.

23 s and reprogramming, we performed integrated epigenetic analysis of murine and human retinoblastomas

24 e, we report the first proteomic and histone epigenetic analysis of patient metastatic melanoma tumor

25 y instructive, and represents a multistable, epigenetic anatomical switch: experimental reversals of

26 Epigenetic and gene expression analysis of The Cancer Ge

27 Epigenetic and genetic cis-regulatory elements in diploi

28 Epigenetic and transcriptional analyses revealed that bo

29 We studied epigenetic and transcriptional changes in HCV-infected l

30 HCC, allowing us to identify pre-neoplastic epigenetic and transcriptional events.

31 -coding RNAs (lncRNAs) play crucial roles in epigenetic and transcriptional regulation in mammals.

32 eing limited to a single cortical region for epigenetic and transcriptomic data, and the use of categ

33 of information from the host transcriptomic, epigenetic and virus response also has the potential to

34 These findings shed light on the epigenetics and cellular origins of lineage-specific lun

35 Epigenetics and experiences of societal inequality (allo

36 thylation on histones is a central player in epigenetics and in gene activation and repression.

37 on, we leveraged neuropathological, genetic, epigenetic, and transcriptional data available for decea

38 We therefore took an epigenetic approach where a single drug would simultaneo

39 pression in somatic cells overcomes an early epigenetic barrier in cellular reprogramming and facilit

40 Together, our study suggests an epigenetic barrier that can be removed by active DNA dem

41 Few methodologies integrate epigenetic based predictions of multiple approaches when

42 vestigate potential combinatorial effects of epigenetic bioactive botanicals including epigallocatech

43 d across tissues, rendering these CpGs novel epigenetic biomarkers for heart failure.

44 characteristics of carcinogens; incorporate epigenetic biomarkers, in silico modelling, high-perform

45 e non-canonical CENP-A nucleosome to enforce epigenetic centromere specification and kinetochore asse

46 After that, epigenetic changes appear to correlate with differences

47 ormance; however, it remains unclear whether epigenetic changes are a cause or a consequence of heter

48 To delineate epigenetic changes associated with EPO signaling, we com

49 s demonstrate that G9a orchestrates critical epigenetic changes in cardiomyocytes in physiological an

50 ate immunity', and is underwritten by stable epigenetic changes in immune and metabolic pathways.

51 In the mouse embryo, global epigenetic changes occur during zygotic genome activatio

52 escribes a process that results in heritable epigenetic changes of gene regulation and trans-homologu

53 nts and some animals, leading to genetic and epigenetic changes that affect gene expression and morph

54 ells but also plays a role in regulating the epigenetic changes that can occur in cells.

55 ion, and memory; animal studies to determine epigenetic changes that reprogram brain development and

56 ng cancer growth and progression, additional epigenetic changes triggered by interaction with the mic

57 chondrial dysfunction, stem cell exhaustion, epigenetic changes, abnormal microRNA profiles, immunose

58 lective toxicity in chiral pesticide, nor on epigenetic changes, such as DNA methylation.

59 T1 may explain the observed p66(Shc)-related epigenetic changes.

60 Longitudinal phenotypic and epigenetic characterization of the memory-precursor effe

61 igenetic predictor of age in mice, the mouse epigenetic clock.

62 r properties to the recently described human epigenetic clock.

63 erase-associated factor complex (PAFc) is an epigenetic co-activator complex that makes direct contac

64 nalling pathways, via a novel combination of epigenetic cofactors.

65 imately resulting in the transcriptional and epigenetic control of gene expression.

66 This bivalent epigenetic control of oncofetal gene expression in cance

67 s with genomic and epigenomic data indicates epigenetic control of Sp1 targets' expression in a cell/

68 d beige/brite adipocytes that might be under epigenetic control.

69 d among ART-conceived infants, suggesting an epigenetic cost.

70 architecture can be predicted de novo using epigenetic data derived from chromatin immunoprecipitati

71 Epigenetic deregulation is a hallmark of cancer characte

72 ein (CENP) A, a histone H3 variant, is a key epigenetic determinant of chromosome domains known as ce

73 social-separation response and suggest that epigenetic down-modulation of OXTR could contribute to b

74 egulating natural killer and CD8(+) T cells, epigenetic downregulation of HLA-E by high-risk HPV E7 m

75 We propose that epigenetic drift is a determinant of lifespan in mammals

76 lation alterations are hallmarks of CRC, and epigenetic driver genes have been identified that are th

77 interplay between 3D chromatin structure and epigenetic dynamics.

78 leukemia (AML) is a disease associated with epigenetic dysregulation.

79 95 as a key player in memory and establishes epigenetic editing as a potential therapy to treat human

80 ssion in human salivary ductal cells through epigenetic editing of the native promoter.

81 stigate this question, we use a CRISPR-dCas9 epigenetic editing tool, where an inactive form of Cas9

82 The epigenetic effect on cortical thickness was replicated i

83 This allows them to serve as protein-based epigenetic elements that are readily broadcast through m

84 Further, epigenetic end points need to be correlated with observa

85 al physics and information theory, we derive epigenetic energy landscapes from whole-genome bisulfite

86 rases (KMTs) represent an important class of epigenetic enzymes that play essential roles in regulati

87 methylation is an important tissue-specific epigenetic event that influences transcriptional regulat

88 These epigenetic events occur before neoplastic transformation

89 ld important insights regarding AML genetic, epigenetic, evolutional, and clinical diversity, all in

90 mouse models lack key NHRS (Nr2e3, RORA) or epigenetic (Ezh2) factors.

91 While epigenetic factors are thought to contribute to this pro

92 l sex, early-life stressors, and genetic and epigenetic factors in individual patients.

93 ced chromatin accessibility, suggesting that epigenetic factors limit regeneration.

94 e network of interacting proteins, including epigenetic factors, telomeric proteins, and the RNA heli

95 n these regions have reduced expression, and epigenetic features of closed chromatin in male germ cel

96 study, we report unique transcriptional and epigenetic features of nearly 3,500 NL-associated genes

97 nvestigators to easily identify regions with epigenetic features unique to specific epigenomes that t

98 al events, microsatellite instability (MSI), epigenetic features, protein expression status, and immu

99 A glycosylase gene is required for long-term epigenetic fidelity in Arabidopsis.

100 n what may be a pharmacologically reversible epigenetic field defect in HCV-infected liver.

101 BHB broadly link the outside environment to epigenetic gene regulation and cellular function, and th

102 ructures with requirements that mirror yeast epigenetic gene silencing in vivo.

103 linking MUC1-C with function of the PRC1 in epigenetic gene silencing.

104 methylated H3K27 (H3K27me3) is implicated in epigenetic gene silencing.

105 advances highlighting the interplay between epigenetics, genetics, and cell-to-cell signaling in can

106 the immunophenotype, biological properties, epigenetics, genetics, and clinical associations of huma

107 Incorporating transgenerational epigenetic heritability into risk assessment procedures

108 The CAPN14 gene is positioned in an epigenetic hotspot regulated by IL-13, a TH2 cytokine wi

109 new avenues for using the full potential of epigenetics in crop improvement.

110 been some progress in revealing the role of epigenetics in ecological processes, studies with non-mo

111 llenging, and site-specific incorporation of epigenetic information and/or modified bases into large

112 r understanding of how nucleosomes and their epigenetic information are maintained through DNA replic

113 Epigenetic information can also be modified as a consequ

114 s the current evidence for transgenerational epigenetic inheritance and summarize the data linking ep

115 hough long thought to be rare, protein-based epigenetic inheritance has now been uncovered in all dom

116 enerational environmental effects, including epigenetic inheritance, contribute to adaptive evolution

117 Arabidopsis by MET1, plays a central role in epigenetic inheritance, we examined genomewide DNA methy

118 Our data provide a basis for genetic/epigenetic investigations to explore the role of miRNA i

119 Epigenetics is the study of biochemical modifications ca

120 y highlight the importance of regulating the epigenetic landscape during cell fate conversion but als

121 iptional activity of alpha-SYN in its native epigenetic landscape which is not achievable using exoge

122 In 1940, Waddington coined the term "epigenetic landscape" as a metaphor for pluripotency and

123 Cancer cells are characterized by aberrant epigenetic landscapes and often exploit chromatin machin

124 extracellular cues determine highly specific epigenetic landscapes and transcriptional profiles to pr

125 s may provide a useful strategy for altering epigenetic landscapes in organisms where histone methylt

126 e type I IFN pathway is dysfunctional at the epigenetic level in systemic sclerosis patients, indicat

127 he transcriptional, post-transcriptional and epigenetic levels.

128 of human right-sided colorectal tumors with epigenetic loss of MLH1.

129 The epigenetic mark 5-hydroxymethylcytosine (5hmC) is a cyto

130 s have allowed large-scale assessment of one epigenetic mark in particular, DNA methylation, in human

131 DNA methylation is a stable epigenetic mark that distinguishes cell types and marks

132 Polycomb repressive complex 2 and the epigenetic mark that it deposits, H3K27me3, are evolutio

133 t its absence results in accumulation of the epigenetic mark, lysine 5-acetylated H2B.

134 DNA methylation, a major epigenetic mark, was investigated using targeted bisulfi

135 A methylation constitutes a rapidly adaptive epigenetic mark.

136 Differences in chromatin modifications and epigenetic markers between subgenomes in several model s

137 ute to single-molecule analysis of important epigenetic markers in DNA, our results provide important

138 life course; and the establishment of human epigenetic markers of iron exposures and oxidative stres

139 results support the notion that differential epigenetic marking may facilitate long-term retention of

140 Surprisingly, the spread of repressive epigenetic marks (histone H3K9me2) to nearby DNA occurs

141 associated with the deposition of activating epigenetic marks across the loop domain, plausibly facil

142 Nuclear foci corresponding to epigenetic marks as well as heterochromatin and the nucl

143 Reversal of the pY88-H4 epigenetic marks by the ACK1 inhibitor (R)-9bMS-sensitiz

144 t area of research focuses on the utility of epigenetic marks in capturing this intersection of genes

145 tle is known about how genetic variation and epigenetic marks interact to shape differences in behavi

146 ons are defined as repressive and activating epigenetic marks that simultaneously decorate the same g

147 ce/absence of mutations, binding, motifs and epigenetic marks) and continuous data (e.g. gene express

148 rther explore the interplay between TADs and epigenetic marks, as tumor mutational burden is known to

149 Here, we have profiled 2 repressive epigenetic marks, H3K9me2 and H3K27me3, which are involv

150 We believe that we have discovered a novel epigenetic mechanism for altering cell signaling and acq

151 ciliogenesis, nuclear translocation, and an epigenetic mechanism that may control timing of terminal

152 DNA methylation is an important epigenetic mechanism that regulates gene expression and

153 our findings identify a new chromatin-based epigenetic mechanism underlying the tumor-suppressive ac

154 d that failure to rerepress chromatin is one epigenetic mechanism underlying transcriptional memory.

155 Variation in DNA methylation, an epigenetic mechanism, is implicated in both neurobiologi

156 orting the likely involvement of an upstream epigenetic mechanism.

157 is intersection of genes and environment, as epigenetic mechanisms are both tightly linked to the gen

158 Epigenetic mechanisms are thought to be important for ba

159 utility of the Lu-iPSC model for elucidating epigenetic mechanisms contributing to pulmonary carcinog

160 Epigenetic mechanisms have been suggested to play a role

161 use of iPSC-derived cellular models to study epigenetic mechanisms impacting on health and disease.

162 ic disorders and suggest that involvement of epigenetic mechanisms in childhood asthma is already dem

163 Previous reports on epigenetic mechanisms involved in alcohol abuse have foc

164 r to modulate cell phenotypes or dissect the epigenetic mechanisms involved in their control.

165 endogenous FA, raising the possibility that epigenetic mechanisms may contribute to FA-mediated carc

166 BACKGROUND & AIMS: Epigenetic mechanisms might be involved in the regulatio

167 Epigenetic mechanisms play a critical role during differ

168 The epigenetic mechanisms that (dys)regulate transcription o

169 ethylomes and point to a divergence in trans-epigenetic mechanisms that govern the organization of ep

170 provides further evidence that PAF activates epigenetic mechanisms to affect important cellular proce

171 sponses among cells and individuals involves epigenetic mechanisms.

172 e development of iNKT cells through multiple epigenetic mechanisms.

173 ay play a role in regulating human growth by epigenetic mechanisms.

174 a demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin resistance in vitro and i

175 In addition, we find evidence of epigenetic memory in the transdifferentiated cells, with

176 The epigenetic memory is likely erased before parasites star

177 Faithful resetting of the epigenetic memory of a somatic cell to a pluripotent sta

178 inheritance of H3K27 trimethylation conveys epigenetic memory.

179 e genes; therefore, more complex genetic and epigenetic methodologies are now being considered.

180 Furthermore, we identified distinct epigenetic methylation patterns that are conserved acros

181 ks metabolic adaptation to transgenerational epigenetic modification in response to acute periods of

182 DNA methylation is a key epigenetic modification involved in gene regulation whos

183 ncy and carcinogenesis involve the selective epigenetic modification of viral and cellular genes.

184 5-Hydroxymethylcytosine (5-hmC) is an epigenetic modification that has not been studied in pan

185 re utilized by chromatin modifiers to affect epigenetic modification.

186 xidize fatty acids to produce acetyl-CoA for epigenetic modifications critical to lymphangiogenesis.

187 tin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and

188 Thus, epigenetic modifications in combination with CTCF bindin

189 riptional programs, but also induces lasting epigenetic modifications in many target tissues.

190 o CCC, but little is known about the role of epigenetic modifications in pathological gene expression

191 However, the significance of epigenetic modifications in plant-pathogen interactions

192 reared salmon provides evidence for parallel epigenetic modifications induced by hatchery rearing in

193 Global DNMT-dependent epigenetic modifications lead to changes in protein expr

194 Epigenetic modifications play critical roles in diverse

195 Epigenetic modifications, including DNA methylation, pla

196 terochromatin and associated with repressive epigenetic modifications, such as H3K9me3 and C5 cytosin

197 synthesis of nucleotides and amino acids and epigenetic modifications.

198 r-changing environment and the influences of epigenetic modifications.

199 Mutations in epigenetic modifiers and signaling factors often co-occu

200 re downregulated due to LOY, KDM5D and KDM6C epigenetic modifiers have functionally-similar X-linked

201 gulatory proteins, including Sin3a and other epigenetic modifiers known to alter Runx1 transcriptiona

202 R mutations relative to mutations in SETBP1, epigenetic modifiers, or the spliceosome has been determ

203 creened a panel of small molecules targeting epigenetic modulators against human metastatic melanoma

204 Using prospective longitudinal epigenetic, neuroimaging and behavioral data from 132 ad

205 tant questions about gene expression and the epigenetics of Goltz syndrome-associated mutations and t

206 with HIRA in chromatin organization to link epigenetic organization to a metabolic circuit.

207 Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the asso

208 lishment and maintenance of tissue-specific, epigenetic pattern is still poorly understood.

209 6-dependent hybrid lethality is a revertible epigenetic phenomenon and provide additional evidence th

210 tes during development and contribute to the epigenetic plasticity that underlies malignant transform

211 Here we identify and characterise an epigenetic predictor of age in mice, the mouse epigeneti

212 Epigenetic processes have been implicated in the pathoph

213 mediated at least partly through changes in epigenetic processes, such as alterations in DNA methyla

214 of previously experienced conditions through epigenetic processes.

215 ic cycle genes is largely suppressed through epigenetic processes.

216 Here, we performed epigenetic profiling of human resting naive, central and

217 reeding, assisted gene flow, conditioning or epigenetic programming, and the manipulation of the cora

218 se data demonstrate that effector-associated epigenetic programs are preserved during cytokine-driven

219 ngs suggest a model whereby linked metabolic-epigenetic programs are selected for enhanced tumorigeni

220 y as we define key transcription factors and epigenetic programs underlying T cell dysfunction and su

221 bnormalities caused by LT-IH are mediated by epigenetic re-programming of the redox state in the CB c

222 gative breast cancer due at least in part to epigenetic reactivation of ERalpha, which in turn increa

223 The epigenetic reader BRD4 plays a vital role in transcripti

224 omatin modification states are recognized by epigenetic reader proteins and how this is linked to the

225 ine 36 methylation (H3K36me) is critical for epigenetic regulation and mutations at or near H3K36 are

226 These results suggest that Lsh exerts epigenetic regulation at key regulators of neural stem c

227 suppression of hepcidin expression involves epigenetic regulation by histone deacetylase 3.Hepcidin

228 Epigenetic regulation in anxiety is suggested, but evide

229 llowed us to classify chromosomal targets of epigenetic regulation into (i) single copy and methylate

230 we provide, for the first time, evidence for epigenetic regulation of an atypical chemokine receptor.

231 and their cytokines and their involvement in epigenetic regulation of barrier function were investiga

232 Epigenetic regulation of chromatin plays a critical role

233 Epigenetic regulation of differentiation-related genes i

234 potential cross talk between metabolism and epigenetic regulation of gene expression.

235 of studies demonstrating that metabolic and epigenetic regulation of gene transcription can influenc

236 Ac, we have focused on the O-GlcNAc-mediated epigenetic regulation of human colon cancer stem cells (

237 independent cohorts, underlining the role of epigenetic regulation of key cardiac transcription regul

238 likely to result, at least in part, from the epigenetic regulation of MYBL1 expression by O-GlcNAc, t

239 8 and IL23R, suggesting an important role of epigenetic regulation of these genes in the inflammatory

240 iagnosis or ethnic variation affecting miRNA epigenetic regulation or sequence of miRNA precursors.

241 In this study, we demonstrate that MOR epigenetic regulation requires multiple coordinated sign

242 ndings suggest that molecular mechanisms for epigenetic regulation within the spinal cord constitute

243 tracellular matrix, immunity, cell adhesion, epigenetic regulation, and airflow obstruction.

244 1), a potent angiogenesis inhibitor, through epigenetic regulation.

245 oH2A1 is a variant of the histone H2A and an epigenetic regulator of stem-cell function, where it pro

246 MECP2) gene, which encodes a multifunctional epigenetic regulator with known links to a wide spectrum

247 tor and memory differentiation; however, the epigenetic regulator(s) underpinning this process remain

248 Histone deacetylase-2 (HDAC2), an epigenetic regulator, is critical for stress-induced car

249 findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signa

250 anscriptional targets include cell cycle and epigenetic regulators (e.g., Foxo3, Plk1, Mycn, Dnmt1, D

251 ork identifies a protein complex linking key epigenetic regulators acting in the molecular control of

252 , we report the stage-specific roles of PRC2 epigenetic regulators in embryonic and adult urothelial

253 Identification of over 500 epigenetic regulators in humans raises an interesting qu

254 These epigenetic regulators may act to facilitate the expressi

255 s that have been characterized by changes in epigenetic regulators such as the lysine demethylase KDM

256 rategies that simultaneously target multiple epigenetic regulators within glioblastomas may be effect

257 This is the first report of an epigenetic-related disorder threatening a major tree cro

258 ociated with the TCA cycle are essential for epigenetic remodeling and are transiently and partially

259 ith T2D, and IGC did not change such adverse epigenetic remodeling.

260 erodimer Partner (SHP) mediates postprandial epigenetic repression of hepatic autophagy by recruiting

261 Here, we demonstrate that G9a, an epigenetic repressor of gene expression, acting in the n

262 ession improves the first cleavage division, epigenetic reprogramming and apoptotic status of bovine

263 ically regulated in quiescent cells and that epigenetic reprogramming can improve outcomes in glomeru

264 human tumors exhibit increased expression of epigenetic reprogramming factors such as Ezh2 and Sox2.

265 The addition of drug then induces epigenetic reprogramming in these cells, converting the

266 Epigenetic reprogramming was therefore not sufficient to

267 ive hypothesis, that captive rearing induces epigenetic reprogramming, by comparing genome-wide patte

268 g, Wnt signaling activation, and evidence of epigenetic reprogramming.

269 energy balance dependent in association with epigenetic reprogramming.

270 Thus refocused, epigenetics research aligns with the field of functional

271 In order to determine the impact of the epigenetic response to traumatic stress on post-traumati

272 ior observation that independent genetic and epigenetic risk factors can converge on the same locus.

273 Altogether, our data indicate an epigenetic role for KDM5B in regulating RNAPII elongatio

274 er and impact cellular phenotype ascribes an epigenetic role to OG.

275 DNA demethylation machinery plays important epigenetic roles in mammalian adult neurogenesis; howeve

276 de transcriptional analyses reveal important epigenetic roles of Tet2 in maintaining the transcriptom

277 e data indicate that MAX can act as a direct epigenetic sensor of E-box cytosine modification states

278 mingham Heart Study participants to identify epigenetic signatures of kidney function.

279 ion is an inherent danger in cells that lose epigenetic silencing during developmental reprogramming.

280 ccRCC harboring epigenetic silencing of NSD1 displayed a specific genome

281 Finally, we show that epigenetic silencing of RAD51C and BRCA1 by promoter met

282 ein (RB)-mediated heterochromatin formation, epigenetic silencing of S-phase genes and permanent cell

283 ology can be used to treat disease caused by epigenetic silencing of specific loci.

284 between isogenic ESC and EGC lines to define epigenetic similarities and differences.

285 r chromatin and DNA structure and an altered epigenetic state that contribute to tumorigenesis.

286 Col-Cvi recombinant inbred lines but have an epigenetic state that is inherently less stable within t

287 /2 in ES cells helps to maintain an ICM-like epigenetic state, prolonged suppression results in irrev

288 ngs provide insights into the problem of how epigenetic states are inherited through cell division, w

289 Epigenetic states are stably propagated in eukaryotes.

290 c mechanisms that govern the organization of epigenetic states at gene promoters.

291 For many years, cancer epigenetics studies relied on the identification of DNA

292 latory impact, serving as a highly important epigenetic system.

293 ablishes new avenues for developing targeted epigenetic therapies against human diseases.

294 ng distinct sets of genes based on different epigenetic therapy combinations.

295 at may be predictive of clinical response to epigenetic therapy.

296 c inheritance and summarize the data linking epigenetics to cardiovascular disease.

297 ecially with respect to identifying genetic, epigenetic, transcriptomic and proteomic profiles of dis

298 a powerful impact in this setting caused by epigenetic upregulation of glutamate decarboxylase 1 (GA

299 Shared epigenetic variation between hatchery-reared salmon prov

300 nomenon and provide additional evidence that epigenetic variation has the potential to limit gene flo