ライフサイエンスコーパス: epigenetic modification

1 re utilized by chromatin modifiers to affect epigenetic modification.

2 DNA methylation is an important epigenetic modification.

3 a critical role for the maintenance of this epigenetic modification.

4 of the inflammatory process, most likely via epigenetic modification.

5 istone H3 at serine 10 (H3S10p), a marker of epigenetic modification.

6 r-changing environment and the influences of epigenetic modifications.

7 regulate sense transcription by induction of epigenetic modifications.

8 of lysines is one of the best characterized epigenetic modifications.

9 leads to downstream changes in TET1-mediated epigenetic modifications.

10 es and genes involved in neuroplasticity and epigenetic modifications.

11 ones as well as on the mechanisms regulating epigenetic modifications.

12 sion, labeling of specific genomic loci, and epigenetic modifications.

13 to subsequent generations through heritable epigenetic modifications.

14 some phytohormones have been shown to affect epigenetic modifications.

15 uracil is one of several recently discovered epigenetic modifications.

16 etic variations, transcriptomes, and certain epigenetic modifications.

17 downregulation resulting in decreased 5-hmC epigenetic modifications.

18 metric insight into the complex reactions of epigenetic modifications.

19 ave occurred through genotoxicity or through epigenetic modifications.

20 e development with distinct requirements for epigenetic modifications.

21 known TGFbeta1 downstream co-activators and epigenetic modifications.

22 l molecular mechanism for PAF, activation of epigenetic modifications.

23 with the complication that they can contain epigenetic modifications.

24 the physiology and behavior of offspring via epigenetic modifications.

25 olve either mitochondrial dysfunction and/or epigenetic modifications.

26 ional activity, splicing, mRNA stability and epigenetic modifications.

27 , indicating a functional consequence of EBV epigenetic modifications.

28 dence that pollutants may cause diseases via epigenetic modifications.

29 such proteins mediate stable inheritance of epigenetic modifications.

30 ight, litter size, maternal cannibalism, and epigenetic modifications.

31 nd serves to coordinate glycolytic flux with epigenetic modifications.

32 tative analysis of 3D nuclear structures and epigenetic modifications.

33 and biology may be gained through studies of epigenetic modifications.

34 nal allele or maternal allele as a result of epigenetic modifications.

35 d affect gene expression in a similar way to epigenetic modifications.

36 ing is often associated with allele-specific epigenetic modifications.

37 egulation and obesity in adult offspring via epigenetic modifications.

38 ip between the function of phytohormones and epigenetic modifications.

39 synthesis of nucleotides and amino acids and epigenetic modifications.

40 quencing technology allow researchers to map epigenetic modifications across the genome, such experim

41 he evolutionary history of chromatin and how epigenetic modifications affect gene expression in respo

42 study demonstrates that diabetes may induce epigenetic modifications affecting neuropathological mec

43 Epigenetic modifications alter transcriptional activity

44 Soy formula and epigenetic modifications: analysis of vaginal epithelial

45 rt, through repressing genes associated with epigenetic modification and cell differentiation.

46 Our studies lay the groundwork for epigenetic modification and mechanistic studies on susce

47 and cell type-specific relationships between epigenetic modifications and binding affinities of TFs.

48 s are intrinsically sensitive to genetic and epigenetic modifications and can therefore be significan

49 e exposure after weaning) induced changes to epigenetic modifications and CTCF binding at select regu

50 of ATRX activates a pathway that integrates epigenetic modifications and DNA repair in response to c

51 rate metastatic potential for differences in epigenetic modifications and expression.

52 terations in gene expression, and that these epigenetic modifications and gene expression profiles ar

53 ect study of functional relevance of precise epigenetic modifications and gene regulation.

54 e authors discuss the expanding landscape of epigenetic modifications and highlight their importance

55 tion kinetics in long noncoding RNA-mediated epigenetic modifications and identify ERI-1 as an import

56 as novel molecular tools have revealed that epigenetic modifications and long noncoding RNAs (lncRNA

57 Epigenetic modifications and other chromatin features pa

58 FI16 restricts chromatinized HPV DNA through epigenetic modifications and plays a broad surveillance

59 of cytosine (5mC) is one of the best-studied epigenetic modifications and plays important roles in di

60 chanistic insight into the crosstalk between epigenetic modifications and post-translational modifica

61 fication of significant associations between epigenetic modifications and specific allelic variants i

62 trends in the associations between these two epigenetic modifications and the characteristics evaluat

63 e utilized in enzymatic reactions leading to epigenetic modifications and transcriptional regulation.

64 rted to alter global gene expression, induce epigenetic modifications, and interfere with complex reg

65 requires both transcription factor (TFs) and epigenetic modifications, and interplays between the two

66 omics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome.

67 structural proteins, transcription factors, epigenetic modifications, and transcription that togethe

68 These long-term epigenetic modifications are a plausible mechanism under

69 nd resistance to chemotherapeutic drugs, and epigenetic modifications are an attractive target in can

70 Epigenetic modifications are capable of shaping and stor

71 Epigenetic modifications are changes to the genome that

72 In contrast to genetic changes, epigenetic modifications are frequently reversible, whic

73 These epigenetic modifications are less stable than genetic al

74 These epigenetic modifications are maintained long-term in viv

75 As layered epigenetic modifications are often interdependent, we pr

76 nted statistical analyses to illustrate that epigenetic modifications are predictive of TF binding af

77 lood lineage emerges, Scl binding and active epigenetic modifications are sustained in hematopoietic

78 ption factors promote cell identities, while epigenetic modifications are thought to contribute to ma

79 Epigenetic modifications are thought to play a particula

80 Analysis of epigenetic modifications around the motifs showed, in mo

81 eukaryotic genome, and CpG methylation is an epigenetic modification associated with gene repression

82 entally regulated enhancers as a new type of epigenetic modification associated with the pathogenesis

83 pact kidney graft survival, especially those epigenetic modifications associated with early transplan

84 Identifying epigenetic modifications associated with elevated adipos

85 ts demonstrate the potential malleability of epigenetic modifications associated with mercury exposur

86 regeneration in adults, because of permanent epigenetic modification at Notch-responsive promoters.

87 CXCL4L1 expression was also controlled by epigenetic modifications at critical CpG islands, which

88 tions disrupting CG-rich loci, we quantified epigenetic modifications at DLGAP4 (SAPAP4), a key post-

89 sms that underlie this dichotomy, we studied epigenetic modifications at the Ccr7 locus of murine cDC

90 ate exposure, which was mediated by specific epigenetic modifications at the corresponding Bdnf gene

91 We suggest that repressive epigenetic modifications at the expanded GAA-FXN locus m

92 8+ T cells exhibited the opposite pattern of epigenetic modifications at the Gcnt1 locus, which encod

93 an important regulator of transcription and epigenetic modification, but the underlying mechanisms r

94 Epigenetic modifications by DNA methylation are associat

95 This method combines analysis of epigenetic modifications by immunostaining, localization

96 PRMT5) molecular complex that make important epigenetic modifications by methylating histone arginine

97 Here, we show that epigenetic modifications can be integrated into a case-c

98 Here we expand on earlier ideas that epigenetic modifications can drive neo- and subfunctiona

99 PRC2 target genes, suggesting that different epigenetic modifications can functionally substitute for

100 A growing body of evidence indicates that epigenetic modifications can provide efficient, dynamic,

101 Hyperglycemia induces SHP-1 promoter epigenetic modifications, causing its persistent express

102 coveries in signal transduction, metabolism, epigenetic modifications, cell cycle and genome maintena

103 whereby SK1 lipid signaling is regulated by epigenetic modifications conferred by KLF14 and p300.

104 long-term risk of postnatal disorders, while epigenetic modifications could be involved.

105 xidize fatty acids to produce acetyl-CoA for epigenetic modifications critical to lymphangiogenesis.

106 the activity of selected clock components or epigenetic modifications, depending on the time delay be

107 r the complex patterns of mutually exclusive epigenetic modifications deposited at different alleles

108 Epigenetic modifications, described as heritable but rev

109 trations of a DNA-protein interaction and an epigenetic modification directly regulating E3 ubiquitin

110 DNA methylation of OXTR, an epigenetic modification, directly influences gene transc

111 how that H3K27me3 is a dynamic and important epigenetic modification during CD4 T cell activation and

112 DNA methylation is an essential epigenetic modification during mammalian development, ye

113 tin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and

114 provides a novel framework for the timing of epigenetic modifications during the lifespan and transge

115 ing to transcription elongation, the role of epigenetic modifications during this critical transition

116 Accurate measurements of these changes of epigenetic modifications, especially the complex histone

117 tion of transcription factor (TF) binding or epigenetic modification events.

118 ducers of DNA damage (group 2), effectors of epigenetic modification (group 3), anthracyclines (group

119 including pioneer factors, coregulators and epigenetic modifications have been identified as regulat

120 Conventional methods for evaluating epigenetic modifications have inherent limitations and,

121 Our results support the notion that epigenetic modifications help define microbial community

122 additional connection between two conserved epigenetic modifications: histone modification and DNA m

123 cury exposure and DNA hydroxymethylation, an epigenetic modification important for tissue differentia

124 dation for future studies exploring this key epigenetic modification in fungal development and pathog

125 Such an epigenetic modification in GALR3, a hyperpolarizing rece

126 he cardiomyocyte and suggest a role for this epigenetic modification in heart development and disease

127 DNA methylation is a key epigenetic modification in mammals and plays important r

128 DNA methylation is an important epigenetic modification in many species that is critical

129 -lysine 27 (H3K27) as a critical residue for epigenetic modification in multiple myeloma.

130 A methylation is an important and widespread epigenetic modification in plant genomes, mediated by DN

131 ks metabolic adaptation to transgenerational epigenetic modification in response to acute periods of

132 the genomic locations of 5hmC, an important epigenetic modification in the DNA of higher organisms.

133 study highlights a critical role for an mRNA epigenetic modification in vivo and identifies regulator

134 sociated with impaired systemic immunity and epigenetic modifications in a key locus involved in atop

135 SF during late gestation induces epigenetic modifications in AdipoQ in male offspring mou

136 animal models have begun to reveal aberrant epigenetic modifications in brain and the periphery link

137 -limited literature that directly implicates epigenetic modifications in chronic pain syndromes.

138 Thus, epigenetic modifications in combination with CTCF bindin

139 he dynamics of transcriptional regulation or epigenetic modifications in complex biological systems.

140 e is a versatile tool to study the effect of epigenetic modifications in differentiation/development,

141 Although the roles of some epigenetic modifications in embryonic development have b

142 Our data demonstrate that epigenetic modifications in human macrophages are associ

143 hildhood asthma begins at birth and involves epigenetic modifications in immunoregulatory and proinfl

144 , we discuss evidence supporting the role of epigenetic modifications in ischemia-reperfusion injury,

145 ymethylcytosine (5hmC) are the two major DNA epigenetic modifications in mammalian genomes and play c

146 riptional programs, but also induces lasting epigenetic modifications in many target tissues.

147 hypothesize that bacteria are able to induce epigenetic modifications in oral epithelial cells mediat

148 o CCC, but little is known about the role of epigenetic modifications in pathological gene expression

149 However, the significance of epigenetic modifications in plant-pathogen interactions

150 d a critical role of Setd1a and its mediated epigenetic modifications in regulating the IgH rearrange

151 se sustained abnormalities are maintained by epigenetic modifications in specific brain regions.

152 Precise epigenetic modifications in stem cells control developme

153 g childhood/adolescence induces irreversible epigenetic modifications in the brain that persist follo

154 ypes; therefore, tools to selectively target epigenetic modifications in the desired cell type and st

155 de the latest findings on the involvement of epigenetic modifications in the development of periodont

156 Transregulation could also arise from epigenetic modifications in the F1.

157 butes to plant phenotypic plasticity because epigenetic modifications, in contrast to DNA sequence va

158 provide evidence on the associations between epigenetic modifications-in our case, CpG methylation-an

159 their relationship with parallel rhythms of epigenetic modification including histone acetylation, a

160 tudy, we found that dysbiosis in vivo led to epigenetic modifications, including acetylation of histo

161 Mammalian genomes undergo epigenetic modifications, including cytosine methylation

162 The reversible nature of epigenetic modifications, including DNA methylation, has

163 Epigenetic modifications, including DNA methylation, pla

164 Epigenetic modifications, including DNA methylation, rep

165 lar metabolites and nutrition levels control epigenetic modifications, including histone methylation.

166 CTCF binding to BCL6 exon1A associates with epigenetic modifications indicative of transcriptionally

167 This study highlights epigenetic modifications induced by captive rearing as a

168 reared salmon provides evidence for parallel epigenetic modifications induced by hatchery rearing in

169 We hypothesized that epigenetic modifications induced by microenvironmental i

170 ransposon insertion, SNP/indel mutation, and epigenetic modification influencing the broad range of n

171 DNA methylation is a key epigenetic modification involved in gene regulation whos

172 DNA methylation is an important epigenetic modification involved in many biological proc

173 DNA methylation is a key epigenetic modification involved in regulating gene expr

174 Cytosine methylation of DNA is an epigenetic modification involved in the repression of ge

175 ct EBV gene expression patterns regulated by epigenetic modifications involving DNA methylation and c

176 l type-specific analysis of nuclear mRNA and epigenetic modifications is crucial.

177 and 5-Hydroxymethylcytosine in DNA are major epigenetic modifications known to significantly alter ma

178 Global DNMT-dependent epigenetic modifications lead to changes in protein expr

179 Epigenetic modification may also affect the germ-line an

180 blood cell DNA methylation, suggesting that epigenetic modifications may be an important pathway und

181 Epigenetic modifications may exert their effect independ

182 Epigenetic modifications may influence the activation, p

183 Recent studies revealed that epigenetic modifications may play a role in the pathogen

184 Epigenetic modifications may play an important role in t

185 Our results suggest that epigenetic modifications may reveal the link between a m

186 nucleus accumbens core, likely mediated via epigenetic modifications, may render individuals more su

187 Whether a dysregulation of epigenetic modifications mediates this disruption in gen

188 In addition, the results show that epigenetic modification models for the predictions of TF

189 zation studies, dynamic expression analyses, epigenetic modification monitoring, and knockdown experi

190 As the most prevalent mammalian mRNA epigenetic modification, N6-methyladenosine (m6A) has be

191 ive/suppressed chromatin, thus qualifying as epigenetic modifications occurring as a result of neonat

192 Epigenetic modification of cancer cell genome is often l

193 her this signaling involves STAT activation, epigenetic modification of chromatin, or both mechanisms

194 DNA methylation is an epigenetic modification of DNA, where a methyl group is

195 5-methylcytosine (5mC) is a widely studied epigenetic modification of DNA.

196 maintained by a mechanism that involves both epigenetic modification of gene expression and antibody-

197 Preclinical studies have identified epigenetic modification of gene expression as one such m

198 Epigenetic modification of gene expression can underlie

199 Targeted epigenetic modification of HS2 silenced the expression o

200 for advanced glycation end products-mediated epigenetic modification of naive T cells leading to p38

201 ion was stable over time and correlated with epigenetic modification of the gene promoter.

202 a-associated neuroinflammation modulated the epigenetic modification of the Nlgn1 promoter, hippocamp

203 knowledge, that Notch signaling can regulate epigenetic modification of the Pgr.

204 e, Bcl-xL exerts metastatic function through epigenetic modification of the TGFbeta promoter to incre

205 , beta-d-glucosyl-hydroxymethyluracil, is an epigenetic modification of thymine in the nuclear DNA of

206 ssion of CD73 and folate receptor 4, and the epigenetic modification of Treg cell signature genes-and

207 ncy and carcinogenesis involve the selective epigenetic modification of viral and cellular genes.

208 Accumulating evidence suggests that epigenetic modifications of cccDNA contribute to viral r

209 t are analogous to the well-known reversible epigenetic modifications of DNA and histone proteins.

210 expression in mammals is how the patterns of epigenetic modifications of DNA are generated, recognize

211 DNA methylation is one of the key epigenetic modifications of DNA that results from the en

212 conditions such as low cholesterol levels by epigenetic modifications of genes.

213 ental stressors, FKBP5 genetic variants, and epigenetic modifications of glucocorticoid-responsive ge

214 Epigenetic modifications of histone tails play an essent

215 as synthetic receptors for the detection of epigenetic modifications of histones in physiological me

216 ional memory processes, particularly in men, epigenetic modifications of NR3C1 might affect the stren

217 sed nuclear localization of mutant TNNT2 and epigenetic modifications of PDE genes in both DCM iPSC-C

218 BAergic synapses onto VTA DA neurons through epigenetic modifications of postsynaptic scaffolding A-k

219 Dose-specific epigenetic modifications of selected genes provide a mec

220 Epigenetic modifications of specific amino acid residues

221 Epigenetic modifications of specific genes in the APC pl

222 Epigenetic modifications of stem cell genome including D

223 Epigenetic modifications of the newly identified loci mi

224 transcription (HSV-1, HCMV, and HPV) through epigenetic modifications of the viral genomes.

225 expression status is strictly controlled by epigenetic modifications on chromatin.

226 However, the impact of epigenetic modifications on the outcomes of kidney trans

227 cancers, were also shown to be influenced by epigenetic modifications on the viral and cellular genom

228 Recent clinical studies have suggested that epigenetic modification, particularly methylation of gen

229 ern of a comprehensive panel of TSGs and the epigenetic modifications, particularly methylation of th

230 sferases conferring widespread variations in epigenetic modification patterns.

231 ndings corroborate the emerging concept that epigenetic modifications play a role in the development

232 Epigenetic modifications play critical roles in diverse

233 Histone tails and their epigenetic modifications play crucial roles in gene expr

234 Transcription factors (TFs) and epigenetic modifications play crucial roles in the regul

235 and memory of honeybees by regulating other epigenetic modification processes.

236 These results suggest the epigenetic modification products of 5caC behave as DNA l

237 The precision manipulation of chromatin and epigenetic modifications provides new ways to interrogat

238 Such EBV-induced epigenetic modification recapitulated the hypermethylate

239 diate phenotypes such as DNA methylation, an epigenetic modification regulating gene expression, may

240 DNA methylation is a major epigenetic modification regulating gene expression.

241 Epigenetic modifications represent a potential mediator

242 rks of cytokines, transcription factors, and epigenetic modifications, resulting in the generation of

243 f factors beyond the DNA sequence, including epigenetic modifications, RNA transcripts, proteins, and

244 exposure to environmental agents), but some epigenetic modifications seem to persist, even for decad

245 Epigenetic modifications sit 'on top of' the genome and

246 Ser-Pro-Thr-Ser-Pro-Ser motif with potential epigenetic modification sites.

247 Although the importance of epigenetic modifications specifically DNA methylation to

248 Epigenetic modifications such as cytosine methylation an

249 Individual studies have shown that epigenetic modifications such as DNA methylation could c

250 Epigenetic modifications such as DNA methylation may pro

251 s less predictive for enhancer activity than epigenetic modifications such as H3K4me1 or the accessib

252 Epigenetic modifications, such as DNA methylation, may c

253 ong-term persistence of specific patterns of epigenetic modifications, such as DNA methylation, we pr

254 terochromatin and associated with repressive epigenetic modifications, such as H3K9me3 and C5 cytosin

255 iated with a number of health outcomes, with epigenetic modification suggested as a potential mechani

256 rrent strategies to alter disease-associated epigenetic modifications target ubiquitously expressed e

257 promoter, concomitant with agonist-specific epigenetic modifications targeting histone H4 lysine ace

258 n and more tolerance-prone immunological and epigenetic modifications than OIT alone.

259 DNA methylation is a key epigenetic modification that can modulate gene expressio

260 DNA methylation is a repressive epigenetic modification that covers vertebrate genomes.

261 DNA methylation is an epigenetic modification that differs between plant organ

262 DNA methylation is an important epigenetic modification that has essential roles in cell

263 5-Hydroxymethylcytosine (5-hmC) is an epigenetic modification that has not been studied in pan

264 a global decrease in histone acetylation, an epigenetic modification that is associated with gene act

265 hylation of CpG dinucleotides is a prevalent epigenetic modification that is required for proper deve

266 DNA methylation is an epigenetic modification that is studied at a single-base

267 e the trimethylation of H3K27 (H3K27me3), an epigenetic modification that marks transcriptional repre

268 DNA methylation is an epigenetic modification that plays a key role in gene re

269 DNA methylation is an epigenetic modification that plays important roles on ge

270 DNA methylation is an important epigenetic modification that regulates development of pl

271 roxymethylcytosine (5hmC) represents a novel epigenetic modification that regulates dynamic gene expr

272 on at the 5-position of cytosine (5mC) is an epigenetic modification that regulates gene expression a

273 lineage-specifying transcription factors and epigenetic modifications that allow appropriate repressi

274 d into adulthood of animals through specific epigenetic modifications that allow for selective gene e

275 response to disuse is accompanied by dynamic epigenetic modifications that are associated with altera

276 odifications, S-nitrosation, and genome-wide epigenetic modifications that can have both tumor-promot

277 to lifelong molecular changes in the form of epigenetic modifications that can set the organism off o

278 scade of activated transcription factors and epigenetic modifications that drive gene transcription r

279 ng cells and provide preliminary evidence of epigenetic modifications that might translate to pulmona

280 ng of transcription factors and accompanying epigenetic modifications that occur during osteogenic an

281 cues can be mechanistically translated into epigenetic modifications that regulate skeletal muscle s

282 adaptive and maladaptive consequences of the epigenetic modifications that result from complex enviro

283 imitations include the tissue specificity of epigenetic modifications, the phenomenologic definition

284 Such epigenetic modifications therefore provide a rapid and g

285 ays involved in the fibrosis and may recover epigenetic modification; therefore, it could possibly be

286 hese data suggest that dietary modulation of epigenetic modifications through elevation of beta-hydro

287 keletal organization and gene expression and epigenetic modification to be in high abundance.

288 evious results, diet-induced obesity induces epigenetic modifications to chromatin in mouse liver.

289 he identification and discrimination of four epigenetic modifications to cytosine in the proposed act

290 TGS can result in long-term stable epigenetic modifications to gene expression that can be

291 vel evidence supporting a potential role for epigenetic modifications to the genome in D. magna envir

292 Trends for both epigenetic modifications were consistent across potentia

293 ine subclones such as structural variants or epigenetic modifications were not assessed.

294 These epigenetic modifications were significantly linked to di

295 CpG methylation in promoters is an epigenetic modification, which regulates gene transcript

296 al stem cells are susceptible to genetic and epigenetic modifications, which facilitate oncogenic tra

297 onary mechanisms, such as gene mutations and epigenetic modifications, which is manifested in the for

298 DNA methylation is a dynamic epigenetic modification with an important role in cell f

299 DNA methylation is an epigenetic modification with important roles in many bio

300 -/-) CD4(+) T cells do not obtain permissive epigenetic modifications within the Th2 locus, which wer