ライフサイエンスコーパス: epigenetically

1 their host, which responds by silencing them epigenetically.

2 elsewhere within the nucleus, are repressed epigenetically.

3 ng that the row type in barley is determined epigenetically.

4 coamplified passenger genes may be silenced epigenetically.

5 pression in premalignant cells are regulated epigenetically.

6 cruitment of a novel RARbeta-TET2 complex to epigenetically activate a specific cohort of gene target

7 2 to recruit histone-remodeling factors that epigenetically activate transcriptionally silent rDNA.

8 both AtDRB7.2 and AtDRB4 participate in the epigenetically activated siRNAs pathway.

9 RNAs could help to tighten the expression of epigenetically activated TEs and genes using the methyla

10 an also give rise to abundant 21-nucleotide 'epigenetically activated' small interfering RNAs (easiRN

11 mation of the chromatin modifier PRC2 and by epigenetically activating NOTCH signals in human colorec

12 RMT5 promotes prostate cancer cell growth by epigenetically activating transcription of the androgen

13 ial and survival of human colorectal CSCs by epigenetically activating Wnt target gene transcription.

14 BPA has been shown to epigenetically affect the developing nervous system, but

15 iscent of defects in dominant mutations that epigenetically affect the specification of female gamete

16 Many imprinted genes are often epigenetically affected in human cancers due to their fu

17 t that 5-HT(2A) receptor-dependent signaling epigenetically affects mGlu2 transcription in mouse fron

18 VHL-deficient ccRCC cells, we discovered an epigenetically altered VHL-HIF response that is specific

19 and the molecular heterogeneity among 1,256 epigenetically analysed cases, and identify subgroup-spe

20 investigate this further, we genetically and epigenetically analyzed 192 ATRTs.

21 odifications to identify multiple classes of epigenetically and functionally distinct cis-regulatory

22 Many of these actions occur epigenetically and result in ever-changing patterns of g

23 hese elements divide the Igh locus into four epigenetically and transcriptionally distinct domains, a

24 ars) become more similar to each other, both epigenetically and transcriptionally, compared with youn

25 strate that cellular plasticity is regulated epigenetically, and that mesenchymal-like tumor cell pop

26 cells that are inconsistent with classical, epigenetically based theories of disease progression, su

27 discuss emerging regulatory implications of epigenetically bookmarking genes during mitosis for phys

28 Rather, they are specified epigenetically by a centromere-specific histone H3 varia

29 timal FAS expression, FAS can be upregulated epigenetically by derepression of the FAS promoter using

30 wever, AID may also regulate gene expression epigenetically by directly deaminating 5-methylcytosine

31 evidence that miR-34a expression is silenced epigenetically by EZH2 and DNA methylation, which promot

32 hed for repetitive sequences, and is defined epigenetically by methylation of histone H3 at lysine 9

33 nal programme of vertebrate cells is carried epigenetically by post-translational modifications of hi

34 In most eukaryotes, centromeres are defined epigenetically by presence of the histone H3 variant CEN

35 t nestin regulation is negatively controlled epigenetically by TET2 via 5-hmC binding at the 3' untra

36 attachment during cell division, are marked epigenetically by the centromere-specific histone H3 var

37 Centromeres are specified epigenetically by the heritable incorporation of the cen

38 Centromeres are specified epigenetically by the incorporation of the histone H3 va

39 enetically disordered, state and a crumpled, epigenetically coherent, one.

40 erning gene expression, we employed a unique epigenetically controlled and highly tissue-specific gre

41 ly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs).

42 MSPC senescence is epigenetically controlled by the polycomb histone methyl

43 A search for epigenetically controlled endothelial lncRNAs yielded ln

44 ARID5B expression, possibly regulated by an epigenetically controlled enhancer, promotes atheroscler

45 signaling pathways or neuroinflammation are epigenetically controlled in the fibrotic disorders invo

46 Epigenetically controlled lncRNAs in human umbilical vei

47 Activated PC epigenetically controls expression of the redox-regulati

48 is a strategy that restricts propagation of epigenetically damaged cells during embryogenesis.

49 TSS(-50kbLoop) was enriched with nucleosomes epigenetically decorated with the transcriptional mark,

50 or chromosome segregation during mitosis, is epigenetically defined by CENP-A containing chromatin.

51 Centromeres of higher eukaryotes are epigenetically defined by centromere protein A (CENP-A),

52 Vertebrate centromeres are epigenetically defined by nucleosomes containing the his

53 ce, whereas regional and holocentromeres are epigenetically defined by the location of cenH3-containi

54 equisite is genome compartmentation into two epigenetically defined chromatin fractions.

55 fic enhancement by CENP-B of the fidelity of epigenetically defined human centromere function.

56 Genetically or epigenetically defined reprogramming is a hallmark of ca

57 ger et al. elegantly demonstrates that three epigenetically defined, and functionally disparate, chro

58 peat sequences (satellite DNA) and for being epigenetically defined.

59 lung maturation in the prenatal period were epigenetically deregulated and could be linked with whee

60 didates for this deadly malignancy, which is epigenetically deregulated but genetically bland.

61 monstrating how it successfully retrieves an epigenetically deregulated gene, previously known to dri

62 f these genes, suggesting that a core set of epigenetically deregulated genes is central to the initi

63 , in the same cancer, FEM identified a novel epigenetically deregulated hotspot, directly upstream of

64 ation prevents adipogenic gene expression by epigenetically deregulating long-range enhancers of the

65 tal myocytes and activate transcription when epigenetically derepressed in FSHD, resulting in the pat

66 The centromere is an epigenetically designated chromatin domain that is essen

67 We have previously described an epigenetically determined reversibly drug-tolerant subpo

68 centromere-specific histone H3 variant that epigenetically determines centromere identity to ensure

69 ells, whereas classical ERalpha signaling is epigenetically disengaged.

70 goes a sharp transition between a stretched, epigenetically disordered, state and a crumpled, epigene

71 These genes are epigenetically disrupted at the earliest stages of malig

72 uenced molecules, indicating the presence of epigenetically distinct cellular subpopulations.

73 How these two epigenetically distinct genomes are spatially organized

74 te that over half of the cases have multiple epigenetically distinct subclones and determine the prim

75 promoter hypermethylation, whereas PMF is an epigenetically distinct subgroup characterized by both a

76 roup, cases with ASXL1 disruptions formed an epigenetically distinct subgroup with relatively increas

77 L LSCs and their blast progeny, and identify epigenetically distinct subgroups of AML likely reflecti

78 Here, we identified an epigenetically distinct subpopulation of breast tumor ce

79 sults illustrate the biological relevance of epigenetically distinct subpopulations that in part unde

80 e chromatin conformations at these loci were epigenetically distinct.

81 ds), which we derived from near-isogenic but epigenetically divergent parents.

82 Adenomas were epigenetically diverse populations, suggesting that they

83 This high degree of epigenetically driven cell autonomy among HSCs implies t

84 We therefore expected that epigenetically driven developmental pathways regulated b

85 We also show that epigenetically driven effects are strongly enriched in r

86 ly pathogenic event, and are associated with epigenetically driven modulations of metabolism.

87 Genomic imprinting is an epigenetically-driven phenomenon that responds to enviro

88 preferentially reduced growth in a subset of epigenetically dysregulated colon cancers characterized

89 Profiling the array of genes that are epigenetically dysregulated in response to neuronal insu

90 Thus, metastasis in ccRCC is based on an epigenetically expanded output of the tumor-initiating p

91 riable, tissue-specific, flux dependent, and epigenetically fixed.

92 y lymphocytes have imprinted their Il4 genes epigenetically for expression in dependence of T cell re

93 The epigenetically forced expression of Runx2/p57 and osteoc

94 g intrauterine growth restriction (IUGR), is epigenetically heritable.

95 moter-independent repression of genes and is epigenetically heritable.

96 le subtypes with genetically and most likely epigenetically heterogeneous tumors composed of numerous

97 Epigenetically, histone deacetylase (HDAC) classes I and

98 and perturbs the expression of a network of epigenetically imprinted genes that have been implicated

99 henotypic state of a cell can be transmitted epigenetically in cell division, leading to correlations

100 -suppressing, paradoxically upregulate c-Myc epigenetically in concert with a cascade of MLL2-associa

101 fusions in which the altered centromere was epigenetically inactivated.

102 lement generates maternal allele identity by epigenetically inactivating the PWS-SRO in oocytes so th

103 , the TEtra factors occupy multiple sites in epigenetically inactive placental genes and in OCT4 Func

104 at the promoters of miR-150 and miR-143 and epigenetically induce their expression.

105 Whereas epigenetically induced changes in gene expression may co

106 Another is the epigenetically induced reprogramming and diversification

107 r, our results reveal the plasticity and the epigenetically inheritable nature of centromeric chromat

108 trains" or "variants," each with a distinct, epigenetically inheritable phenotype.

109 Polycomb group (PcG) proteins contribute to epigenetically inheritable phenotypic variability.

110 tein receptor-2 or activin-like kinase-1, or epigenetically inherited (as a result of epigenetic sile

111 spanned 4-4.5 kbp, consistent with regional epigenetically inherited centromeres.

112 chromatin-level silencing that in plants is epigenetically inherited from generation to generation.

113 Heterochromatin can be epigenetically inherited in cis, leading to stable gene

114 These domains can be epigenetically inherited when epe1(+) , encoding an enzy

115 es lack a conserved sequence and instead are epigenetically inherited.

116 n the environment but that it potentially is epigenetically inherited.

117 ing RNAs (siRNAs) and modify TE chromatin to epigenetically inhibit transcription.

118 In summary, MO epigenetically limits the expansion capacity of offsprin

119 This developmentally patterned and epigenetically maintained commitment of stem cells is li

120 FLC repression is also epigenetically maintained during subsequent development

121 Thus, epigenetically marked cis-elements can protect cell iden

122 iched for links between active promoters and epigenetically marked enhancers.

123 tromere protein A (CENP-A), is essential for epigenetically marking centromere location.

124 tion in human and mouse MDS and suggest that epigenetically, MDS displays an accelerated aging phenot

125 Collectively, these results suggest that an epigenetically mediated immune response is a predictor o

126 hlight the relevance of the NF-kB pathway in epigenetically mediated miRNA control in B cell transfor

127 inhibitor-refractory tumors, which supports epigenetically mediated reversal of treatment resistance

128 underpins how discrete polyphenic traits in epigenetically metastable conditions can contribute to a

129 s been related to 5-methylcytosine (5mC), an epigenetically modified base which resides in CpGs and p

130 ly synthesized DNA from the incorporation of epigenetically modified forms of cytosine.

131 one-pot gene-assembly method by preparing an epigenetically modified variant of the iLOV gene.

132 that can be pharmacologically addressed with epigenetically modifying drugs, such as histone deacetyl

133 eactive oxygen and nitrogen species that can epigenetically modulate DNA methylation, histone deacety

134 Furthermore, microRNA-200a expression is epigenetically modulated by both DNA methylation at the

135 Together, these results suggest that KLF4 epigenetically modulates podocyte phenotype and function

136 that Mel-18 negatively regulates the EMT by epigenetically modulating miR-205.

137 entation of chromosomes specifically for the epigenetically most modified TADs.

138 es, yet centromere function can be specified epigenetically on single-copy DNA by the presence of nuc

139 indicating that cardiac form and function is epigenetically optimized to accommodate vortex ring form

140 and developmental cues, and then maintained epigenetically over many cell divisions, remains poor.

141 ors but can also regulate gene expression by epigenetically phosphorylating histone H3 on tyrosine 41

142 pmentally critical genes is maintained in an epigenetically poised (bivalent) state from embryonic st

143 We propose that the epigenetically poised condition of these developmental g

144 ure ILCs but have these signature loci in an epigenetically poised configuration.

145 The present study aimed to test whether MO epigenetically predisposes adipocyte progenitors in the

146 These epigenetically "preprogrammed" macrophages result in poi

147 Naive CD4(+) T cells lacking Ezh2 were epigenetically primed for overproduction of IFN-gamma in

148 atopoietic and cardiac enhancers that become epigenetically primed in multipotent cardiovascular meso

149 This intervention epigenetically primes the expression of neuroplasticity-

150 l regulators of animal development gained an epigenetically privileged state in germ cells, manifeste

151 man lung epithelial cells, some of which are epigenetically programmed at the level of miRNA regulati

152 Here, we show that sperm is epigenetically programmed to regulate embryonic gene exp

153 r earliest life forms, on which CSCs have an epigenetically programmed, targetable dependence.

154 a type II neuroblast functional identity by epigenetically promoting Btd expression, thereby maintai

155 ity drives the malignant behavior of MECs by epigenetically promoting C/EBPbeta expression to directl

156 Dnmt1 epigenetically propagates symmetrical CG methylation in

157 st organisms, centromere activity is defined epigenetically, rather than by specific DNA sequences.

158 ansposon transcripts, but only when they are epigenetically reactivated during reprogramming of the g

159 HDACs epigenetically regulate cellular processes by modifying

160 In addition, tyrosine kinases epigenetically regulate DNA damage signaling pathways by

161 Tet3 serves as a synaptic activity sensor to epigenetically regulate fundamental properties and meta-

162 mmals use X chromosome inactivation (XCI) to epigenetically regulate gene expression from approximate

163 erized subclass of long ncRNAs (lncRNAs) can epigenetically regulate protein-coding genes by interact

164 hancers of BMP-targeted cardiogenic genes to epigenetically regulate their expression.

165 We also found that miR-124-3p is epigenetically regulated and its interaction with the RN

166 ls, continuously evading host immunity using epigenetically regulated antigenic variation of virulenc

167 d also indicate that they are differentially epigenetically regulated beyond X chromosome imprinting.

168 igated whether the expression of miR-133a is epigenetically regulated by class I and IIb HDACs during

169 genes involved in synaptic communication are epigenetically regulated by H3K9me1 in dependent rats.

170 echanism by which drug-induced senescence is epigenetically regulated by macroH2A1 and DNA methylatio

171 messenger RNA and protein downregulation is epigenetically regulated by microRNAs from brain astrocy

172 These gene expression asymmetries were epigenetically regulated by miRNA expression asymmetries

173 rental level, suggesting that miR-663 may be epigenetically regulated by retrograde signaling.

174 ppa physiology, whereby this receptor may be epigenetically regulated by stressful experiences, in pa

175 vel computational method that identified 840 epigenetically regulated candidate genes and predicted t

176 This study identifies a novel epigenetically regulated circuit that integrates microRN

177 nes within virions but are chromatinized and epigenetically regulated following delivery to the host

178 epressing the FOXO/c-Myc axis, unraveling an epigenetically regulated FOXO/c-Myc axis as a potential

179 ive tools are important for the discovery of epigenetically regulated gene modules or molecular pathw

180 Epigenetically regulated heterochromatin domains govern

181 gene expression changes were PYGM, which was epigenetically regulated in both groups, and ANGPTL4, wh

182 PTX3 expression was epigenetically regulated in selected human tumors (e.g.,

183 Most of the genes are epigenetically regulated independently of underlying mut

184 Known imprinted regions are enriched among epigenetically regulated loci, but we also observe sever

185 cing we demonstrate that miR-663 promoter is epigenetically regulated not only by genetic but also by

186 These findings establish VAV1 as a critical epigenetically regulated oncogene with a key role in MBS

187 ternative splicing (AS) is a genetically and epigenetically regulated pre-mRNA processing to increase

188 In this study, we identified miR-192 as an epigenetically regulated suppressor gene with predictive

189 ng not only the protein isoforms but also an epigenetically regulated transcriptional program at the

190 ession data led to the identification of the epigenetically regulated tumor modulating genes GPX3, RB

191 miR-376 and miR-154 - which localized to the epigenetically regulated, maternally imprinted chromosom

192 evidence that inflammation in PTSD could be epigenetically regulated.

193 at structural changes and polymer length are epigenetically regulated.

194 l genomic regions (e.g., HOX genes) as being epigenetically regulated.

195 d (ASM or mQTL) and 14% as being putatively epigenetically regulated.

196 on during the prophase I arrest is primarily epigenetically regulated.

197 Thus, Smarcd3/Baf60c epigenetically regulates EMT by activating WNT signaling

198 PRC2 epigenetically regulates gene expression by applying met

199 The histone acetyltransferase (HAT) Tip60 epigenetically regulates genes enriched for neuronal fun

200 These results strongly argue that O-GlcNAc epigenetically regulates MYBL1, functioning similarly to

201 interplay between HMGNs and H1 in chromatin epigenetically regulates the expression of OLIG1&2, ther

202 n important role for the Tet2-Foxo3a axis in epigenetically regulating critical genes in aNSCs during

203 eration during cardiovascular development by epigenetically regulating expression of a set of cell cy

204 We aimed at investigating EZH2's role in epigenetically regulating Wnt/beta-catenin signaling fol

205 e FLC chromatin state, and how this state is epigenetically remembered.

206 E3A was sufficient to stabilize SIRT6 and to epigenetically repress ANXA2, a key mediator of UBE3A on

207 We show that 3-OST3A is epigenetically repressed in all breast cancer cell lines

208 em in which avian sarcoma virus (ASV) DNA is epigenetically repressed in mammalian cells, we previous

209 repeats of the ERV9/LTR12 family, which are epigenetically repressed in virtually all normal cells.

210 mpromise that the maternal allele has become epigenetically repressed rather than genetically deleted

211 We used these data to identify epigenetically repressed tumor suppressor genes with pro

212 (OCT4 and NANOG) were transcriptionally and epigenetically repressed.

213 ressor 1 (Rcor1) and regulates cell fates by epigenetically repressing gene targets.

214 study uncovers a critical role for MYSM1 in epigenetically repressing plasma cell differentiation an

215 rect deployment of developmental programs by epigenetically repressing target gene expression.

216 contrast, PcG members restrain senescence by epigenetically repressing the expression of these SA-miR

217 ith the LC3B, WIPI1, and DOR gene promoters, epigenetically repressing them.

218 ize to inhibit nucleotide excision repair by epigenetically repressing XPC and inhibiting the E2F4/DP

219 overweight around the time of conception can epigenetically reprogram father's germ-line and modulate

220 EBV can epigenetically reprogram lymphocyte-specific processes a

221 rable upregulation of stem cell markers that epigenetically reprogram these cells.

222 ma with aging and mechanistic connections to epigenetically reprogramed genes.

223 indicate that dividing CB CD34+ cells can be epigenetically reprogrammed by treatment with VPA so as

224 Newly generated beta-like cells are epigenetically reprogrammed, functional and glucose resp

225 n of highly heterogeneous clones of HSC with epigenetically scripted behaviors.

226 ecent findings indicate little plasticity of epigenetically scripted hematopoietic stem/progenitors.

227 Centromeric chromatin epigenetically seeds new CENP-A nucleosome formation, th

228 ogether, these results suggest that UPEC can epigenetically silence BIM expression, a molecular switc

229 cation and the activation of mechanisms that epigenetically silence the genes encoded by the foreign

230 echanistically, BIM expression appears to be epigenetically silenced by a decrease in histone 4 acety

231 t in eukaryotic genomes which are in general epigenetically silenced by DNA methylation and/or histon

232 e promiscuous expression of genes previously epigenetically silenced by Polycomb group proteins.

233 FLC is epigenetically silenced by prolonged cold in a process c

234 emethylation treatment showed that NR4A3 was epigenetically silenced by promoter DNA methylation in S

235 The locus is epigenetically silenced by the repressive Polycomb compl

236 ERVs are epigenetically silenced during development, yet the cell

237 e progenitor genes and cell cycle genes were epigenetically silenced during retinogenesis, the most d

238 erferes with this polymerization, but HbF is epigenetically silenced from infancy onward by DNA methy

239 action for nicotinamide in reactivating the epigenetically silenced FXN gene and therefore support t

240 turn, these microRNAs induce reexpression of epigenetically silenced genes by targeting DNA methyltra

241 Restoring the expression of the epigenetically silenced genes in wild-type fibroblasts w

242 Here, we determine the contribution of epigenetically silenced genes to the development of PDAC

243 its ability to reactivate the expression of epigenetically silenced genes.

244 Importantly, we found that SPARC was epigenetically silenced in aggressive cells by promoter

245 xpression of gamma interferon (IFN-gamma) is epigenetically silenced in anergic effector TH1 cells.

246 in And Metalloproteinase 23 (ADAM23) gene is epigenetically silenced in different types of tumors, an

247 ylated, indicating that these genes were not epigenetically silenced in HNSCC tumors.

248 cer 1) is a tumor suppressor gene frequently epigenetically silenced in human cancers.

249 in elucidating genes and microRNAs that are epigenetically silenced in lung cancer and highlights ho

250 tion of SPINT2, suggesting that this gene is epigenetically silenced in malignant melanomas.

251 The tumor suppressor gene RASSF1A is epigenetically silenced in most human cancers.

252 The paternal UBE3A/Ube3a allele becomes epigenetically silenced in most neurons during postnatal

253 (m-/p+) mice, because the paternal allele is epigenetically silenced in most neurons.

254 -506 acts as a tumor suppressor miRNA and is epigenetically silenced in pancreatic cancer.

255 as-GTPase-activating protein, was frequently epigenetically silenced in RCC, and DAB2IP loss was corr

256 APs) with dual RasGAP/RapGAP specificity, is epigenetically silenced in several tumor types.

257 s a chaperone of vitamin A (retinol) that is epigenetically silenced in ~25% of human breast cancers.

258 rasites pfap2-g appears to be among a set of epigenetically silenced loci prone to spontaneous activa

259 nificant tumor regression and restoration of epigenetically silenced RAR-beta expression.

260 ter regulator of sexual development, from an epigenetically silenced state during asexual replication

261 son theory of aging, which hypothesizes that epigenetically silenced TEs become deleteriously activat

262 ion that threatens genome integrity, TEs are epigenetically silenced through several pathways, and th

263 of MOAP-1) is one of the earliest detectable epigenetically silenced tumor suppressor proteins in can

264 se findings demonstrate that GPC5 is a novel epigenetically silenced tumor suppressor, which inhibits

265 a subset of TSs (CDKN1A and FOXO3A) that are epigenetically silenced via DNA methylation, and cytopla

266 In conclusion, we found that WIF1 is epigenetically silenced via promoter DNA methylation in

267 cancer genes, BRM is not mutated, but rather epigenetically silenced.

268 Taken together, aberrant JAK/STAT3 signaling epigenetically silences a potential tumor suppressor, NR

269 udy, we investigated the role of EZH2, which epigenetically silences gene expression by histone methy

270 SIRTs mediate KSHV latency by epigenetically silencing a key KSHV lytic replication ac

271 e the miR-34a promoter simultaneously, hence epigenetically silencing miR-34a expression independent

272 ghts on the healthy cell types that are more epigenetically similar to the disease samples.

273 In most organisms, centromeres are epigenetically specified and propagated by nucleosomes c

274 dependent on DNA sequence, but rather it is epigenetically specified by the histone H3 variant centr

275 that control chromosome segregation, and are epigenetically specified by the presence of the CENP-A c

276 Centromeres are epigenetically specified by the presence of the histone

277 indicate that the food-derived compound SFN epigenetically stimulates osteoblast activity and dimini

278 ants quantitatively sense long-term cold and epigenetically store this cold-exposure information to r

279 In vitro, TbetaRIII expression was epigenetically suppressed by MYCN-mediated recruitment o

280 which modulate the fibrotic reaction and are epigenetically suppressed in SSc dermal fibroblasts, Fri

281 otic stress can release the transcription of epigenetically suppressed transposons and, noticeably, t

282 n and Hedgehog signaling whereby menin/PRMT5 epigenetically suppresses Hedgehog signaling, revealing

283 fferentiation of hESCs at least partially by epigenetically sustaining miR-302 expression and that JM

284 ectly and indirectly modulate over a hundred epigenetically targeted circadian "output" genes in the

285 L31 locus as an example, we demonstrate that epigenetically targeted sequences function as distantly-

286 pproach, we applied this method to screen an epigenetically targeted small molecule library by evalua

287 Centromeres are specified epigenetically through the deposition of the centromere-

288 vertebrate cells, centromeres are specified epigenetically through the deposition of the centromere-

289 which immunological memory state is encoded epigenetically, through poising and transcriptional memo

290 Responses to hypoxia can be mediated epigenetically, thus we investigated whether BETi JQ1 co

291 esults in a decreased IP7 concentration that epigenetically translates to reduced levels of trimethyl

292 e contains several prion elements, which are epigenetically transmitted as self-perpetuating protein

293 be, which has been implicated in inducing an epigenetically transmitted prion state.

294 ate that H3K27me and PRC2 each contribute to epigenetically transmitting the memory of repression acr

295 The present results uncover a spectrum of epigenetically unique adaptive NK cell subsets that dive

296 nd that the orphan nuclear receptor NR2F1 is epigenetically upregulated in experimental head and neck

297 oleraceum and Zea mays, although specifying epigenetically weaker centromeres that result in genome

298 on DNMT1 to modulate the expression of foxp3 epigenetically, which marks mother cell iTreg lineage ch

299 ternal chromosome are present, but repressed epigenetically, which provides an opportunity for the us

300 ome positioning and so alter gene expression epigenetically (without changing DNA sequence).