ライフサイエンスコーパス: epigenetics

1 ergence of a novel mechanism coupling AS and epigenetics.

2 Bisulfite sequencing is a key methodology in epigenetics.

3 kely influence the broader research field of epigenetics.

4 field of biology referred to as the study of epigenetics.

5 one modification events studied by classical epigenetics.

6 terpret results in the fast growing field of epigenetics.

7 itable differences that could be mediated by epigenetics.

8 elopmental plasticity and may be mediated by epigenetics.

9 ging, but not yet fully elucidated, field of epigenetics.

10 link between the primed state in plants and epigenetics.

11 cium tetraurelia, a long-standing problem in epigenetics.

12 sion, and metastasis; energy metabolism; and epigenetics.

13 remodeling of nuclear factors that influence epigenetics.

14 rds developmental and environmental cues, is epigenetics.

15 pathways and molecular mechanisms including epigenetics.

16 rition can affect hypothalamic developmental epigenetics.

17 ientists in advancing the field of synthetic epigenetics.

18 be largely explained by disordered stem cell epigenetics.

19 ng appreciation for the role of ncRNA in RNA epigenetics.

20 in after thoracic surgery may be mediated by epigenetics.

21 egulates cell stress responses, mitosis, and epigenetics.

22 ogy, epidemiology, disease surveillance, and epigenetics.

23 therefore be included in analyses of cancer epigenetics.

24 -molecule probe of chromatin and its role in epigenetics.

25 arded as the most indispensible phenomena in epigenetics.

26 for mammalian transcriptional regulation and epigenetics.

27 d in the fields of genomics, proteomics, and epigenetics.

28 group metabolism can significantly influence epigenetics.

29 ular choreography is central to the field of epigenetics.

30 rtunities to explore in translational cancer epigenetics.

31 challenge for current and future research in epigenetics.

32 iscovered to the present day of big data and epigenetics.

33 suggest a connection between metabolism and epigenetics.

34 llmarks associated with protein turnover and epigenetics.

35 via alterations of local gene expression or epigenetics.

36 atures collectively constitute architectural epigenetics, a novel and essential mechanism that convey

37 ckground, we hypothesize that differences in epigenetics account for the striking functional differen

38 xamples in which chromatin modifications and epigenetics affect important plant processes.

39 The importance of genetic susceptibility, epigenetics, aging, and the modern-day environment are h

40 e against generically equating chromatin and epigenetics; although many examples of epigenetics invol

41 These methods will open up epigenetics analyses to the proteomics community who do

42 t disease and supports a key contribution of epigenetics and a prenatal cell of origin during a criti

43 mechanisms to suppress genome dynamism (e.g. epigenetics and activity of transposable elements).

44 that have critical roles in gene expression, epigenetics and cancer.

45 n synthesis, providing a direct link between epigenetics and cell-cycle progression.

46 These findings shed light on the epigenetics and cellular origins of lineage-specific lun

47 omic distances, and the relationship between epigenetics and chromatin structure and how they relate

48 providing new insights into the link between epigenetics and developmental patterning.

49 cise overview of the fundamental concepts in epigenetics and discuss how epigenetics may be incorpora

50 omatin plasticity, cell differentiation, and epigenetics and discusses current progress and future pe

51 provide an overview of the current state of epigenetics and epigenetic therapy in AML and will descr

52 nd macromolecules such as starch and lipids, epigenetics and epigenomics, genome-wide association stu

53 Epigenetics and experiences of societal inequality (allo

54 cs is defined in opposition to developmental epigenetics and implies an absence of resetting of epige

55 thylation on histones is a central player in epigenetics and in gene activation and repression.

56 e level of not only gene expression but also epigenetics and inter-individual variation.

57 and DNA methylation; the connection between epigenetics and metabolic pathways; new studies on the m

58 s of the brain, providing a resource for the epigenetics and neuroscience research communities.

59 quantify links between tumour metabolism and epigenetics and outline clinical implications.

60 e main tasks on Infectious Diseases (ID) and Epigenetics and Post-translational Modifications (EPI),

61 ptome, and also emphasises the importance of epigenetics and post-translational modifications in long

62 .0% F1) and Task 2 (53.9%), 2nd place in the Epigenetics and Post-translational Modifications track (

63 Despite growing evidence associating epigenetics and psychiatric disorders, it is unclear how

64 roles of the chromatin-modifying enzymes in epigenetics and structural similarity among many PMTs, w

65 ting the lack of standardized definitions of epigenetics and the limited empirical support for potent

66 icroenvironment has a broad impact in cancer epigenetics and therapeutics.

67 Metabolism has been shown to integrate with epigenetics and transcription to modulate cell fate and

68 icance of an RNA silencing signal to embrace epigenetics and transcriptional gene silencing and suppo

69 Over the past 25 years, the broad field of epigenetics and, over the past decade in particular, the

70 This field is called "epigenetics" and broadly encompasses changes in the meth

71 onsideration of gene-gene, environment-gene (epigenetics), and sex-gene interactions, genome-wide ass

72 onal annotation, protein structure modeling, epigenetics, and association studies to identify and ext

73 erial choline metabolism on host metabolism, epigenetics, and behavior.

74 f their roles in transcriptional regulation, epigenetics, and cancer.

75 Genetics, epigenetics, and environment may together affect the sus

76 tigate the effect of genetic predisposition, epigenetics, and environmental exposures, avoiding pitfa

77 sregulated circuits, memory reconsolidation, epigenetics, and genetic factors.

78 scientists and inspired the age of genetics, epigenetics, and genomics.

79 ration are necessary for cell proliferation, epigenetics, and HIF-1 activation.

80 ronmental and stochastic factors impact upon epigenetics, and how such studies can provide a comprehe

81 Epigenetics, and in particular DNA methylation marks, ha

82 ulation, and the structure of gene networks, epigenetics, and novel genes.

83 Many cancers, including STS, contain altered epigenetics, and our findings define an epigenetic mecha

84 erosis: dominance, overdominance, epistasis, epigenetics, and protein metabolite changes.

85 es that aging exerts a profound influence on epigenetics, and vice versa.

86 ombinant antibodies performed well in common epigenetics applications, and enabled us to identify pos

87 affinity, and they performed well in common epigenetics applications.

88 g tools, bioinformatics, transcriptomics and epigenetics are in the vanguard of biotechnological prog

89 Thus, signal transduction and epigenetics are linked in these processes of differentia

90 and areas of opportunity that discoveries in epigenetics are providing to the discipline of neuroscie

91 Epigenetics are the heritable changes in gene expression

92 We conclude that IUGR disrupts developmental epigenetics around distal GHREs on the rat hepatic IGF-1

93 Here, we review and update novel findings on epigenetics as it applies to pancreatic cancer.

94 n living systems that has been implicated in epigenetics as well as in the pathologies of various can

95 rmation independent of the DNA sequence, the epigenetics, as well as gene transcription are profoundl

96 provides the first proof of principle for an epigenetics-based therapy for PWS.

97 ic expression poses an intriguing problem in epigenetics because it requires the unequal treatment of

98 polymorphism poses an intriguing problem in epigenetics because it requires the unequal treatment of

99 plicates regulation involving metabolism and epigenetics, beyond EMT driven by injury and repair in c

100 In addition, epigenetics blossomed with new insights about gene modif

101 use of the terms chromatin modifications and epigenetics can help separate the biochemical mechanisms

102 There is increasing evidence that epigenetics can play a key role in the etiology of disea

103 regulators (CRs), which are indispensable in epigenetics, can mediate HMs to adjust chromatin structu

104 f mammalian systems, related to development, epigenetics, cancer, brain function and hereditary disea

105 ns on several topics including: genetics and epigenetics; cancer origin and evolution; microenvironme

106 e CR Cistrome is a valuable resource for the epigenetics community.

107 Epigenetics comprises the umbrella of biochemical reacti

108 We conclude by discussing epigenetics, conceptual implications within an evolution

109 Hence, DNA epigenetics constitutes the main and previously missing

110 ic information as cells divide, and how does epigenetics contribute to trans-generational inheritance

111 These findings indicate that epigenetics contributes substantially to variation in pl

112 It is hypothesized that epigenetics contributes to plant phenotypic plasticity b

113 Evidence from epigenetics could lead to ways to detect, prevent, and r

114 Epigenetics describes processes that modify gene express

115 PURPOSE OF REVIEW: Epigenetics dictate how the genetic blueprint is ultimat

116 ll also highlight recent successes in cancer epigenetics drug discovery and consider important factor

117 cial insects are promising model systems for epigenetics due to their immense morphological and behav

118 ed the Workshop on Mitochondria, Energetics, Epigenetics, Environment, and DNA Damage Response on 25-

119 The field of epigenetics explores changes in DNA structure that influ

120 M) signatures remains a daunting task in the epigenetics field.

121 techniques remains a major challenge in the epigenetics field.

122 gered an explosion of new information in the epigenetics field.

123 also deficient along with other biologic and epigenetics findings in the tumor microenvironment, conf

124 eview, we briefly outline some principles of epigenetics, focusing on highlighting important consider

125 Understanding the significance of epigenetics for plant ecology requires increased transfe

126 ated inactivation of tumor suppressor genes (epigenetics), for example, are reversible as demonstrate

127 al signals have transformed our knowledge of epigenetics from a collection of curious biological phen

128 a personal perspective on the development of epigenetics, from its historical origins to what we defi

129 A report on the Plant Epigenetics: From Genotype to Phenotype Keystone Symposi

130 ferase 1 (DNMT1) and thereby modify cellular epigenetics, gene expression, and differentiation.

131 advances highlighting the interplay between epigenetics, genetics, and cell-to-cell signaling in can

132 the immunophenotype, biological properties, epigenetics, genetics, and clinical associations of huma

133 information is relevant to gene regulation, epigenetics, genome-wide association studies, evolutiona

134 of genetics, recent work (e.g. in genomics, epigenetics, genomic plasticity) obliges us to criticall

135 Epigenetics has an important role for the success of foo

136 Certain PTMs' contribution to epigenetics has been extensively expounded; yet more eff

137 As a newly emerged research area, RNA epigenetics has drawn increasing attention recently for

138 The field of epigenetics has exploded in the last two decades, with i

139 While research on epigenetics has grown exponentially over the past few ye

140 colorectal cancer and illustrates the impact epigenetics has had on this field.

141 Epigenetics has progressed rapidly from an obscure quirk

142 Although epigenetics has received significant attention in the fi

143 The past decade of discovery in cancer epigenetics has revealed a number of similarities betwee

144 The field described as 'epigenetics' has captured the imagination of scientists

145 t years spectacular advances in the field of epigenetics have taken place.

146 ics, lymphocytic mitochondrial outcomes, and epigenetics (histone H3 Lys-4 trimethylation and 5-methy

147 The study of cancer epigenetics holds great promise for expanding the range

148 sist latently for years by manipulating host epigenetics; however, its molecular essence remains undi

149 ividual mechanisms to the systems, including epigenetics, human in vitro immunology, systems biology,

150 te improved measurements of host (genomics), epigenetics, identification of agents (metabolomics, pro

151 establish a new experimental model to study epigenetics in aging and behavior.

152 at it is time to embrace the central role of epigenetics in cancer.

153 y appreciated, only a few studies focused on epigenetics in CKD-associated cardiovascular disease, vi

154 To study epigenetics in clear-cell ovarian cancer, fresh frozen t

155 ion and are key to understanding the role of epigenetics in complex diseases.

156 new avenues for using the full potential of epigenetics in crop improvement.

157 rom the same genotype, suggesting a role for epigenetics in deriving these behaviorally different phe

158 among monozygotic twins suggested a role for epigenetics in disease manifestation.

159 themes that will be addressed on the role of epigenetics in disease pathogenesis include current unde

160 will allow us to tackle the dysregulation of epigenetics in disease.

161 been some progress in revealing the role of epigenetics in ecological processes, studies with non-mo

162 only nucleotide variant studied in terms of epigenetics in eukaryotes.

163 se a new non-Lamarckian theory for a role of epigenetics in evolution.

164 These findings support a potential role of epigenetics in fetal reprogramming by PAH-induced enviro

165 ment interaction, gene-gene interaction, and epigenetics in food allergy remains largely unexplored.

166 be recalibrated to improve understanding of epigenetics in hard-to-access tissues (e.g. atrium) and

167 Our emerging understanding of the role of epigenetics in health and biological function across the

168 nique opportunity to learn about the role of epigenetics in health and disease.

169 made within our review series on the role of epigenetics in hematology.

170 re prove very useful in studying the role of epigenetics in human disease.

171 ts may spur further research in the field of epigenetics in kidney disease and point to new therapeut

172 veral studies that have revealed the role of epigenetics in multigenerational transmission of develop

173 been implicated in this process, the role of epigenetics in OFT development remains largely unexplore

174 ompounds, suggesting a role of environmental epigenetics in ovarian disease etiology.

175 marize our knowledge about transgenerational epigenetics in plants, which entails heritable changes i

176 est achieved through carrying out studies of epigenetics in populations as a part of an integrated fu

177 ecent research suggests an important role of epigenetics in shaping and maintaining cell identity in

178 olism (cellular and whole body), the role of epigenetics in the developing prenatal and postnatal bra

179 To investigate the role of epigenetics in the development of PFC, we examined DNA m

180 This genomic plasticity suggests a role for epigenetics in the establishment of seasonal reproductiv

181 at it is a critical period for developmental epigenetics in the mouse hypothalamus.

182 and the role of environmental factors and/or epigenetics in the pathophysiology of CAKUT.

183 ur understanding of the role of genetics and epigenetics in this common disease.

184 Current knowledge about the role of epigenetics in type 2 diabetes (T2D) remains limited.

185 genes, gene-environmental interactions, and epigenetics) in early CF pathogenesis; (5) defining earl

186 ndividual regulatory process that constitute epigenetics, including DNA methylation, histone modifica

187 ways and facilitate studies of epistasis and epigenetics; infrastructures for candidate gene validati

188 her development of strategies to incorporate epigenetics into breeding.

189 ave the path for realistically incorporating epigenetics into evolutionary theory.

190 Previous attempts to incorporate epigenetics into evolutionary thinking have focused on L

191 n and epigenetics; although many examples of epigenetics involve chromatin changes, those chromatin c

192 ries, we suggest here a framework for cancer epigenetics involving three types of genes: 'epigenetic

193 ylation is a key regulatory control route in epigenetics, involving gene silencing and chromosome ina

194 Therefore, epigenetics is a key area of clinical investigation in d

195 Epigenetics is a term that encompasses a variety of regu

196 Epigenetics is an area of increasing interest for drug d

197 Epigenetics is an exciting field that is serving as a li

198 Epigenetics is being evaluated for its ability to influe

199 Transgenerational epigenetics is defined in opposition to developmental ep

200 Epigenetics is emerging as an attractive mechanism to ex

201 A central enigma in epigenetics is how epigenetic factors are guided to spec

202 prisingly, it is also becoming apparent that epigenetics is intimately involved in neurological disea

203 The burgeoning field of epigenetics is making a significant impact on our unders

204 nd a greater understanding of cardiovascular epigenetics is needed to increase the translational pote

205 Epigenetics is receiving growing attention in the plant

206 However, epigenetics is such a new field that in most of these ar

207 Epigenetics is the study of biochemical modifications ca

208 Epigenetics is the study of nonsequence-based changes, s

209 Epigenetics is the study of stable and heritable changes

210 ce the human genome was sequenced, the term "epigenetics" is increasingly being associated with the h

211 The epigenetics landscape of cells plays a key role in the e

212 o emerge, as are the roles of the metabolism-epigenetics link in tumorigenesis.

213 Functional analyses identifies epigenetics marks, gene ontology categories and disease

214 ntal concepts in epigenetics and discuss how epigenetics may be incorporated into research studies in

215 ide methylation patterns, and to what extent epigenetics may be involved in environmental stress resp

216 velopment and disease are poorly understood: epigenetics may be involved.

217 control of normal stem cell differentiation, epigenetics may offer a useful arena to develop strategi

218 Chromatin modifications and epigenetics may play important roles in many plant proce

219 ALL is more than a genetic disease and that epigenetics may uncover novel mechanisms of disease with

220 te that non-clinical factors (e.g. genetics, epigenetics) may have more potential to predict longer t

221 This indicates that neuroimaging and epigenetics measures of ageing can provide complementary

222 rking in different areas of cancer research (epigenetics, metabolism and the mTOR pathway, cell death

223 inases and intracellular signaling pathways, epigenetics, metabolism, nuclear-cytoplasmic transport,

224 The mechanisms are largely unknown, but epigenetics most likely plays a role.

225 at affects potential markers associated with epigenetics, neuronal, glial, and vascular components of

226 This review focuses on the epigenetics of colorectal cancer and illustrates the imp

227 rapidly take a snapshot of the genetics and epigenetics of each specific human centromere in nondisj

228 tant questions about gene expression and the epigenetics of Goltz syndrome-associated mutations and t

229 Beyond the epigenetics of mechanosensing, the scaling in cancer of

230 nsiders selected updates on the genetics and epigenetics of smoking behavior and associated cardiovas

231 This Review summarizes recent studies in the epigenetics of social behaviour and offers perspectives

232 opose two key principles that may govern the epigenetics of stress and glucocorticoids along the life

233 the development of osteoarthritis, however, epigenetics of subchondral bone has not been extensively

234 iation, gene expression, DNA methylation and epigenetics of tumor samples and cancer cell lines.

235 A deep understanding of epigenetics offers the potential for fresh insights into

236 e review how recent progress in the field of epigenetics opens potential mechanism-based therapeutic

237 The Keystone Symposium on Chromatin and Epigenetics, organized by Luciano Di Croce (Center for G

238 We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across

239 Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the asso

240 and psychiatric disorders, it is unclear how epigenetics, particularly DNA methylation, relate to bra

241 ave been made in our understanding of cancer epigenetics, particularly regarding aberrant DNA methyla

242 ic inquiry, including the basis of behavior, epigenetics, plasticity, stress, memory, and learning.

243 There is emerging evidence that epigenetics play an important role in health and disease

244 Epigenetics plays a key role in cellular development and

245 Epigenetics plays critical roles in controlling stem cel

246 methylation have not established population-epigenetics principles to guide design, efficient statis

247 National Institutes of Health (NIH) Roadmap Epigenetics Program have now annotated more than 80% of

248 Epigenetics refers to changes in phenotype that are not

249 Epigenetics refers to heritable changes caused by mechan

250 Epigenetics refers to heritable changes in patterns of g

251 The term epigenetics refers to stable patterns of gene expression

252 The term epigenetics refers to the heritable changes in gene expr

253 Emerging evidence suggests that epigenetics regulates telomere dynamics in adults.

254 The term epigenetics relates to changes in gene expression that a

255 ratio and OXPHOS, and eventually upregulate epigenetics remodeling complex SWI/SNF in CHME-5 cells.

256 (OXPHOS), BRSKs, CDC25B/C, MAP/Tau, Wee1 and epigenetics remodeling complex SWI/SNF.

257 -dependent manner, reinforcing the idea that epigenetics represents an important regulatory mechanism

258 Thus refocused, epigenetics research aligns with the field of functional

259 m, we explore how non-human animal research, epigenetics research and genome-wide association studies

260 Here, we summarize current progress on HBV epigenetics research and the therapeutic implications fo

261 er the state of the science in environmental epigenetics research and to focus on DNA methylation and

262 The field of epigenetics research developed rapidly and provided us w

263 Epigenetics research does not so much need paradigm shif

264 more than 3 decades ago, progress in cancer epigenetics research has been exponential.

265 Surprisingly, epigenetics research is still limited in ecotoxicology.

266 field of biomedicine during the last years, epigenetics research is surprisingly very limited in eco

267 l modifications (PTMs) are critical tools in epigenetics research, particularly in the widely used ch

268 erves as a central experimental technique in epigenetics research, yet there are serious drawbacks: i

269 e utilization of this powerful technology in epigenetics research.

270 s (PTMs) is a widely recognized hindrance in epigenetics research.

271 gs, and discuss the future for environmental epigenetics research.

272 an cell types provides a new tool for cancer epigenetics research.

273 at the intersection between neurobiology and epigenetics, Rett syndrome (RTT) has garnered intense in

274 sents a new area to explore in translational epigenetics.Significance: This study offers a first look

275 the new resource by selecting the subset of epigenetics-specific data from general-purpose archives,

276 ted this resource by selecting the subset of epigenetics-specific data from the Gene Expression Omnib

277 For many years, cancer epigenetics studies relied on the identification of DNA

278 e understanding of nutritional influences on epigenetics suggests that nutrients that are part of met

279 variant counterparts, is an entire branch of epigenetics that has received limited attention in the b

280 Prions are an unusual form of epigenetics: Their stable inheritance and complex phenot

281 Albeit in respect to epigenetics, this concept has been challenged.

282 In this review, we will introduce lupus epigenetics through reviewing historical key findings, t

283 To begin to understand the contribution of epigenetics to ASD, we have examined DNA methylation (DN

284 c inheritance and summarize the data linking epigenetics to cardiovascular disease.

285 y a direct genetic basis, but the utility of epigenetics to improve complex traits is unclear.

286 Here, we specifically define epigenetics to include the key aspects of heritability (

287 The application of epigenetics to investigate the enantioselective toxicity

288 mber of central biological pathways spanning epigenetics to one-carbon metabolism.

289 to discuss the relevance of research in pain epigenetics to patients with persistent pain after thora

290 ic analyses to elucidate the contribution of epigenetics to plant phenotypes, stress responses, adapt

291 se central roles, there is the potential for epigenetics to play a role in crop improvement strategie

292 ast and present observations in the field of epigenetics to propose a model in which the epigenome ca

293 The central importance of epigenetics to the aging process is increasingly being r

294 aborate system, particularly with respect to epigenetics, transcription, and noncoding RNAs.

295 ic sessions on clinical trials, genetics and epigenetics, tumor microenvironment, immune suppression,

296 ng (December 2008) regarding chromatin-based epigenetics was hosted by the Banbury Conference Center

297 rmore, metabolic alterations directly impact epigenetics well beyond classical mechanisms of tumor pa

298 ucts is a powerful tactic to study bacterial epigenetics, which is poised to make novel and far-reach

299 Therefore, epigenetics with its molecular basis (DNA methylation an

300 ) plasticity, niche construction theory, and epigenetics with transgenerational epigenetic inheritanc