ライフサイエンスコーパス: epigenome

1 that such factors have large effects on the epigenome.

2 ive traits, or through the regulation of the epigenome.

3 esting a feedback loop in the control of the epigenome.

4 uncover novel roles and consequences to the epigenome.

5 in genes encoding proteins that control the epigenome.

6 ow intrinsic and extrinsic signals shape the epigenome.

7 ons and affect hundreds of regions in the F2 epigenome.

8 appreciated that material cues modulate the epigenome.

9 isolation include the interpretation of the epigenome.

10 8) translocation and mutations affecting the epigenome.

11 importance and complexity of the eukaryotic epigenome.

12 ounding genetic mutations reshape the cancer epigenome.

13 lar alterations including a highly distorted epigenome.

14 the therapeutic potential within the cancer epigenome.

15 ong non-coding RNAs function to regulate the epigenome.

16 e useful for future studies of the placental epigenome.

17 ve as a link between the environment and the epigenome.

18 inks the environment (UV radiation) with the epigenome.

19 cipants, we quantified the transcriptome and epigenome.

20 by providing appropriate oscillations to the epigenome.

21 re and expression patterns of the genome and epigenome.

22 ry modulation to alterations in the prostate epigenome.

23 chromatin and heterochromatin regions of the epigenome.

24 cts of vitamin B12 or MTX on fitness and the epigenome.

25 icial effects, in part, by modulation of the epigenome.

26 the CRISPR/Cas9-based tools to engineer the epigenome.

27 tegrative analysis and reconstruction of the epigenome.

28 ovel remodeling of non-random regions of the epigenome.

29 view of the complexity and diversity of the epigenome.

30 bgroup of newborns who have highly disrupted epigenomes.

31 unctional, multiscale organization of cancer epigenomes.

32 lected in their gene-expression profiles and epigenomes.

33 ying GR actions for modulating the "inflamed epigenome."

34 However, the dynamics of transcriptomes and epigenomes acting in concert with initial cell fate comm

35 Recent integrative epigenome analyses highlight the importance of functiona

36 While epigenome analysis has been applied to genomes from sing

37 d dissection of the relationship between the epigenome and gene regulation.

38 erochromatinization and stabilization of the epigenome and genome of pre-malignant, oncogene-expressi

39 ution has also affected understanding of the epigenome and has provided unique opportunities for the

40 m how maternal folate impacts the developing epigenome and health outcomes in offspring.

41 A better understanding of the status of the epigenome and its contribution to agronomic performance

42 nmental influences like drugs can affect the epigenome and potentially rescue genetically determined

43 Molecular analyses of the epigenome and single-cell transcriptome reveal enrichmen

44 xpression programs through modulation of the epigenome and speculate as to how this may influence con

45 at SSCs encode innate plasticity through the epigenome and that both conversion of promoter chromatin

46 interspecific hybridization, we examined the epigenome and the enhancer landscape in X. tropicalis x

47 for 38 transcription factors with extensive epigenome and transcriptional data across the differenti

48 tin interaction maps with haplotype-resolved epigenome and transcriptome data sets, we find widesprea

49 s an information-theoretic representation of epigenomes and corrects for external covariate factors t

50 We examine 20 immune cell epigenomes and perform a focused analysis on primary mon

51 We explored the epigenomes and transcriptomes of human pluripotent stem

52 e association studies (LEWAS) of the genome, epigenome, and environment.

53 duplication at the level of the genome, the epigenome, and gene expression.

54 g interrogations at the level of the genome, epigenome, and transcriptome, many of which have yielded

55 r test by choosing different combinations of epigenomes, and choosing different classification algori

56 terminants encoded in vertebrate genomes and epigenomes, and that these combine variously for differe

57 uce IDEAS, an integrative and discriminative epigenome annotation system, for jointly characterizing

58 owever, methods that probe the status of the epigenome are lacking.

59 ception that environmental influences on the epigenome are pervasive and profound, there has been lit

60 Perturbations within the epigenome are thought to be a key feature of many, perha

61 Alterations to the epigenome are thought to capture and mediate the effects

62 zed that the landscapes of tumor genomes and epigenomes are tightly interconnected.

63 A cell's epigenome arises from interactions among regulatory fact

64 ive treatment strategies on the basis of the epigenome as a novel therapeutic target in triple-negati

65 ionally enhanced genes, implicating the PDAC epigenome as a presumptive point of convergence between

66 As epigenetic drugs target the epigenome as a whole, these true 'genomic medicines' les

67 ss multiple tissues will allow validation of epigenome association studies and exploration of new bio

68 parisons of ChIP-Seq datasets from the Human Epigenome Atlas and FANTOM CAGE to demonstrate its wide

69 The impact of diet on the metabolism-epigenome axis is poorly understood but could alter gene

70 The epigenome-based latent early-life associated regulation

71 rtilization, the initially distinct parental epigenomes become largely equalized with the exception o

72 visualized and further explored in the WashU Epigenome Browser.

73 ine modified histones in the barley seedling epigenome by chromatin immunoprecipitation next-generati

74 ings demonstrate how characterization of the epigenome can contribute to our understanding of disease

75 ings reveal that the combination of distinct epigenomes can be viewed as an epigenomic shock, which i

76 ploidy levels and have investigated how the epigenome changes during endoreduplication cycles.

77 tudy, we provide a comprehensive analysis of epigenome changes during the compatible interaction betw

78 To determine how the epigenome changes during tumorigenesis and reprogramming

79 ch to identify genome-wide transcriptome and epigenome changes that occur during homeostasis at criti

80 a unique, dynamic and remarkably diversified epigenome characterized by the presence of both euchroma

81 h-throughput approaches for the study of the epigenome (chromatin immunoprecipitation sequencing) and

82 This system, comprised of both genome and epigenome components, collectively interacts with the en

83 such as controlling transcription, modifying epigenomes, conducting genome-wide screens and imaging c

84 NCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA met

85 ts by the members of the International Human Epigenome Consortium have generated volumes of functiona

86 In particular, the colon cancer epigenome contains specific genomic regions that, along

87 The DNA methylome, as part of the epigenome, contributes significantly to age-related phen

88 In cancer, many aspects of the epigenome, controlled by DNA methylation, chromatin, and

89 Computational integration of these data with epigenome data, including ATAC-seq on skeletal muscle, a

90 Aberrant epigenomes define many childhood and adult brain cancers

91 To provide a basis for studying epigenome deregulation in CLL, here we present genome-wi

92 stablished a community resource for studying epigenome deregulation in leukaemia and demonstrated the

93 d uncover a previously unappreciated role of epigenome deregulation in the genesis of 13% of HPV-nega

94 knowledge about the temporal changes to the epigenome during fetal brain development has, to date, b

95 Epigenome editing confirmed that the rs339331 region pos

96 tion and broaden the application of targeted epigenome editing for a better understanding of human de

97 Targeted epigenome editing is an emerging technology to specifica

98 Technologies developed for epigenome editing now enable direct study of functional

99 CRISPR-Cas9-based epigenome editing technologies have enabled precise pert

100 We review the design and state of epigenome editing tools, highlighting the unique regulat

101 Epigenome editing with the CRISPR (clustered, regularly

102 wers, which are collectively referred to as 'epigenome editing'.

103 t do not permanently alter the DNA sequence (epigenome editing) may be powerful instruments.

104 or genome editing, transcription factors for epigenome editing, and other emerging applications.

105 Recent developments in targetable epigenome-editing tools enable us to assign direct trans

106 We are entering an era of epigenome engineering.

107 few and computational algorithms to quantify epigenome evolution remain scarce.

108 Accordingly, a quantitative model of epigenome evolution remains to be established.

109 rd to build a coherent quantitative model of epigenome evolution.

110 The cancer epigenome exhibits global loss of DNA methylation, which

111 odomain binding, could impact the final male epigenome features.

112 the potential effects of PEPs on the overall epigenome following exposure.

113 rmore, the potential targets provided by the epigenome for the development of future diagnostics, pre

114 allow characterization of transcriptomes and epigenomes for individual cells under different conditio

115 rated the largest collection so far of human epigenomes for primary cells and tissues.

116 m involving a departure of the cardiomyocyte epigenome from its adult cellular identity to a reprogra

117 ber of chromatin state maps to 127 reference epigenomes from ENCODE 2012 and Roadmap Epigenomics, inc

118 Epigenomes from TGCTs may illuminate reprogramming in bo

119 at allows to classify 42 human healthy blood epigenomes from the BLUEPRINT, NIH ROADMAP and ENCODE co

120 By applying ChromDiff to the 127 epigenomes from the Roadmap Epigenomics and ENCODE proje

121 integrative analysis of 111 reference human epigenomes generated as part of the programme, profiled

122 ctivator MED1, RNA polymerase II, as well as epigenome (H3K4me1/2/3, H3K9me2, H3K27me3, H3K36me3, H3K

123 characteristics, we produced transcriptome, epigenome H3K4me3, H3K27me3, and CpG methylation maps of

124 nd metastasis, suggesting that the pre-tumor epigenome has prognostic value.

125 -generation sequencing of cancer genomes and epigenomes has defined large numbers of driver mutations

126 Disturbances of the epigenome have generally been hypothesized as the molecu

127 riters, and erasers" of the cytoskeleton and epigenome have heretofore been distinct.

128 , histone deacetylases (HDACs), regulate the epigenome; however, their functions within the second he

129 We explore the role of the bacterial epigenome in antibiotic stress survival using classical

130 l introduce the concept of the environmental epigenome in asthmatic patients, summarize previous publ

131 s ranging from understanding the role of the epigenome in development to targeting the transcription

132 served that the perturbation of the oocyte's epigenome in early oogenesis, through depletion of the d

133 ation for future studies on resetting of the epigenome in hPGCLCs and hPGCs for totipotency and the t

134 Resetting of the epigenome in human primordial germ cells (hPGCs) is crit

135 amic interplay between the transcriptome and epigenome in single embryonic stem cells and induced plu

136 We found that epigenomes in adult mouse intestine and other self-renew

137 comprehensively map neuronal and nonneuronal epigenomes in hundreds of specimens.

138 ing task is to combine and compare different epigenomes in order to identify regions with epigenomic

139 The inclusion of leukemia epigenomes in the healthy hematological chromatin sample

140 The extraembryonic epigenome includes specific de novo methylation at hundr

141 discovery efforts has been on targeting the epigenome, including DNA methylation and histone modific

142 Neuronal epigenomes, including chromosomal loopings moving distal

143 ISL1 and JMJD3 partner to alter the cardiac epigenome, instructing gene expression changes that driv

144 hromatin shapes pathways that promote genome-epigenome integrity in response to DNA damage is an issu

145 Integrating various components of the epigenome into multi-omics measurements allows for study

146 methylation is an important feature of plant epigenomes, involved in the formation of heterochromatin

147 The epigenome is a key determinant of transcriptional output

148 Characterization of the epigenome is a primary interest for children's environme

149 The epigenome is associated with biological factors, such as

150 These findings indicate that the CRC epigenome is defined by highly recurrent epigenetic alte

151 However, it remains unknown how the germline epigenome is distinctly established from that of somatic

152 cing of single cells, we show that the liver epigenome is highly unstable with an epivariation freque

153 into intratumoral heterogeneity (ITH) of the epigenome is in a formative stage.

154 ethylation in the organization of the cancer epigenome is not well understood.

155 As for a maturing organism, PCa's epigenome is plastic and evolves from the pre-neoplastic

156 on future longitudinal studies in which the epigenome is profiled over time, over changing environme

157 tive we discuss how understanding the cancer epigenome is providing insights into disease pathogenesi

158 network during establishment of EpiLCs, the epigenome is reset for cell fate determination.

159 ons can extend lifespan, their impact on the epigenome is uncharacterised.

160 challenge in interpreting cancer genomes and epigenomes is distinguishing which genetic and epigeneti

161 Retrospective profiling of neuronal epigenomes is likely to illuminate epigenetic determinan

162 assembly following DNA replication controls epigenome maintenance and genome integrity.

163 The Human Reference Epigenome Map, generated by the Roadmap Epigenomics Cons

164 The retinoblastoma epigenome mapped to the developmental stage when retinal

165 Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project

166 We present a ChIP-seq pipeline for epigenome mapping in the neuronal and nonneuronal nuclei

167 We integrate the eQTLs with immune cell epigenome maps, RA GWAS risk loci, and adjustment for li

168 re suggests that long-lasting changes in the epigenome may be a mechanism by which experiences early

169 er understand the multiple ways in which the epigenome may respond to environmental stimuli.

170 nse maternal diet structures the offspring's epigenome, metabolome, and intestinal microbiome.

171 The epigenome might provide the unifying mechanism that tran

172 Here we find that depletion of the epigenome modifier histone deacetylase 3 (HDAC3) specifi

173 ecruitment of transcriptional modulators and epigenome-modifying factors to any genomic site, leading

174 stochastic or preexisting differences in the epigenome occurring at repetitive regions of the Arabido

175 grin alpha6beta4 can dramatically impact the epigenome of cancer cells, direct global DNA methylation

176 s a valuable in vivo tool for monitoring the epigenome of cells that have emerged from a global DNA d

177 duties at least in part via safeguarding the epigenome of ESCs.

178 d PRC2 in DIPG pathogenesis, we profiled the epigenome of H3K27M-mutant DIPG cells and found that H3K

179 abolic responses.We investigated whether the epigenome of human adipose tissue is affected differentl

180 hypothesized that irradiation reprograms the epigenome of metabolic progenitor cells, which could acc

181 The epigenome of retinoblastomas was more similar to that of

182 ovalbumin and peanut allergy and affects the epigenome of T cells, thereby promoting stable Treg diff

183 The epigenome of the donor may also impact kidney graft surv

184 OCM short-term alteration on the fitness and epigenome of the keystone species, Daphnia.

185 ive complex 1 (PRC1), establishes the unique epigenome of the male germline through two distinct anti

186 Therefore, we investigated how the epigenome of the tissue-of-origin influences the positio

187 enome-wide epigenomic datasets that describe epigenomes of a variety of different human tissue and ce

188 -the-art algorithms is that IDEAS integrates epigenomes of many cell types simultaneously in a way th

189 NA methylation at enhancers by comparing the epigenomes of the HCT116 cell line and its highly demeth

190 This limits the ability to study the epigenomes of valuable, clinically annotated tissue reso

191 The epigenome orchestrates genome accessibility, functionali

192 o study transcriptome and cell type-specific epigenome plasticity in the brain and peripheral organs.

193 ate that the early programming of the oocyte epigenome primes meiotic chromatin for subsequent functi

194 nt and application of methods for widespread epigenome profiling and engineering may generate new ave

195 hematopoietic cell types from the Blueprint Epigenome project.

196 The 1001 Epigenomes Project provides a comprehensive resource for

197 The epigenome provides a mechanistic link between environmen

198 The elucidation of the G. sinense genome and epigenome provides an unparalleled opportunity to advanc

199 rosstalk between cellular metabolism and the epigenome regulates epigenetic and metabolic homeostasis

200 Though mechanistic insights about the epigenome remain sparse, accumulating data in humans and

201 hanges in lifestyle and habitat on the human epigenome remain unknown.

202 While the epigenome remains sensitive to stressors throughout life

203 erentiation process that involves widespread epigenome remodeling.

204 cription of the parameters of such synthetic epigenome remodellers is still lacking.

205 These factors converge at the level of the epigenome, representing a unified node that can be disru

206 platform to study histone variants via yeast epigenome reprogramming.

207 This network also initiates comprehensive epigenome resetting, including global DNA demethylation

208 the contributing cell types possess distinct epigenomes shaping diverse gene expression.

209 e of distinct life periods, during which the epigenome shows heightened plasticity to stress exposure

210 t the CD14+ blood monocyte transcriptome and epigenome signatures associated with human atheroscleros

211 ine CD14+ blood monocyte's transcriptome and epigenome signatures to find differential methylation an

212 ed Modules Integrating the Transcriptome and Epigenome (SMITE) approach was developed to integrate tr

213 Here we introduce 'NeuroDam' to assess epigenome status retrospectively.

214 esearch, and comparative nematode genome and epigenome studies.

215 (mCH) is a distinct feature of the neuronal epigenome that is differentially distributed between mal

216 g of the information-theoretic nature of the epigenome that leads to a powerful approach for studying

217 with epigenetic features unique to specific epigenomes that they choose, making detection of common

218 nknown, limiting the development of targeted epigenome therapy.

219 The reprogramming of the epigenome through silencing of genes and microRNAs by cy

220 However, the mechanisms that guide the epigenome through this transition and their evolutionary

221 vidence is accumulating to indicate that the epigenome, through which the environment regulates gene

222 ively define the Drosophila female germ line epigenome throughout oogenesis and show that the oocyte

223 a quorum-sensing molecule regulating a host epigenome to enable tolerance of infection.

224 ffers for investigating and manipulating the epigenome to facilitate further understanding of stem ce

225 This study surveyed the epigenome to identify functionally and clinically releva

226 elopment involves major reprogramming of the epigenome to prime the zygote for totipotency.

227 KSHV achieves this by tethering its epigenome to the host chromosome by latency associated n

228 Loss of NR2E3 in rods shifts their epigenomes to a more cone-like state.

229 cellular factors instruct innate immune cell epigenomes to engage specific differentiation states.

230 Furthermore, using phenotypically relevant epigenomes to weight the GWAS single-nucleotide polymorp

231 the transcriptome and no differences in the epigenome up to 24 h.

232 anscriptomes (using GRO-seq and RNA-seq) and epigenomes (using ChIP-seq) of 11 different human breast

233 ellular metabolism dynamically regulates the epigenome via availability of the metabolite substrates

234 To edit the epigenome we developed the FIRE-Cas9 system for rapid an

235 trate that by using specific combinations of epigenomes we can detect developmental lineage-specific

236 quencing to examine uncharted regions of the epigenome, we identify a type of far-reaching DNA methyl

237 ncipled comparison of evolutionarily distant epigenomes, we must consider species-specific biases suc

238 on histones, play a significant role in the epigenome, where they function as "readers" that ultimat

239 are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA re

240 s changes in signaling pathway activities or epigenome, which are generally difficult, but important,

241 that MLL4 and CBP drive the dynamic enhancer epigenome, which correlates with the dynamic transcripto

242 idence in support of smoking's impact on the epigenome, which may be an important contributor to canc

243 rovides a new direction for consideration in epigenome wide association studies (EWAS).

244 Findings emerging from epigenome-wide analyses have led to new discoveries with

245 ment, we perform integrative genome-wide and epigenome-wide analyses.

246 Epigenome-wide assessment of DNA methylation in the plac

247 Here, we report an epigenome-wide association analysis comparing IDU+/ HCV+

248 Epigenome-wide association scans (EWAS) are an increasin

249 Existing epigenome-wide association studies (EWAS) have successfu

250 We performed a meta-analysis of epigenome-wide association studies (EWAS) of serum C-rea

251 In epigenome-wide association studies (EWAS), different met

252 molecular mediators of epigenetic changes by epigenome-wide association studies (EWAS).

253 of the foremost challenges currently facing Epigenome-Wide Association Studies (EWAS).

254 ut when searching for non-genetic effects in epigenome-wide association studies (EWAS).

255 to the identification of biomarkers in large Epigenome-Wide Association Studies (EWAS).

256 nfinium HumanMethylation450 BeadChip enables epigenome-wide association studies at a reduced cost.

257 Epigenome-wide association studies can provide novel ins

258 Here we present epigenome-wide association studies of eGFR and CKD using

259 ine mapping and Mendelian randomization with epigenome-wide association studies to evaluate the causa

260 e-wide DNA methylation profiles have enabled epigenome-wide association studies to identify specific

261 tion450 BeadChip is increasingly utilized in epigenome-wide association studies, however, this array-

262 50 BeadChip has been extensively utilized in epigenome-wide association studies.

263 mpact as potential sources of confounding in epigenome-wide association studies.

264 In this study, we performed an epigenome-wide association study (EWAS) for RA with thre

265 We conducted an epigenome-wide association study (EWAS) on anxiety in a

266 Here we present an epigenome-wide association study across 406,365 CpGs in

267 In an epigenome-wide association study adjusted for WBC types

268 ological approach that can be used to inform epigenome-wide association study analyses of other compl

269 ing proficiency, allows an easy execution of Epigenome-Wide Association Study analysis pipeline under

270 Epigenome-wide association study begun in 2008 using DNA

271 algorithm SEPIRA will be useful to the wider epigenome-wide association study community as a means of

272 nt study provides to our knowledge the first epigenome-wide association study in living patients with

273 We conducted an epigenome-wide association study in whole blood for live

274 Specifically, we report the results of an epigenome-wide association study meta-analysis of EA bas

275 To examine this possibility, we performed an epigenome-wide association study of methylation of cytos

276 ) was associated with total IgE levels in an epigenome-wide association study of white subjects.

277 In this study, we carried out a three-stage epigenome-wide association study to identify disease-ass

278 A two-stage epigenome-wide association study was performed, with a d

279 We performed a multi-stage epigenome-wide association study, quantifying genome-wid

280 owed association with season of birth in the epigenome-wide association study.

281 Here we use epigenome-wide association to show that body mass index

282 Here we observe epigenome-wide DNA methylation differences in 240 newly-

283 between prenatal maternal lead exposure and epigenome-wide DNA methylation in umbilical cord blood n

284 a HumanMethylation450 BeadChip, we evaluated epigenome-wide DNA methylation in vaginal cells from fou

285 maternal plasma folate during pregnancy and epigenome-wide DNA methylation using Illumina's HumanMet

286 Whole blood epigenome-wide DNA methylation was measured, and season-

287 an methylation 450 was used for high-density epigenome-wide mapping of DNA methylation in left-ventri

288 Additional epigenome-wide methylation analyses using whole blood hi

289 fects of prenatal lead on the offspring, but epigenome-wide methylation data for low levels of prenat

290 We screened for epigenome-wide methylation differences associated with m

291 the association between tobacco smoking and epigenome-wide methylation in non-tumor lung (NTL) tissu

292 The epigenome-wide scan suggested differences in methylation

293 corrected P</=0.05), with 3 of them reaching epigenome-wide significance at P</=5x10(-8).

294 posure with DNA methylation in cord blood at epigenome-wide significance level [false discovery rate

295 CpG cg10773601 showed an epigenome-wide significant negative association with pre

296 emonstrating an improved capacity to explain epigenome-wide variation in DNA methylation within two l

297 posed by LEARn are testable via longitudinal epigenome-wide, envirome-wide, and exposome-wide associa

298 The dynamic nature of the epigenome will require an emphasis on future longitudina

299 It also modifies the epigenome, with changes in DNA methylation, due to both

300 sons and other structural variants shape the epigenome, with dramatic effects on immunity genes.