ライフサイエンスコーパス: epimer

1 hydroxy acid 25 (Ki = 1.5 mM as a mixture of epimers).

2 ion was also induced by largazole and its C2 epimer.

3 trans-5R,6R equilibrium favors the cis-5R,6S epimer.

4 the undesired but thermodynamically favored epimer.

5 nd it was also more cytotoxic than the 6beta-epimer.

6 different conformational properties of each epimer.

7 action rates for radical formation from each epimer.

8 ys an important role in distinguishing these epimers.

9 und exists in an equilibrium between several epimers.

10 n the coprolite had been converted to sterol epimers.

11 phered via the syntheses of both of its C7'' epimers.

12 reater destabilization characteristic of (R)-epimers.

13 ated counterparts than the corresponding (R)-epimers.

14 from potential interferences, especially its epimers.

15 e) as the alpha (C4'alpha) or beta (C4'beta) epimers.

16 staglandins, lipoxins, and their natural C15-epimers.

17 at lead to two unequally populated rotameric epimers.

18 xist as a mixture of rapidly interconverting epimers.

19 oth mannuronate and guluronate, which are C5 epimers.

20 quenching of 14a provides access to the 7(R)-epimer (14b).

21 d structure of cycloinumakiol (1) and its C5 epimer (18) are achieved in a concise and efficient fash

22 Both 1a and its 8-endo epimer 1b experience appreciable epimerization and fragm

23 The 8-endo epimer 1b, which yields no [1,3] product, experiences pr

24 transformed to neplanocin A (1a) and its 3'-epimer (1b).

25 The C-2 epimer, (1R/S,4R/S)-6R/S-(N, N-dimethylamino)-5R/S-pheny

26 The conformers of epimers (1S)-2e,f show high rotational barriers of up to

27 trated that the parent nucleoside and its 2'-epimer 2'-C-cyano-2'-deoxy-2-ribo-pentofuranosylcytosine

28 in contrast to that of its D-apio-L-furanose epimer 2, was readily incorporated into a DNA template b

29 racid-1 (1), the syntheses of its C(1)-C(20) epimer (2) and of several truncated analogues for biolog

30 total synthesis of psymberin (1) and its C4 epimer (2).

31 the targeted compounds (1a,b) and their C-20 epimers (2 and 3).

32 ixture of the desired PMB product 21 and the epimer 23.

33 The corresponding deshydroxy epimer (3'S)-14 was 7-fold more potent than its 3'R coun

34 cyclic uracil polyoxin C (+)-2 and its alpha-epimer (-)-3 were synthesized in an efficient fashion fr

35 quilibration between alantrypinone 4 and its epimer 31 or between its ester analogues 23 and 24 has b

36 (3), (15R)-vinyl-nor-brefeldin A (5), their epimers 4 and 6 as well as (15S)-ethyl-nor-brefeldin A (

37 t the human metabolite of DHA is the 12alpha-epimer 5.

38 Mitsunobu inversion of the C-7 alcohol 51 to epimer 52, and conversion of this compound to tetracycli

39 binding modes lead mainly to the ineffective epimer 6-epi-pravastatin.

40 udy was performed on the complex formed from epimer A and a recombinant, uniformly (15)N-labeled F22W

41 ssignment of the earlier 7R configuration of epimer A and the 7S configuration of epimer B.

42 hain nitrogens of Lys135 in epimer B than in epimer A.

43 ise to a previously inaccessible spiroacetal epimer, a new method to synthesize thioketene acetals fr

44 different chemical yields obtained from each epimer, a result not rationalized by the previous model.

45 of beta-(1, 4)-D-mannuronate (M) and its C-5 epimer alpha-(1, 4)-L-guluronate (G).

46 Interestingly, the C-2 epimer alpha-D-talose binds almost as well as D-galactos

47 beta(R)-epimers were preferred to 1 alpha(S)-epimers, although ipecoside (1 beta(R)) is a major alkal

48 solution mass spectrometry (TIMS-CID-MS) for epimer analysis.

49 B2 is over 12-fold more potent than the C8,9-epimer and C18-epimer in human DU145 prostate cancer cel

50 In addition to RvD1, its aspirin-triggered epimer and RvD1 analogs each dose dependently and effect

51 the anomeric center than in its unnatural 7R-epimer and, therefore, better able to support incipient

52 ve recently identified several highly active epimers and analogues.

53 iological roles of 1 alpha(S)- and 1 beta(R)-epimers and for the involvement of IpeGlu1 in the metabo

54 demonstrated by its reduction to two alcohol epimers and its reaction with a methylene ylide.

55 lective total syntheses of omuralide, its C7-epimer, and (+)-lactacystin.

56 ce for the unnatural epimer over the natural epimer, and a slower overall rate of peptide coupling.

57 techin-3-gallate, (-)-epicatechin, and their epimers, and black tea polyphenols, theaflavin, theaflav

58 y carbon source D: -glucose, various glucose epimers, and several acetylated hexosamines.

59 Thus, the DNA ligands can discriminate sugar epimers, anomers, and disaccharide linkages.

60 alkaloid cycloclavine and its unnatural C(5)-epimer are described.

61 ilignan natural product tatanan A and its C3 epimer are described.

62 ifferences between this isomer and its (16R)-epimer are only +/-5-10 ppb (+/-0.005-0.01 ppm).

63 Adenosine (Ado)-5'-carboxaldehyde and its 4'-epimer are potent inhibitors of S-adenosyl-L-homocystein

64 When pairs of C-4 epimers are available, the rule indicates that, when the

65 Lipoxins and their aspirin-triggered 15-epimers are endogenous anti-inflammatory agents that blo

66 ructural analyses showed that the (S)-C5'-Me epimers are spatially and structurally more similar to t

67 separation and identification of uronic acid epimers as well as geometric sulfation isomers.

68 f the aldehyde group and condensation to the epimer at C-4.

69 synthesis of (+)-gabosine J and that of the epimer at C4 of its enantiomer have been accomplished th

70 conversion of d-erythronate and l-threonate (epimers at carbon-3) to dihydroxyacetone phosphate and C

71 Epimers at the 2-, 3-, and 4-position of xylose also wer

72 (1a) and D (1d) and their analogues 3a, 3d (epimers at the indicated site) and 4a, 4d (epimers at th

73 (epimers at the indicated site) and 4a, 4d (epimers at the indicated site).

74 The preparation of the two epimers at the quaternary carbon of the 6-deoxy-C-altros

75 lvin D1 (RvD1) and its aspirin-triggered 17R epimer (AT-RvD1) with compounds prepared by total organi

76 y from the side chain nitrogens of Lys135 in epimer B than in epimer A.

77 ments previously based solely on results for epimer B, a (15)N[(19)F] REDOR NMR study was performed o

78 tion of epimer A and the 7S configuration of epimer B.

79 x copolymer of alpha-L-guluronate and its C5 epimer beta-D-mannuronate.

80 sed affinity and potency compared with the R-epimer, but was more rapidly inactivated than RvE1 by de

81 Quantitation of peptide epimers by RDD is also described.

82 ions obtained by EDD of the tetrasaccharide epimers can be rationalized by simple alpha-cleavage of

83 Fragmentation of epimers can enhance their identification and further imp

84 ulose (CDP-cereose) and likely generated a 4-epimer CDP-3-C-methyl-6-deoxyallose (CDP-cillose).

85 etic approach leading to the 1 alpha-hydroxy epimers complements our previously reported synthesis of

86 4 nM vs 159 nM for cocaine), whereas the C-8 epimer, compound 14, was somewhat less potent (IC(50) =

87 Both 4'-OMe epimers conferred increased nuclease resistance, which c

88 leads to the production of two pairs of C1' epimers containing a pyranose and a furanose, respective

89 e in six steps; however, both alpha and beta epimers could be obtained by a nonstereoselective approa

90 AlsK phosphorylates the glucose epimer, d-allose, with a k(cat)/K(m) value of 6.5 x 10(4

91 thioether-cleaving activity with the beta(S)-epimer, demonstrating that LigG is a stereospecific beta

92 racid-3, whereas the previously assigned 20R epimer did not.

93 ions afford easily separable mixtures of two epimers differing in the configuration of the center der

94 in some cases with the use of metal adducts, epimer discrimination is optimized.

95 on forming equal amounts of two albaflavenol epimers, each of which is oxidized in turn to albaflaven

96 Lipoxins (LX) and their aspirin-triggered 15-epimer endogenous isoforms are endogenous anti-inflammat

97 tubulysin U, tubulysin V, and its unnatural epimer epi-tubulysin V, is reported.

98 y an abrupt increase in coprostanol (and its epimer epicoprostanol) in the sediments and an associate

99 ric fragment ions resulting from d/l-peptide epimers exhibit conformational differences, thus showing

100 esulted in decreased activity, with only one epimer exhibiting anti-HIV activity.

101 D-amino acid-containing peptides (which are epimers) for identification.

102 The alpha-epimer generally conceded similar thermal stability as u

103 MlghC is specific for the double C3/C5 epimer generated by MlghB and produces L-gluco-heptose v

104 HA08, which is 100-fold more potent than the epimer HA09, can enhance dendritic spine number and alte

105 nantiomers of muricatacin as well as the C-5-epimer has been developed.

106 Separation of the epimers has been accomplished by RP-HPLC, allowing full

107 Two urinary steroid epimers have now been shown to be components of a courts

108 However, in this paper we show that the two epimers have similar conformational properties, which im

109 The epimer having the 6alpha-acetamido substituent was more

110 Distinguishing the epimers iduronic acid (IdoA) and glucuronic acid (GlcA)

111 to EDD, NETD is also able to distinguish the epimers iduronic acid from glucuronic acid in heparan su

112 old more potent than the C8,9-epimer and C18-epimer in human DU145 prostate cancer cells.

113 hat stereospecifically hydrolyzes 3 alpha(S)-epimer in terpenoid-indole alkaloid biosynthesis, IpeGlu

114 the cis-5R,6S and trans-5R,6R thymine glycol epimers in duplex DNA was affected by the identity of th

115 nvestigations of important but low abundance epimers in isomeric mixtures.

116 yzed hydrolysis of a mixture of C-35 acetoxy epimers indicated a 35R absolute configuration for 2.

117 ion resulted in up to 80% of the non-natural epimer, indicating that it can be the major product in s

118 one beta-position as an equimolar mixture of epimers, inferring rapid isomerization of the kineticall

119 The epimers involved in the isomerization mechanism were inv

120 The noncharged microspecies of the cis-epimer is 30 900 times as lipophilic as its zwitterionic

121 mer, while the analogous ratio for the trans-epimer is around 15 800.

122 conrotatory mode that leads to the C5-alpha epimer is disfavored due to higher levels of allylic str

123 the system can sense galactose as well, this epimer is not a potential interfering substance since it

124 8-OMs and 22-OMs in comparison to the 7alpha epimers is attributed to concerted antiperiplanar Wagner

125 ard six ergot alkaloids and their respective epimers is described.

126 st is employed, a 5.3:1 equilibrium ratio of epimers is established quickly, but when a first-generat

127 products N-deacetylisoipecoside (1 alpha(S)-epimer) is considered to be a part of the reactions for

128 ) and each pair of sugars can form different epimers (isomers around the stereocentres connecting the

129 epimerization of D-glucuronic acid to its C5-epimer L-iduronic acid, which is essential for the funct

130 nuronate (M) and variable amounts of its C-5-epimer, l-guluronate (G).

131 teins were compared using cellobiose and its epimer, lactose, as the substrates.

132 as unmodified nucleotides, whereas the beta-epimer led to significant destabilization.

133 VSEFLKQAWFIENEEQEYVQTVK), 2.5 mug/kg] and 15-epimer-lipoxin A4 (15-epi-LXA4; FPR2/ALX specific, 12.5

134 f carbon 15 epimeric LXs, and both series of epimers (LX and aspirin-triggered 15-epi-LX) display cou

135 e charge state were resolved in another, and epimers merged as protonated species were resolved upon

136 side, trachelosperogenin E, ellagic acid, an epimer mixture of (+)-gallocatechin and (-)-epigallocate

137 siRNAs containing several C4'alpha-epimer monomers in the sense or antisense strands trigge

138 emetine biosynthesis, whereas its 1 beta(R)-epimer N-deacetylipecoside is converted to ipecoside in

139 iven domain can vary in terms of uronic acid epimer, N- and O-sulfate, and N-acetate content.

140 om the far more abundant isobaric galactosyl epimers naturally occurring in white matter.

141 y reductive N-methylation, provided the C(2)-epimer of (-)-preussin B and (+)-preussin B as the major

142 preussin B over seven steps, 8% for the C(2)-epimer of (-)-preussin B over nine steps, and 7% for (+)

143 metric syntheses of (+)-preussin B, the C(2)-epimer of (-)-preussin B, and 3-deoxy-(+)-preussin B hav

144 atives, N-thioglycolyl-D-glucosamine (7, C-4 epimer of 1), and alpha-O-benzyl 2-acetamido-2-deoxy-D-g

145 energies of reactions leading to either C17 epimer of 13.

146 ith benzoyl-CoA to form predominantly one 3'-epimer of 2'-deoxytaxol.

147 The non-naturally occurring 20R epimer of 20-hydroxyvitamin D3 is synthesized based on c

148 Chromatographic resolution of the 3-epimer of 25(OH)D(3) proved to be essential for accurate

149 o known as megalin) with 25(OH)D3 and the C3 epimer of 25(OH)D3 [3-epi-25(OH)D3]; cubilin (CUBN) with

150 mation of one covalent adduct (cis-isomer, S-epimer of [TAM]G) formed from the reaction of tamoxifen

151 The C-2 epimer of aceric acid was also synthesized using thiazol

152 of ursodeoxycholic acid, the 7 beta-hydroxy epimer of chenodeoxycholic acid, was investigated in thr

153 yxose (Lyx), rarely found in biology, but an epimer of D-arabinose, a key component of the mycobacter

154 An epimer of dG-N2-trans-TAM showed targeted mutations rang

155 The 4'-epimer of doxorubicin, epidoxorubicin, reacts with forma

156 phosphorylation of d-glucuronic acid, the 4-epimer of GalA.

157 D-mannose, a C-2 epimer of glucose, exists naturally in many plants and f

158 s a member of the aldohexose family and a C3 epimer of glucose.

159 so accepts hapalindole A, a halogenated C-10 epimer of hapalindole U, and catalyzes normal prenylatio

160 A sample of the (4'R,4''S)-epimer of hopromine was also produced using this approac

161 applied to the smooth preparation of the 11R-epimer of ipomoeassin F for the first time.

162 Erythorbic acid, an epimer of L-ascorbic acid, is used in the United States

163 new natural product was determined to be an epimer of latrunculin B (1), which was found in the same

164 xide to methionine and is specific for the S epimer of methionine sulfoxide.

165 D-chiro-Inositol is an epimer of myo-inositol that is found in certain mammalia

166 al injection of 2.5 micrograms of the 3 beta-epimer of pregnanolone did not affect behavior in the pl

167 a-5Z,7E,9E,13Z,15E,19Z-hexaenoic acid, a 17R-epimer of RvD3, for in vivo experiments.

168 ypothesis, the reaction of DesII with the C4-epimer of TDP-quinovose (TDP-fucose) was examined.

169 c acid (ursodiol), a naturally occurring 7-B-epimer of the bile component chenodeoxycholic acid, for

170 n, and the minor adduct was identified as an epimer of the cis form.

171 synthesis of frondosin B led to the opposite epimer of the natural product, suggesting an unusual lat

172 th a 3-5 kcal/mol preference for the C5-beta epimer of the ring-closed cation.

173 uct was identified chromatographically as an epimer of the trans form of alpha-(N2-deoxyguanosinyl)ta

174 antaginaceae family) are derived from the C7 epimer of this scaffold.

175 The methyl ester of the 3'-epimer of thymidylic acid 9 was also prepared from thymi

176 modified oligodeoxynucleotides containing an epimer of trans- and cis-forms of dG-N2-tamoxifens were

177 The 3-alpha(axial)-epimer of ursolic acid suppressed de novo formation of C

178 syntheses of (-)-hyacinthacine B4 and of two epimers of (+)-hyacinthacine C5, allowing a suggestion o

179 Thus, the corresponding epimers of (S(S),S)-2-substituted pyrrolidines were synt

180 The C(23) epimers of 1alpha,23,25(OH)3-24-oxovitamin D3, a major n

181 e, providing access to either alpha- or beta-epimers of 4-acetylpyrrolidine depending on the reaction

182 9alpha-Methyl-1alpha,25-(OH)2D3, both epimers of 9-methylene-10,19-dihydro-1alpha,25-(OH)2D3 a

183 Epimers of D-galactose at C-3 (D-gulose) and C-4 (D-gluc

184 In fact, the epimers of each of chol 4-OOH, 6-OOH, and 7-OOH are read

185 Three epimers of ethylene glycol bis(tropane-3-carboxylate) (3

186 so promotes the generation of a series of 15-epimers of LXA(4), known as aspirin-triggered lipoxins (

187 The epimers of the catechins showed similar inhibitory effec

188 ations of the acetamido substituents in both epimers of the final product were determined by NOESY NM

189 This route provided both C-13 epimers of the macrolactone by using either enantiomeric

190 UDP-glucose or the galactose epimers of the normal substrates did not substitute.

191 The total synthesis of both side chain epimers of the originally reported structure of circuloc

192 are affected by stereochemistry, since five epimers of the pentapeptide, H2N-Gly-Leu-Ser-Phe-Ala-OH

193 both compounds was confirmed by synthesizing epimers of the proposed structures.

194 ution by triggering biosynthesis of specific epimers of these mediators.

195 ations to investigate how two diastereomers (epimers) of dihydrofuroaporphine bind to the serotonin 5

196 , distinguishing, for example, between sugar epimers or structurally similar anions.

197 n, an energetic preference for the unnatural epimer over the natural epimer, and a slower overall rat

198 pylidene-alpha-D-xylofuranose 9 for the 9:10 epimer pair, and equatorial 1-deoxy-1-pyridyldimethylgly

199 ylidene- alpha-D-glucofuranose 4 for the 4:5 epimer pair, exo-3-deoxy-3-pyridyldimethylglyoximatocoba

200 enzyl-beta-D-gl ucopyranose 12 for the 12:13 epimer pair.

201 the 7:3 cis-(5R,6S):trans-(5R,6R) mixture of epimers paired opposite adenine in the 5'-GTgG-3' sequen

202 ynthesis of (-)-podophyllotoxin and its C(2)-epimer, (-)-picropodophyllin.

203 The solvolysis of the endo epimer presents a more complex picture, reacting via a c

204 ore significantly, EDD of HS tetrasaccharide epimers produces diagnostic product ions that can be use

205 Budesonide epimer R (BUDeR) and dexamethasone (DEX) were studied as

206 owth medium as early as 1 h after budesonide epimer R treatment.

207 methasone and, in particular, the budesonide epimer R were shown to effectively and rapidly induce tr

208 sing haptophilicity, assessed as the product epimer ratio, for the groups studied was R = CH(2)NH(2),

209 s-5R,6S epimer; the level of the trans-5R,6R epimer remained below the level of detection by NMR.

210 In contrast, the antagonist epimer remained firmly stabilized in the binding pocket.

211 imes that of the noncharged form for the two epimers, respectively.

212 and computational investigation of the alpha-epimer revealed that the 4'-OMe imparts a conformational

213 These epimer-sensitive fragmentations should allow this approa

214 ursue the tedanolide synthesis via C(15)-(S)-epimers, since this stereochemical change would destabil

215 PKSs support that C2-type KRs cooperate with epimer-specific ketosynthases to set the configurations

216 long with synthetic elaboration to their C14-epimers starting from d-glucose using beta-glycosylation

217 For the cis-(5R, 6S) epimer Tg and A are inserted into the helix, remaining i

218 threonine (Thr) as well as their side chain epimers (the allo counterparts).

219 To avoid costly fractionation of the epimer, the enzyme was evolved to invert stereoselectivi

220 pectra in D(2)O for pairs of unprotected C-4 epimers, the spectra were recorded at approximately the

221 rans-5R,6R equilibrium favored the cis-5R,6S epimer; the level of the trans-5R,6R epimer remained bel

222 s a mixture of cis-(5R,6S) and trans-(5R,6R) epimers; these modulate base excision repair.

223 ported synthesis of the corresponding 1 beta-epimers, thus producing all stereoisomers of these versa

224 equent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose.

225 ntrast, its homologue DdahC only uses the C3 epimer to yield d-altro-heptose via C4 reduction.

226 For each epimer, variable-temperature NMR experiments, including

227 This provided largazole along with its C2-epimer via an unexpected inversion of the alpha-stereoce

228 the D-isoform are distinguished from their L-epimers via differences in the relative amounts of speci

229 unnelling (RT) can classify many anomers and epimers via the current fluctuations they produce when c

230 as an "all-R" stereoisomer mixed with its 3S-epimer was confirmed.

231 The C4'alpha epimer was synthesized by a stereoselective route in six

232 total synthesis of berkelic acid and its C22 epimer was thus completed in a 10 step linear sequence a

233 e equilibrium ratio of cis-5R,6S:trans-5R,6R epimers was 7:3 for the duplex containing the Tg(6) x A

234 guration at the beta-position (i.e. its beta-epimer)) was produced only in the LigF-catalyzed reactio

235 smethyl-25,26-dihydrodictyostatin and its C6 epimer were chosen as potentially potent yet accessible

236 apoptosis assays on ipomoeassin F and/or its epimer were conducted.

237 The spectroscopic data of these epimers were in complete agreement with those for the na

238 ecificity for its substrates where 1 beta(R)-epimers were preferred to 1 alpha(S)-epimers, although i

239 Briefly, the d/l-peptide epimers were separated by online reversed-phase liquid c

240 ations of both 20S,23S/R-dihydroxyvitamin D3 epimers were unambiguously assigned by NMR and Mosher es

241 These epimers were unexpected based on the belief that tea PAs

242 dihydroxy-2-methylenevitamin D3 and its C-20 epimer, were found to be almost as active as 2-methylene

243 on is diastereoselective, in favor of the 1S epimer, when large groups are attached to the phenyl rin

244 beta-S-glutathionyl-alpha-veratrylglycerone) epimers, whereas the other diastereomer (differing in co

245 hiles is base sensitive and might afford two epimers which differ at one chirality center.

246 osaccharide building blocks are often simple epimers, which when combined produce diastereomeric glyc

247 h more active in vivo than the corresponding epimers with 2beta-configuration.

248 tegy was demonstrated by analysis of peptide epimers with different molecular sizes, [d-Trp]-melanocy

249 hile being capable of utilizing two distinct epimers with the same efficiency to generate five distin

250 e (3'R)-10 diastereomer and a set of related epimers, with the goal of defining the stereochemical ro

251 ds, concanavalin A discriminated between C-2 epimers, with the manno configuration binding more tight

252 eric 2,2-diaryl-cis-4,6-dimethyl-1,3-dioxane epimers, X-ray crystallography, (1)H NOESY analysis, and