ライフサイエンスコーパス: epiregulin

1 n of the overlying epidermis is an effect of epiregulin.

2 clin D2, aromatase, inhibin-alpha, SF-1, and epiregulin.

3 -1 (SF-1), cholesterol side chain (SCC), and epiregulin.

4 D2, inhibin-alpha, aromatase, SCC, SF-1, and epiregulin.

5 y, we found that the addition of recombinant epiregulin, amphiregulin, CX3CL1, and interleukin-11 sig

6 75% amino acid sequence identity with mouse epiregulin, an epidermal growth factor (EGF)-related gro

7 Epiregulin, an epidermal growth factor family member, ac

8 factor receptor (HER) ligands neuregulin and epiregulin and activation of the HER2 and HER3 receptors

9 ors that have high gene expression levels of epiregulin and amphiregulin and patients with wild-type

10 that express high levels of the EGFR ligands epiregulin and amphiregulin are more likely to have dise

11 ate-induced but not constitutive shedding of epiregulin and had no effect on betacellulin (BTC) proce

12 epidermal growth factor (EGF)-family ligands epiregulin and HB-EGF, the chemokine CX3CL1, and the tra

13 ET-1 also activated two other genes epiregulin and HB-EGF.

14 th factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin.

15 F-like growth factor (HB-EGF), betacellulin, epiregulin, and epigen.

16 nd ANGPTL-2), as well as ErbB (amphiregulin, epiregulin, and neuregulins) and TGF-ss, which activate

17 oliferation, expression of the hepatomitogen epiregulin, and prevention of apoptosis.

18 wo additions to the family, betacellulin and epiregulin, are exquisitely restricted to the mouse uter

19 inding EGF-like growth factor, amphiregulin, epiregulin, betacellulin, or heregulin beta1 that bind t

20 In addition, epiregulin caused rapid EGF receptor activation in RASM

21 uxtamembrane stalks of either pro-BTC or pro-epiregulin ectodomains in vitro.

22 Epiregulin (EPR) is a recently described member of the e

23 ied with a variety of EGF-like ligands--EGF, epiregulin (EPR), heparin binding EGF (HB-EGF), and here

24 ith amphiregulin (AR), betacellulin (BTC) or epiregulin (EPR), increased fetal type II cell different

25 RNA expression of EGFR ligands epiregulin (EREG) and amphiregulin (AREG) may correlate

26 her approaches, we show how the EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different

27 idermal growth factor receptor (EGFR) ligand epiregulin (EREG) from the basolateral to the apical cel

28 ling, we observed differential expression of epiregulin (EREG) in mouse models of colitis-associated,

29 GFR) pathway, including amphiregulin (AREG), epiregulin (EREG), and ectodomain cleavage protease MMP1

30 h factor C (VEGFC), betacellulin (BTC), EGF, epiregulin (EREG), and other members of the transforming

31 eptor (EGFR) ligands amphiregulin (AREG) and epiregulin (EREG), and systemic lipopolysaccharide admin

32 ated a role for EGFR and its natural ligand, epiregulin (EREG), in pain processing.

33 eptor (EGFR) ligands amphiregulin (AREG) and epiregulin (EREG).

34 luding Tenascin C (Tnc), Jagged1 (Jag1), and Epiregulin (Ereg).

35 tive genes were also identified (e.g. Egr-1, epiregulin, Fra-1, and ABCA1).

36 LacZ identification of epiregulin from epiregulin-null mice and immunohistochem

37 The epiregulin gene (Ereg) is located on mouse chromosome 5

38 several EGFR family ligands (EGF, HB-EGF and epiregulin), however only increases in HB-EGF were detec

39 evidence that expression of betacellulin and epiregulin in the uterus requires the presence of an act

40 Taken together, these results indicate that epiregulin is a potent VSMC-secreted mitogen, induced in

41 Although epiregulin is broadly expressed and regulated both spati

42 released by mesenchymal cells, revealed more epiregulin mRNA in fibroblast-like angiofibroma and peri

43 Elevation of epiregulin mRNA was confirmed with real-time PCR, and in

44 LacZ identification of epiregulin from epiregulin-null mice and immunohistochemical staining of

45 al staining of wild type mice confirmed that epiregulin, one of the limbal epithelium-enriched genes,

46 also demonstrate that amphiregulin, but not epiregulin, partially compensates for the loss of HB-EGF

47 and beta) receptor 2, decorin, osteoglycin, epiregulin, proliferins 2 and 3, stromal cell-derived fa

48 lso suppressed cyclin D2, inhibin-alpha, and epiregulin promoter-reporter activities.

49 with real-time PCR, and increased amounts of epiregulin protein were demonstrated with immunoprecipit

50 r progression and metastasis, including EREG/epiregulin, PTGS2/COX2, MMP1, MMP2, and CD44, along with

51 (epidermal growth factor), amphiregulin and epiregulin, resulting in autocrine activation of the EGF

52 ectively, our data indicate that Yap-induced Epiregulin signaling promotes the identity of SMG ductal

53 Epiregulin stimulated keratinocyte proliferation and pho

54 the epidermal growth factor receptor ligand epiregulin, the cyclooxygenase COX2, and the matrix meta

55 We cloned the cDNA for rat epiregulin to determine its pattern of expression in G-p

56 ET-1, or alpha-Thr for 1 h, induction of two epiregulin transcripts was observed, including a 4.8-kb

57 lulin, and ADAM17 as the major convertase of epiregulin, transforming growth factor alpha, amphiregul

58 Mice deficient in either amphiregulin or epiregulin, two EGFR ligands, display delayed or reduced

59 Here we found that the expression of epiregulin, urokinase-type plasminogen activator (uPA),

60 Recombinant rat epiregulin was strongly mitogenic for RASM cells, stimul

61 regulin, follistatin, and inhibin-beta-A and epiregulin were activated by an autocrine loop involving

62 eptor tyrosine phosphorylation stimulated by epiregulin were less than those induced by EGF or betace

63 oduction of a potent epidermal growth factor epiregulin, which may serve as a paracrine survival and

64 reduced expression of the EGF family member Epiregulin, which we show is required for the expansion