ライフサイエンスコーパス: epithelial Na channel

1 nd gamma, contribute to the formation of the epithelial Na+ channel.

2 bunits of the vertebrate amiloride-sensitive epithelial Na+ channel.

3 bunits of the vertebrate amiloride-sensitive epithelial Na+ channel.

4 is that ENaCs form a core conduction unit of epithelial Na+ channels.

5 m for examining the interactions of CFTR and epithelial Na+ channels.

6 ial cells in culture overexpressing CFTR and epithelial Na+ channels.

7 cation or activity but not the expression of epithelial Na(+) channel.

8 e and processing of the gamma isoform of the epithelial Na(+) channel.

9 he epithelial Na(+) channel (ENaC) family of epithelial Na(+) channels.

10 membrane conductance regulator regulation of epithelial Na(+) channel activity and an absence of expr

11 onductance regulator (CFTR) directly affects epithelial Na+ channel activity by co-incorporating into

12 In the colon, epithelial Na+ channel activity is increased and colonic

13 Renal epithelial Na+ channel activity is tonically inhibited b

14 arge part by increasing transcription of the epithelial Na(+) channel alpha-subunit (alpha-ENaC) expr

15 associated with increased expression of the epithelial Na+ channel alpha subunit (alphaENaC).

16 CFTR and either heterologously expressed rat epithelial Na+ channel ( alpha,b eta,gamma-rENaC) or an

17 Conductance of heterotrimeric rat epithelial Na+ channels (alpha, beta, gamma-rENaCs) for

18 which has loss-of-function mutations of the epithelial Na+ channel and an increased volume of airway

19 ,gamma-rENaCs form a core conduction unit of epithelial Na+ channels and that interaction of these ch

20 amiloride, an inhibitor of Na/H exchange and epithelial Na channels, and resuscitation with hypertoni

21 dinated regulation of (a) absorption, by the epithelial Na+ channel, and (b) secretion, by the Ca2+-a

22 Overexpression of the epithelial Na(+) channel beta subunit (Scnn1b gene, beta

23 Treatment with the epithelial Na(+) channel blocker amiloride, improving ai

24 ential role in diminishing the activation of epithelial Na(+) channels by serine proteases.

25 ecific proteases have been shown to activate epithelial Na+ channels by cleaving channel subunits at

26 with the pore-forming 150-kDa subunit of an epithelial Na+ channel complex initially purified by Ben

27 n (INa2), with properties consistent with an epithelial Na+ channel current in some cells, and a calc

28 thway involving three factors: the degenerin/epithelial Na(+) channel (DEG/ENaC) class of mechanosens

29 ICs) are H(+)-gated members of the degenerin/epithelial Na(+) channel (DEG/ENaC) family in vertebrate

30 channel (BASIC) is a member of the degenerin/epithelial Na(+) channel (Deg/ENaC) family of ion channe

31 he mechanically gated depolarizing degenerin/epithelial Na+ channels (DEG/ENaC), but it inhibits two

32 hannels (ASICs), newly discovered members of epithelial Na+ channels/degenirin superfamily, are widel

33 rotein ligase that reduces expression of the epithelial Na(+) channel ENaC at the cell surface.

34 As a pathway for Na(+) reabsorption, the epithelial Na(+) channel ENaC is critical for Na(+) home

35 across epithelia is mediated in part by the epithelial Na(+) channel ENaC.

36 eater expression of the alpha-subunit of the epithelial Na channel (ENaC) compared with age-matched c

37 ns of thiazide-sensitive NaCl cotransporter, epithelial Na channel (ENaC), aquaporin-2, ROMK, and NaK

38 Changes in amiloride-sensitive epithelial Na(+) channel (ENaC) activity (NP(o)) in the

39 Inhibition of epithelial Na(+) channel (ENaC) activity by high concent

40 The regulation of epithelial Na(+) channel (ENaC) activity by Na(+) was st

41 Epithelial Na(+) channel (ENaC) activity is regulated, i

42 erone-sensitive distal nephron downregulates epithelial Na(+) channel (ENaC) activity, we tested whet

43 orter (NCC), claudin-7, and cleaved forms of epithelial Na(+) channel (ENaC) alpha and gamma subunits

44 a(+) currents that depend on both the apical epithelial Na(+) channel (ENaC) and basolateral Na(+),K(

45 uptake of sodium via the amiloride-sensitive epithelial Na(+) channel (ENaC) and nonselective cyclic-

46 was consistent with Na(+) absorption by the epithelial Na(+) channel (ENaC) and was blocked by the E

47 Recent studies identify the epithelial Na(+) channel (ENaC) as a channel sensitive t

48 quitin ligase that reduces expression of the epithelial Na(+) channel (ENaC) at the cell surface.

49 Extracellular Zn(2+) activates the epithelial Na(+) channel (ENaC) by relieving Na(+) self-

50 present study investigates regulation of the epithelial Na(+) channel (ENaC) by Rho GTPases.

51 unction implications of loss of function for epithelial Na(+) channel (ENaC) containing a pseudohypoa

52 CFTR inhibits epithelial Na(+) channel (ENaC) currents in many epithel

53 CFTR inhibits epithelial Na(+) channel (ENaC) currents in many epithel

54 y overstimulation of the amiloride-sensitive epithelial Na(+) channel (ENaC) expressed by epithelial

55 The renal epithelial Na(+) channel (ENaC) expression and function

56 he hypothesis that subunits of the mammalian epithelial Na(+) channel (ENaC) family are expressed in

57 ent whose characteristics match those of the epithelial Na(+) channel (ENaC) family of epithelial Na(

58 Epithelial Na(+) channel (ENaC) function is regulated by

59 The epithelial Na(+) channel (ENaC) functions as a pathway f

60 The epithelial Na(+) channel (ENaC) functions as a pathway f

61 uggests that the extracellular domain of the epithelial Na(+) channel (ENaC) functions as a sensor th

62 acts in large part through induction of the epithelial Na(+) channel (ENaC) gene in the renal collec

63 The epithelial Na(+) channel (ENaC) has a key role in the re

64 The epithelial Na(+) channel (ENaC) has three subunits; the

65 In mammals, the epithelial Na(+) channel (ENaC) helps clear liquid from

66 Na(+) reabsorption by the epithelial Na(+) channel (ENaC) in cortical collecting d

67 anscriptional repression of alpha-subunit of epithelial Na(+) channel (ENaC) in lung and salivary epi

68 4-2) binds to and regulates stability of the epithelial Na(+) channel (ENaC) in salt-absorbing epithe

69 The epithelial Na(+) channel (ENaC) in the aldosterone-sensi

70 The epithelial Na(+) channel (ENaC) in the aldosterone-sensi

71 The epithelial Na(+) channel (ENaC) is comprised of three ho

72 The epithelial Na(+) channel (ENaC) is critical for Na(+) ho

73 The extracellular domain of the epithelial Na(+) channel (ENaC) is exposed to a wide ran

74 dosterone-sensitive distal nephron where the epithelial Na(+) channel (ENaC) is expressed, we hypothe

75 The epithelial Na(+) channel (ENaC) is implicated in the pat

76 Activity of the epithelial Na(+) channel (ENaC) is limiting for Na(+) re

77 The epithelial Na(+) channel (ENaC) is modulated by membrane

78 The activity of the epithelial Na(+) channel (ENaC) is modulated by Na(+) se

79 Activity of the epithelial Na(+) channel (ENaC) is modulated by Na(+) se

80 The epithelial Na(+) channel (ENaC) is often the rate limiti

81 Activity of the epithelial Na(+) channel (ENaC) is rate-limiting for Na(

82 The epithelial Na(+) channel (ENaC) is regulated by a variet

83 The epithelial Na(+) channel (ENaC) is typically formed by t

84 The epithelial Na(+) channel (ENaC) mediates Na(+) transport

85 The epithelial Na(+) channel (ENaC) mediates the rate-limiti

86 The epithelial Na(+) channel (ENaC) plays a central role in

87 The amiloride-sensitive epithelial Na(+) channel (ENaC) plays a critical role in

88 The epithelial Na(+) channel (ENaC) plays a critical role in

89 In the current study, domains within the epithelial Na(+) channel (ENaC) reactive at the plasma m

90 We report here activation of the epithelial Na(+) channel (ENaC) reconstituted in Chinese

91 The epithelial Na(+) channel (ENaC) regulates epithelial sal

92 Regulation of epithelial Na(+) channel (ENaC) subunit levels by protei

93 ABSTRACT: All three epithelial Na(+) channel (ENaC) subunits (alpha, beta an

94 Epithelial Na(+) channel (ENaC) subunits contain both mo

95 Ion channels, including the epithelial Na(+) channel (ENaC), are intrinsic membrane

96 e if this apical entry step occurred via the epithelial Na(+) channel (ENaC), studies were performed

97 now demonstrate that WNK4 also inhibits the epithelial Na(+) channel (ENaC), the major mediator of a

98 d triggers Na(+) hyperabsorption through the epithelial Na(+) channel (ENaC), which contribute to red

99 elial clone 1 (SPLUNC1) effectively inhibits epithelial Na(+) channel (ENaC)-dependent Na(+) absorpti

100 Regulation of epithelial Na(+) channel (ENaC)-mediated transport in th

101 the activity of ion channels, including the epithelial Na(+) channel (ENaC).

102 cessary and sufficient for activation of the epithelial Na(+) channel (ENaC).

103 other epithelial ion channels including the epithelial Na(+) channel (ENaC).

104 bsorption is governed by the activity of the epithelial Na(+) channel (ENaC).

105 ation plays a key role in trafficking of the epithelial Na(+) channel (ENaC).

106 andem P domain K(+) channels (TREK1) and the epithelial Na(+) channel (ENaC).

107 regulator (CFTR) and the amiloride-sensitive epithelial Na(+) channel (ENaC).

108 everal ion transport proteins, including the epithelial Na(+) channel (ENaC).

109 ial evidence implicates hyperactivity of the epithelial Na(+) channel (ENaC).

110 protease trypsin can indirectly activate the epithelial Na(+) channel (ENaC).

111 (+)-gated channel of the amiloride-sensitive epithelial Na(+) channel (ENaC)/degenerin family.

112 e signature biophysical properties of cloned epithelial Na(+) channels (ENaC) (conductance, ion selec

113 cells, Na(+) crosses the apical membrane via epithelial Na(+) channels (ENaC) and is extruded into th

114 ansport proteins such as amiloride-sensitive epithelial Na(+) channels (ENaC) and Na,K-ATPases.

115 colonic Na(+) absorption is mediated by both epithelial Na(+) channels (ENaC) and Na-H exchangers (NH

116 Amiloride-sensitive epithelial Na(+) channels (ENaC) are responsible for tra

117 vivo and the activity of amiloride-sensitive epithelial Na(+) channels (ENaC) by measuring AFC in mic

118 The delta-subunit of epithelial Na(+) channels (ENaC) is predominately expres

119 Epithelial Na(+) channels (ENaC) participate in the regu

120 Epithelial Na(+) channels (ENaC) regulate salt and water

121 h Gi(alpha-3) and PIP(2) bind beta and gamma epithelial Na(+) channels (ENaC), but not alpha ENaC.

122 resent data that TI cells contain functional epithelial Na(+) channels (ENaC), pimozide-sensitive cat

123 pical membrane permeability by activation of epithelial Na(+) channels (ENaC).

124 mice with airway-specific overexpression of epithelial Na(+) channels (ENaC).

125 itutively active Na(+) currents generated by epithelial Na(+) channels (ENaC).

126 lar and intracellular proteases can activate epithelial Na(+) channels (ENaC).

127 where apical Na(+) transport is mediated by epithelial Na(+) channels (ENaC).

128 The epithelial Na+ channel (ENaC) absorbs Na+ across the api

129 ated that CFTR-dependent changes in apparent epithelial Na+ channel (ENaC) activity could be accounte

130 Airway epithelia absorb Na+ through the epithelial Na+ channel (ENaC) and secrete Cl- through th

131 by mechanisms that control expression of the epithelial Na+ channel (ENaC) at the cell surface.

132 The epithelial Na+ channel (ENaC) belongs to the structurall

133 paB kinase-beta (IKKbeta) interacts with the epithelial Na+ channel (ENaC) beta-subunit and enhances

134 E3 ubiquitin-protein ligase that targets the epithelial Na+ channel (ENaC) for degradation.

135 The epithelial Na+ channel (ENaC) forms the pathway for Na+

136 ic tails of the mouse alpha, beta, and gamma epithelial Na+ channel (ENaC) important to protein-prote

137 We investigated purinergic regulation of the epithelial Na+ channel (ENaC) in mammalian collecting du

138 The epithelial Na+ channel (ENaC) is a tetramer of two alpha

139 The epithelial Na+ channel (ENaC) is assembled in the endopl

140 The epithelial Na+ channel (ENaC) is composed of three homol

141 The epithelial Na+ channel (ENaC) is essential for Na+ homeo

142 is hypertransport is that the activity of an epithelial Na+ channel (ENaC) is inversely related to th

143 Activity of the epithelial Na+ channel (ENaC) is limiting for Na+ absorp

144 The epithelial Na+ Channel (ENaC) mediates Na+ reabsorption

145 The epithelial Na+ channel (ENaC) plays a critical role in N

146 The degenerin/epithelial Na+ channel (ENaC) superfamily is a group of

147 enic hypertension caused by mutations in the epithelial Na+ channel (ENaC) that interfere with its ub

148 sor AMP-activated kinase (AMPK) inhibits the epithelial Na+ channel (ENaC) through decreased plasma m

149 s were infected in vivo for determination of epithelial Na+ channel (ENaC) total and cell surface pro

150 The epithelial Na+ channel (ENaC) transports Na+ across tigh

151 on is available regarding domains within the epithelial Na+ channel (ENaC) which participate in amilo

152 regulated genes--including that encoding the epithelial Na+ channel (ENaC), a key arbiter of Na+ tran

153 Dietary salt intake controls epithelial Na+ channel (ENaC)-mediated Na+ reabsorption

154 lete or disrupt a C-terminal PY motif in the epithelial Na+ channel (ENaC).

155 d against an amiloride binding domain on the epithelial Na+ channel (ENaC).

156 epithelial-expressed AKAPs in regulating the epithelial Na+ channel (ENaC).

157 All members of the epithelial Na+ channel (ENaC)/Degenerin (Deg) channel su

158 sensing ion channels (ASICs), members of the epithelial Na+ channel (ENaC)/degenerin (DEG) family of

159 eteromeric combinations of subunits from the epithelial Na+ channel (ENaC)/degenerin superfamily, whi

160 dd4L gene) regulates the amiloride-sensitive epithelial Na+ channel (ENaC/SCNN1) to mediate Na+ homeo

161 Epithelial Na+ channels (ENaC) coexist with a family of

162 Streaming potentials across cloned epithelial Na+ channels (ENaC) incorporated into planar

163 lement formed by the alpha-subunit of cloned epithelial Na+ channels (ENaC) was studied in planar lip

164 ms by which RSV inhibits amiloride-sensitive epithelial Na+ channels (ENaC), the main pathways throug

165 e in response to amiloride (a blocker of the epithelial Na(+) channel, ENaC).

166 The epithelial Na(+) channel, ENaC, and the Cl(-)/HCO(3)(-)

167 The epithelial Na(+) channel, ENaC, is exposed to a wide ran

168 embrane conductance regulator, CFTR, and the epithelial Na(+) channel, ENaC.

169 bolism, and sodium (Na(+)) transport via the epithelial Na(+) channel, ENaC.

170 ical and pharmacological properties with the epithelial Na+ channel, ENaC.

171 (+) absorption and Scnn1g mRNA (encoding the epithelial Na(+) channel ENaCgamma) expression through a

172 Epithelial Na(+) channels (ENaCs) are activated by extra

173 Epithelial Na(+) channels (ENaCs) are expressed in the m

174 Epithelial Na(+) channels (ENaCs) are members of the ENa

175 TS: A growing body of evidence suggests that epithelial Na(+) channels (ENaCs) in the brain play a si

176 Epithelial Na(+) channels (ENaCs) play an essential role

177 lar fluid clearance because of inhibition of epithelial Na(+) channels (ENaCs) promotes cardiogenic l

178 Epithelial Na(+) channels (ENaCs) selectively conduct Na

179 Na(+) transport through amiloride-sensitive epithelial Na(+) channels (ENaCs).

180 ant role in the maturation and activation of epithelial Na(+) channels (ENaCs).

181 Previous studies have shown that epithelial Na+ channels (ENaCs) are activated by laminar

182 Epithelial Na+ channels (ENaCs) are regulated by the pho

183 Epithelial Na+ channels (ENaCs) comprise three subunits

184 Epithelial Na+ channels (ENaCs) mediate sodium reabsorpt

185 luid volume and blood pressure by activating epithelial Na+ channels (ENaCs).

186 Epithelial Na+ channels facilitate the transport of Na+

187 e transient receptor potential and degenerin/epithelial Na+ channel families are likely to be transdu

188 e alphabetagamma trimer dramatically reduces epithelial Na(+) channel function and surface expression

189 rmine the subunit stoichiometry of the human epithelial Na+ channel (hENaC), we expressed the three w

190 Similarly, coexpression of KS-WNK1 and the epithelial Na(+) channel in Fischer rat thyroid epitheli

191 died the pharmacological responses of native epithelial Na(+) channels in human Clara cells and human

192 wing beta-adrenoceptor-mediated control over epithelial Na(+) channels in the apical plasma membrane.

193 length on the alpha, beta, gamma-rENaC (rat epithelial Na+ channel) in planar lipid bilayers.

194 Human AT2 cells exhibited both epithelial Na(+) channel-mediated Na(+) absorption and c

195 ses in ASL height and MCC, via inhibition of epithelial Na(+)-channel-mediated Na(+) absorption and s

196 CFTR inhibits murine or rat epithelial Na+ channel (mENaC or rENaC) currents in many

197 tain the alpha-, beta-, and gamma-rENaC (rat epithelial Na+ channels) mRNAs; reconstitution of an ATI

198 Neuronal DEG/ENaC (degenerin and epithelial Na(+) channel) Na(+) channels have been impli

199 e vasopressin-sensitive, and actin-regulated epithelial Na+ channel of A6 cells, including a 6-7 pS s

200 sporter of the distal convoluted tubule, the epithelial Na+ channel of the collecting duct, and the b

201 lieved to be mediated by DEG/ENaC (degenerin/epithelial Na+ channel) proteins in nematodes and mammal

202 A cloned rat epithelial Na+ channel (rENaC) was studied in planar lip

203 eotide-gated cation (pacemaker) channels nor epithelial Na+ channels, respectively, transduce sour ta

204 nopus oocytes with the three subunits of the epithelial Na+ channel results in a significantly enhanc

205 In contrast, defects in the epithelial Na(+) channel (SCNN1) have been associated wi

206 type 2 airway inflammation in juvenile beta-epithelial Na(+) channel (Scnn1b)-transgenic (Tg) mice.

207 a.AF9 complex represses transcription of the epithelial Na(+) channel subunit alpha (alpha-ENaC) gene

208 says showed that no activation of the -ENaC (epithelial Na+ channel -subunit) promoter was discernibl

209 The extracellular regions of epithelial Na(+) channel subunits are highly ordered str

210 These data suggest that the epithelial Na+ channel subunits form high order oligomer

211 Members of the degenerin/epithelial Na(+) channel superfamily of ion channels sub

212 -zipper protein and the alpha-subunit of the epithelial Na(+) channel, supporting impaired MR signali

213 mily that includes subunits of the mammalian epithelial Na+ channel, the Caenorhabditis elegans degen

214 ly up-regulated colonic H(+),K(+)-ATPase and epithelial Na(+) channel to mediate electrolyte and flui

215 ays from damage, and limit the activation of epithelial Na(+) channels via serine proteases.

216 The idea that luminal Na+ can regulate epithelial Na+ channels was tested in the cortical colle

217 in degradation of membrane proteins, such as epithelial Na(+) channel, we examined the effect of Nedd

218 the alpha-, beta-, and gamma-subunits of the epithelial Na(+) channel were reduced.

219 conclude that PKGII is an activator of lung epithelial Na(+) channels, which may expedite the resolu