ライフサイエンスコーパス: epithelial Na channel

1 nd gamma, contribute to the formation of the epithelial Na+ channel.

2 bunits of the vertebrate amiloride-sensitive epithelial Na+ channel.

3 bunits of the vertebrate amiloride-sensitive epithelial Na+ channel.

4 is that ENaCs form a core conduction unit of epithelial Na+ channels.

5 m for examining the interactions of CFTR and epithelial Na+ channels.

6 ial cells in culture overexpressing CFTR and epithelial Na+ channels.

7 cation or activity but not the expression of epithelial Na(+) channel.

8 e and processing of the gamma isoform of the epithelial Na(+) channel.

9 he epithelial Na(+) channel (ENaC) family of epithelial Na(+) channels.

10 membrane conductance regulator regulation of epithelial Na(+) channel activity and an absence of expr

11 onductance regulator (CFTR) directly affects epithelial Na+ channel activity by co-incorporating into

12 In the colon, epithelial Na+ channel activity is increased and colonic

13 Renal epithelial Na+ channel activity is tonically inhibited b

14 arge part by increasing transcription of the epithelial Na(+) channel alpha-subunit (alpha-ENaC) expr

15 associated with increased expression of the epithelial Na+ channel alpha subunit (alphaENaC).

16 CFTR and either heterologously expressed rat epithelial Na+ channel ( alpha,b eta,gamma-rENaC) or an

17 Conductance of heterotrimeric rat epithelial Na+ channels (alpha, beta, gamma-rENaCs) for

18 which has loss-of-function mutations of the epithelial Na+ channel and an increased volume of airway

19 ,gamma-rENaCs form a core conduction unit of epithelial Na+ channels and that interaction of these ch

20 amiloride, an inhibitor of Na/H exchange and epithelial Na channels, and resuscitation with hypertoni

21 dinated regulation of (a) absorption, by the epithelial Na+ channel, and (b) secretion, by the Ca2+-a

22 Overexpression of the epithelial Na(+) channel beta subunit (Scnn1b gene, beta

23 Treatment with the epithelial Na(+) channel blocker amiloride, improving ai

24 ential role in diminishing the activation of epithelial Na(+) channels by serine proteases.

25 ecific proteases have been shown to activate epithelial Na+ channels by cleaving channel subunits at

26 long with a compensatory upregulation of the epithelial Na(+) channel, caused hypokalemic metabolic a

27 with the pore-forming 150-kDa subunit of an epithelial Na+ channel complex initially purified by Ben

28 DD4-2 is implicated in the regulation of the epithelial Na(+) channel critical for proper airway surf

29 n (INa2), with properties consistent with an epithelial Na+ channel current in some cells, and a calc

30 thway involving three factors: the degenerin/epithelial Na(+) channel (DEG/ENaC) class of mechanosens

31 ICs) are H(+)-gated members of the degenerin/epithelial Na(+) channel (DEG/ENaC) family in vertebrate

32 channel (BASIC) is a member of the degenerin/epithelial Na(+) channel (Deg/ENaC) family of ion channe

33 he mechanically gated depolarizing degenerin/epithelial Na+ channels (DEG/ENaC), but it inhibits two

34 the least understood member of the mammalian epithelial Na(+) channel/degenerin (ENaC/DEG) superfamil

35 hannels (ASICs), newly discovered members of epithelial Na+ channels/degenirin superfamily, are widel

36 protease (Furin)-mediated activation of the epithelial Na(+) channel ENaC (a bona fide Nedd4-2 subst

37 rotein ligase that reduces expression of the epithelial Na(+) channel ENaC at the cell surface.

38 As a pathway for Na(+) reabsorption, the epithelial Na(+) channel ENaC is critical for Na(+) home

39 ivity of diverse ion channels to include the epithelial Na(+) channel ENaC.

40 across epithelia is mediated in part by the epithelial Na(+) channel ENaC.

41 eater expression of the alpha-subunit of the epithelial Na channel (ENaC) compared with age-matched c

42 ns of thiazide-sensitive NaCl cotransporter, epithelial Na channel (ENaC), aquaporin-2, ROMK, and NaK

43 Changes in amiloride-sensitive epithelial Na(+) channel (ENaC) activity (NP(o)) in the

44 Inhibition of epithelial Na(+) channel (ENaC) activity by high concent

45 The regulation of epithelial Na(+) channel (ENaC) activity by Na(+) was st

46 enuated a high-salt (HS)-induced increase in epithelial Na(+) channel (ENaC) activity in the cortical

47 Epithelial Na(+) channel (ENaC) activity is regulated, i

48 erone-sensitive distal nephron downregulates epithelial Na(+) channel (ENaC) activity, we tested whet

49 orter (NCC), claudin-7, and cleaved forms of epithelial Na(+) channel (ENaC) alpha and gamma subunits

50 a(+) currents that depend on both the apical epithelial Na(+) channel (ENaC) and basolateral Na(+),K(

51 filtered Na(+) is reabsorbed mainly via the epithelial Na(+) channel (ENaC) and Na(+) -coupled co-tr

52 uptake of sodium via the amiloride-sensitive epithelial Na(+) channel (ENaC) and nonselective cyclic-

53 was consistent with Na(+) absorption by the epithelial Na(+) channel (ENaC) and was blocked by the E

54 Recent studies identify the epithelial Na(+) channel (ENaC) as a channel sensitive t

55 quitin ligase that reduces expression of the epithelial Na(+) channel (ENaC) at the cell surface.

56 Extracellular Zn(2+) activates the epithelial Na(+) channel (ENaC) by relieving Na(+) self-

57 present study investigates regulation of the epithelial Na(+) channel (ENaC) by Rho GTPases.

58 unction implications of loss of function for epithelial Na(+) channel (ENaC) containing a pseudohypoa

59 CFTR inhibits epithelial Na(+) channel (ENaC) currents in many epithel

60 CFTR inhibits epithelial Na(+) channel (ENaC) currents in many epithel

61 y overstimulation of the amiloride-sensitive epithelial Na(+) channel (ENaC) expressed by epithelial

62 functions as a molecular chaperone to reduce epithelial Na(+) channel (ENaC) expression and activity

63 The renal epithelial Na(+) channel (ENaC) expression and function

64 he hypothesis that subunits of the mammalian epithelial Na(+) channel (ENaC) family are expressed in

65 ent whose characteristics match those of the epithelial Na(+) channel (ENaC) family of epithelial Na(

66 Ion channels of the degenerin (DEG)/epithelial Na(+) channel (ENaC) family serve diverse fun

67 Canonical vertebrate epithelial Na(+) channel (ENaC) formed by alpha-, beta-,

68 Epithelial Na(+) channel (ENaC) function is critical to

69 Epithelial Na(+) channel (ENaC) function is regulated by

70 The epithelial Na(+) channel (ENaC) functions as a pathway f

71 The epithelial Na(+) channel (ENaC) functions as a pathway f

72 uggests that the extracellular domain of the epithelial Na(+) channel (ENaC) functions as a sensor th

73 acts in large part through induction of the epithelial Na(+) channel (ENaC) gene in the renal collec

74 The epithelial Na(+) channel (ENaC) has a key role in the re

75 The epithelial Na(+) channel (ENaC) has three subunits; the

76 In mammals, the epithelial Na(+) channel (ENaC) helps clear liquid from

77 Na(+) reabsorption by the epithelial Na(+) channel (ENaC) in cortical collecting d

78 anscriptional repression of alpha-subunit of epithelial Na(+) channel (ENaC) in lung and salivary epi

79 4-2) binds to and regulates stability of the epithelial Na(+) channel (ENaC) in salt-absorbing epithe

80 The epithelial Na(+) channel (ENaC) in the aldosterone-sensi

81 The epithelial Na(+) channel (ENaC) in the aldosterone-sensi

82 Activity of the Epithelial Na(+) Channel (ENaC) in the distal nephron fi

83 Scnn1b-Tg mice overexpress the epithelial Na(+) channel (ENaC) in their lungs, driving

84 The epithelial Na(+) channel (ENaC) is activated by proteoly

85 The epithelial Na(+) channel (ENaC) is comprised of three ho

86 The epithelial Na(+) channel (ENaC) is critical for Na(+) ho

87 The extracellular domain of the epithelial Na(+) channel (ENaC) is exposed to a wide ran

88 dosterone-sensitive distal nephron where the epithelial Na(+) channel (ENaC) is expressed, we hypothe

89 The epithelial Na(+) channel (ENaC) is implicated in the pat

90 Activity of the epithelial Na(+) channel (ENaC) is limiting for Na(+) re

91 The epithelial Na(+) channel (ENaC) is modulated by membrane

92 The activity of the epithelial Na(+) channel (ENaC) is modulated by Na(+) se

93 Activity of the epithelial Na(+) channel (ENaC) is modulated by Na(+) se

94 The epithelial Na(+) channel (ENaC) is often the rate limiti

95 Activity of the epithelial Na(+) channel (ENaC) is rate-limiting for Na(

96 The epithelial Na(+) channel (ENaC) is regulated by a variet

97 The epithelial Na(+) channel (ENaC) is typically formed by t

98 The epithelial Na(+) channel (ENaC) mediates Na(+) transport

99 The epithelial Na(+) channel (ENaC) mediates the rate-limiti

100 The epithelial Na(+) channel (ENaC) plays a central role in

101 The amiloride-sensitive epithelial Na(+) channel (ENaC) plays a critical role in

102 The epithelial Na(+) channel (ENaC) plays a critical role in

103 In the current study, domains within the epithelial Na(+) channel (ENaC) reactive at the plasma m

104 We report here activation of the epithelial Na(+) channel (ENaC) reconstituted in Chinese

105 The epithelial Na(+) channel (ENaC) regulates epithelial sal

106 Regulation of epithelial Na(+) channel (ENaC) subunit levels by protei

107 ABSTRACT: All three epithelial Na(+) channel (ENaC) subunits (alpha, beta an

108 Epithelial Na(+) channel (ENaC) subunits contain both mo

109 Ion channels, including the epithelial Na(+) channel (ENaC), are intrinsic membrane

110 The epithelial Na(+) channel (ENaC), by mediating the flow o

111 e if this apical entry step occurred via the epithelial Na(+) channel (ENaC), studies were performed

112 now demonstrate that WNK4 also inhibits the epithelial Na(+) channel (ENaC), the major mediator of a

113 d triggers Na(+) hyperabsorption through the epithelial Na(+) channel (ENaC), which contribute to red

114 ng triggers sodium (Na(+)) entry through the epithelial Na(+) channel (ENaC), which depolarizes cells

115 Higher activity of the epithelial Na(+) channel (ENaC), which provides the driv

116 elial clone 1 (SPLUNC1) effectively inhibits epithelial Na(+) channel (ENaC)-dependent Na(+) absorpti

117 Regulation of epithelial Na(+) channel (ENaC)-mediated transport in th

118 protease trypsin can indirectly activate the epithelial Na(+) channel (ENaC).

119 the activity of ion channels, including the epithelial Na(+) channel (ENaC).

120 cessary and sufficient for activation of the epithelial Na(+) channel (ENaC).

121 other epithelial ion channels including the epithelial Na(+) channel (ENaC).

122 bsorption is governed by the activity of the epithelial Na(+) channel (ENaC).

123 ation plays a key role in trafficking of the epithelial Na(+) channel (ENaC).

124 andem P domain K(+) channels (TREK1) and the epithelial Na(+) channel (ENaC).

125 regulator (CFTR) and the amiloride-sensitive epithelial Na(+) channel (ENaC).

126 everal ion transport proteins, including the epithelial Na(+) channel (ENaC).

127 ial evidence implicates hyperactivity of the epithelial Na(+) channel (ENaC).

128 (+)-gated channel of the amiloride-sensitive epithelial Na(+) channel (ENaC)/degenerin family.

129 e signature biophysical properties of cloned epithelial Na(+) channels (ENaC) (conductance, ion selec

130 cells, Na(+) crosses the apical membrane via epithelial Na(+) channels (ENaC) and is extruded into th

131 ansport proteins such as amiloride-sensitive epithelial Na(+) channels (ENaC) and Na,K-ATPases.

132 colonic Na(+) absorption is mediated by both epithelial Na(+) channels (ENaC) and Na-H exchangers (NH

133 Amiloride-sensitive epithelial Na(+) channels (ENaC) are responsible for tra

134 vivo and the activity of amiloride-sensitive epithelial Na(+) channels (ENaC) by measuring AFC in mic

135 The delta-subunit of epithelial Na(+) channels (ENaC) is predominately expres

136 Epithelial Na(+) channels (ENaC) participate in the regu

137 Epithelial Na(+) channels (ENaC) regulate salt and water

138 h Gi(alpha-3) and PIP(2) bind beta and gamma epithelial Na(+) channels (ENaC), but not alpha ENaC.

139 resent data that TI cells contain functional epithelial Na(+) channels (ENaC), pimozide-sensitive cat

140 pical membrane permeability by activation of epithelial Na(+) channels (ENaC).

141 mice with airway-specific overexpression of epithelial Na(+) channels (ENaC).

142 itutively active Na(+) currents generated by epithelial Na(+) channels (ENaC).

143 lar and intracellular proteases can activate epithelial Na(+) channels (ENaC).

144 where apical Na(+) transport is mediated by epithelial Na(+) channels (ENaC).

145 The epithelial Na+ channel (ENaC) absorbs Na+ across the api

146 ated that CFTR-dependent changes in apparent epithelial Na+ channel (ENaC) activity could be accounte

147 Airway epithelia absorb Na+ through the epithelial Na+ channel (ENaC) and secrete Cl- through th

148 by mechanisms that control expression of the epithelial Na+ channel (ENaC) at the cell surface.

149 The epithelial Na+ channel (ENaC) belongs to the structurall

150 paB kinase-beta (IKKbeta) interacts with the epithelial Na+ channel (ENaC) beta-subunit and enhances

151 E3 ubiquitin-protein ligase that targets the epithelial Na+ channel (ENaC) for degradation.

152 The epithelial Na+ channel (ENaC) forms the pathway for Na+

153 ic tails of the mouse alpha, beta, and gamma epithelial Na+ channel (ENaC) important to protein-prote

154 We investigated purinergic regulation of the epithelial Na+ channel (ENaC) in mammalian collecting du

155 The epithelial Na+ channel (ENaC) is a tetramer of two alpha

156 The epithelial Na+ channel (ENaC) is assembled in the endopl

157 The epithelial Na+ channel (ENaC) is composed of three homol

158 The epithelial Na+ channel (ENaC) is essential for Na+ homeo

159 is hypertransport is that the activity of an epithelial Na+ channel (ENaC) is inversely related to th

160 Activity of the epithelial Na+ channel (ENaC) is limiting for Na+ absorp

161 The epithelial Na+ Channel (ENaC) mediates Na+ reabsorption

162 The epithelial Na+ channel (ENaC) plays a critical role in N

163 The degenerin/epithelial Na+ channel (ENaC) superfamily is a group of

164 enic hypertension caused by mutations in the epithelial Na+ channel (ENaC) that interfere with its ub

165 sor AMP-activated kinase (AMPK) inhibits the epithelial Na+ channel (ENaC) through decreased plasma m

166 s were infected in vivo for determination of epithelial Na+ channel (ENaC) total and cell surface pro

167 The epithelial Na+ channel (ENaC) transports Na+ across tigh

168 on is available regarding domains within the epithelial Na+ channel (ENaC) which participate in amilo

169 regulated genes--including that encoding the epithelial Na+ channel (ENaC), a key arbiter of Na+ tran

170 Dietary salt intake controls epithelial Na+ channel (ENaC)-mediated Na+ reabsorption

171 lete or disrupt a C-terminal PY motif in the epithelial Na+ channel (ENaC).

172 d against an amiloride binding domain on the epithelial Na+ channel (ENaC).

173 on was caused by stimulation of the alveolar epithelial Na+ channel (ENaC).

174 epithelial-expressed AKAPs in regulating the epithelial Na+ channel (ENaC).

175 All members of the epithelial Na+ channel (ENaC)/Degenerin (Deg) channel su

176 sensing ion channels (ASICs), members of the epithelial Na+ channel (ENaC)/degenerin (DEG) family of

177 eteromeric combinations of subunits from the epithelial Na+ channel (ENaC)/degenerin superfamily, whi

178 dd4L gene) regulates the amiloride-sensitive epithelial Na+ channel (ENaC/SCNN1) to mediate Na+ homeo

179 Epithelial Na+ channels (ENaC) coexist with a family of

180 Streaming potentials across cloned epithelial Na+ channels (ENaC) incorporated into planar

181 lement formed by the alpha-subunit of cloned epithelial Na+ channels (ENaC) was studied in planar lip

182 ms by which RSV inhibits amiloride-sensitive epithelial Na+ channels (ENaC), the main pathways throug

183 e in response to amiloride (a blocker of the epithelial Na(+) channel, ENaC).

184 The epithelial Na(+) channel, ENaC, and the Cl(-)/HCO(3)(-)

185 The epithelial Na(+) channel, ENaC, is exposed to a wide ran

186 o diverse ion channels (Ca(V)2.2; KCNQ1; and epithelial Na(+) channel, ENaC, with a Liddle syndrome m

187 embrane conductance regulator, CFTR, and the epithelial Na(+) channel, ENaC.

188 bolism, and sodium (Na(+)) transport via the epithelial Na(+) channel, ENaC.

189 ical and pharmacological properties with the epithelial Na+ channel, ENaC.

190 (+) absorption and Scnn1g mRNA (encoding the epithelial Na(+) channel ENaCgamma) expression through a

191 Epithelial Na(+) channels (ENaCs) are activated by extra

192 Epithelial Na(+) channels (ENaCs) are activated by prote

193 Epithelial Na(+) channels (ENaCs) are expressed in the m

194 Epithelial Na(+) channels (ENaCs) are members of the ENa

195 TS: A growing body of evidence suggests that epithelial Na(+) channels (ENaCs) in the brain play a si

196 Epithelial Na(+) channels (ENaCs) play an essential role

197 lar fluid clearance because of inhibition of epithelial Na(+) channels (ENaCs) promotes cardiogenic l

198 Epithelial Na(+) channels (ENaCs) selectively conduct Na

199 Na(+) transport through amiloride-sensitive epithelial Na(+) channels (ENaCs).

200 ant role in the maturation and activation of epithelial Na(+) channels (ENaCs).

201 Previous studies have shown that epithelial Na+ channels (ENaCs) are activated by laminar

202 Epithelial Na+ channels (ENaCs) are known to affect bloo

203 Epithelial Na+ channels (ENaCs) are regulated by the pho

204 Epithelial Na+ channels (ENaCs) comprise three subunits

205 Epithelial Na+ channels (ENaCs) mediate sodium reabsorpt

206 luid volume and blood pressure by activating epithelial Na+ channels (ENaCs).

207 Epithelial Na+ channels facilitate the transport of Na+

208 e transient receptor potential and degenerin/epithelial Na+ channel families are likely to be transdu

209 e alphabetagamma trimer dramatically reduces epithelial Na(+) channel function and surface expression

210 rmine the subunit stoichiometry of the human epithelial Na+ channel (hENaC), we expressed the three w

211 TRESK homodimer was connected with two ENaC (epithelial Na(+) channel) heterotrimers, and the Na(+) c

212 Similarly, coexpression of KS-WNK1 and the epithelial Na(+) channel in Fischer rat thyroid epitheli

213 died the pharmacological responses of native epithelial Na(+) channels in human Clara cells and human

214 wing beta-adrenoceptor-mediated control over epithelial Na(+) channels in the apical plasma membrane.

215 length on the alpha, beta, gamma-rENaC (rat epithelial Na+ channel) in planar lipid bilayers.

216 Human AT2 cells exhibited both epithelial Na(+) channel-mediated Na(+) absorption and c

217 ses in ASL height and MCC, via inhibition of epithelial Na(+)-channel-mediated Na(+) absorption and s

218 CFTR inhibits murine or rat epithelial Na+ channel (mENaC or rENaC) currents in many

219 tain the alpha-, beta-, and gamma-rENaC (rat epithelial Na+ channels) mRNAs; reconstitution of an ATI

220 Neuronal DEG/ENaC (degenerin and epithelial Na(+) channel) Na(+) channels have been impli

221 e vasopressin-sensitive, and actin-regulated epithelial Na+ channel of A6 cells, including a 6-7 pS s

222 sporter of the distal convoluted tubule, the epithelial Na+ channel of the collecting duct, and the b

223 lieved to be mediated by DEG/ENaC (degenerin/epithelial Na+ channel) proteins in nematodes and mammal

224 A cloned rat epithelial Na+ channel (rENaC) was studied in planar lip

225 eotide-gated cation (pacemaker) channels nor epithelial Na+ channels, respectively, transduce sour ta

226 nopus oocytes with the three subunits of the epithelial Na+ channel results in a significantly enhanc

227 In contrast, defects in the epithelial Na(+) channel (SCNN1) have been associated wi

228 type 2 airway inflammation in juvenile beta-epithelial Na(+) channel (Scnn1b)-transgenic (Tg) mice.

229 a.AF9 complex represses transcription of the epithelial Na(+) channel subunit alpha (alpha-ENaC) gene

230 says showed that no activation of the -ENaC (epithelial Na+ channel -subunit) promoter was discernibl

231 pendent up-regulation of beta and gammaENaC (epithelial Na(+) channel) subunit expression.

232 The extracellular regions of epithelial Na(+) channel subunits are highly ordered str

233 These data suggest that the epithelial Na+ channel subunits form high order oligomer

234 Members of the degenerin/epithelial Na(+) channel superfamily of ion channels sub

235 -zipper protein and the alpha-subunit of the epithelial Na(+) channel, supporting impaired MR signali

236 mily that includes subunits of the mammalian epithelial Na+ channel, the Caenorhabditis elegans degen

237 ly up-regulated colonic H(+),K(+)-ATPase and epithelial Na(+) channel to mediate electrolyte and flui

238 ays from damage, and limit the activation of epithelial Na(+) channels via serine proteases.

239 The idea that luminal Na+ can regulate epithelial Na+ channels was tested in the cortical colle

240 in degradation of membrane proteins, such as epithelial Na(+) channel, we examined the effect of Nedd

241 the alpha-, beta-, and gamma-subunits of the epithelial Na(+) channel were reduced.

242 conclude that PKGII is an activator of lung epithelial Na(+) channels, which may expedite the resolu