ライフサイエンスコーパス: epithelial barrier

1 barrier integrity in AR, maintaining a leaky epithelial barrier.

2 adherin, resulting in the dysfunction of the epithelial barrier.

3 basal polarity and in the maintenance of the epithelial barrier.

4 , penetration efficiency was low across this epithelial barrier.

5 ens; they help maintain the integrity of the epithelial barrier.

6 , in which virions must cross the intestinal epithelial barrier.

7 romal lymphopoietin, IL-25, and IL-33 at the epithelial barrier.

8 orously respond to pathogens that breach the epithelial barrier.

9 ell-cell adhesion and a key regulator of the epithelial barrier.

10 nomedicines that can overcome the intestinal epithelial barrier.

11 tinal proliferation to maintain an effective epithelial barrier.

12 s and supports maintenance of the intestinal epithelial barrier.

13 timate goal of protecting, or restoring, the epithelial barrier.

14 despite the presence of a previously intact epithelial barrier.

15 wound closure and recovery of the intestinal epithelial barrier.

16 ch was associated with a more intact colonic epithelial barrier.

17 g denuded surfaces to recover the intestinal epithelial barrier.

18 to act as an enterotoxin, disrupting the gut epithelial barrier.

19 regulation and maintenance of the intestinal epithelial barrier.

20 tional tension necessary to build an in vivo epithelial barrier.

21 l microenvironments and drug-delivery across epithelial barriers.

22 mbrane tight-junction proteins that regulate epithelial barriers.

23 and novel mechanism for VDR by regulation of epithelial barriers.

24 c inflammatory cytokines, and destruction of epithelial barriers.

25 t gain access to sterile sites via disrupted epithelial barriers.

26 oles in regulating cationic gradients across epithelial barriers.

27 , (2) invasion of bacteria across the apical epithelial barrier, (3) nuclear factor-kappaB activation

28 to maintain the integrity of the intestinal epithelial barrier, a role that may have important clini

29 tes transport of intact IgG across polarized epithelial barriers, a pathway that is attractive for de

30 esis, resulting in downstream hair shaft and epithelial barrier abnormalities.

31 complexes, emphasizing how regulation of the epithelial barrier affects innate and adaptive immunity.

32 itor, elafin, is a critical component of the epithelial barrier against neutrophil elastase (NE).

33 ty; its activation by Metformin protects the epithelial barrier against stress and suppresses tumorig

34 te lymphoid cells (ILCs) function to protect epithelial barriers against pathogens and maintain tissu

35 f the immune system that function to protect epithelial barriers against pathogens and maintain tissu

36 Disruption of the intestinal epithelial barrier allows bacterial translocation and pr

37 Patients also had profound disruption of the epithelial barrier along the entire gastrointestinal tra

38 R4 signaling was associated with an impaired epithelial barrier, altered expression of antimicrobial

39 The disruption of the intestinal epithelial barrier and consequent escape of microbial pr

40 COPD allows colonizing bacteria to cross the epithelial barrier and drive persistent inflammation and

41 The mutant mice had severe disruption of the epithelial barrier and early death.

42 jured mucosa that accelerated restoration of epithelial barrier and function.

43 helial cells in mice and maintains intestine epithelial barrier and homeostasis.

44 intestine epithelium without disrupting the epithelial barrier and how these antigen delivery pathwa

45 ry route by which MNV crosses the intestinal epithelial barrier and infects underlying immune cells d

46 s a consequence of C. albicans breaching the epithelial barrier and invading surrounding tissues.

47 ll as inflammatory mediators that affect the epithelial barrier and mucosal repair.

48 naling in the maintenance and restitution of epithelial barrier and of the temporal regulation of the

49 ence that EoE is associated with an abnormal epithelial barrier and postulates that CS therapy, by re

50 sease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens.

51 cohol consumption can disrupt the intestinal epithelial barrier and result in increased gut permeabil

52 ls are often implicated in the regulation of epithelial barrier and secretomotor functions of the int

53 ial cell activity in the acute regulation of epithelial barrier and secretomotor functions of the int

54 ffect of miR-143 and miR-145 on the cervical epithelial barrier and to elucidate the mechanisms by wh

55 tic approach to support the integrity of the epithelial barrier and to protect from chronic colitis.

56 these regulation mechanisms compromises the epithelial barrier, and therefore, the barrier may be mo

57 g inhibits colitis by protecting the mucosal epithelial barrier, and this anticolitic activity is ind

58 omprises particular immune cell populations, epithelial barriers, and numerous secretory mediators in

59 gammadelta T cells located near the epithelial barrier are integral components of local infl

60 a critical role in regulating the intestinal epithelial barrier as well as monitoring bacterial trans

61 galectin-3 contribute to maintenance of the epithelial barrier at the ocular surface.

62 to maintain the integrity of the intestinal epithelial barrier because of its constant exposure to a

63 IL-22 targets our external epithelial barriers, bolstering our defenses, and has lo

64 miR-145 play a significant role in cervical epithelial barrier breakdown through diverse mechanisms

65 of alveolar edema across the normally tight epithelial barrier can be up-regulated by cyclic adenosi

66 duced phenotypic breakdown of the intestinal epithelial barrier caused by an increase in extracellula

67 rect functional link between collecting duct epithelial barrier characteristics, which appear to prev

68 and immunofluorescence techniques to examine epithelial barrier components.

69 isease (IBD), compromised restitution of the epithelial barrier contributes to disease severity.

70 ated with severe weakening of the intestinal epithelial barrier, culminating in increased colonic inf

71 Here, we show an intestinal epithelial barrier defect in the PTPsigma(-/-) mouse, de

72 Indications of epithelial barrier defects in association with epithelia

73 factorial, involving genetic predisposition, epithelial barrier defects, dysregulated immune response

74 s review, we discuss the individual roles of epithelial barrier defects, dysregulated innate and adap

75 Stat3(DeltaCD4) mice exhibited intestinal epithelial barrier defects, including downregulation of

76 patients and their association with possible epithelial barrier defects.

77 Defects in colonic epithelial barrier defenses are associated with ulcerati

78 nicity-14 (ST14) gene, which is critical for epithelial barrier development and homeostasis.

79 s that include enhancement of the intestinal epithelial barrier, development of the immune system and

80 Microbial products elicited by tumorous epithelial barrier disruption correlated with inflammato

81 y a dysregulated mucosal immune response and epithelial barrier disruption.

82 When unanticipated insults breach epithelial barriers, dormant programmes of tissue repair

83 monstrated increased colonic hyperplasia and epithelial barrier dysfunction (P < .0001 and P < .05, r

84 n of XRN2 are involved in the development of epithelial barrier dysfunction and gastroenteropathy.

85 Epithelial barrier dysfunction and increased permeabilit

86 Epithelial barrier dysfunction during human immunodefici

87 e role of histamine and TH2 cells in driving epithelial barrier dysfunction in AR.

88 y available transcriptomes demonstrated that epithelial barrier dysfunction in asthma is characterize

89 nvestigate the role of oncostatin M (OSM) in epithelial barrier dysfunction in human mucosal disease.

90 nces in the control of ion transport lead to epithelial barrier dysfunction in patients with colitis.

91 esults suggest that OSM might play a role in epithelial barrier dysfunction in patients with CRS and

92 Epithelial barrier dysfunction is a central feature in t

93 In the intestines, epithelial barrier dysfunction is a major contributor to

94 Epithelial barrier dysfunction is thought to play a role

95 Gut epithelial barrier dysfunction, innate immune activation

96 antibodies restored the TH1- and TH2-induced epithelial barrier dysfunction, respectively.

97 ologic function of TRAF2 that contributes to epithelial barrier dysfunction, which is attenuated by k

98 e-stranded RNA (dsRNA) mimetic, cause airway epithelial barrier dysfunction, which is reactive oxygen

99 Multiple organ systems require epithelial barriers for normal function, and barrier los

100 ce proteolytic cascade that is essential for epithelial barrier formation and homeostasis.

101 pithelial cells, Grhl2 inactivation impaired epithelial barrier formation and inhibited lumen expansi

102 e that PKD negatively regulates human airway epithelial barrier formation and integrity through down-

103 idate a role for mTORC1 in the regulation of epithelial barrier formation, cytoskeletal tension, and

104 stasin are components of a common intestinal epithelial barrier-forming pathway.

105 phil extracellular traps help to protect the epithelial barrier from C. albicans breach.

106 nutrition (TPN) led to a loss of intestinal epithelial barrier function (EBF), with an associated up

107 in intestinal mucosal atrophy and decreased epithelial barrier function (EBF).

108 participants, genes that promoted epidermal/epithelial barrier function (eg, filament-aggregating pr

109 ory response that results from disruption of epithelial barrier function after injury results in exce

110 TLR5, IL-1R and CD11c+ cells in constitutive epithelial barrier function against P. aeruginosa, with

111 Previously we reported that corneal epithelial barrier function against Pseudomonas aerugino

112 matory bowel disease, have direct effects on epithelial barrier function and are involved in epitheli

113 We measured epithelial barrier function and gastrointestinal motilit

114 s essential for ILC-dependent restoration of epithelial barrier function and maintenance of tissue ho

115 acrylic acid (IA), which promotes intestinal epithelial barrier function and mitigates inflammatory r

116 presented new approaches for improvement of epithelial barrier function and novel biologicals used i

117 nteric glial function in these mice restores epithelial barrier function and reduces bacterial transl

118 ion of TcdA replicates the disruption of the epithelial barrier function and structure observed in HI

119 consideration of MTAs in the maintenance of epithelial barrier function and the management of inflam

120 for growth rate, apical surface morphology, epithelial barrier function and transfection efficiency.

121 ngs reveal several undefined deficiencies in epithelial barrier function at the burn margin, potentia

122 ecessary and sufficient to diminish alveolar epithelial barrier function by impairing the ability of

123 important role in controlling the intestinal epithelial barrier function by serving as a precursor fo

124 play an important role in the protection of epithelial barrier function during periods of inflammati

125 ic patients abnormalities in many aspects of epithelial barrier function have been identified.

126 Loss of claudin-18 was sufficient to impair epithelial barrier function in 16HBE cells and in mouse

127 ts on the esophageal epithelium by impairing epithelial barrier function in association with loss of

128 nisms by which local burn injury compromises epithelial barrier function in burn margin, containing t

129 We found impaired nasal epithelial barrier function in patients with HDM-induced

130 AT3 in CD4(+) cells shaped strong intestinal epithelial barrier function in vitro and in vivo through

131 y on infection-induced changes in intestinal epithelial barrier function in vitro and on Citrobacter

132 n of NLRP3 by demonstrating that it protects epithelial barrier function independently of inflammasom

133 Alterations of the epithelial barrier function induced by EMD were investig

134 Increasing evidence indicates that defective epithelial barrier function is a feature of airway infla

135 Understanding the regulation of airway epithelial barrier function is a new frontier in asthma

136 Epithelial barrier function is defined principally by ti

137 Epithelial barrier function is maintained by continuous

138 Epithelial barrier function is maintained by tight junct

139 We find that epithelial barrier function is not disrupted during cyto

140 Precise regulation of epithelial barrier function is therefore required for ma

141 Here, we demonstrate that perturbations in epithelial barrier function lead to increased sodium flu

142 decline in epithelial cell proliferation and epithelial barrier function loss.

143 We discuss why defective epithelial barrier function might be linked to TH2 polar

144 The disruption of the intestinal epithelial barrier function occurs commonly in various p

145 Strikingly, the epithelial barrier function of differentiated keratinocy

146 eral genetic defects that disturb intestinal epithelial barrier function or affect innate and adaptiv

147 Regulation of epithelial barrier function requires targeted insertion

148 Prolonged breaches in epithelial barrier function result in inflammation and f

149 s that claudin-18 is a determinant of airway epithelial barrier function that is downregulated by IL-

150 for the host colonic epithelium and enhance epithelial barrier function through unclear mechanisms.

151 and E-cadherin expression, and restored the epithelial barrier function to a nearly normal level.

152 of immunological dysregulation and impaired epithelial barrier function to allergic diseases is stil

153 (GI) (patho)physiology; from GI motility and epithelial barrier function to enteric neuroinflammation

154 eracts with HuR and regulates the intestinal epithelial barrier function via the H19-encoded miR-675

155 Epithelial barrier function was measured by transepithel

156 tokine production cell-autonomously, impairs epithelial barrier function, and induces immune cell inf

157 ced changes in the intestinal immune system, epithelial barrier function, and other host features tha

158 CD73 deficiency led to a loss of endometrial epithelial barrier function, and pharmacological CD73 in

159 romoting antibacterial immunity, maintaining epithelial barrier function, and supporting tissue repai

160 SPs was associated with a local decrease in epithelial barrier function, bacterial invasion, product

161 cultured human cells in vitro and disrupted epithelial barrier function, consistent with the mucosal

162 of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate o

163 are involved in immunological regulation or epithelial barrier function, emphasizing the role of bot

164 claudins 2 and 4 have reciprocal effects on epithelial barrier function, exhibit differential FRAP d

165 gest that, in addition to its importance for epithelial barrier function, IRF6 also contributes to ho

166 y of allergens and the latter with a role in epithelial barrier function, were DA in patients with SA

167 HPV downregulated many genes involved in epithelial barrier function, which involves structural r

168 elial cells and their possible influences on epithelial barrier function.

169 ed genes associated with immune response and epithelial barrier function.

170 nsmigration of neutrophils, and improved the epithelial barrier function.

171 teins, cellular migration, ion transport and epithelial barrier function.

172 in the apical junctional complex and loss of epithelial barrier function.

173 to allergic disorders in part by disrupting epithelial barrier function.

174 r integrators in the control of motility and epithelial barrier function.

175 ss of goblet cells and failure of intestinal epithelial barrier function.

176 larity signals that are essential for normal epithelial barrier function.

177 , which is required for disruption of airway epithelial barrier function.

178 tween prostasin and matriptase in intestinal epithelial barrier function.

179 rocess of colonic epithelium renewal and the epithelial barrier function.

180 of albumin into airways, reflecting loss of epithelial barrier function.

181 contribute to UC inflammation by disrupting epithelial barrier function.

182 immune responses to pathogens and regulates epithelial barrier function; polymorphisms in TLR2 have

183 that colonic mucins confer both luminal and epithelial barrier functions and that, in the absence of

184 elial-mesenchymal transition and facilitated epithelial barrier functions by AJ localization of phosp

185 endent cellular processes, including loss of epithelial barrier functions, induction of apoptosis, an

186 brogated its AJ localization and compromised epithelial barrier functions.

187 ing relationship between innate immunity and epithelial barrier functions.

188 alization of beta-catenin and maintenance of epithelial barrier functions.

189 innate cytokines on T-cell responses at the epithelial barrier has led to new asthma paradigms.

190 ells; however, its function in lung alveolar epithelial barrier has not been addressed in genetic mod

191 meostasis and permeability of the intestinal epithelial barrier (IEB).

192 thma and other lung diseases associated with epithelial barrier impairment, whereby ASM cells respond

193 eurotoxins (BoNTs) cross the host intestinal epithelial barrier in foodborne botulism is poorly under

194 a genetic basis for modulation of intestinal epithelial barrier in IBD, and we have identified MAGI3

195 ed specific glucose flux through the gastric epithelial barrier in jejunal loops and in vivo followin

196 s were published emphasizing the role of the epithelial barrier in patients with allergic diseases.

197 MSC-Ex recovered the destruction of the epithelial barrier in the differentiated Caco-2 cells in

198 that HIV-1 could directly impair the mucosal epithelial barrier in the FRT.

199 Maintenance of the epithelial barrier in the intestinal tract is necessary

200 1 plays a significant role in maintenance of epithelial barrier in the intestine via regulation of ap

201 SEVI decreases HIV-1 penetration of squamous epithelial barriers in humans and macaques.

202 microcirculation and subsequent crossing of epithelial barriers in mucosa-lined organs such as the l

203 hich proteins and other large cargo traverse epithelial barriers in normal tissue.

204 ne protease matriptase is a key regulator of epithelial barriers in skin and intestine.

205 itive effects, such as in the maintenance of epithelial barriers in the gastrointestinal tract, but a

206 ortant for the maintenance and protection of epithelial barriers in the intestinal mucosa.

207 Importantly, rIFN-lambdas enhanced epithelial barriers in vitro, preventing transcellular b

208 Defects in the innate function of the airway epithelial barrier, including diminished expression of a

209 gene expression associated with the physical epithelial barrier, including keratinocyte cytoskeleton,

210 microbes at the luminal surface of a healthy epithelial barrier influence immune cell mobilization to

211 (NY1682) is more infectious and causes more epithelial barrier injury, although it stimulates less c

212 e intestinal tract, where they contribute to epithelial barrier integrity and host responses to comme

213 crophages are involved in the maintenance of epithelial barrier integrity and the elimination of inva

214 id cells (ILCs) are critical for maintaining epithelial barrier integrity at mucosal surfaces; howeve

215 Mast cells and TH2 cells might decrease epithelial barrier integrity in AR, maintaining a leaky

216 ety was evaluated by examining its impact on epithelial barrier integrity in polarized cultures and t

217 c inflammatory mediators in modulating nasal epithelial barrier integrity in the pathophysiology in A

218 iopathic rhinitis patients rapidly decreased epithelial barrier integrity in vitro.

219 ession has a key role maintaining intestinal epithelial barrier integrity in vivo during experimental

220 Epithelial barrier integrity is dependent on progenitor

221 Plasma gut epithelial barrier integrity markers (intestinal fatty a

222 of USP48 increases E-cadherin expression and epithelial barrier integrity through reducing TRAF2 stab

223 al disorders pathogenesis to disturbances in epithelial barrier integrity, abnormal entero-endocrine

224 ic antiviral immunity, type III IFNs protect epithelial barrier integrity, an activity that would ben

225 nses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic transl

226 epithelial)-cadherin expression and enhances epithelial barrier integrity, while knockdown of USP48 a

227 sion of genes involved in the maintenance of epithelial barrier integrity, with a variety of function

228 hat LPA1 is important for the maintenance of epithelial barrier integrity.

229 ression, reduced redox stress, and increased epithelial barrier integrity.

230 DSS-induced destruction of colonic epithelial barrier/integrity was prevented by AS101, via

231 the peripheral blood across the endothelial-epithelial barrier into the alveolar airspace is highly

232 Dysfunction of the epithelial barrier is a hallmark of inflammatory intesti

233 To facilitate nutrient uptake, the host's epithelial barrier is composed of a single layer of cell

234 Alveolar epithelial barrier is composed of flat type I cells, whi

235 oducing the nephrotoxin, Cyclosporine A, the epithelial barrier is disrupted in a dose-dependent mann

236 However, it remains largely unknown how the epithelial barrier is maintained after damage.

237 The intestinal epithelial barrier is maintained by expression of tight

238 The integrity of the lung alveolar epithelial barrier is required for the gas exchange and

239 sue location, the homeostatic balance of the epithelial barrier is skewed toward loss of differentiat

240 nal relevance of this strong collecting duct epithelial barrier is unresolved.

241 The role of HDAC activation on epithelial barrier leakiness was confirmed by HDAC inhib

242 However, the molecular processes regulating epithelial barrier maturation are not fully elucidated.

243 hich have the potential to cross the gastric epithelial barrier, may mediate delivery of these molecu

244 n, causes disruption of the gastrointestinal epithelial barrier, microbial translocation, and general

245 rfilamentous C. albicans strain breaches the epithelial barrier more frequently and causes mortality

246 physiology reveal a complex interplay of the epithelial barrier, mucosal and systemic immune response

247 hogen colonization in the context of the gut epithelial barrier of an arthropod vector.

248 s when microbial products traverse the tight epithelial barrier of the gastrointestinal tract.

249 protein exchange across the endothelial and epithelial barriers of the lung under both normal and pa

250 Epithelial barriers of the skin, gastrointestinal tract,

251 existing disease and its underlying abnormal epithelial barrier or, alternatively, is linked to corti

252 ific manner, which restricts its activity to epithelial barriers, particularly those corresponding to

253 merous gastrointestinal functions, including epithelial barrier permeability and motility.

254 n, IL-1beta levels, endothelial and alveolar epithelial barrier permeability, remodelling and fibrosi

255 ay disease in mice, including an increase in epithelial barrier permeability.

256 The intestinal epithelial barrier plays a critical role in the mucosal

257 An inflammatory microenvironment affects epithelial barrier properties and mucosal homeostasis by

258 the claudin family of TJ proteins determines epithelial barrier properties.

259 HA plays an unanticipated important role in epithelial barrier protection of the lower reproductive

260 Maintenance of epithelial cell polarity and epithelial barrier relies on the spatial organization of

261 The functional integrity of the intestinal epithelial barrier relies on tight coordination of cell

262 ysiological effects of LPS on the intestinal epithelial barrier remain unclear.

263 ls to fibrinogen, a significant component of epithelial barrier repair and remodeling.

264 ndings indicate that AS II can contribute to epithelial barrier repair following intestinal injury, a

265 y bowel disease, are associated with a leaky epithelial barrier, resulting in excessive exposure to m

266 sure in mice caused damage to the intestinal epithelial barrier, resulting in increased permeability

267 junctional structures should also reduce the epithelial barrier's capacity to maintain its integrity

268 Thus, in addition to their function as epithelial barrier structures, TCJs serve as polarity cu

269 important role in innate immune responses at epithelial barriers such as the skin.

270 ed population of immune cells that reside at epithelial barrier surfaces such as the skin, lung, and

271 The complex immunoregulatory network of the epithelial barrier surveillance also involves NK gene co

272 indicate the efficacy of a platelet-induced epithelial barrier that functions to prevent bacterial a

273 AECs form an intact epithelial barrier that is destroyed by H1N1pdm09 infect

274 At the mucus-coated columnar epithelial barrier, the HIV-1/SEVI interaction is disrup

275 found previously to regulate the intestinal epithelial barrier through activation of the PI3K/AKT pa

276 these findings, we examined if SCFAs promote epithelial barrier through IL-10RA-dependent mechanisms.

277 Grainyhead transcription factors control epithelial barriers, tissue morphogenesis, and different

278 memory T (TRM) cells persist indefinitely in epithelial barrier tissues and protect the host against

279 roles in the development and homeostasis of epithelial barrier tissues; how MASPs are activated in m

280 em in which the virus must cross a confluent epithelial barrier to access underlying B cells.

281 18 is an essential contributor to the airway epithelial barrier to aeroantigens.

282 Lysine depletion impairs the dental epithelial barrier to bacterial proinflammatory products

283 It has been previously reported that the epithelial barrier to bacterial proinflammatory products

284 ow an enteric virus overcomes the intestinal epithelial barrier to infect underlying target cells.

285 mary cells and the integrity of the alveolar epithelial barrier to influenza.

286 MNV) pathogenesis is crossing the intestinal epithelial barrier to reach the target cells for replica

287 are the first IFNs produced that act at the epithelial barrier to suppress initial viral spread with

288 human oropharynx that occasionally breaches epithelial barriers to cause invasive diseases.

289 virus to penetrate female reproductive tract epithelial barriers to infect underlying target cells.

290 Disruption of the intestinal epithelial barrier was evident along with the increased

291 howed chronic inflammation, and the alveolar epithelial barrier was leaky to (125)I-albumin tracer co

292 Disruption of the epithelial barrier was manifested by EC apoptosis and lo

293 These defects in the epithelial barrier were corrected in Nr1i2(-/-)Tlr4(-/-)

294 Psigma is a positive regulator of intestinal epithelial barrier, which mediates its effects by modula

295 co-basolateral markers and disruption of the epithelial barrier, which normally blocks free diffusion

296 The meninges forms a critical epithelial barrier, which protects the central nervous s

297 he secretion of immunoglobulins (Igs) across epithelial barriers, which is achieved via the polymeric

298 The disruption of the epithelial barrier with dextran sodium sulfate leads to

299 nto the lumen of iHOs was able to invade the epithelial barrier, with many bacteria residing within S

300 their increase following a breach in the gut epithelial barrier would be protective.