ライフサイエンスコーパス: epithelial sodium channel

1 ity of a nonselective cation channel and the epithelial sodium channel.

2 lectrolyte regulation via proteolysis of the epithelial sodium channel.

3 in kinase SGK1, leading to activation of the epithelial sodium channel.

4 K1, which impacts membrane expression of the epithelial sodium channel.

5 e for the attenuated response is through the epithelial sodium channel.

6 ack the normal tonic inhibition of the renal epithelial sodium channel.

7 f epithelial Na(+) transport mediated by the epithelial sodium channel.

8 quid secretion is minor and does not involve epithelial sodium channels.

9 ably due to an action on amiloride sensitive epithelial sodium channels.

10 y the regulation by methylation reactions of epithelial sodium channels.

11 ubunits of the mammalian amiloride-sensitive epithelial sodium channels.

12 y and belong to the superfamily of degenerin/epithelial sodium channels.

13 t addition of 10-4 M amiloride (a blocker of epithelial sodium channels) abolished the adrenaline-ind

14 ion is required for SGK1 phosphorylation and epithelial sodium channel activation.

15 lysis to investigate the effect of PIP(2) on epithelial sodium channel activity in A6 cells.

16 pertension, can be affected by modulation of epithelial sodium channel activity.

17 ation, we examined skin of mice in which the epithelial sodium channel alpha subunit had been deleted

18 The amiloride-sensitive epithelial sodium channel alpha, beta, and gamma subunit

19 s to the regulation of the gene encoding the epithelial sodium channel alpha, ENaCalpha, in renal tub

20 renal expression of the aldosterone-induced epithelial sodium channel alpha-ENaC, greater medullary

21 ta decreased basal and dexamethasone-induced epithelial sodium channel alpha-subunit (alpha ENaC) mRN

22 the alpha-subunit of the amiloride-sensitive epithelial sodium channel (alpha-ENaC) was identified as

23 ary culture express the alpha-subunit of the epithelial sodium channel (alpha-ENaC).

24 The mRNA expression of both human epithelial sodium channel-alpha and -beta increased duri

25 Both human epithelial sodium channel-alpha and -beta were localized

26 decreased the expression and/or activity of epithelial sodium channel-alpha, renal outer medullary p

27 d via regulation of the alpha subunit of the epithelial sodium channel (alphaENaC).

28 This drug is known to interact with the epithelial sodium channel and acid-sensing ion channel p

29 e Cyp4a10-/- mice had a dysfunctional kidney epithelial sodium channel and became normotensive when a

30 for Period 1 in the regulation of the renal epithelial sodium channel and more broadly implicate the

31 involved in ion transport, specifically the epithelial sodium channel and sodium proton exchangers.

32 distal tubules via activation of the apical epithelial sodium channel and the basolateral Na(+)/K(+)

33 und closure in diabetic animals by targeting epithelial sodium channels and stimulating keratinocyte

34 rations in the gating activity of the kidney epithelial sodium channel, and (c) identify a conceptual

35 e mediated largely through activation of the epithelial sodium channel, and inactivating or activatin

36 nters through apical channels, primarily the epithelial sodium channel, and is pumped into the lung i

37 An epithelial sodium channel antagonist normalized plasma v

38 l activities for the Na(+), K(+)-ATPase, and epithelial sodium channel are markedly increased in the

39 e chain reaction revealed that expression of epithelial sodium channel beta was reduced in distal col

40 Part of the last exon of the epithelial sodium-channel beta subunit from genomic DNA

41 ve mice received HS containing a long acting epithelial sodium channel blocker (P308); isotonic salin

42 contribution of sodium was minimized by the epithelial sodium channel blocker amiloride.

43 Amiloride, an epithelial sodium channel blocker, suppresses the respon

44 The epithelial sodium-channel blocker amiloride has been sho

45 e have shown that amiloride, an inhibitor of epithelial sodium channels, blocks synthesis of differen

46 transport regulator, interacting with Na(+) (epithelial sodium channel), Cl(-), renal outer medullary

47 nd the 5' flanking region of a member of the epithelial sodium channel complex.

48 Ion channels in the degenerin-epithelial sodium channel (DEG-ENaC) family perform dive

49 NIFICANCE STATEMENT Members of the degenerin/epithelial sodium channel (DEG/ENaC) family are broadly

50 Degenerin/epithelial sodium channel (DEG/ENaC) family members are

51 of the MD neuron subtype-specific degenerin/epithelial sodium channel (DEG/ENaC) family protein Pick

52 odes an ion channel subunit of the degenerin/epithelial sodium channel (DEG/ENaC) family.

53 lex that contains the pore-forming degenerin/epithelial sodium channel (DEG/ENaC) proteins MEC-4 and

54 a proton-gated ion channel of the degenerins/epithelial sodium channel (DEG/ENaC) receptor family is

55 pocket (ppk) gene, which encodes a Degenerin/Epithelial Sodium Channel (DEG/ENaC) subunit, is require

56 ral sensory neurons expressing the Degenerin/Epithelial sodium channel (DEG/ENaC) subunit, Pickpocket

57 , a gene that encodes a Drosophila degenerin/epithelial sodium channel (DEG/ENaC), regulates neuronal

58 Degenerin/epithelial sodium channels (DEG/ENaCs) are luminaries of

59 The protein family of degenerin/epithelial sodium channels (DEG/ENaCs) is composed of di

60 roton-activated receptors that belong to the epithelial sodium channel/degenerin family of ion channe

61 Na(+) channels (ASIC) are new members of the epithelial sodium channel/degenerin gene family.

62 nsitive ion channels (ASICs), members of the epithelial sodium channel/degenerin superfamily, were or

63 ve parallel absorption of sodium through the epithelial sodium channel ENaC and the sodium-driven chl

64 ree subunits (alpha, beta, and gamma) of the epithelial sodium channel ENaC and two subunits of Na(+)

65 To test a proposed role for the epithelial sodium channel ENaC in thiazolidinedione-indu

66 The extracellular domain of the epithelial sodium channel ENaC is exposed to a wide rang

67 s that include yeast carboxypeptidase S, the epithelial sodium channel ENaC, and epidermal growth fac

68 These taste cells express the epithelial sodium channel ENaC, and mediate behavioural

69 receptor-alpha, chloride channel CLCN5, and epithelial sodium channel ENaC, can selectively bind to

70 of several different effectors, such as the epithelial sodium channel ENaC, the protease-activated r

71 n in epithelial cells is rate-limited by the epithelial sodium channel (ENaC) activity in lung, kidne

72 ng patch clamp techniques, we found that the epithelial sodium channel (ENaC) activity in the apical

73 Conversely, epithelial sodium channel (ENaC) activity was largely pr

74 lular functions, including proliferation and epithelial sodium channel (ENaC) activity.

75 ineralocorticoid receptors (MRs) to increase epithelial sodium channel (ENaC) activity.

76 lies have been considered: these include the epithelial sodium channel (ENaC) and acid-sensing ion ch

77 Na(+) uptake through the apically expressed epithelial sodium channel (ENaC) and basolaterally local

78 unction mutations of the amiloride-sensitive epithelial sodium channel (ENaC) and characterized by ne

79 Epithelial sodium channel (ENaC) and cystic fibrosis tra

80 Cyp2c44(-/-) mice show a hyperactive kidney epithelial sodium channel (ENaC) and reductions in ERK1/

81 in connecting tubule mass and attenuation of epithelial sodium channel (ENaC) and ROMK expression and

82 SGK1 increases membrane expression of the epithelial sodium channel (ENaC) and sodium reabsorption

83 gh Na(+) transport by the apically expressed epithelial sodium channel (ENaC) and the basolaterally e

84 more, dKO mice displayed upregulation of the epithelial sodium channel (ENaC) and the Ca(2+)-activate

85 collecting duct, where activity of both the epithelial sodium channel (ENaC) and the pendrin/Na(+)-d

86 sion is decreased by ER stress, activate the epithelial sodium channel (ENaC) and translocate FoxO3a

87 Amiloride (1), the prototypical epithelial sodium channel (ENaC) blocker, has been admin

88 We examined activation of the human epithelial sodium channel (ENaC) by cleavage.

89 omoted internalization of the alphabetagamma epithelial sodium channel (ENaC) complex from the alveol

90 The amiloride-sensitive epithelial sodium channel (ENaC) complex is made up of a

91 entry is controlled by the regulation of the epithelial sodium channel (ENaC) complex.

92 The epithelial sodium channel (ENaC) constitutes the rate-li

93 sterone-induced increases in apical membrane epithelial sodium channel (ENaC) density and Na transpor

94 erinatal lethality associated with increased epithelial sodium channel (ENaC) expression in lung and

95 ocket1 (PPK1) is a Drosophila subunit of the epithelial sodium channel (ENaC) family displaying limit

96 or AF17 upregulates the transcription of the epithelial sodium channel (ENaC) genes, but whether AF17

97 The epithelial sodium channel (ENaC) has an important role i

98 Inhibitors of the epithelial sodium channel (ENaC) have therapeutic potent

99 ic evidence supports a critical role for the epithelial sodium channel (ENaC) in both clearance of fe

100 The epithelial sodium channel (ENaC) in particular is tightl

101 tional expression of the amiloride-sensitive epithelial sodium channel (ENaC) in select epithelia is

102 osatrienoic acid (11,12-EET) can inhibit the epithelial sodium channel (ENaC) in the cortical collect

103 The activity of the epithelial sodium channel (ENaC) in the distal nephron i

104 Epithelial sodium channel (ENaC) in the kidneys is criti

105 Maturation of the epithelial sodium channel (ENaC) involves furin-dependen

106 pathway implicated in ubiquitination of the epithelial sodium channel (ENaC) involves Nedd4-2 regula

107 The epithelial sodium channel (ENaC) is a heteromultimer com

108 The epithelial sodium channel (ENaC) is a heterotrimeric pro

109 Activity of the epithelial sodium channel (ENaC) is a key determinant of

110 The epithelial sodium channel (ENaC) is a member of the ENaC

111 To test the hypothesis that the renal epithelial sodium channel (ENaC) is a target of oxidativ

112 The epithelial sodium channel (ENaC) is activated upon endop

113 Enhanced Na(+) absorption through the epithelial sodium channel (ENaC) is attributed to the fa

114 The epithelial sodium channel (ENaC) is believed to represen

115 The epithelial sodium channel (ENaC) is composed of a single

116 The amiloride-sensitive, epithelial sodium channel (ENaC) is composed of at least

117 The epithelial sodium channel (ENaC) is composed of three ho

118 An epithelial sodium channel (ENaC) is composed of three ho

119 The epithelial sodium channel (ENaC) is composed of three ho

120 The epithelial sodium channel (ENaC) is expressed in the ald

121 ose responses to amiloride indicate that the epithelial sodium channel (ENaC) is involved in the move

122 The activity of the amiloride-sensitive epithelial sodium channel (ENaC) is modulated by F-actin

123 The activity of the epithelial sodium channel (ENaC) is modulated by multipl

124 The epithelial sodium channel (ENaC) is one of the central e

125 The epithelial sodium channel (ENaC) is regulated by multipl

126 The epithelial sodium channel (ENaC) is responsible for Na+

127 The epithelial sodium channel (ENaC) is the limiting entry p

128 The epithelial sodium channel (ENaC) is the prototype of a n

129 The epithelial sodium channel (ENaC) is ubiquitinated by the

130 sed renal cortical mRNA content of all three epithelial sodium channel (ENaC) isoforms, and total cel

131 The amiloride-sensitive epithelial sodium channel (ENaC) mediates Na(+) reabsorp

132 The epithelial sodium channel (ENaC) of the kidney is necess

133 includes subunits of the amiloride-sensitive epithelial sodium channel (ENaC) of vertebrate colon, lu

134 d DeltaF508-CFTR results in an excess of the epithelial sodium channel (ENaC) on the apical plasma me

135 The epithelial sodium channel (ENaC) participates in the reg

136 The epithelial sodium channel (ENaC) plays a major role in t

137 The epithelial sodium channel (ENaC) plays an important role

138 The epithelial sodium channel (ENaC) plays an important role

139 A common human epithelial sodium channel (ENaC) polymorphism, alphaT663

140 The epithelial sodium channel (ENaC) present in the kidney c

141 The renal epithelial sodium channel (ENaC) provides regulated sodi

142 Recent molecular cloning of the epithelial sodium channel (ENaC) provides the opportunit

143 The epithelial sodium channel (ENaC) provides the rate-limit

144 red cell model systems commonly used in lung epithelial sodium channel (ENaC) studies.

145 m-1 because of loss-of-function mutations in epithelial sodium channel (ENaC) subunits exhibit meibom

146 ide cotransporter (NCC) and alpha- and gamma-epithelial sodium channel (ENaC) subunits from the disco

147 ila miR-263a downregulates the expression of epithelial sodium channel (ENaC) subunits in enterocytes

148 Proteolytic processing of epithelial sodium channel (ENaC) subunits occurs as chan

149 in reactions, expression of all three cloned epithelial sodium channel (ENaC) subunits was detected i

150 teracted with the carboxyl termini of murine epithelial sodium channel (ENaC) subunits.

151 in AS(-/-) mice, whereas upregulation of the epithelial sodium channel (ENaC) sufficient to increase

152 n channel assembled from subunits of the Deg/epithelial sodium channel (ENaC) superfamily, in the reg

153 d the hypothesis that co-expression of delta-epithelial sodium channel (ENaC) underlies, at least in

154 demonstrated that (1) ATP inhibits the renal epithelial sodium channel (ENaC) via a phospholipase C-d

155 Here we present evidence that the epithelial sodium channel (ENaC), a heteromeric membrane

156 The epithelial sodium channel (ENaC), a heterotrimeric compl

157 dosterone is to increase the activity of the epithelial sodium channel (ENaC), although ENaC mRNA and

158 modulates the cell surface expression of the epithelial sodium channel (ENaC), an ion channel that is

159 -Cl co-transporter, the alpha-subunit of the epithelial sodium channel (ENaC), and the 70-kD dimer of

160 sodium chloride cotransporter (NCC) and the epithelial sodium channel (ENaC), are regulated is param

161 cause amiloride is a potent inhibitor of the epithelial sodium channel (ENaC), ENaC has been proposed

162 gase NEDD4-2, which negatively regulates the epithelial sodium channel (ENaC), Na(+)/Cl(-) cotranspor

163 d K+ handling in these nephron segments--the epithelial sodium channel (ENaC), paracellular Cl- flux,

164 of the Na(+):Cl(-) cotransporter (NCC), the epithelial sodium channel (ENaC), the renal outer medull

165 y transduction channel for sodium taste, the epithelial sodium channel (ENaC), throughout development

166 ansmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC), two major ion channels

167 recessive PHAI results from mutations in the epithelial sodium channel (ENaC), whereas autosomal domi

168 Regulation of the epithelial sodium channel (ENaC), which regulates fluid

169 miRs separately or in combination increased epithelial sodium channel (ENaC)-mediated sodium transpo

170 -sensitive Na-Cl cotransporter (NCC) and the epithelial sodium channel (ENaC).

171 ed by excessive Na(+) absorption through the epithelial sodium channel (ENaC).

172 ifferential effects on the expression of the epithelial sodium channel (ENaC).

173 regulate the activity and trafficking of the epithelial sodium channel (ENaC).

174 bsorption is governed by the activity of the epithelial sodium channel (ENaC).

175 o the alpha, beta, and gamma subunits of the epithelial sodium channel (ENaC).

176 dium and water homeostasis via action of the epithelial sodium channel (ENaC).

177 t directly with other channels including the epithelial sodium channel (ENaC).

178 the renal collecting duct by activating the epithelial sodium channel (ENaC).

179 tations in the beta- or gamma-subunit of the epithelial sodium channel (ENaC).

180 reabsorption through the amiloride-sensitive epithelial sodium channel (ENaC).

181 olytic activation is a unique feature of the epithelial sodium channel (ENaC).

182 (CFTR) combined with hyperactivation of the epithelial sodium channel (ENaC).

183 n clearance by proteolytic activation of the epithelial sodium channel (ENaC).

184 egulates sodium transport by stimulating the epithelial sodium channel (ENaC).

185 d inhibit the open probability (P(o)) of the epithelial sodium channel (ENaC).

186 a multiforme express multiple members of the epithelial sodium channel (ENaC)/Degenerin family, chara

187 encoding subunits of the amiloride-sensitive epithelial sodium channel (ENaC; refs 2,3).

188 Epithelial sodium channels (ENaC) are composed of three

189 Epithelial sodium channels (ENaC) are expressed in the a

190 Epithelial sodium channels (ENaC) are regulated by vario

191 Heteromeric alpha,beta,gamma-epithelial sodium channels (ENaC) associated with diseas

192 ses the regulation of the activity of single epithelial sodium channels (ENaC) by cAMP.

193 Epithelial sodium channels (ENaC) have a crucial role in

194 We examined how formaldehyde regulates human epithelial sodium channels (ENaC) in H441 and expressed

195 The amiloride-sensitive epithelial sodium channels (ENaC) mediate Na(+) reabsorp

196 Amiloride-sensitive epithelial sodium channels (ENaC) play an important role

197 One explanation is that alcohol regulates epithelial sodium channels (ENaC) via oxidant signaling

198 fects the conductance of amiloride-sensitive epithelial sodium channels (ENaC) was studied in planar

199 he number (N) and open probability (P(o)) of epithelial sodium channels (ENaC).

200 e along its electrochemical gradient through epithelial sodium channels (ENaC).

201 iated by taste receptor cells expressing the epithelial sodium channel, ENaC, but the cellular substr

202 uct, the 70 kDa form of the y-subunit of the epithelial sodium channel, ENaC, exhibited an increase i

203 only the 70 kDa form of the y-subunit of the epithelial sodium channel, ENaC, exhibited an increase i

204 ical membrane where the amiloride-sensitive, epithelial sodium channel, ENaC, facilitates sodium entr

205 The epithelial sodium channel, ENaC, plays a critical role i

206 opposed by fluid absorption, mainly via the epithelial sodium channel, ENaC.

207 sed in cells transfected with siRNAs against epithelial sodium channel ENaCalpha or ENaCdelta compare

208 rboxyl termini of beta and gamma subunits of epithelial sodium channels (ENaCs) and causes an increas

209 sodium flux in keratinocytes is mediated by epithelial sodium channels (ENaCs) and causes increased

210 Epithelial sodium channels (ENaCs) are assembled in the

211 Epithelial sodium channels (ENaCs) are composed of three

212 pression and function of amiloride-sensitive epithelial sodium channels (ENaCs) have not been elucida

213 Epithelial sodium channels (ENaCs) mediate Na(+) entry a

214 luding hormones and growth factors, modulate epithelial sodium channels (ENaCs), which fine-tune Na(+

215 of extracellular protons on the activity of epithelial sodium channels (ENaCs).

216 a Drosophila homolog of mammalian Degenerin/epithelial sodium channels, encodes an acid-sensing sodi

217 sensing ion channel-3 (ASIC3) is a degenerin/epithelial sodium channel expressed in the peripheral ne

218 egenerin channel (of Caenorhabditis elegans)/epithelial sodium channel family of ion channels, is the

219 Here we identify a member of the degenerin/epithelial sodium channel family, PPK28, as an osmosensi

220 ed by lower wet/dry weight ratios, increased epithelial sodium channel gamma expression, and more lym

221 the N-terminal tail (APGEKIKAKIKK) of gamma-epithelial sodium channel (gamma-ENaC) were truncated by

222 tate mRNA levels of the gamma subunit of the epithelial sodium channel (gammaENaC) in rat colon.

223 tissue was dissected and analyzed for gamma-epithelial sodium channel (gammaENaC), sodium-potassium

224 Amiloride (10-4 M), a blocker of epithelial sodium channels, had no additive effect to th

225 The human epithelial sodium channel (hENaC) is a hetero-oligomeric

226 The human epithelial sodium channel (hENaC) mediates Na+ transport

227 ee subunits of the human amiloride sensitive epithelial sodium channel (hENaC): SCNN1B and SCNN1G on

228 In order to ascertain the role of the epithelial sodium channel in epidermal differentiation,

229 ted receptor-gamma agonist activation of the epithelial sodium channel in the distal collecting duct,

230 tion reaction contributes to the activity of epithelial sodium channels in A6 cells and is directed t

231 ecific subunits of amiloride-sensitive human epithelial sodium channels in relation to differentiatio

232 alt-fed DBH-ET(B);ET(B)(sl/sl) rats when the epithelial sodium channel is blocked with amiloride.

233 The epithelial sodium channel is expressed in epidermis and

234 We also show that the activity of the epithelial sodium channel is not altered in FHHt mice, s

235 dinated expression of subunits suggests that epithelial sodium channels may play an important part in

236 units, and are members of the superfamily of epithelial sodium channels, mechanosensitive and FMRF-am

237 These data suggest that the epithelial sodium channel modulates ionic signaling for

238 rome, a rare inherited form of hypertension, epithelial sodium channel mutations appear to cause high

239 ion channel genes belonging to the degenerin/epithelial sodium channel/pickpocket (ppk) family, ppk23

240 rminal portion of the beta- and/or gamma-rat epithelial sodium channel (rENaC) subunits block constit

241 rm of hypertension in which mutations of the epithelial sodium channel result in increased renal sodi

242 enes for subunits of the amiloride-sensitive epithelial sodium channel: SCNN1B and SCNN1G on 16p and

243 al colon, whereas colonic H,K-ATPase and the epithelial sodium channel showed massive up-regulation i

244 tions disrupting expression of the Degenerin/Epithelial Sodium Channel subunit, Pickpocket1(PPK1) or

245 Pickpocket genes encode Degenerin/Epithelial Sodium channel subunits (DEG/ENaC).

246 We used amiloride, a blocker of epithelial sodium channels, to evaluate its pharmacologi

247 adult mice in which the alpha-subunit of the epithelial sodium channel was conditionally deleted in t

248 Whereas the beta subunit of human epithelial sodium channel was induced by elevated concen

249 another substrate, the alpha subunit of the epithelial sodium channel, was Pdi1 independent.

250 alpha and regulatory beta subunits of human epithelial sodium channels were expressed both in cultur

251 ystin-2, TRPC1, and interestingly, the alpha-epithelial sodium channel, were immunodetected in this o

252 es from biochemical studies of the mammalian epithelial sodium channels where glycosylation mutants i