ライフサイエンスコーパス: epithelial tumor

1 r, probably a leiomyosarcoma, rather than an epithelial tumor.

2 1(+) EMT cells had the ability to seed a new epithelial tumor.

3 o thirds of which develop ovarian or uterine epithelial tumors.

4 ice that subsequently developed reproductive epithelial tumors.

5 mplicated in the development of lymphoid and epithelial tumors.

6 ctivity in mice is found to result in ureter epithelial tumors.

7 R is a major anticancer drug target in human epithelial tumors.

8 hamartomas and a susceptibility to malignant epithelial tumors.

9 leted in non-Hodgkin's lymphomas and various epithelial tumors.

10 both steroid and growth factor signaling in epithelial tumors.

11 m, and ErbB-2 is frequently overexpressed in epithelial tumors.

12 t within the stroma of the majority of human epithelial tumors.

13 and Ras-transformed fibroblasts and in many epithelial tumors.

14 ase reduced neuroendocrine transition of the epithelial tumors.

15 ed with the development of both lymphoid and epithelial tumors.

16 cal behavior and prognosis for several human epithelial tumors.

17 t contribute to the progression of glandular epithelial tumors.

18 isoforms is frequently deregulated in human epithelial tumors.

19 aberrant promoter methylation in aggressive epithelial tumors.

20 inates gastrointestinal (GI) carcinoids from epithelial tumors.

21 in activated dendritic cells, and in several epithelial tumors.

22 tase is a highly consistent feature of human epithelial tumors.

23 genomic instability and tumor development in epithelial tumors.

24 in hematopoietic malignancies, as well as in epithelial tumors.

25 nd cancer progression in a variety of common epithelial tumors.

26 ry cycle and influence the growth of ovarian epithelial tumors.

27 asiveness and poor prognosis of a variety of epithelial tumors.

28 ncluding leukemias, lymphomas, sarcomas, and epithelial tumors.

29 for gene delivery into epithelial tissues or epithelial tumors.

30 family that is abnormally activated in many epithelial tumors.

31 expression, predominantly in differentiated epithelial tumors.

32 e with a poor prognosis for several types of epithelial tumors.

33 BRLF1 proteins for treatment of EBV-positive epithelial tumors.

34 KT prosurvival signal independent of PTEN in epithelial tumors.

35 ered that it is deleted in a large number of epithelial tumors.

36 phogenesis, wound healing, and metastasis of epithelial tumors.

37 EGF) receptor is frequently overexpressed in epithelial tumors.

38 delta T cells and is frequently expressed in epithelial tumors.

39 ression was undetectable in more than 60% of epithelial tumors.

40 ensitive marker for detection and staging of epithelial tumors.

41 miniscent of papillae seen in ovarian serous epithelial tumors.

42 with characteristics of both mesenchymal and epithelial tumors.

43 epeatedly reported in colon cancer and other epithelial tumors.

44 sarcomas presaged a widespread discovery in epithelial tumors.

45 t may help to assess and characterize thymic epithelial tumors.

46 e women; age range, 35-71 years) with thymic epithelial tumors.

47 or to generate cell lines from EBV-infected epithelial tumors.

48 ffective therapeutic immunity against lethal epithelial tumors.

49 helial cells targeted by cytomegalovirus and epithelial tumors.

50 ibrosis; and the stromal reaction to certain epithelial tumors.

51 n contribute to the growth and malignancy of epithelial tumors.

52 clear whether these cells also contribute to epithelial tumors.

53 and progression of many hormonally regulated epithelial tumors.

54 have implications for the treatment of human epithelial tumors.

55 causally linked to differentiation blocks in epithelial tumors.

56 How epithelial tumors acquire anchorage independence for sur

57 terest in the role of fusion genes in common epithelial tumors after the discovery of recurrent TMPRS

58 he following: (1) CD4+ CD25+ Foxp3+ surround epithelial tumor aggregates; (2) Immature dendritic cell

59 ese cells, we examined primary human ovarian epithelial tumors and found that MEF is expressed in a s

60 tumor, but also is found expressed in other epithelial tumors and in a subset of normal epithelia.

61 important consequences in the progression of epithelial tumors and in determining the outcome of chem

62 More strikingly, tempol delayed the onset of epithelial tumors and increased the mean epithelial tumo

63 FIP1 is commonly observed during invasion of epithelial tumors and is associated with poor prognosis

64 sociated with a number of human lymphoid and epithelial tumors and lymphoproliferative diseases in im

65 e that LIN28A is reactivated in about 10% of epithelial tumors and promotes cell cycle progression by

66 ue to the absence of C/EBPalpha mutations in epithelial tumors and the lethal effect of C/EBPalpha de

67 er propagating stem-like cell populations in epithelial tumors and, especially, glioblastomas.

68 nt tumorigenicity, ability to reestablish an epithelial tumor, and enhanced resistance to drugs and r

69 Twenty-four patients had epithelial tumors, and 20 had sarcomatous or mixed histo

70 few fusion oncogenes have been identified in epithelial tumors, and BRD4-NUT is the first fusion onco

71 is frequently lost or suppressed in several epithelial tumors, and studies of its cellular function

72 rface glycoprotein has been reported in most epithelial tumors, and the overexpressions of this mRNA

73 mily members are frequently overexpressed in epithelial tumors, and their expression is associated wi

74 In this model, surface epithelial tumors are divided into two broad categories

75 Various epithelial tumors are linked to EGFR overexpression or e

76 Thymic epithelial tumors are rare malignancies, and there is no

77 The possibility that ovarian epithelial tumors arise from remnants of mullerian ducts

78 smembrane glycoprotein, is expressed in most epithelial tumors as a heterodimer consisting of an extr

79 on is an attractive therapeutic strategy for epithelial tumors, as ligand-induced erbB2/EGFR heterodi

80 ategy for the treatment of ovarian and other epithelial tumors associated with elevated levels of EGF

81 ntiation of stratified epithelia and induces epithelial tumors at a high frequency.

82 Gli protein and induces Shh target genes and epithelial tumors at anagen but not other stages, pointi

83 erous cystadenoma (SCA), presenting as large epithelial tumors bearing conspicuous gross and histolog

84 Somatic insertions were present in epithelial tumors but not in blood or brain cancers.

85 to delay the growth kinetic of an aggressive epithelial tumor, but also to shape its histology.

86 ily member Bmi1 is overexpressed in numerous epithelial tumors, but its role in their development has

87 Fbxo7 was highly expressed in epithelial tumors, but not in normal tissues, suggesting

88 eature of the tumor microenvironment in some epithelial tumors, but their role in the malignant progr

89 y by immune cells, may promote the growth of epithelial tumors by mediating increased proliferation a

90 cer cells can also migrate collectively from epithelial tumors by wrapping around vessels or muscle f

91 Gynecologic epithelial tumors can be grouped into two major categori

92 stasis and establish the concept that K14(+) epithelial tumor cell clusters disseminate collectively

93 L) clones in promoting specific TCR-mediated epithelial tumor cell cytotoxicity.

94 Previous work using an epithelial tumor cell line showed that a Chlamydia-speci

95 not the RelB form of NF-kappaB in a mucosal epithelial tumor cell line.

96 the current study, we use the murine mammary epithelial tumor cell lines 4T1 and 4T07; these cells ar

97 Most hematopoietic and epithelial tumor cell lines can only transport vitamin C

98 We have generated mouse ovarian epithelial tumor cell lines that contain various combina

99 onal regulation of OPN in the murine mammary epithelial tumor cell lines, 4T1 and 4T07, which are sub

100 synthase kinase-3beta inhibition in several epithelial tumor cell lines, and by Snail1 overexpressio

101 Because CML28 was highly expressed in epithelial tumor cell lines, anti-CML28 responses were a

102 expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoi

103 In a panel of human breast cancer and other epithelial tumor cell lines, HER2-overexpressing tumors

104 f centromeric regions that distinguishes the epithelial tumor cell lines.

105 ive gene signature that may be a response to epithelial tumor cell overcrowding.

106 mal transition is frequently associated with epithelial tumor cell progression from a comparatively b

107 disruption of colonic homeostasis, fulminant epithelial/tumor cell proliferation, and activation of t

108 animal model by implanting ER- mouse mammary epithelial tumor cells (CSMLO) in syngeneic A-J mice.

109 Akt1-deficient mammary epithelial tumor cells (MEC) were reduced in size and pr

110 implicated in multiple signaling pathways in epithelial tumor cells and lack of Tiam1 in tumor cells

111 enesis, and homing on target organs) between epithelial tumor cells and neighboring stromal cells, su

112 ancer have focused on genetic changes in the epithelial tumor cells and therefore have not robustly t

113 or cells provides a unique approach to study epithelial tumor cells and to gain an insight into signa

114 nascent tumors grow and undergo progression, epithelial tumor cells are intimately associated with st

115 ses the invasion of breast tumors; moreover, epithelial tumor cells coxenografted with Snail1-deplete

116 lyses of MIC gene 5'-end flanking regions in epithelial tumor cells defined minimal core promoters th

117 Additionally, in vitro analyses of epithelial tumor cells derived from the Apc(1638N/wt);Tg

118 human breast cancer cells and mouse mammary epithelial tumor cells engineered to lack PTPN12 exhibit

119 utaneous inoculation of nude mice with human epithelial tumor cells engineered to secrete corticotrop

120 Expression of WSX1 in epithelial tumor cells enhances NK cell cytolytic activi

121 The SCCs that lacked p53 and alphav in the epithelial tumor cells exhibited high Akt activity, lack

122 We show here that malignant human ovarian epithelial tumor cells express very high levels of strom

123 at both cytokines can have direct effects on epithelial tumor cells expressing appropriate receptors.

124 ted against these peptides specifically lyse epithelial tumor cells expressing Ep-CAM but not normal

125 cells and NK cells against transfectants and epithelial tumor cells expressing MICA.

126 microdissection (LCM) technology to capture epithelial tumor cells from 28 lymph node-negative breas

127 ead T256A mutant Sgk, protected Con8 mammary epithelial tumor cells from serum starvation-induced apo

128 FE can "retarget" adenovirus to CEA-positive epithelial tumor cells in cell culture, in s.c. tumor gr

129 lation of stromal cells that are adjacent to epithelial tumor cells in three mouse carcinoma models (

130 tiate tumor progression by inducing adjacent epithelial tumor cells into EMT.

131 (EMT) is implicated in converting stationary epithelial tumor cells into motile mesenchymal cells dur

132 une cells, the antitumor activity of WSX1 in epithelial tumor cells is independent of IL-27 signaling

133 Expression of oncogenic Ras in epithelial tumor cells is linked to the loss of transfor

134 and filtered using the Isolation by Size of Epithelial Tumor cells method.

135 leukemic cells and its stable expression in epithelial tumor cells sensitized to IR.

136 Expression of exogenous WSX1 in epithelial tumor cells suppresses tumorigenicity in vitr

137 rapidly (within 15 minutes) bound to various epithelial tumor cells suspended in cell medium.

138 cells were then compared with findings from epithelial tumor cells that aberrantly express R-ras.

139 Epithelial tumor cells that have undergone epithelial-to

140 xposure of cultured and primary leukemic and epithelial tumor cells to clinically relevant nanomolar

141 l transition (EMT), a key mechanism enabling epithelial tumor cells to disseminate and metastasize.

142 y intercellular junctions which tightly link epithelial tumor cells to each another.

143 activated CD8 T cells can stimulate mammary epithelial tumor cells to undergo epithelial-mesenchymal

144 Epithelial tumor cells transit to a mesenchymal state in

145 To acquire these characteristics, epithelial tumor cells undergo epithelial-to-mesenchymal

146 Recent studies indicate that epithelial tumor cells upregulate a stress-induced MHC c

147 evel of WSX1 expression in multiple types of epithelial tumor cells when compared with normal epithel

148 the antineoplastic effects of FTIs in human epithelial tumor cells with diverse genetic backgrounds.

149 Mixing the epithelial tumor cells with Matrigel or primary human ma

150 Invasive growth of epithelial tumor cells, a major cause of death from canc

151 Thus, interactive forces between CTL and epithelial tumor cells, mainly regulated by integrin eng

152 In Con8 rat mammary epithelial tumor cells, the synthetic glucocorticoid dex

153 In Con8 mammary epithelial tumor cells, we have documented previously th

154 In Con8 mammary epithelial tumor cells, we have previously documented th

155 ry functions, but they are also expressed by epithelial tumor cells, where they have been implicated

156 s, where it orchestrates the cross-talk with epithelial tumor cells.

157 uclear localization of IKKalpha in prostatic epithelial tumor cells.

158 e latter was especially obvious on malignant epithelial tumor cells.

159 ale embryos and the proliferation of ovarian epithelial tumor cells.

160 previously been shown to be induced on most epithelial tumor cells.

161 a cells, but exerts no such effects on other epithelial tumor cells.

162 eased phosphorylation of p53 on serine-15 in epithelial tumor cells.

163 thelial cells, but downregulated in invasive epithelial tumor cells.

164 er, MICA/B are expressed on diverse cultured epithelial tumor cells.

165 ation of tight junctions in rat Con8 mammary epithelial tumor cells.

166 I expression in T cells but represses it in epithelial tumor cells.

167 tly with elevated cytoplasmic eIF3e level in epithelial tumor cells.

168 sential for both the excess proliferation of epithelial/tumor cells and the disruption of colonic hom

169 ells from patients with early and late-stage epithelial tumors contain increased proportions of CD4(+

170 e develop ovarian tubular adenomas, a benign epithelial tumor corresponding to surface epithelial inv

171 Therefore, epithelial tumors could survive in the absence of exogen

172 d gives new insight into the pathogenesis of epithelial tumors, demonstrating that the penetrance and

173 genesis has been used to study mechanisms of epithelial tumor development by oncogenic Hras.

174 enesis inhibitor thrombospondin-1 (TSP-1) in epithelial tumor development has remained controversial.

175 To examine the function of C/EBPalpha in epithelial tumor development, an epidermal-specific C/EB

176 Several epithelial tumors display epidermal growth factor recept

177 iants, which can be selected for to generate epithelial tumors during metastatic colonization.

178 Many epithelial tumors (e.g., colon, lung, and breast) expres

179 of clinical significance in the treatment of epithelial tumors especially with respect to the enhance

180 , and the impact of, p53 inactivation during epithelial tumor evolution in a transgenic brain tumor m

181 r cell lines derived from breast and ovarian epithelial tumors examined by Western blotting, Dab2 exp

182 applicable immunotherapies for common solid epithelial tumors expressing CEA.

183 dels in identifying causal genetic events in epithelial tumor formation.

184 of epithelial tumors and increased the mean epithelial tumor-free survival time by 38% (P < 0.0001),

185 play an important role in the transition of epithelial tumors from a benign to an invasive state.

186 ers the possibility of monitoring changes in epithelial tumor genotypes during the course of treatmen

187 ells impairs the WSX1-mediated inhibition of epithelial tumor growth.

188 Most human epithelial tumors harbor numerous alterations, making it

189 However, ovarian epithelial tumors have not been documented in p53 homozy

190 Like many epithelial tumors, head and neck squamous cell carcinoma

191 mong peptides eluted from HPV-16-transformed epithelial tumor HLA-A*0201 immunoprecipitates was analy

192 a novel suppressor of cancer progression in epithelial tumors; however, its role in hematologic mali

193 dney is sufficient to induce primitive renal epithelial tumors; however, when compounded with activat

194 melanoma (HR, 0.74; 95% CI, 0.36 to 1.55) or epithelial tumors (HR, 0.89; 95% CI, 0.48 to 1.64).

195 -NKG2D system was proposed to participate in epithelial tumor immune surveillance.

196 reviously reported an increased incidence of epithelial tumors in Fancd2 knockout mice.

197 of autonomous growth and the progression of epithelial tumors in mouse skin.

198 CD25+ lymphocytes inhibit colitis-associated epithelial tumors in Rag-deficient mice.

199 and enzootic nasal tumor virus (ENTV) induce epithelial tumors in the airways of sheep and goats.

200 in the stromal microenvironment can lead to epithelial tumors in the colon.

201 Then, chemically-induced epithelial tumors in the hamster cheek pouch were treate

202 sporadic cancers, such as breast or ovarian epithelial tumors, in the general population.

203 sociated with several types of lymphomas and epithelial tumors including Burkitt's lymphoma (BL), HIV

204 found to be overexpressed in a wide range of epithelial tumors, including breast cancer.

205 ed at significant frequency in various human epithelial tumors, including colorectal cancer, and is s

206 venile development are resistant not only to epithelial tumors, including liver (60-80%) and lung tum

207 ly, we found that LZTFL1 is downregulated in epithelial tumors, including lung cancer, and functions

208 uences, have been observed in multiple human epithelial tumors, including malignant gliomas.

209 ed and aberrantly glycosylated on many human epithelial tumors, including more than 90% of human brea

210 ts in cultured human cell lines derived from epithelial tumors, including prostate and lung carcinoma

211 ucial for the migration and invasion of many epithelial tumors, including prostate cancer.

212 to be frequently hypermethylated in various epithelial tumors, including small cell lung, breast, bl

213 suppressor PTEN are found in many different epithelial tumors, including thyroid neoplasia.

214 d increase in the percentage of fish bearing epithelial tumors, indicating that separase is a tumor s

215 t decreases the incidence and growth of lung epithelial tumors initiated by oncogenic Kras, suggestin

216 uption of cell polarity is a prerequisite in epithelial tumor initiation, the roles of CDC42 in tumor

217 Metastatic progression of most common epithelial tumors involves a heterogeneous, transient lo

218 Cyclooxygenase-2 (COX-2) expression in epithelial tumors is frequently associated with a poor p

219 Because this class of epithelial tumors is generally intractable to currently

220 ssociated with the metastatic progression of epithelial tumors is the dynamic regulation of cadherins

221 Although glandular inversion in epithelial tumors is thought to be a potential mechanism

222 he development and/or progression of various epithelial tumors, is uniformly present in all breast ca

223 involved in T-lymphocyte recruitment within epithelial tumor islets and intratumoral early T-cell si

224 NAi) decreased cell motility in four of four epithelial tumor lines tested.

225 Mammalian epithelial tumors lose polarity as they progress toward

226 As serous tumors are the most common surface epithelial tumors, low-grade serous carcinoma is the pro

227 proach to the preparation of variants of the epithelial tumor marker MUC1 carrying one or more Tn, T,

228 mone receptor signaling in the initiation of epithelial tumors may help define this axis as a target

229 apeutically relevant immunity against lethal epithelial tumors may require targeting tumor-induced im

230 rful agent to retarget adenovirus vectors to epithelial tumor metastases.

231 Epithelial tumor metastasis is preceded by an accumulati

232 to decrease tumor size in hematological and epithelial tumor models by interfering with the protecti

233 delta T cells have been observed in various epithelial tumors; moreover, MICA/B are expressed on div

234 Mean ADC value of both readings of thymic epithelial tumors (n = 30) was 1.24 x 10(-3) mm(2)/sec a

235 In the EBV-associated epithelial tumor nasopharyngeal carcinoma (NPC), the vir

236 reactive stroma provides a prelude to breast epithelial tumors observed in these animals.

237 Conjunctival papilloma is a benign epithelial tumor occurring in both children and adults w

238 decreased in the progression of common solid epithelial tumors of adulthood, including lung, prostate

239 We used ovarian epithelial tumors of different malignant potential to lo

240 a major factor in the development of common epithelial tumors of humans, but it extends over decades

241 nstrate the functional expression of CD40 in epithelial tumors of the cervix and support the clinical

242 ceptor gamma (PPAR gamma) gene in follicular epithelial tumors of the human thyroid gland.

243 omeobox gene HOXA7 as encoding an antigen in epithelial tumors of the ovary.

244 Epithelial tumors of the pancreas exhibit a wide spectru

245 eborrheic keratoses (SKs) are common, benign epithelial tumors of the skin that do not, or very rarel

246 These tumors and other epithelial tumors often express both cyclooxygenase-2 (C

247 Epithelial tumors often secrete abundant amounts of the

248 that of seven genes frequently methylated in epithelial tumors, only RASSF1A gene was frequently meth

249 response, which was not detected in cells of epithelial tumor origin, was apoptosis.

250 ssion correlates with good prognosis in some epithelial tumors, our findings may encourage a reevalua

251 Epithelial tumors overexpress MHC class I chain-related

252 nd advanced stages (stage III, IV) of thymic epithelial tumors (P = .006 and .005, respectively).

253 7.5 months in mesenchymal versus 5 months in epithelial tumors (P = .02).

254 spontaneous cancers with a diverse range of epithelial tumors, particularly cutaneous adnexal tumors

255 region 3p14.2, FHIT, that is inactivated in epithelial tumors, particularly in tumors resulting from

256 s with increased overall survival and a more epithelial tumor phenotype in patients with KRAS mutant

257 a functional Brca1 increases murine ovarian epithelial tumor predisposition by increasing estrogen s

258 ased expression of Stat3 downstream genes in epithelial tumor progenitor cells.

259 A hallmark characteristic of epithelial tumor progression as well as some processes o

260 and furthermore that p53 loss can facilitate epithelial tumor progression by a mechanism in addition

261 During epithelial tumor progression, the loss of E-cadherin exp

262 ely 25% of patients with melanoma and common epithelial tumors, represents an attractive target for i

263 Many epithelial tumors show deletion of the short arm of chro

264 tion of chemical changes in fibroblasts upon epithelial tumor signaling is poorly understood.

265 was reactivated in about 10% (7.1-17.1%) of epithelial tumors (six tumor types, n = 369).

266 otch1 in human cancer, the role of Notch3 in epithelial tumors, such as lung carcinomas, has not been

267 for dissection of cell-specific programs of epithelial tumor suppression.

268 owever, direct evidence for C/EBPalpha as an epithelial tumor suppressor is lacking due to the absenc

269 sensus that they function as cell-autonomous epithelial tumor suppressors.

270 OPC, this mechanism may also apply to other epithelial tumor systems modulated by COX activity.

271 sary to identify low versus high risk thymic epithelial tumors (TETs) before operation to guide optim

272 We analyzed 28 thymic epithelial tumors (TETs) using next-generation sequencin

273 vivo was approximately 1.5 times greater in epithelial tumors than EMT tumors.

274 , the occurrence of multifocal and recurrent epithelial tumors that are preceded by and associated wi

275 eral, metastatic, multifocal primitive renal epithelial tumors that have the histologic and staining

276 l program for the invasion and metastasis of epithelial tumors that involves loss of cell-cell adhesi

277 signaling to form metastatic primitive renal epithelial tumors that mimic the epithelial component of

278 Craniopharyngiomas are epithelial tumors that typically arise in the suprasella

279 and LMO4-overexpressing mice develop mammary epithelial tumors, the mechanisms involved are unknown.

280 of two oncogenes commonly over-expressed in epithelial tumors: the p53 homologue DeltaNp63alpha and

281 determine whether p53-/- ovaries can develop epithelial tumors, they were transplanted into the ovari

282 st epithelial tissue as compared with breast epithelial tumor tissue.

283 fresh and paraffin embedded invasive ovarian epithelial tumor tissues.

284 ditioning regimen to enhance the response of epithelial tumors to ALA-PDT, possibly broadening its cl

285 tifying breast cancers and potentially other epithelial tumor types for targeted therapies aimed at t

286 n various normal tissues and multiple common epithelial tumor types.

287 ntibody cetuximab shows activity in multiple epithelial tumor types; however, responses are seen in o

288 The extracellular matrix of epithelial tumors undergoes structural remodeling during

289 echanisms by which STAT3 inhibits intestinal epithelial tumors using Apc(min)(/+)/Stat3(IEC-KO) mice

290 , we analyzed gene expression in 113 ovarian epithelial tumors using oligonucleotide microarrays.

291 nt diffusion coefficient (ADC) of the thymic epithelial tumors was calculated by the same observer at

292 l-to-mesenchymal transition of metastasizing epithelial tumors, we generated citrullinated vimentin p

293 umor-associated fibroblasts and pericytes in epithelial tumors, we set out to investigate the role of

294 an times to detection of an UTT or prostatic epithelial tumor were 56 months and 11 months, respectiv

295 gs were similar when borderline and invasive epithelial tumors were considered separately.

296 Epithelial tumors were highly vascularized with tight ce

297 Finally, epithelial tumors were more susceptible to elimination b

298 The frequent downregulation of Rap1GAP in epithelial tumors where alterations in cell/cell and cel

299 CD44 is broadly expressed in hematologic and epithelial tumors, where it contributes to the cancer st

300 Twenty patients with epithelial tumors who underwent high-dose cisplatin lava