ライフサイエンスコーパス: epitope

1 ining the immunogenicity of each IgE binding epitope.

2 uence constitutes a PC-specific neutralizing epitope.

3 tor target, but by recognition of a distinct epitope.

4 s and neutralization than the native peptide epitope.

5 sociated with the general variability of the epitope.

6 like receptors, and allotypes having neither epitope.

7 ELISAs, probably via exposure of additional epitopes.

8 from children and adults reacted to unknown epitopes.

9 arly identical profile of cross-neutralizing epitopes.

10 ssed ligands, cancer neoantigens, and T cell epitopes.

11 of different PGs and their assorted sulfated epitopes.

12 enicity breakthrough to conserved protective epitopes.

13 ssible state and which expose V1V2 and/or V3 epitopes.

14 e CRD to glycans that contain Manalpha1-2Man epitopes.

15 lycan, indicating an overlap between the two epitopes.

16 primarily due to the inaccessibility of the epitopes.

17 CD8(+) T cell response to two immunodominant epitopes.

18 izing epitopes and few to no nonneutralizing epitopes.

19 liminated the induction of tier-1 NAbs to V3-epitopes.

20 ontains important CD8(+), CD4(+), and B cell epitopes.

21 n to automatically extract reactive chemical epitopes.

22 B cells that recognize broadly neutralizing epitopes.

23 d further to incorporate specific biological epitopes.

24 capture of the physiological immunodominant epitopes.

25 ics to focus vaccine responses on protective epitopes.

26 as an intact protein bearing multiple linear epitopes.

27 Patterns of epitope abundance and the sequential release of cell wal

28 A total of 106 epitopes accounted for half of the total T cell response

29 The two other VHHs, E1 and V1C7, bind epitopes adjacent to V5E1 but display only weak toxin ne

30 efore, we set out to map H2-IA(b)-restricted epitopes along the PVM proteome.

31 ceptors of NK cells, allotypes having the C1 epitope also recognized by killer cell Ig-like receptors

32 As IgE glyco-epitopes, also referred to as cross-reactive carbohydrat

33 ay explain the genetic conservation of these epitopes among flaviviruses.

34 on-associated spikes present nearly all bnAb epitopes and are therefore promising vaccine antigens.

35 n of 836 bp, which contains the major immune epitopes and drug resistance mutations.

36 brid molecule was designed to cover relevant epitopes and evaluated in silico.

37 displays predominantly broadly neutralizing epitopes and few to no nonneutralizing epitopes.

38 xplain amino acid preferences in immunogenic epitopes and highlight opportunities for structural cons

39 e human genome, the links between the T-cell epitopes and low immunogenicity of H7 HA remains unknown

40 d activation of gB through different surface epitopes and mechanisms.

41 The RBD contains critical neutralizing epitopes and serves as an important vaccine target.

42 matically reduces exposure of CD4i HIV-1 Env epitopes and therefore reduce the susceptibility of HIV-

43 perimental data (analysis of guard cell wall epitopes and treatment of tissue with cell wall digestin

44 ased on a random forest algorithm trained on epitopes annotated from antibody-antigen protein structu

45 rum IgE antibodies directed to the alpha-gal epitope are associated with hypersensitivity to equine a

46 er of clones for the CTL response against an epitope are inversely associated with the general variab

47 SEPIa was applied to a test protein whose epitopes are known, human beta2 adrenergic G-protein-cou

48 lexes shows that the conserved neuraminidase epitopes are located on the head of the molecule and tha

49 ponses, such as those against oxidized lipid epitopes, are thought to mainly derive from T cell-indep

50 support the feasibility of exploring the V3 epitope as a HIV-1 vaccine target in nonhuman primates.

51 rrelated with Abs that reacted with a linear epitope at a lysine residue at position 169 (K169) in th

52 of the most potent bnAbs target a quaternary epitope at the apex of the surface HIV envelope (Env) tr

53 Quaternary epitopes at the apex of the spike are recognized by some

54 e vaccine candidate, but variation in B-cell epitopes at the dimer interface of DBP leads to inductio

55 ts of protective immunity are conformational epitopes at the dimer interface.

56 f effector memory CD8 T cells, regardless of epitope avidity.

57 monstrate that ectopic expression of insulin epitope B:9-23 (InsB9-23) by thymic APCs is insufficient

58 Epitope-based matching has been applied not only to iden

59 restored the immunoreactivity of mAbs whose epitope being within residues 44-65 against reconstitute

60 Cross-reactive epitopes bind with higher affinity to alpha/beta dimers

61 Epitope binding affinities were mapped for human cross-r

62 phA2 internalization rate, binding affinity, epitope binding, and hydrophobicity.

63 basophil activation tests, determination of epitope binding, DNA methylation signatures, and bioinfo

64 Epitope binning studies showed that the majority of neut

65 (JUNV GP1-GD01) reveals largely overlapping epitopes but highly distinct antibody-binding modes.

66 emonstrated that modification of a single H7 epitope by changing 3 amino acids so that it is homologo

67 we report the identification of an energetic epitope by determining the interfacial hot-spot that dom

68 Structural mimicry of the DENV E epitope by the E1 combining site is achieved via the for

69 at focus on conserved elements of the target epitope, by thwarting strain-specific and distracted lin

70 ide evidence that antibody binding to a PorB epitope can be altered by sequence mutations in non-epit

71 mmune recognition of capsular polysaccharide epitopes can aid in the design of novel glycoconjugate v

72 n of red blood cells expressing self-antigen epitopes can alleviate and even prevent signs of disease

73 containing lethal mutations upstream of CTL epitopes can also be recognized by CTLs, potentially thr

74 GFR Abs directed against clinically relevant epitopes can be converted into mAb with unprecedented CD

75 ecognize this relatively featureless peptide epitope (canonical TCRs).

76 s revealed that the targeted type III repeat epitopes cluster on the inner strands of both beta-sheet

77 nternal destructive cleavages within the ALY epitope compared with the constitutive proteasome.

78 ty depends on the recognition of MHC class I-epitope complexes at the cell surface.

79 igens and predicted cross-reactive microbial epitopes, consistent with neoantigen molecular mimicry.

80 After identification of T cell epitope-containing parts on each of the 3 parental aller

81 le to identify a MHCII-restricted CD4 T cell epitope, corresponding to amino acids 37-47 in the PVM m

82 The 5B4 epitope corresponds to a peptide sequence (I56-K68) over

83 e of these V2 Abs revealed how the linear V2 epitope could be engaged, despite the lack of aspartic a

84 e novo design of antibodies binding specific epitopes could greatly accelerate discovery of therapeut

85 or sequence-based epitope prediction both on epitope data derived from solved 3D structures, and on a

86 lts in the majority of the latest two Immune Epitope Database (IEDB) weekly automated benchmark datas

87 The antibodies reduced tau uptake in an epitope-dependent manner: N-terminal (Tau13) and middoma

88 IgE and IgG4 binding to sequential epitopes derived from five major CM proteins were measur

89 boosted with molecules containing the B cell epitope-derived peptide without carrier or linked to oth

90 Tara) to be another such protein through an epitope discovery and proteomics approach by comparing p

91 eutralizing antibodies that targeted similar epitope domains at the EDI/II hinge region.

92 uctures, and on a large collection of linear epitopes downloaded from the IEDB database.

93 se mutations is able to generate and present epitopes downstream of the termination codon.

94 that mutations at the C-terminal end of this epitope dramatically improve presentation to these T cel

95 formational change in a loop within the PL-2 epitope due to a serine-to-proline mutation, locking the

96 in mice, those recognizing the DENV E-dimer epitope (EDE) can neutralize ZIKV infection in cell cult

97 proposal that prolonged exposure of the bNAb epitope enabled the maturation of the bNAb lineage.

98 entially be leveraged in HIV cure efforts if epitope escape and lack of sustained effector memory res

99 both CD4 reactivity and CD4-induced non-nAb epitope exposure, and increase thermal stability while m

100 n the immediate-early MCMV gene ie2 The same epitope expressed within the early M45 gene provided no

101 CA2a 971-990 can potentially act as a common epitope for both T cells and B cells.

102 ble multivalent display of potential allergy epitopes for determining the immunogenicity of each IgE

103 f three peptides that include immunodominant epitopes for gluten-specific CD4-positive T cells.

104 ulent PEDV, but the virus may lose important epitopes for inducing robust protective immunity.IMPORTA

105 first generation native-like trimers expose epitopes for non-neutralizing antibodies (non-nAbs), whi

106 Even if FaEO lacks epitopes for stable or transient membrane-interactions,

107 C1, 3B10, and 2H7, which recognize different epitopes, for further evaluation.

108 dase coupled with MALDI-MS allowed these two epitopes, for the first time, to be directly identified

109 ve mass spectrometric analyses to define the epitopes formed in tolerant and hypersensitive patients

110 ariants of p145, a conserved helical peptide epitope from the M protein of Streptococcus pyogenes, we

111 eukocyte antigen (HLA)-E and specific for an epitope from UL40 (VMAPRTLIL), which is characterized by

112 alysis of CD8+ T cells specific for a single epitope from Yellow Fever Virus (YFV), we show that the

113 lved sophisticated strategies to conceal Env epitopes from ADCC-mediating antibodies present in HIV+

114 ds to very few representative immunodominant epitopes from pathogenic insults.

115 tential HLA-A*02:01-restricted CD8(+) T-cell epitopes from the 693-amino-acid sequence of the VP13/14

116 rays of synthetic oligosaccharides, the LM26 epitope has been identified as a beta-1,6-galactosyl sub

117 hput methods that generate vast libraries of epitopes have been applied.

118 nogens produced robust antibody responses to epitope I, and their serum could neutralize HCV.

119 combinant vaccinia virus expressing the same epitope if KCSRNRQYL is expressed within the immediate-e

120 nly 13% of sample pairs sharing at least one epitope in alphas1 -casein to 73% in kappa-casein.

121 ng preferences and present the alpha3135-145 epitope in different binding registers.

122 Insertion of a 9-residue hemagglutinin epitope in IS1S2, but not in IS5S6 or in IIS5S6, prevent

123 sponses to the Plasmodium berghei GAP5040-48 epitope in mice expressing the MHC class I allele H-2D(b

124 We also identify a conserved inflammatory epitope in related proteins from diverse families, and d

125 an anti-iC3b mAb that was shown to target an epitope in the CUB region.

126 to a complex, 3-monomer spanning quaternary epitope in the DENV3 envelope (E) protein, but it is unc

127 tations destroying the conserved fusion-loop epitope in the E protein.

128 eloped higher IgG responses against a linear epitope in the gp120 C1 region of the HIV-1 envelope gly

129 46B8 binds to a conserved epitope in the vestigial esterase domain of hemagglutini

130 immunofluorescence studies indicate that MLG epitopes in brown algae are unmasked by a pre-treatment

131 Two epitopes in CFP-10 were characterized, and the MHC class

132 alleles for immunodominant Gag CD4(+) T cell epitopes in clade C virus infection, constructed MHC cla

133 nto these processes, 27 antibodies targeting epitopes in CMV virion glycoprotein complexes, including

134 ntibodies that target conserved neutralizing epitopes in E2 (HC33.4, HC84.26, and AR3B) and the E1E2

135 immunoinformatic analysis identified T-cell epitopes in H7 hemagglutinin (HA) which potentially enha

136 anti-SEE antibodies recognize nonoverlapping epitopes in SEE.

137 e genetic restrictions identified within the epitopes in the EDII fusion loop likely explain the sequ

138 ch protein component masked the IgE-reactive epitopes in the other protein component more effectively

139 alizing antibodies targeting CD4-induced Env epitopes in the presence of soluble CD4 (sCD4).

140 like trimers that reduce exposure of non-nAb epitopes in the V3-loop and trimer base, minimize both C

141 s, indicating that RSV F internalization was epitope independent.

142 pe microspores contained primexine-localized epitopes indicative of the presence of xylan, but these

143 arger portions of the DENV3-specific 5J7 mAb epitope into dengue virus serotype 4 (DENV4).

144 This functionally conserved epitope is a potential target for vaccines against P. fa

145 hinge-spanning region of the 5J7 quaternary epitope is a target for serotype-specific neutralizing a

146 actions and confirms that the conformational epitope is not required for antigen recognition.

147 lic (Allium sativum) bulbs in which the LM26 epitope is widespread throughout most cell walls includi

148 s engineered to improve exposure of specific epitopes is critical for HIV-1 vaccine development.

149 e ability to monitor the occurrence of these epitopes is important as structural changes are associat

150 In this study we tested the low-avidity epitope KCSRNRQYL, and show that a mouse CMV (MCMV) vect

151 ng the identical HLA-B*2705-restricted HIV-1 epitope KK10 (KRWIILGLNK).

152 57727-734, and the normally subdominant LCMV epitope L2062-2069, indicating a profound private specif

153 ray crystallography and EM to identify their epitope locations.

154 ertoire of 29 CTL responses against 23 HIV-1 epitopes longitudinally in nine chronically infected unt

155 loops both adjacent and non-adjacent to the epitope loop can enhance or diminish antibody binding, a

156 can be altered by sequence mutations in non-epitope loops.

157 T-cell responses, epitope mapping and cross-reactivity to profilins (Phl p

158 ells were determined by a novel CD154 T cell epitope mapping assay.

159 arrays were generated to enable the detailed epitope mapping of two monoclonal antibodies known to re

160 Epitope mapping was performed by pepscan analysis, site-

161 Previous epitope-mapping of autoantibodies (AutoAbs) from prostat

162 ues of E1E2 also resulted in identifying the epitope maps of diverse mAbs and the disulfide connectiv

163 R spectroscopy is extensively used to obtain epitope maps of ligands binding to protein receptors, th

164 oclonal antibodies (NAbs) targeting distinct epitopes may be necessary for protective immunity.

165 ized alloimmune risk determined by HLA-DR/DQ epitope mismatch.

166 shorter sequences and occupy nonoverlapping epitopes more frequently than aptamers with single modif

167 we identified a pathogenic CD8(+) T cell MPO epitope (MPO431-439) and found that cotransfer of MPO431

168 Infectious HCV epitope mutants encoding the well-defined genotype 1a-de

169 These results show that CTLs constantly lag epitope mutation, suggesting that preventing HIV-1 escap

170 ques have been used to prove the "junctional epitope" nature of VHH6, a camelid single domain antibod

171 alization by MAbs targeting the neutralizing epitope (NE) antigenic site.

172 oth antibodies bound to quaternary structure epitopes near the hinge region between envelope protein

173 Four antibodies reacted with linear epitopes near the N terminus of gH, exhibited strain spe

174 found that both HVEM and UL144 bind a common epitope of BTLA, whether engaged in trans or in cis, tha

175 results identify differences in the binding epitope of cytb 5 in the presence and absence of membran

176 erent residue types to map integratively the epitope of human interleukin-6 receptor (IL-6R) for two

177 response of EF4.1 mice to an I-Ab-associated epitope of the F-MuLV envelope protein is dominated by c

178 one of these sites broadly overlaps with the epitope of the well-known 4B7 mouse antibody, which can

179 Thus, sequence homology between T cell epitopes of 2 self-proteins and a related order of gut m

180 vivo model of TCD8 responses to well-defined epitopes of a clinically relevant oncoprotein, large T A

181 extracts is mainly related to bromelain-type epitopes of a newly identified cypress PG.

182 ry, Abseq uses specific antibodies to detect epitopes of interest; however, unlike these methods, ant

183 Rs from T cells that recognize the same pMHC epitope often share conserved sequence features, suggest

184 inding, despite the location of the antibody epitope on a domain (Ig1) not reported to bind NK1 or HG

185 Ab that selectively recognize the alpha-gal epitope on BGG.

186 -determining regions to bind to a quaternary epitope on each side of the dimeric capsid spike.

187 oparticles (immunogold) to map the available epitopes on a transferrin grafted silica particle (SiO2-

188 riants obtained by evolving murine antigenic epitopes on an AAV serotype 1 capsid template can evade

189 In this study, we mapped and characterized epitopes on DENV4 recognized by neutralizing antibodies

190 xin, suggesting that human B cells recognize epitopes on the dimerized form of LukAB during natural i

191 tructural features (measured by integrity of epitopes on the Env trimer) in a geographically defined

192 the gap in knowledge of protective antibody epitopes on the HAstV capsid surface.

193 A CD8(+) T cell epitope peptide from OVA (CSIINFEKL) and CpG were co-con

194 b-dependent cellular phagocytosis favored an epitope positioned further away.

195 orm other available tools for sequence-based epitope prediction both on epitope data derived from sol

196 ed on several bioinformatic tools for linear epitope prediction, a set of seven peptides was successf

197 limitations of SEPIa and of all other B-cell epitope predictors are discussed.

198 he induction of CD4 T cell responses and the epitope preferentially binds MHC class II/IA(k) rather t

199 5B4 and 6H4 recognize structurally distinct epitopes present in the vast majority of Bet v 1 isoform

200 ying the contribution of factors critical to epitope presentation, such as protein cleavage and gene

201 e cells respond to an insulin B-chain (InsB) epitope presented by the HLA-DQ8 molecule associated wit

202 accine, based on priming with multiple ASYMP epitopes (prime) and neurotropic TG delivery of the T ce

203 ght to investigate whether food-specific IgA epitope profiles differ intra-individually between mothe

204 VST tracking by epitope profiling revealed persistence of functional VST

205 a single MHC class I-restricted high-avidity epitope provided strong, T cell-dependent protection aga

206 Directed epitope rearrangements combined with a knowledge-based s

207 Moreover, since the alpha-(1-4)-glucan epitope recognised by INCh1 is also a component of glyco

208 the apoplastic presence of endogenous auxin epitopes recognised by an anti-IAA antibody.

209 ere we characterized a distinct mode of V1V2 epitope recognition by the new bNAb BG1 in which two Fab

210 The differential epitope recognition was not due to differences in HLA cl

211 ly, these data reveal an innate-like mode of epitope recognition with potential implications for the

212 ntified a major difference in conformational epitope recognition, with the nonpathogenic infection be

213 n this study, we report the structure of the epitope recognized by a monoclonal antibody with opsonop

214 nt functional type: allotypes having the Bw4 epitope recognized by killer cell Ig-like receptors of N

215 Characterization of the epitope recognized by protective antibodies may facilita

216 ivotal in the generation of the K-epsilon-GG epitope recognized during IAP, here we developed a large

217 The epitopes recognized following rDEN2Delta30 infection and

218 The specific epitopes recognized in this study can potentially be tes

219 g that these mAbs specifically recognize the epitope region in a random coil state.

220 structural characterization of these glycan epitopes remains a significant challenge in mAb preclini

221 ll and serum antibody responses with broader epitope representation and greater durability than with

222 ion of DENV NS1 in which host-cross-reactive epitopes reside.

223 e p17 R76G mutant which enables a functional epitope(s), masked in refp17, to elicit B-cell growth-pr

224 thermore, HLA-DR molecules encoded by shared-epitope (SE) alleles were predicted to bind these self-

225 (HLA)-DRB1 gene (HLA-DRB1) encode a "shared epitope" (SE) associated with rheumatoid arthritis (RA),

226 it is homologous with a known H3 immunogenic epitope sequence significantly improved the immunogenici

227 active between a newly defined putative MCMV epitope sequence, M57727-734, and the normally subdomina

228 DOSCATs combine a series of epitope sequences concatenated with tryptic peptides in

229 However, the epitope sequences within the PC that are recognized by t

230 One epitope, SERCA2a 971-990, induces widespread atrial infl

231 These antibodies define common epitopes shared by many viral isolates.

232 bergine glycans contain abundant heteroxylan epitopes, some of which are associated with both pectin

233 rphism shapes the relative abundance of self-epitope specific Treg cells that leads to protection or

234 icroscopy (dSTORM) to show that certain CD4i epitopes specific to transition state structures are exp

235 Our results confirm that a diverse set of epitope-specific AHAs can be isolated from a single huma

236 pt application for the rational design of an epitope-specific antibody binding with the target protei

237 VRC03, VRC-PG04, PGT128, and the quaternary epitope-specific bNAbs PGT145 and PGDM1400.

238 To determine whether HCMV epitope-specific CD4(+) T cell memory inflation occurs d

239 n determining immunodominance hierarchy, and epitope-specific CD8(+) T cell requirements for costimul

240 Increased binding of serum epitope-specific IgA to CM in mothers of infants with CM

241 Our analyses demonstrate that each epitope-specific repertoire contains a clustered group o

242 to the generalizable, underlying features of epitope-specific repertoires and adaptive immune recogni

243 Notably, the cyclic designs induced greater epitope-specific responses and neutralization than the n

244 report the in-depth characterization of ten epitope-specific TCR repertoires of CD8(+) T cells from

245 1 and block the Keap1-Nrf2 interaction in an epitope-specific way.

246 humoral assays, we evaluated the magnitudes, epitope specificities, avidities, and functions of syste

247 Evaluation of the epitope specificities, locations (systemic or mucosal),

248 There was significant discordance in epitope specificity between BM and maternal sera ranging

249 eling of monoclonal AQP4-IgGs with differing epitope specificity bound to isolated tetramers (M1-AQP4

250 Antibody, cellular immune responses, and epitope specificity in sensitized mice were investigated

251 hat it may be possible to predictively model epitope specificity.

252 ugh MCMV vectors expressing the high-avidity epitope SSIEFARL induced protective immunity irrespectiv

253 itive to antibodies targeting nonoverlapping epitopes, such as the anti-CD4-binding-site antibodies 3

254 ted Cas9 protein fused to repetitive peptide epitopes (SunTag) recruiting multiple copies of antibody

255 By studying epitope-tagged derivatives of mouse astrotactin-2 (Astn2

256 lymphoblastoid cell lines (LCLs), expressing epitope-tagged EBNA3A, EBNA3B or EBNA3C from EBV-recombi

257 Co-immunoprecipitation studies with epitope-tagged PP1c and Gbeta1 revealed that Gbeta1 inte

258 eneration of sequence-specific mutations and epitope tagging at an endogenous locus.

259 ription factor genes; (3) simple knock-in of epitope tags and fluorescent reporters (e.g. Sox2-V5 and

260 in expressing two Cdc20 genes with different epitope tags, we show by co-immunoprecipitation that thi

261 The neutralizing antibody responses and the epitopes targeted against DENV4 have not been characteri

262 y affinity maturation pathways and divergent epitope targeting.

263 n addition, MSB0010853 contains a third HER3 epitope that binds albumin to extend its circulation tim

264 zed the lateral patch, the principal exposed epitope that did not change when pdm2009 displaced previ

265 , the V2 Ab response was focused on a linear epitope that did not include K169.

266 of the TcdA CROPs helped define a conserved epitope that is distinct from previously identified carb

267 nogens based on the structure of a conserved epitope that is the target of broadly neutralizing antib

268 referential loss of T-cell reactivity to Mtb epitopes that are homologous to bacteria in the microbio

269 inhibited the response to two immunodominant epitopes that are known to be dependent on Ag cross-pres

270 Identification of epitopes that are recognized by diabetogenic T cells and

271 ptor:chemokine interfaces, and suggest novel epitopes that can be exploited to overcome these challen

272 nt variants, and the presence of distracting epitopes that entropically disfavor the evolution of bnA

273 mino acids within the antigenic determinant (epitope), the whole proteome can be represented by a ran

274 emblies of peptides and the relevant protein epitopes, this work illustrates a bioinspired approach t

275 ed with the glycoprotein B DYSNTHSTRYV (DYS) epitope to characterize circulating CD4(+) T cells in co

276 lls in case of toxicity; and (4) a CD34-CD20 epitope to facilitate selection of the engineered cell p

277 following delivery of its own TonB1-binding epitope to the periplasm.

278 inactivation; and (iii) exposure of cryptic epitopes to antibodies, allowing virus neutralization.

279 tates cross-presentation of disease-relevant epitopes to CD8(+) T cells.

280 The cross-reactivity of ZIKV epitopes to dengue virus (DENV) was tested using IFN-gam

281 , gamma-gliadins, LMW subunits and antigenic epitopes to gain a better understanding of the technolog

282 of experimentally mapped Der f 1/Der p1 IgG epitopes to the same surface patch on Blo t 1, as well a

283 ique to Zika and Dengue, but also identified epitopes unique to each Dengue serotype.

284 From this analysis, we not only identified epitopes unique to Zika and Dengue, but also identified

285 pecific IgE and challenged with Pen a 1 (IgE epitope valency of >/=8), although measurable responses

286 The composition of TCRs targeting each epitope varied considerably in stability over time, alth

287 NV4/3 virus containing the most expanded 5J7 epitope was also significantly more sensitive than WT DE

288 or histocompatibility complex class (MHC-II) epitope was identified, based on in silico prediction co

289 ility, cluster size and accessibility to myc-epitopes we show that forces acting on the transmembrane

290 ts of immunodominance among several dominant epitopes, we utilized a cell free antigen processing sys

291 d HLA-A2-restricted HCV NS3-1073 or NS5-2594 epitope were generated from a genotype 2a-derived HCV cl

292 t neutralized DENV4 were isolated, and their epitopes were finely mapped using recombinant viruses an

293 lar cytotoxicity favored a membrane-proximal epitope, whereas Ab-dependent cellular phagocytosis favo

294 ldren recognize deamidated and native gluten epitopes, whereas T cells from adults only recognize dea

295 and identify an immune-dominant neutralizing epitope, which can be exploited for vaccine development.

296 y a monomer that does not display quaternary epitopes, which may explain the modest success with solu

297 d not inhibit the response to "inflationary" epitopes whose responses can be sustained by infected no

298 had an immunodominant response to the Gag293 epitope with a functional avidity intermediate between t

299 al antibody (mAb) LE2E9 revealed overlapping epitopes with murine C1-specific group A mAbs including

300 r the discovery of a continuous neutralizing epitope within the UL128 subunit of the PC that could be