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1 ase in the cardioprotective eicosanoid 14,15-epoxyeicosatrienoic acid.
2 ive in the metabolism of arachidonic acid to epoxyeicosatrienoic acids.
3 ic acid to hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids.
4 N1 and CYP2N2 metabolize arachidonic acid to epoxyeicosatrienoic acids.
5 ncluding nitric oxide, prostacyclin, and the epoxyeicosatrienoic acids.
6 logically active hydroxyeicosatetraenoic and epoxyeicosatrienoic acids.
7 2+ channels, cytosolic phospholipase A2, and epoxyeicosatrienoic acids.
8 arachidonic acid, to physiologically active epoxyeicosatrienoic acids.
9 e P450 epoxygenase, the synthetic enzyme for epoxyeicosatrienoic acids.
12 f CYP2C23 but not CYP2J2 and increased 11,12-epoxyeicosatrienoic acid (11,12-EET) levels in isolated
13 action was enhanced by the addition of 11,12-epoxyeicosatrienoic acid (11,12-EET), a cytochrome P450-
14 peak, containing both the 11-hydroxy-14, 15-epoxyeicosatrienoic acid (11-H-14,15-EETA) and 15-H-11,1
16 poxygenase arachidonic acid metabolite 14,15-epoxyeicosatrienoic acid (14,15-EET) inhibits apoptosis
17 nd the molecular mechanisms underlying 14,15-epoxyeicosatrienoic acid (14,15-EET)-induced angiogenesi
23 0 mV) in rat myocytes were inhibited by 8, 9-epoxyeicosatrienoic acid (8,9-EET) in a dose-dependent m
24 ydroxyeicosatetraenoic acid and 14(S), 15(R)-epoxyeicosatrienoic acid (80 and 20% of total products,
25 poxidizes arachidonic acid to 11,12- and 8,9-epoxyeicosatrienoic acids (80 and 20% of total metabolit
27 We present evidence in astrocytes that 5,6-epoxyeicosatrienoic acid, a cytochrome P450 epoxygenase
30 he osmotransducing cytosolic messenger 5'-6'-epoxyeicosatrienoic acid and allowed channel activation
31 arachidonic acid to 14,15-, 11,12-, and 8, 9-epoxyeicosatrienoic acids and 11- and 15-hydroxyeicosate
32 arachidonic acid to 14,15-, 11,12-, and 8, 9-epoxyeicosatrienoic acids and 19-hydroxyeicosatetraenoic
33 rachidonic acid into 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic
35 he cytochrome P450 (cP450) pathway producing epoxyeicosatrienoic acids and hydroxyeicosatetraenoic ac
37 CYP4A3 metabolizes arachidonic acid to both epoxyeicosatrienoic acids and vasoconstrictive 19,20-hyd
38 2J4 convert arachidonic acid to vasodilative epoxyeicosatrienoic acids, and CYP4A3 metabolizes arachi
39 ctive products, including PGs, leukotrienes, epoxyeicosatrienoic acids, and hydroxyeicosatetraenoic a
41 ubules and collecting ducts, sites where the epoxyeicosatrienoic acids are known to modulate fluid/el
44 id epoxygenases and that CYP2J products, the epoxyeicosatrienoic acids, are endogenous constituents o
48 THETAs join prostacyclin, nitric oxide, and epoxyeicosatrienoic acids as new members of the family o
49 -dependent metabolism of arachidonic acid to epoxyeicosatrienoic acids as the principal reaction prod
50 -phorbol-12,13-didecanoate and 5,6- or 14,15-epoxyeicosatrienoic acid, as well as thapsigargin, a kno
51 unts of arachidonic, eicosapentaenoic or 8,9-epoxyeicosatrienoic acids, but some uptake persisted eve
52 in epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids (catalytic turnover 65 pmol of
53 These results show that an impaired role of epoxyeicosatrienoic acids contributes, together with an
54 ts (+/-)-8,9-, (+/-)-11,12-, and (+/-)-14,15-epoxyeicosatrienoic acid (EET) (total turnover of approx
56 synthesis of the ethyl esters of both 11,12-epoxyeicosatrienoic acid (EET) and 11S,12S-dihydroxyeico
57 of Ca2+ pools were compared; 8,9- and 11,12-epoxyeicosatrienoic acid (EET) at 1.5 microM were comple
59 r the kidney Cyp2c44 epoxygenase and for its epoxyeicosatrienoic acid (EET) metabolites in the in viv
60 s), exogenous AA induced significant 14S,15R-epoxyeicosatrienoic acid (EET) production (241.82 ng/10(
61 epoxygenases convert arachidonic acid into 4 epoxyeicosatrienoic acid (EET) regioisomers, which were
62 hibition prevents hydrolysis of the enzymes' epoxyeicosatrienoic acid (EET) substrates, so they accum
63 tography; and the results showed that 11,12- epoxyeicosatrienoic acid (EET) was the major product met
65 ibition is likely a result of an increase in epoxyeicosatrienoic acid (EET)-mediated generation of RO
66 hat targeting the formation of proangiogenic epoxyeicosatrienoic acids (EET) by the cytochrome P450 a
68 during cirrhosis, focusing on the actions of epoxyeicosatrienoic acids (EET), known to be potent regu
70 aenoic acid, and leukotriene B4), TRPV4 (5,6-epoxyeicosatrienoic acid [EET] and 8,9-EET), and TRPA1 (
71 -derived metabolites of arachidonic acid the epoxyeicosatrienoic acids (EETs) and hydrogen peroxide (
72 tes biologically active compounds, including epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetrae
73 ncubation with 17 mm glucose increased media epoxyeicosatrienoic acids (EETs) and reduced cell membra
75 idonic acid to 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETs) and to 19- and 20-hydro
85 rachidonic acid epoxygenase metabolites, the epoxyeicosatrienoic acids (EETs) are powerful, nonregios
91 m to conduct a chemical screen, and identify epoxyeicosatrienoic acids (EETs) as a family of lipids t
92 However, AA is also converted to natural epoxyeicosatrienoic acids (EETs) by cytochrome P450 enzy
93 coronary arteries through its metabolism to epoxyeicosatrienoic acids (EETs) by cytochrome P450, we
94 CYP) epoxygenases CYP2C8 and CYP2J2 generate epoxyeicosatrienoic acids (EETs) from arachidonic acid.
95 ed from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic acids (EETs) from the cytochrome P45
101 of the CYP2B19 metabolites 11,12- and 14,15-epoxyeicosatrienoic acids (EETs) on keratinocyte transgl
107 eans to enhance the biological activities of epoxyeicosatrienoic acids (EETs) to treat cardiac hypert
108 TEs), hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatri
109 ovascular endothelial cells, total levels of epoxyeicosatrienoic acids (EETs), but not epoxydocosapen
110 activation of KCa channels, and whether the epoxyeicosatrienoic acids (EETs), derived via cytochrome
111 zes lipid signaling molecules, including the epoxyeicosatrienoic acids (EETs), epoxidized lipids prod
112 are metabolites of arachidonic acid (AA) and epoxyeicosatrienoic acids (EETs), have been identified a
113 rachidonic acid epoxygenase metabolites, the epoxyeicosatrienoic acids (EETs), in ENaC activity have
116 nt in the kidney where its products, the cis-epoxyeicosatrienoic acids (EETs), modulate sodium transp
117 chrome P450 metabolites of arachidonic acid, epoxyeicosatrienoic acids (EETs), potently activate card
122 unds including 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETs), their corresponding di
123 unds including 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETs), their corresponding di
124 n the metabolism of arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs), which affect multiple
133 zed by cytochrome P-450 epoxygenases to four epoxyeicosatrienoic acids (EETs): 14,15-, 11,12-, 8,9-,
134 ids, including 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETs); 5-, 8-, 9-, 12-, and 1
135 t in heart and active in the biosynthesis of epoxyeicosatrienoic acids (EETs); however, the functiona
136 lial metabolism (-35%, p < 0.01), vasoactive epoxyeicosatrienoic acids (EETs; -60%, p < 0.001) synthe
138 ality of CYP2J2 products matched that of the epoxyeicosatrienoic acid enantiomers present, in vivo, i
140 port that the 5,6-epoxide of anandamide, 5,6-epoxyeicosatrienoic acid ethanolamide (5,6-EET-EA), is a
142 contrast, the parental arachidonic acid and epoxyeicosatrienoic acids failed to activate CB1 or CB2
143 revealed that 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids formed by these pathways have
144 ti-inflammatory epoxy fatty acids, including epoxyeicosatrienoic acids from arachidonic acid to the c
147 pe channel) and to the osmotransducing lipid epoxyeicosatrienoic acid in heterologous expression stud
148 menting, for the first time, the presence of epoxyeicosatrienoic acids in human jejunum by gas chroma
149 In light of the well documented effects of epoxyeicosatrienoic acids in modulating renal tubular tr
150 was suggested by documenting the presence of epoxyeicosatrienoic acids in the human heart using gas c
152 lites derived from omega-6 arachidonic acid, epoxyeicosatrienoic acids, increase angiogenesis and tum
154 ups after the Ca2+ ionophore A23187 or 14,15-epoxyeicosatrienoic acid, independent of store depletion
156 hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids into less active eicosanoids,
157 the cytochrome P450 epoxygenase product 5,6-epoxyeicosatrienoic acid is primarily responsible for hy
161 e can result in an increase in the levels of epoxyeicosatrienoic acids, leading to the attenuation of
162 In summary, our results suggest that 5,6-epoxyeicosatrienoic acid may be a component of calcium i
163 id pools in rat heart myocytes and (b) 11,12-epoxyeicosatrienoic acid may play an important functiona
164 smooth muscle and endothelium suggests that epoxyeicosatrienoic acids may also be involved in the mo
165 achidonic acid pools in human heart and that epoxyeicosatrienoic acids may, therefore, play important
166 SFZ further stimulated the production of non-epoxyeicosatrienoic acid metabolites, suggesting a metab
169 ional and biological approaches, the role of epoxyeicosatrienoic acids, nitric oxide (NO)/reactive ox
172 ctive with preferential formation of (8R,9S)-epoxyeicosatrienoic acid (optical purities are 91 and 90
173 2N1 and CYP2N2, respectively) and (11R, 12S)-epoxyeicosatrienoic acid (optical purities are 92 and 70
174 y, such as hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids, play novel roles in glomerula
177 ular tone by K(+)(Ca) channel activation and epoxyeicosatrienoic acid release and that endothelium-de
178 of K(+)(Ca) channels is only partly through epoxyeicosatrienoic acid release, indicating the presenc
179 lead to an increase in circulating levels of epoxyeicosatrienoic acids, resulting in the potentiation
182 ted by blockade of the two critical steps in epoxyeicosatrienoic acid synthesis: release of arachidon
183 nic acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be further metabolize
184 over, 5,6-epoxyeicosatrienoic acid and 14,15-epoxyeicosatrienoic acid, the cytochrome P450-dependent
186 onversion of the protective eicosanoid 14,15-epoxyeicosatrienoic acid to 14,15-dihydroxyeicosatrienoi
188 poxide hydrolase catalyzes the hydrolysis of epoxyeicosatrienoic acids to dihydroxyeicosatrienoic aci
190 ated a significantly increased production of epoxyeicosatrienoic acids, vasodilator metabolites of CY
194 the epoxidation of arachidonic acid to form epoxyeicosatrienoic acids, which modulate bronchial smoo
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