ライフサイエンスコーパス: equipotent

1 do analogues 19, 22, and 28 were found to be equipotent.

2 tripeptide 4k (Cbz-Leu-Leu-D,L-Phe-CH2F) is equipotent.

3 ition state inhibitor and contrasts with the equipotent 2',5'-dd-3'ATP, a post-transition state nonco

4 At equipotent acetylcholine concentrations, alpha 3 beta 2

5 One of these frontrunner compounds, 15, was equipotent across the two strains (K1 = 25.0 nM, NF54 =

6 whereas flagellin and TNFalpha seemed to be equipotent activators of p38 mitogen-activated protein k

7 lso found that all four EET regioisomers are equipotent activators of the K(ATP) channels, reducing t

8 er of targeted covalent EGFR inhibitors with equipotent activity across mutants EGFR and good WT-EGFR

9 r of IRAK4 kinase activity that demonstrates equipotent activity against multiple MyD88-dependent res

10 ovalent mutant-selective EGFR inhibitor with equipotent activity on both oncogenic and T790M-resistan

11 atives such as 54j and 54k which demonstrate equipotent activity versus the KDM4 (JMJD2) and KDM5 (JA

12 al agonist/antagonist profile and bound with equipotent affinity (K(i) approximately 0.5 nM) to both

13 d orally bioavailable inhibitor of CDK8 with equipotent affinity for CDK19.

14 t liver-stage malaria parasites and are also equipotent against a panel of pathogenic protozoan paras

15 nce of either 2 mug/mL AZM or 16 mug/mL AMX (equipotent against A. actinomycetemcomitans).

16 Both enantiomers are equipotent against human cytomegalovirus (HCMV) and vari

17 is reversible; moreover, rustmicin is nearly equipotent against the solubilized enzyme.

18 onal P2Y2 receptors at which UTP and ATP are equipotent agonists.

19 nt respiratory depression, in contrast to an equipotent analgesic dose of morphine.

20 ile the much more lipophilic but essentially equipotent analog 8 performed poorly.

21 An equipotent analog of dolastatin 10, lacking the thiazole

22 structure-guided modification, a truncated, equipotent analogue of CTX-I, and demonstrate, using var

23 la24], [Ala25], [Ala26], and [Ala29] yielded equipotent analogues and [Ala7], [Ala12], [Ala17], [Ala2

24 oxygen by either nitrogen or sulfur yielded equipotent analogues.

25 ve to enprofylline 2b, pentoxifylline 35 was equipotent and 1-propylxanthine 3 was >13-fold more pote

26 Because ATP and UTP appear equipotent and equieffective in regulating ion transport

27 ceiving a treatment with imidazenil in doses equipotent and with a schedule identical to that of diaz

28 blast cells are known to be developmentally equipotent and yet eventually contribute distinct sets o

29 genous analog lithocholic acid was virtually equipotent), and the most potent inverse GSM identified

30 that corneal and conjunctival epithelia are equipotent, and that identical oligopotent stem cells ar

31 selective COX-2 inhibitors in vitro, showed equipotent anti-inflammatory activity compared to the co

32 ch are distinct from bortezomib, and exhibit equipotent anti-multiple myeloma activities, are undergo

33 anticoagulated with heparin compared with an equipotent anti-Xa concentration of enoxaparin.

34 For example, compounds 4.11 and 4.13 are as equipotent as AMP with regard to FBPase inhibition.

35 via KOP receptor-mediated mechanisms, being equipotent as an analgesic to the KOP agonist U50,488.

36 methyl (15) and ethyl (16) esters are about equipotent at A1 but not at A2a receptors.

37 l substituted analogue (38c) was found to be equipotent at AMPA and GLUK5-containing kainate receptor

38 om both normal controls and CGD patients are equipotent at arresting the growth of Aspergillus conidi

39 190-fold, respectively) but were essentially equipotent at DAT and sigma(1) receptors (10; K(i) = 77

40 fect, despite the fact that both stimuli are equipotent at inducing Ig class switching and Ig secreti

41 o(4,3-b)-1,4-oxazin+ ++-9-ol (PD 128907) was equipotent at inhibiting the activity of both population

42 gth isotypes of ApoE produced in E. coli are equipotent at inhibition.

43 hate-6-azophenyl-2', 4'-disulfonic acid were equipotent at P2X(1) and P2X(1/5) receptors; however, th

44 The corresponding 5-methylphosphonate was equipotent at P2X1 receptors.

45 Several analogues were nearly equipotent at rat and human A3 receptors.

46 peritonitis in vivo, RvD1 and AT-RvD1 proved equipotent (at nanogram dosages), limiting polymorphonuc

47 upper airway epithelium is maintained by an equipotent basal progenitor cell population, in which th

48 xposure concentrations were calibrated to be equipotent based on the yeast estrogen screen (YES), whi

49 Propranolol, administered at equipotent beta-blocking dosage, reduced the number of a

50 he S1 subsite pocket were found to be nearly equipotent between the human and the murine enzymes.

51 even-membered ring analogs are approximately equipotent, binding affinities of those having three- to

52 group of 1 resulted in the identification of equipotent (both against the enzyme and in cell culture)

53 regulates the developmental potential of two equipotent cells along the dorsoventral axis.

54 -P equivalence group' take place between the equipotent cells themselves.

55 e two different tissues from a population of equipotent cells.

56 than CXCR1, although both receptors mediated equipotent chemotaxis and exocytosis in RBL.

57 Both (R)-1 and (R)-3 are about equipotent, comparable to DOI in activity but about 10-f

58 t, suppressing global protein synthesis with equipotent concentrations of cycloheximide actually prev

59 Following incubation of cells with equipotent concentrations of IFN-alpha or IFN-lambda, Hu

60 However, equipotent concentrations of NMDA, a nontransported agon

61 cal processes were indistinguishable between equipotent concentrations of the three chemicals.

62 ranscriptome and whole proteome responses to equipotent concentrations of three agonists of the AHR,

63 At equipotent concentrations, isoflurane, but not sevoflura

64 Here we show that azumolene, an equipotent dantrolene analog, inhibits a component of SO

65 cortistatinone, Delta(16)-cortistatin A (the equipotent direct precursor to cortistatin A), and its r

66 8) of the beta2-receptor were randomized to equipotent dosages of carvedilol or metoprolol for two 6

67 Similarly, i.t. co-injection of almost equipotent dosages of reactive red 2 (30 micrograms) and

68 a]pyridazine]-8'-carboxamide (BMS-591348) at equipotent doses for Ca(2+)-mobilization.

69 Isoflurane, but not sevoflurane, at equipotent doses induced cell damage determined by both

70 ough bispectral index values may differ with equipotent doses of different agents.

71 ne (control, n = 8), or with the addition of equipotent doses of epinephrine 1 microM (n = 8), dobuta

72 d primary cortical neurons were treated with equipotent doses of isoflurane and sevoflurane.

73 We have also monitored parasite responses to equipotent doses of the clinical antimalarial inhibitors

74 sms play upon the determinative machinery of equipotent early RPCs to drive clonal variability.

75 '-O-(3-thiotriphosphate) being approximately equipotent (EC(50) = 1 microM) in eliciting extracellula

76 UTP and ATP were equipotent (EC50 approximately 25 microM) in stimulating

77 Both the peptide and analogue were equipotent (ED50=0.5 microg) in significantly increasing

78 motif led to the discovery of compound 3, an equipotent enzyme inhibitor with significant improvement

79 odules with collagen results in four broadly equipotent FN-collagen interaction sites.

80 ring around the ratio at which the MAbs were equipotent for a given HIV-1 strain (on the basis of the

81 roup generated a compound, BX 511, which was equipotent for both human and mouse CCR1.

82 + ++amin o]-4-methylpentanoic acid (22), was equipotent for ECE-1 and NEP.

83 tive binding assay and isoliquiritigenin was equipotent for ER subtypes.

84 ken with the fact that the two compounds are equipotent for inhibiting adenylyl cyclase activity, the

85 ary CD34(+) CML cells, nilotinib and IM were equipotent for inhibition of BcrAbl activity, producing

86 cs for BrAAP activity are also approximately equipotent for inhibition of the chymotrypsin-like (ChT-

87 Compound 18 was equipotent for ROCK1 (IC(50) = 650 nM) and ROCK2 (IC(50)

88 ctivation of wake-promoting systems at doses equipotent for sleep induction.

89 After erlotinib commencement, SBRT with equipotent fractionation was delivered to all sites of d

90 r molecule, were synthesized and found to be equipotent free radical scavengers in solution as assess

91 is sufficient to select a single R8 from an equipotent group of cells called the intermediate group

92 Competition binding analysis revealed equipotent, high affinity binding of NmU isopeptides to

93 Adenosine and AMP were equipotent human A(1)R agonists in our real-time assay a

94 ) and R(-) enantiomers of isoflurane are not equipotent, implying involvement of proteins.

95 MPC-6827 was equipotent in an in vitro growth inhibition assay in sev

96 inhibitors activate p53, the inhibitors were equipotent in arresting the cell cycle in isogenic breas

97 nical development in multiple sclerosis, was equipotent in both assays (EC50 1.5 and 1.1 nM, respecti

98 rom rat fetal cortices, BDNF and NT-4/5 were equipotent in inducing NPY production but NT-3 and NGF w

99 or aspirin-triggered LXA(4)) are essentially equipotent in inhibiting human polymorphonuclear leukocy

100 Nifedipine (30 microM) was equipotent in inhibiting the firing rate of control (51.

101 ross-linking studies showed that heparin was equipotent in inhibiting the formation of 125I-IGF-I-K13

102 comparable with human abuse levels were not equipotent in maintaining male sexual behavior patterns

103 ore importantly, compound 10 was found to be equipotent in MES-SA cells and paclitaxel-resistant, p-g

104 revealed that hypercholesterolemic DCs were equipotent in naive CD4(+) T-cell priming efficacy with

105 This potentiation is equipotent in portal vein-ligated and sham rats, immedia

106 lude that at the dosages used, ML and FP are equipotent in reducing Qaw in patients with mild asthma,

107 Methysergide and phentolamine were equipotent in reversing increases in SMR thresholds.

108 and 3'-O-(4-benzoyl)benzoyl-ATP were roughly equipotent in rising [Ca2+]i in gonadotrophs, while ADP

109 in permeabilized cells showed that InsP3 was equipotent in SH-SY5Y and AR4-2J cells but was approxima

110 All three chloro-isomers of PBG were equipotent in stimulating PI turnover.

111 The anti-CD28 dAb is equipotent in the inhibition of CD80- and CD86-mediated

112 contrast, 5,6-cis-EET and 5,6-trans-EET were equipotent in their capacity to inhibit collagen-induced

113 The two proteins proved equipotent in this assay, arguing that interaction of MI

114 At concentrations adjusted to give equipotent increases in the cytosolic Ca(2+), both agent

115 ose structural analogue 1031U89, which is an equipotent inhibitor of TS but is a less efficient subst

116 prothrombin fragment 1 (residues 1-155) were equipotent inhibitors of [125I]prothrombin and [125I]fac

117 s in CDK4 affinity, giving ligands that were equipotent inhibitors of CDK4 and CDK2.

118 At equipotent inotropic doses and matched preload, EMD-5703

119 Because 7 and 8 are approximately equipotent, it appears that the orientation of the pepti

120 with either Nal(2') or D-Nal(2') resulted in equipotent melanocortin receptor potency, suggesting tha

121 ontrast, the S-enantiomer of propafenone, an equipotent Na channel blocker but much weaker RyR2 inhib

122 This resulted in equipotent nanomolar inhibitors of DNA gyrase from Esche

123 amiloride with hydrochlorothiazide, at doses equipotent on blood pressure, prevents glucose intoleran

124 34c was found to be equipotent on chloroquine-sensitive and -resistant cell

125 the synthesis of several analogues that are equipotent or exceed the potency of the natural product.

126 benzimidazolones and benzimidazolinones gave equipotent or more potent analogues.

127 respectively, providing compounds that were equipotent or more potent than 1.

128 These optimized siRNAs were generally equipotent or superior to native siRNAs and exhibited in

129 entification of a number of simpler, and yet equipotent, or even more potent, antibacterial agents th

130 Results indicated that the equipotent P2Y2 receptor agonists UTP or ATP (1-100 micr

131 The FKN-K7A mutant acted as an equipotent partial agonist, whereas the FKN-R47A mutant

132 ous MaSC populations that function as single equipotent pools in the long term.

133 onstrates that intestinal stem cells form an equipotent population in which the loss of a stem cell i

134 Ryanodine (1) and dehydroryanodine (2) are equipotent probes for the ryanodine receptor (ryr) of ca

135 ay acts as a bipotential cell-fate switch on equipotent progenitor populations in other settings.

136 ighbours, and it is unclear how chromatin in equipotent progenitors undergoing lateral inhibition qui

137 R1 and CXCR2 bind IL-8 to produce a group of equipotent responses, but their ability to generate othe

138 in which the retina is derived from a set of equipotent retinal progenitor cells (RPCs) that are subj

139 of the acinar cell compartment as a pool of equipotent secretory cells.

140 Wnt activity is associated with maintaining equipotent stem cells (SC), Paneth cells and common gobl

141 in activating the IGF-1 receptor, they were equipotent stimulators of ERK1/2.

142 3,5,3'-triiodo-L-thyronine (T3) and T4 were equipotent stimulators of PCNA accumulation in C6, F98,

143 A CF5 cocultured-DC cytokine milieu drove an equipotent Th1 and Th17 response, while M68 promoted gre

144 alpha; therefore, although the factors were equipotent, the maximal effect of LIF > CNTF.

145 contains about a dozen parallel and roughly equipotent through-pathways.

146 s follows from the proliferative activity of equipotent tips that stochastically branch and randomly

147 Compounds 13 and 27, which are practically equipotent to 1, represent minimalistic fragments of the

148 leoyl-2-hydroxyethyl-1-phosphate, was nearly equipotent to 1-oleoyl LPA in both assays.

149 24-oxovitamin D3 is S and this metabolite is equipotent to 1alpha,25(OH)2D3 in suppressing PTH secret

150 The 3-oxatrien-11-yne analogue, 5, is equipotent to 2 in an animal model of inflammation but h

151 idinoacetic acid analogue 7 were found to be equipotent to 2, leading eventually to the discovery of

152 809 because the S809A mutation made 2-BisPEB equipotent to 3- and 4-BisPEB (IC(50), 1-2.5 muM).

153 ropyl analog 23 was subsequently found to be equipotent to 5, whereas analogs bearing smaller and bra

154 at ranged in pharmacological properties from equipotent to a loss of melanocortin receptor activity a

155 Analogues 8, 15-17, 22, and 23 were equipotent to acyline (IC(50) = 0.69 nM) and degarelix (

156 e-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH(2) that is equipotent to alpha-MSH at the mMC1, mMC3, and mMC5 rece

157 Moreover, C2'deOAmB is nearly equipotent to AmB against yeast but, within the limits o

158 IC(50) = 1.52 +/- 0.05 muM), and it was also equipotent to camptothecin as a Top1 inhibitor.

159 igation has provided optimal Top1 inhibitors equipotent to camptothecin that demonstrate low nanomola

160 lative to CCK-8, some of these compounds are equipotent to CCK as anorectic agents in rats following

161 lls and non-transformed IEC6 cells, HBD2 was equipotent to CCL20 in stimulating migration.

162 Several compounds were equipotent to chloroquine as inhibitors of the 3D7 strai

163 It is equipotent to cocaine at inhibiting dopamine uptake in-v

164 the shortest reported analogue of CRF to be equipotent to CRF (70% IA), the corresponding linear ana

165 ys33,Nle38]hCRF(8-41), the shortest sequence equipotent to CRF reported to date.

166 = 1.47 nM) (32) yielded analogues that were equipotent to degarelix (2) in vitro (IC(50) = 1.64 nM)

167 d by the didemnin analogue, tamandarin A, is equipotent to didemnin B.

168 behaviors maintained by food, with 34 and 36 equipotent to each other and both more potent in behavio

169 mptothecin against the type I enzyme but was equipotent to etoposide against topoisomerase IIalpha.

170 we found that 7alpha-fluoro ginkgolide B was equipotent to ginkgolide B underlining the critical impo

171 In vitro, stressin1-A was equipotent to h/rCRF to release ACTH.

172 homopiperidine analogue 11, was found to be equipotent to haloperidol.

173 ts, suggesting that such combinations may be equipotent to higher-dose single agents.

174 ethyl group of adenophostin, was found to be equipotent to Ins(1,4,5)P3, demonstrating the tolerance

175 CSF-1 is equipotent to insulin in its ability to stimulate 2-[3H]

176 Deglycosylated glycodelin was equipotent to intact glycodelin in the monocyte migratio

177 m-LHRH was equipotent to l-LHRH-III to release FSH, but also had a

178 nists with antiparkinsonian effects that are equipotent to levodopa is unknown.

179 of LPA, although none of the compounds were equipotent to LPA.

180 irmed this prediction, as (R)-2 proved to be equipotent to LSD in rats trained to discriminate LSD fr

181 of 1 was fully efficacious and approximately equipotent to morphine in the mouse warm water tail with

182 d all-D-amino acid (enantio) C-peptides were equipotent to native C-peptide, which indicates that the

183 [Ala(14)]-MCH was equipotent to native MCH in its ability to bind to and a

184 pounds were more potent than benztropine and equipotent to or slightly less potent than their previou

185 HSP90alpha/beta inhibitors were found to be equipotent to pan-HSP90 inhibitors in promoting the clea

186 ain revealed that a trisaccharide variant is equipotent to QS-21, while the corresponding disaccharid

187 One of the engineered compounds is equipotent to salinosporamide A in inhibition of the chy

188 12 +/- 3 microM, where the trans isomer was equipotent to that of the saturated C(10)-DECA.

189 und with an EC50 of 100 picomolar, which was equipotent to the 332-amino acid natural cytokine in cel

190 a multiple myeloma cell line and found to be equipotent to the best current N-BP drugs.

191 AC) inhibitors is finding alternative motifs equipotent to the classic and ubiquitously used hydroxam

192 C-terminal domain of AGRP, AGRP(87-132), is equipotent to the full-length peptide, further truncatio

193 12; these inhibitors were thus approximately equipotent to the known inhibitor 14(IC50 = 0.22 nM) fro

194 tic biotin-avrainvillamide conjugate, nearly equipotent to the natural product in inhibiting the grow

195 PC-1505 was essentially equipotent to the original C34 peptide and to T-20 in vi

196 scomycin, C24-deoxyascomycin was found to be equipotent to the parent compound both in its immunosupp

197 atent EGF receptor, Ras-dependent pathway is equipotent to the Ras-independent pathway, but is masked

198 ue was a pure P2Y(1) receptor antagonist and equipotent to the ribose analogue (MRS 2179).

199 and CSM cells, bimatoprost was approximately equipotent to the selective FP receptor agonists flupros

200 Rivastigmine was equipotent to the specific acetylcholinesterase inhibito

201 -40% relative potency), and 4 analogues were equipotent to the standard.

202 d all D-amino acid containing analogues were equipotent to their counterparts in a cell-based assay w

203 The effects of ANP were equipotent to those caused by C-ANP 4-23, a peptide that

204 ibitors, paroxetine and imipramine, in doses equipotent to those of fluoxetine in inhibiting brain se

205 , including Fab59, which was estimated to be equipotent to TPO.

206 Also unexpectedly, TxA(3) is about equipotent to TxA(2) at the TP alpha receptor.

207 5-Iodo-UDP 32 (EC50 = 0.15 microM) was equipotent to UDP, while substitutions of the 2'-hydroxy

208 4-Thio analogue 13 was equipotent to UDPG, but S-alkylation was detrimental.

209 rans)-1-aza-5-phenyl[4.4.0]decane (12a), was equipotent to unconstrained threo-MP against [(3)H]WIN35

210 thanocarba-uridine 5'-triphosphate (UTP) was equipotent to UTP as an agonist at human P2Y2 receptors

211 e identified seven analogues that are either equipotent to, or 3 times more potent than, the assay st

212 neurons differentiate from among a field of equipotent undifferentiated cells is the process of R8 p

213 ol, two new long-acting beta 2-agonists were equipotent (values of negative log molar concentration e

214 n reciprocal signaling between the AC and an equipotent VU cell.

215 Two equipotent water-soluble amide analogues of nocathiacin

216 lpha-isomer 19b (Ki = 211 nM) and was nearly equipotent with (-)-19a and (+)-20a as well as with coca

217 In addition, 3 was equipotent with 1 and 2 in [(3)H]dopamine uptake inhibit

218 The C-2 H E isomer was found to be equipotent with 1, while the C-2 Me Z isomer was inactiv

219 regioisomers 5,6-, 8,9- and 14,15-DHET were equipotent with 11,12-DHET in activating BK channels.

220 n binding and functional cellular assays and equipotent with 17.

221 at concentrations as low as 10(-)12 M and is equipotent with 1alpha, 25(OH)2D3.

222 nist of the rapid, nongenomic responses, was equipotent with 1alpha, 25-(OH)2D3 in inducing PI3 kinas

223 ed potency: 47 is less potent than 1, 83m is equipotent with 2, and 86 is less potent than 2.

224 The (2R,3S)-analogue of 6 was equipotent with 6 while the (2S,3S)- and (2R,3R)-analogu

225 high affinity for the GnRH receptor and were equipotent with acyline in the AOA.

226 Importantly, most betide diastereomers were equipotent with Acyline.

227 he peracetyl glycosides were, in most cases, equipotent with aglycones.

228 T cell activation and expansion was equipotent with CD55 or CD28 costimulation; however, CD5

229 nsion and multifunctional cytokine responses equipotent with conventional injectable routes of immuni

230 5 has greater potency than verapamil and is equipotent with cyclosporin A, for inhibiting P-glycopro

231 monosubstituted analogues, which are roughly equipotent with each other.

232 e with a cyclohexylmethyl P1 substituent was equipotent with its difluoro ketone counterpart, providi

233 Estrone quinol was also equipotent with its parent estrogen in reducing lesion v

234 tion products of LXB4 isolated from PMN were equipotent with LXB4 for monocyte adherence.

235 idamole analogue has been identified that is equipotent with NBMPR.

236 than the MDAN congeners and were essentially equipotent with one another and oxymorphone.

237 N-AB-PT was found equipotent with paclitaxel in promoting microtubule poly

238 PhTX-343 against NMDA, but was approximately equipotent with PhTX-343 against a kainate challenge.

239 by bacterial expression, demonstrated to be equipotent with PKIbeta-70, and also now demonstrated to

240 ely 2.3 nM for A549 human lung cancer cells, equipotent with PTX in vitro.

241 Synthetic rANP(REA18) was equipotent with rANP in stimulating cGMP production from

242 Compound (-)-(1R, 2R)-11 was equipotent with RSR13 in whole blood, is a candidate for

243 ed in two analogues that were less potent or equipotent with similar selectivity, respectively.

244 This mitogenic effect was equipotent with that of platelet-derived growth factor w

245 (+)-20a (Ki = 60 nM) were found to be almost equipotent with the high-affinity binding components of

246 corresponding gamma-glutamyl conjugate were equipotent with the parent compounds.

247 These stabilized analogues are nearly equipotent with their parent peptide in cyclic AMP activ

248 al effects of these drugs were approximately equipotent with those of cocaine.

249 A vitronectin-binding mutant of PAI-1 was equipotent with wild-type PAI-1 in inducing collagen acc

250 terized by the S- and R-isomers being nearly equipotent, with IC50 values of 51 and 22 microM in the