ライフサイエンスコーパス: era

1 describe contemporary times as a 'post-truth era'.

2 ic orthologue of Ls in Antirrhinum, ERAMOSA (ERA).

3 -valent PCV era), and in 2012 (13-valent PCV era).

4 ic reticulum-associated protein degradation (ERAD).

5 lin is triaged by ER-associated degradation (ERAD).

6 asmic reticulum (ER)-associated degradation (ERAD).

7 ER-associated degradation (a process called ERAD).

8 ical AVR in the transcatheter valve-in-valve era.

9 portant glycosaminoglycan to the premetazoan era.

10 iction is a key challenge in the post-genome era.

11 ng the most severe threats to the antibiotic era.

12 ted neurocognitive disorders in the post-ARV era.

13 engine increased during the modern satellite era.

14 he post-genome-wide-association-study (GWAS) era.

15 ion of SDD after PCI during the contemporary era.

16 bility to adapt during the conjugate vaccine era.

17 have become amplified in the postindustrial era.

18 ssions since the beginning of the industrial era.

19 challenging tasks of the post-GWAS research era.

20 interval [CI], .50-.57), but differed by PCV era.

21 pact the prognosis of patients in the modern era.

22 ed to prevent a return to the pre-antibiotic era.

23 f fossil fuels marked the beginning of a new era.

24 l for glioblastoma (GBM) in the temozolomide era.

25 , and the current intravitreal antimicrobial era.

26 the DAA era (P < 0.001) compared to the IFN era.

27 in global trade in the post-financial-crisis era.

28 and discusses future prospects in the omics era.

29 besity and lipohypertrophy in the modern ART era.

30 a cast doubts on its validity in the current era.

31 at the highest residual risk in the present era.

32 CM have improved survival in the more recent era.

33 ed heart-lung transplantation in the current era.

34 o in the Ordovician period, early Palaeozoic Era.

35 lenge for cancer genomes in the post-genomic era.

36 uickly become a global health threat in this era.

37 mes from a single center in the contemporary era.

38 us coronary intervention in the contemporary era.

39 in the pre-Model for End-stage Liver Disease era.

40 k for inherited PCA in the multigene testing era.

41 be 500 km further south in the contemporary era.

42 es of HF in the antiretroviral therapy (ART) era.

43 rgery optic neuropathy (PCSON) in the modern era.

44 grammes in the Sustainable Development Goals era.

45 of ocean reanalysis products in the pre-Argo era.

46 olding intermediates from being targeted for ERAD.

47 the glycan trimming and dislocation steps of ERAD.

48 it rate) as direct inhibitors of VCP/p97 and ERAD.

49 ain sequestered in the ER to block reductase ERAD.

50 omeric species that are competent to undergo ERAD.

51 during the infection period when it inhibits ERAD.

52 nesis and ERAD, suggesting a role for LDs in ERAD.

53 co-evolution with their hosts over geologic eras.

54 ntation, which was equally prevalent in both eras.

55 annual savings of 80-100% across four study eras.

56 stent across all species from all geological eras.

57 up Rhodophyta evolved in the Mesoproterozoic Era (1,600-1,000 Mya), crown groups Chlorophyta and Stre

58 ed and who lived during the early industrial era (1800s to early 1900s; n = 1,581) and the modern pos

59 nt era (ie, studies before 1946), the middle era (1946-80), and the recent era (after 1980).

60 ce in the prevaccine (2003-2006) and vaccine eras (2007-2010 and 2011-2014).

61 ly correlated with that in the post-pandemic era (2010-2015) at the regional level.

62 Here, this analysis is undertaken using the ERA-20CM-R river flow reconstruction for the twentieth c

63 ecreased in the PI (-17%; P = 0.002) and DAA eras (-24%; P < 0.001).

64 for clearance by ER-associated degradation (ERAD), a sophisticated process that mediates the ubiquit

65 In this high-throughput sequencing era, a tremendous amount of RNA-seq data is accumulating

66 mothripsis and leading to high expression of ERAS, a constitutively active RAS protein normally expre

67 In the modern era, active infection continues to pose the greatest thr

68 ERAD activity in the brain decreased with aging, and upr

69 on of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetica

70 6), the middle era (1946-80), and the recent era (after 1980).

71 17; P < 0.001), respectively, independent of era, age, and initial immunosuppression.

72 ements in clinical outcomes and cost, making ERAS an important example of value-based care applied to

73 ars in the Model for End-stage Liver Disease era and 1.71 years in the pre-Model for End-stage Liver

74 challenges of clinical trials in the genomic era and proposes ways to address these challenges.

75 iency and SCD-associated UBIAD1 on reductase ERAD and cholesterol synthesis.

76 e ER stress, resulting in HA degradation via ERAD and consequent inhibition of IAV replication.

77 BIAD1 from reductase, permitting its maximal ERAD and ER-to-Golgi transport of UBIAD1.

78 ERAD and VCP/p97 have been implicated in a multitude of

79 to 2009 (pre-PCV era), in 2010 (7-valent PCV era), and in 2012 (13-valent PCV era).

80 howed that older age at diagnosis, treatment era, and higher doses of brain and chest radiation are s

81 ra, the predominantly systemic antimicrobial era, and the current intravitreal antimicrobial era.

82 a eukaryotic chaperone that is essential for ERAD, and is transiently expressed by O. tsutsugamushi d

83 contribution to antigen cross-presentation, ERAD, and transport of internalized antigens into the cy

84 cytosol as full-length intermediates during ERAD, and we have investigated how they maintain substra

85 uring the 1(st) millennium before the Common Era (BCE), nomadic tribes associated with the Iron Age S

86 with the inverse association observed in the era before 2000, yet the effect modification by HT sugge

87 ative postmenopausal women, conducted in the era before mammography screening, among the 652 women wi

88 mination of the data from the two diagnostic eras (before 1988 and 1988 or later) shows that the HR i

89 In the pre-vaccination era, before 2008, women from ethnic minorities in Englan

90 all of the cocirculating strains during this era, but the chosen wild-type vaccine strains were not a

91 via the fecal-oral route; (2) in the modern era, C. trachomatis causes "opportunistic" infection at

92 Therefore, the focus in this new era, characterized by the confluence of understanding LS

93 f the Consequences of the Protease Inhibitor Era) cohort, a clinic-based cohort of individuals receiv

94 th in people diagnosed with HIV in the HAART era compared with the general population.

95 Constituents of the ERAD complex and its role in neurodegeneration are not y

96 ndoplasmic reticulum-associated degradation (ERAD) complex, participates in IP3R1 degradation and Ca(

97 onstrate that the ER protein membralin is an ERAD component, which mediates degradation of ER luminal

98 Our data supported ERA control of AM formation during both the vegetative a

99 eam consisting of surgeons, anesthetists, an ERAS coordinator (often a nurse or a physician assistant

100 traits; and to reevaluate the candidate gene era data through the Broad Antisocial Behavior Consortiu

101 ndance had remained the same between the two eras despite the poleward advance of sea surface isother

102 rformance during the screen-film mammography era, diagnostic digital performance showed increased abn

103 The systemic treatment era did not significantly affect outcomes (HR, 0.82; 95%

104 d degradation (ERAD) through upregulation of ERAD-enhancing alpha-mannosidase-like proteins (EDEMs) p

105 Under an era focused on optimal allocation of evidence-based inte

106 of empirical dosing and fractionation to an era focused on the development of evidence to guide pers

107 o decades, contributing to the rise of a new era for psychiatry.

108 of 1D thread-like devices may open up a new era for ultraflexible and human adaptable electronic sys

109 predominant position in the post Java-applet era for web-based visualization of molecular structures.

110 ographic diversity, and were performed in an era for which laboratory methods no longer reflect prese

111 onself" or misfolded protein and sorts HA to ERAD for degradation, resulting in inhibition of IAV rep

112 We also found a novel fusion involving USP9X-ERAS formed by chromothripsis and leading to high expres

113 This USP9X-ERAS fusion appeared highly oncogenic on the basis of it

114 The ERAS group had shorter LOS (P = 0.049) and fewer total i

115 The genetic era has revolutionized our perception of biological inva

116 the enhanced recovery after surgery pathway (ERAS) has emerged as one of the best strategies to impro

117 ck carbon emissions for the early industrial era have high uncertainty, however, because direct envir

118 among the countries during the post-pandemic era (i.e. Week 1, 2010 to Week 40, 2015).

119 ied by sex, age at diagnosis, and diagnostic era (ie, diagnosis before 1988 v in 1988 or later).

120 e divided into three eras: the pre-treatment era (ie, studies before 1946), the middle era (1946-80),

121 odds of acute rejection, independent of age, era, immunological status, and initial immunosuppression

122 ng patients undergoing colorectal resection, ERAS implementation was associated with decreased rates

123 e is to steer reefs through the Anthropocene era in a way that maintains their biological functions.

124 ies (ACTs) in the early 2000s heralded a new era in effectively treating drug-resistant Plasmodium fa

125 the Special Issue on Trauma, describe a new era in exploration of the biology of injury response and

126 dered trimeric symmetry has ushered in a new era in HIV-1 vaccination.

127 trategies will help overcome the correlation era in microbiome research and lead to a rational evalua

128 e second decade of the 21(st) century, a new era in nuclear medicine was initiated by the clinical in

129 nd large ground-based telescopes opens a new era in searches for Earth-analog exoplanets with conditi

130 therapeutic agent, cisplatin, launched a new era in the application of transition metal complexes for

131 ment of patients with CLL and heralded a new era in the clinical treatment of this disease.

132 This milestone marked the beginning of a new era in the field of porphyrinoids and presented opportun

133 ogenic oncolytic virus (OV) has opened a new era in the treatment of advanced melanoma; however, appr

134 rsonalized nutrition might be in the current era in which data-intensive biomedical characterization

135 derpinnings of LSCs are now being made in an era in which drug development pipelines offer the potent

136 Neuroscience is entering a collaborative era in which powerful new technologies, generated by lar

137 undation places us at the beginning of a new era in which researchers will be able to work towards ne

138 rovide evidence that LDs are dispensable for ERAD in mammalian cells.

139 results of this study demonstrate a role for ERAD in neuroendocrine cells and serve as a clinical exa

140 hild-mother dyads from 2007 to 2009 (pre-PCV era), in 2010 (7-valent PCV era), and in 2012 (13-valent

141 to those encountered in the pre-chemotherapy era, including the inability to cure tuberculosis, high

142 vidence of the beginning of a new geological era, informally named the Anthropocene.

143 Using station observations, ERA-Interim and MERRA2 reanalysis, we find that wet seas

144 ian trajectory approach applied to the ECMWF-ERA-interim reanalysis data.

145 ecies strongly supported the hypothesis that ERA is a phylogenetic orthologue of Ls, although it play

146 e in the modern antiretroviral therapy (ART) era is essential given their elevated risk for many canc

147 ndoplasmic-reticulum-associated degradation (ERAD) is an important protein quality control system whi

148 t that Sel1L-Hrd1 ER-associated degradation (ERAD) is responsible for the clearance of misfolded pro-

149 asmic reticulum (ER)-associated degradation (ERAD) is the movement, or retrotranslocation, of ubiquit

150 Enhanced Recovery After Surgery (ERAS) is a paradigm shift in perioperative care, resulti

151 l autonomy, as constructed in the postmodern era, is violated by stereotypes, which makes stereotype

152 In this postgenomic era it is now recognized that there may be from 10(5) to

153 lumen or membrane are discarded through the ERAD-L and ERAD-M pathways, respectively.

154 0s; n = 1,581) and the modern postindustrial era (late 1900s to early 2000s; n = 819).

155 g constraint on preindustrial vs. industrial-era LUC emissions and suggests that upper-end scenarios

156 eded for the solubility of retrotranslocated ERAD-M intermediates.

157 embrane are discarded through the ERAD-L and ERAD-M pathways, respectively.

158 n vivo assay, we show that retrotranslocated ERAD-M substrates are moved to the cytoplasm as part of

159 binding to retrotranslocated, ubiquitinated ERAD-M substrates is required for their solubility; remo

160 Multispanning ER membrane proteins, called ERAD-M substrates, are retrotranslocated to the cytosol

161 Cdc48-Npl4-Ufd1 were present in solubilized ERAD-M substrates.

162 ves as a critical "retrochaperone" for these ERAD-M substrates.

163 During the Millennium Development Goal (MDG) era, many countries in Africa achieved marked reductions

164 ion patients after conventional (n = 46) and ERAS (n = 69) care.

165 The era of 'big data' is also the era of abundant data, crea

166 The era of 'big data' is also the era of abundant data, creating new opportunities for stu

167 In this era of advanced high-tech imaging, the utility of plain

168 e cardiovascular outcomes, ushering in a new era of anti-inflammatory therapies for atherosclerosis.

169 In the era of antiretroviral therapy (ART), HIV-1 infection is

170 e most common AIDS-defining condition in the era of antiretroviral therapy (ART).

171 In this era of big data, we are amassing large amounts of inform

172 organs of the body including the skin is in era of big data.

173 In the era of bundled health care payment, strategies should be

174 A new era of collaboration and harmonization is required if we

175 n of viremia with increased longevity in the era of combined antiretroviral therapy, chronic inflamma

176 propriate management of the condition in the era of community-associated methicillin-resistant Staphy

177 cated by DC has decreased by over 30% in the era of DAA therapy.

178 ward best practices for this new and dynamic era of data intensive dermatology.

179 In the era of direct-acting antivirals (DAAs), it is unclear wh

180 In the era of drug-eluting stents, large-scale randomized trial

181 new treatment shift that moves away from an era of empirical dosing and fractionation to an era focu

182 ment through NLP should be considered in the era of EMRs because it can enable large-scale clinical s

183 n of CRISPR/Cas9 system has brought in a new era of gene editing.

184 In the era of genome-wide association studies (GWAS) and person

185 In the new era of genomics, the challenging interpretation of indiv

186 escribe the milestones that have led to this era of global transcriptional analysis, how these approa

187 In an era of graphene-based nanomaterials as the most widely s

188 etection of merging black holes in 2015, the era of gravitational wave (GW) astrophysics began.

189 Remote monitoring has ushered in an era of greater safety and the ability to respond to devi

190 ded to expand coverage and bring about a new era of health-care access.

191 years old-especially those born in the peak era of hepatitis C virus infection and among whites/Cauc

192 particularly important consideration in the era of high-throughput sequencing, when the discovery of

193 In the era of highly effective direct-acting antivirals (DAAs),

194 gy to S. aureus infection can usher in a new era of highly focused personalized therapy that may be p

195 severe infections, garnering notoriety in an era of increasing resistance to antibiotics.

196 d by plaque erosion may be on the rise in an era of intense lipid lowering.

197 Era of listing was divided into interferon (IFN; 2003-20

198 As the era of mass incarceration peaks, we argue that the time

199 An exciting era of microbe discovery, now under way, holds great pro

200 agas' disease, with other etiologies, in the era of modern HF therapies.

201 he past two decades, building on a preceding era of morphological cladistic studies, molecular data h

202 the scene as the field prepares to enter an era of novel therapies.

203 Although the risk remains very low in the era of nucleic acid testing, we hypothesized that this l

204 zing the limitations of such detection in an era of optical coherence tomography detection of diabeti

205 mour exome sequencing have signalled the new era of personalized immunotherapy with patient-specific

206 Because we are now entering the era of personalized medicine, a systems biology approach

207 ing from a theoretical stage to this hopeful era of possibilities, new challenges expectedly arise, a

208 In the era of precision medicine and with the advent of powerfu

209 The era of precision medicine has arrived and conveys tremen

210 atment, radiotherapy has not yet entered the era of precision medicine, and there have been no approa

211 As we enter into an era of precision oncology, a more comprehensive awarenes

212 works and drug sensitivity/resistance in the era of precision oncology.

213 gment-elevation myocardial infarction in the era of primary percutaneous coronary interventions.

214 approaches outline a potential roadmap to an era of quantum phenomena on demand.

215 al ecoregion maps, especially in our current era of rapid and unpredictable ecological change.

216 olutionary priority effects to persist in an era of rapid global change remains unclear.

217 ontrol of pathogenic bacterial growth, in an era of rapidly increasing antibiotic resistance.

218 for colorectal liver metastases (CLM) in the era of RAS mutation analysis.

219 ng these processes, paving the way for a new era of rational piloting of the gut microbiome functions

220 mortality among people with HIV, and in this era of safer and more effective hepatitis C therapy, non

221 This divergence time is well within the era of speciation between Homo sapiens and Neanderthals/

222 Japan has entered the era of super-ageing and advanced health transition, whic

223 In the era of systems biology, multi-target pharmacological str

224 volume samples, advancing prospects of a new era of systems immunology.

225 oval will hopefully mark the beginning of an era of targeted agents for the treatment of molecularly

226 Thus, even in the era of targeted therapies, CLL with alterations in the A

227 luate the epidemiology of PTLD in the modern era of transplant immunosuppression.

228 As sub-Saharan Africa transitions to a new era of universal antiretroviral therapy (ART), up-to-dat

229 In the era of value-based medicine, costs must be considered al

230 e strategies are inadequate to address a new era of western wildfires.

231 In the era of widespread rituximab use for Waldenstrom's macrog

232 rapped in these high-MW complexes, enhancing ERAD of Akita proinsulin and restoring WT insulin secret

233 minus of Sil1 results in the Doa10-dependent ERAD of this mutant protein.

234 ress by promoting ER-associated degradation (ERAD) of misfolded proteins.

235 erol-accelerated, ER-associated degradation (ERAD) of reductase, one of several mechanisms for feedba

236 linkage switching reaction is essential for ERAD, oleic acid and acid pH resistance in yeast.

237 WL for DC in NASH increased by 41% in the PI era (P < 0.001) and 81% in the DAA era (P < 0.001).

238 in the PI era (P = 0.004) and 32% in the DAA era (P < 0.001) compared to the IFN era.

239 in the PI era (P < 0.001) and 81% in the DAA era (P < 0.001).

240 DC in HCV patients decreased by 5% in the PI era (P = 0.004) and 32% in the DAA era (P < 0.001) compa

241 populations increased in both the PI and DAA eras (P < 0.001 for all) whereas HCC WL in HBV remained

242 UBIAD1 as a central player in the reductase ERAD pathway and regulation of isoprenoid synthesis.

243 and identified new drugs against the VCP/p97/ERAD pathway in human diseases.

244 moved to the cytoplasm as part of the normal ERAD pathway, where they are part of a solely proteinace

245 ch for patients both using and not using the ERAS pathway to reduce opioid consumption.

246 The ER-associated protein degradation (ERAD) pathway, an important UPR function for destruction

247 er of the ER-associated protein degradation (ERAD) pathway.

248 S of 4.4 d (95% CI: -6.8, -2.0 d; P < 0.001).ERAS patients consumed more protein due to the inclusion

249 By 72 h, ER stress is alleviated and ERAD proceeds unhindered.

250 eams from hospitals are trained to implement ERAS processes.

251 Multicenter implementation of an ERAS program among patients undergoing elective colorect

252 -scale implementation of a multidisciplinary ERAS program is feasible and effective in improving surg

253 comes of an enhanced recovery after surgery (ERAS) program among 2 target populations: patients under

254 Implementation of ERAS programs results in major improvements in clinical

255 iety that promotes, develops, and implements ERAS programs, publishes updated guidelines for many ope

256 During the reproductive phase ERA promotes the establishment of the stem niche at the

257 refore, upregulation of EDEM function in the ERAD protects against ER proteinopathy in vivo and thus

258 of hospital stay (LOS) in patients receiving ERAS protocols and conventional care.We conducted a pros

259 Enhanced Recovery After Surgery (ERAS) protocols are evidence-based care bundles that red

260 The post-GWAS era provides an opportunity for cross-phenotype analyses

261 3-2014 incidence of CM comparable to pre-ART era rates in South Africa.

262 s largest population-in the mass vaccination era remains poorly understood.

263 The ERAS Society conducts structured implementation programs

264 The ERAS Society, an international nonprofit professional so

265 Even in the vaccine era, Streptococcus pneumoniae (the pneumococcus) remains

266 o the long known ATP-dependent extraction of ERAD substrates during retrotranslocation, the Cdc48 com

267 ansport enables UBIAD1 to modulate reductase ERAD such that synthesis of nonsterol isoprenoids is mai

268 pheric black carbon for the early industrial era, suggesting that the contribution of black carbon to

269 e, impairs lipid droplet (LD) biogenesis and ERAD, suggesting a role for LDs in ERAD.

270 ferences in age, country, hospital location, era, systolic pressure, mean arterial pressure, lactate,

271 ics had significantly greater changes in the ERAS target populations after implementation compared wi

272 on rates were also significantly lower among ERAS target populations after implementation.

273 Local ERAS teams from hospitals are trained to implement ERAS

274 iated with increased CVD risk, in the modern era, the majority of incident CVD events occur in US adu

275 Relative to the modern era, the MM shows a factor 2 reduction in near-Earth hel

276 ve existed and include the pre-antimicrobial era, the predominantly systemic antimicrobial era, and t

277 ncluded studies, which we divided into three eras: the pre-treatment era (ie, studies before 1946), t

278 ssociated UBIAD1 variant inhibited reductase ERAD, thereby stabilizing the enzyme and contributing to

279 In a genomic era these results illustrate, and remind us, that sequen

280 pace, as it was in the ocean before the Argo era, these mechanisms may be insufficient to dampen the

281 tion in New York City from the preindustrial era through 2300 CE.

282 that promotion of ER-associated degradation (ERAD) through upregulation of ERAD-enhancing alpha-manno

283 el to clinical data from the prechemotherapy era, thus identifying the rates of progression and recov

284 omized clinical trials are needed in current era to evaluate long-term outcomes in routine use of EPD

285 Ectopically expressed Ank4 blocks ERAD to phenocopy O. tsutsugamushi infection.

286 e intracellular bacterial pathogen modulates ERAD to satisfy its nutritional virulence requirements.

287 ledge and technology available in particular eras to treat a specific, identifiable, and lethal disea

288 ological data sets from the modern satellite era, to examine the temporal characteristics of the Lore

289 but has gone largely ignored in the genomics era until recently.

290 Sustained inhibition of ERAD using RNA interference results in an O. tsutsugamus

291 that coincided with onset of the industrial-era warming.

292 rge HIV cohort in the antiretroviral therapy era, we found evidence that dysfunctional immune activat

293 of paramount importance, particularly in an era when TAVR expansion toward treating lower-risk patie

294 In studies in the recent era, when most children had tuberculosis treatment, the

295 roved bioinformatic tools are ushering in an era where complete genome assembly will become common fo

296 for biotechnology discovery programmes in an era where resistance to existing antibiotics is rapidly

297 nd preserved left ventricular function in an era where surgical aortic valve replacement was the sole

298 We are entering an exciting era where the ancient wisdom distilled into the world's

299 In the current era, with long-term survival after systemic treatment, t

300 s disease are moving into a new and exciting era, with several groups pursuing clinical trials with p