ライフサイエンスコーパス: eradicate

1 y exotic plant invasions are so difficult to eradicate.

2 ofilm-based infections that are difficult to eradicate.

3 ifficult Gram-negative bacteria to treat and eradicate.

4 ART), HIV persists in its hosts and is never eradicated.

5 strategy providing evidence that LSCs can be eradicated.

6 , and even very large tumors were completely eradicated.

7 d disease, after smallpox, to have ever been eradicated.

8 and in some experimental animals, completely eradicated.

9 appear to be sporadic and thus may never be eradicated.

10 free of rats and 37 from which rats had been eradicated.

11 . stomatis was internalized, it was promptly eradicated.

12 nce all types of wild polioviruses have been eradicated.

13 nvestments have been made, over 30 years, to eradicate a human pathogen from the world for the second

14 opulation, TRBC-targeted immunotherapy could eradicate a T cell malignancy while preserving sufficien

15 til the mid-20th century, after which it was eradicated across the region.

16 cover natural killer cell alloreactions that eradicated acute myeloid leukemia and improved survival.

17 rther investigated as a potential measure to eradicate additional potentially virulent organisms beyo

18 zine 14 proved to be the most potent biofilm-eradicating agent (>/=99.9% persister cell killing) agai

19 pparently curative treatment for PTB may not eradicate all of the MTB bacteria in most patients.

20 entional therapies or immunotherapies cannot eradicate all tumor cells for most patients.

21 ropyl alcohol (e.g., alcohol wipes or soaks) eradicated all viable virus.

22 cle and temperatures of approximately 300 K, eradicating all forms of life.

23 eting of CSCs will therefore be necessary to eradicate and cure cancer.

24 sms that form biofilms are very difficult to eradicate and thus are a frequent source of life-threate

25 native passerines was remarkably similar on eradicated and historically rat-free islands, community

26 at the assigned interval until varices were eradicated and then at 3 and 9 months after eradication.

27 Rinderpest virus has been eradicated, and it is only the second virus for which th

28 biota transplantation (FMT) could be used to eradicate ARB in humans.

29 utralization reduces but does not completely eradicate asthma exacerbations.

30 sal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, re

31 T cells engineered with a CD19-specific CAR eradicated B cell malignancies in mice.

32 oscopy suggest that sulfono-gamma-AApeptides eradicate bacteria by taking a mode of action analogous

33 Thus, the quest for new methods to eradicate bacterial infection is increasingly important

34 t indigenous microbiota and commonly fail to eradicate bacterial spores, two key factors that allow r

35 ngly, this isotype was the most effective in eradicating BCL1 lymphoma but had limited efficacy in s.

36 factors it produces, and it is difficult to eradicate because of its intrinsic resistance to antibio

37 rococci are opportunistic pathogens, hard to eradicate because of their unusually robust resistance t

38 upport the hypothesis that AMF exposures can eradicate biofilm on metal implants, and may enhance the

39 Unlike antimicrobial peptide mimics that eradicate biofilms through the general lysing of membran

40 biotics or biocides are often ineffective in eradicating biofilms.

41 py (SYMPHONY) having the potential to safely eradicate both primary tumors and distant metastatic foc

42 inhibitors in diminishment of breast CSCs to eradicate breast cancer.

43 not all types of wild polioviruses had been eradicated, but it might increase the cost of OPV withdr

44 ating diseases in human history until it was eradicated by a worldwide vaccination campaign.

45 rvoir of infected CD4(+) T cells that is not eradicated by antiretroviral therapy (ART).

46 tive impairment that cannot be prevented nor eradicated by antiretroviral therapy.

47 that this Treg subset may be preferentially eradicated by low-dose cyclophosphamide treatment.

48 protein and PCSK9 gene transcription can be eradicated by proteasome inhibitors.

49 wing chemotherapy, adverse effects that were eradicated by stem cell transplantation.

50 developed and remains the only human disease eradicated by vaccination.

51 d radiotherapy have been extensively used to eradicate cancer based on their direct cytocidal effects

52 new vulnerabilities that can be exploited to eradicate cancer cells responsible for tumor relapse.

53 dy's own immune system to target, fight, and eradicate cancer cells without destroying healthy cells

54 apse after treatment may occur by failure to eradicate cancer stem cells.

55 cell responses generally lack the potency to eradicate cancer.

56 aimed that inhibition of the enzyme MTH1 can eradicate cancer.

57 s a disease-selective therapeutic target for eradicating cancer cells while sparing healthy cells.

58 enerated from a polymerization initiator for eradicating cancer cells.

59 blasts, established protracted synapses, and eradicated CD19-negative leukemia, leading to prolonged

60 sessment of whole-genome sequencing of HIV-1 eradicated cells ruled out any off-target effects by our

61 We find MMC effectively eradicates cells grown in numerous different growth stat

62 rther improvements in efficacy are needed to eradicate challenging refractory tumors, such as gliobla

63 The ideal future goal of treatment is to eradicate chronic HBV infection globally.

64 Direct-acting antivirals (DAAs) effectively eradicate chronic hepatitis C virus (HCV) infection, alt

65 Pseudomonas aeruginosa virulence or that can eradicate chronic P. aeruginosa lung infections associat

66 a need for disease-modifying drugs that can eradicate clonal hematopoiesis and/or prevent progressio

67 Identifying therapeutic targets to eradicate CML LSCs may be a strategy to cure CML.

68 ilotinib led to complete disease control and eradicated CML xenograft tumours without recurrence afte

69 tochondrial protein translation, selectively eradicates CML LSCs both in vitro and in a xenotransplan

70 V investigation, development of treatment to eradicate covalently closed circular HBV DNA, and develo

71 3-IGF1R cascade as a therapeutic strategy to eradicate CSC.

72 ng C1572 as a promising therapeutic agent to eradicate CSCs for drug-resistant TNBC treatment.

73 lutionarily conserved catabolic process that eradicates damaged and aging macromolecules and organell

74 ukemia (AML), but they are not successful in eradicating de novo AML.

75 interventions for widespread application to eradicate dental caries (tooth decay) within a decade.

76 logic inhibition of casein kinase 2 (CK2) to eradicate disease in high-risk B-cell acute lymphoblasti

77 Therefore, research focused on eradicating disease and optimizing clinical management i

78 access across the board, mitigating or even eradicating disparities in certain cases.

79 prevents resistance to TORC1/2 inhibitors by eradicating drug-resistant CSCs in TNBC, and may thus re

80 rom reinfection when patients in whom HCV is eradicated during treatment become infected with a new H

81 These conjugates reduced tumor growth and eradicated E7-positive TC-1 tumors in mice after a "sing

82 ocus on on-off dosing that has been shown to eradicate each subpopulation alone.

83 c rationale to target IKBKE as a strategy to eradicate EGFR-TKI-resistant NSCLC cells.

84 It has proven possible to eradicate epidemic diseases, often without the availabil

85 y reversal and viral clearance strategies to eradicate established HIV infection.

86 he body controls it without drugs and (3) to eradicate established infection.

87 both innate and adaptive immune effectors to eradicate established tumors.

88 lls (HEK 293) at a concentration at which it eradicates established bacterial biofilms.

89 Phylogenetic analysis of the eradicated European P. vivax mtDNA genome indicates that

90 e recognizing developing countries' right to eradicate extreme poverty.

91 ompared to the reference mitigation pathway, eradicating extreme poverty increases the effort by 2.8%

92 We find that eradicating extreme poverty, i.e., moving people to an i

93 sbiosis and systemic inflammation in CKD, we eradicated facultative anaerobic microbiota with antibio

94 Sylvatic rabies has been eradicated from most of Central Europe, but cases still

95 If it is not eradicated from the wound, it translocates to the bloods

96 as drug-delivery vehicles for targeting and eradicating GBM cells in vivo.

97 rapeutic strategies that aim to specifically eradicate genetically compromised stem cells.

98 ant and is a promising treatment regimen for eradicating HCV in this patient population.

99 Success in eradicating helminths has limited helminth-induced morbi

100 ells have demonstrated tremendous success in eradicating hematologic malignancies (e.g., CD19 CARs in

101 Ledipasvir-sofosbuvir is effective at eradicating hepatitis C virus (HCV) infection in the gen

102 delines suggest that EMR-RFA is effective at eradicating HGD.

103 entrations in HIV reservoir sites to control/eradicate HIV as well as mitigate systemic side effects.

104 ead preventive measures and the inability to eradicate HIV from infected cells highlight the signific

105 undetectable plasma viral loads, it does not eradicate HIV infection.

106 has stimulated the search for strategies to eradicate HIV or to induce long-term remission without r

107 be key to designing effective strategies to eradicate HIV reservoirs.

108 rance of this reservoir will be necessary to eradicate HIV-1 in infected individuals.

109 adoptive transfer may support strategies to eradicate HIV-1 infection or to safely deescalate antire

110 whether IFN-alpha2 combined with ARVs might eradicate HIV-1 infections.

111 HIV latency is the chief obstacle to eradicating HIV but is widely believed to be an evolutio

112 voirs are considered the primary obstacle to eradicating HIV-1 from patients, and multiple strategies

113 ost effective antibodies for controlling and eradicating HIV-1 infection would likely have the dual c

114 scent infection highlights the challenges in eradicating HIV.

115 ese challenges and structure a framework for eradicating HIV/AIDS using gene therapy.

116 ens to overcome resistance to treatments and eradicate HNSCC metastasis.

117 aemopoietic stem-cell transplantation (HSCT) eradicates host haemopoiesis before venous infusion of h

118 In addition, atovaquone eradicates hypoxia in FaDu, HCT116 and H1299 spheroids.

119 How such tumour-eradicating immunity is initiated remains unknown, altho

120 e of cattle that is difficult to control and eradicate in part due to the costly nature of surveillan

121 Smallpox was declared eradicated in 1980 after an intensive vaccination progra

122 was the first animal disease to be globally eradicated in 2011 and is only the second disease, after

123 ough rheumatic heart disease has been nearly eradicated in high-income countries, 3 in 4 children gro

124 Although rinderpest virus (RPV) has been eradicated in the wild, efforts are still continuing to

125 lymphocytes are effector CD8(+) T cells that eradicate infected and malignant cells.

126 R5, selectively entered B cell follicles and eradicated infected TFH cells and B cells.

127 onding resident macrophages phagocytosed and eradicated infecting mycobacteria, suggesting that to es

128 nduced cell-mediated immune responses rarely eradicate infection.

129 ng granulomas develop rapidly and eventually eradicate infection.

130 This consistently improves the success of eradicating infections, uses less antibiotic than tradit

131 Tracking and eradicating infiltrating GBM cells and tumor microsatell

132 should be further explored for preventing or eradicating inhibitors to therapeutically administered F

133 pre-existing Allee effects and consequently eradicate insect pests.

134 currently there is no successful therapy to eradicate integrated proviruses.

135 n vivo by cobalt protoporphyrin-IX treatment eradicated intestinal inflammation and fully protected K

136 A bacteremia, could not penetrate the KCs to eradicate intracellular MRSA.

137 Additionally, auranofin is capable of eradicating intracellular MRSA present inside infected m

138 CD8+ T cells play a central role in eradicating intracellular pathogens, but also are import

139 molecule HSP90 inhibitor (Gamitrinib), which eradicated intrinsically resistant cells and augmented t

140 system cells that play an essential role in eradicating invading pathogens.

141 lly rat-free islands, community structure on eradicated islands was more similar to that of rat-infes

142 transform the malaria community's ability to eradicate it globally.

143 formation of a biofilm and the difficulty to eradicate it.

144 engineered to enable rapid purification, to eradicate its binding to albumin, and to enable rapid bl

145 Eradicating JD is a difficult task due to the long incub

146 al immunocytokine in murine tumor models can eradicate large tumors and metastases, eliciting an in s

147 oral delivery of HMGN1 and R848 plus Cytoxan eradicated large established CT26 tumors.

148 led both cancer cells and tumor vasculature, eradicating large established tumors and metastases, and

149 Strategies to eradicate latent infection can only be evaluated with ro

150 trategies currently under development aim to eradicate latent provirus, or prevent viral replication,

151 Eradicating latent virus has become an important but elu

152 V replication in most individuals but cannot eradicate latently infected cells established before ART

153 ty may be especially important to efforts to eradicate latently infected cells.

154 olutionized disease management, but fails to eradicate leukaemic stem cells (LSCs), which maintain CM

155 a cells, and is thus a potential approach to eradicate leukemia stem and progenitor cells that are re

156 relapse, and they also complicate efforts to eradicate leukemia through therapeutic targeting of LSCs

157 erentiation in some ATRA-resistant cells and eradicate leukemia-initiating cells in vivo.

158 Short TSLPR CAR T cells also eradicated leukemia in 4 xenograft models of human CRLF2

159 e inhibitor Sorafenib (SFB) usually fails to eradicate liver cancer.

160 ors may be potential therapeutic targets for eradicating liver CSCs.

161 Resistance, or actions of the host to eradicate living microbes, in the lungs involves a combi

162 pliment tyrosine kinase inhibitors (TKIs) to eradicate LSC in chronic phase (CP) chronic myeloid leuk

163 nd implies that approaches to treatment must eradicate LSCs for cure.

164 s) can effectively redirect T lymphocytes to eradicate lymphoid malignancies of B-cell origin.

165 Donor T-cell immune responses can eradicate lymphomas after allogeneic hematopoietic stem

166 To eradicate malaria new technologies are needed, not least

167 ence is an integral component of the goal to eradicate malaria.

168 ey intervention target of ongoing efforts to eradicate malaria.

169 oo long plagued humanity and the prospect of eradicating malaria is an optimistic, but reachable, tar

170 DLIs frequently are not effective at eradicating malignancy and often cause graft-versus-host

171 responses, STING agonists can also directly eradicate malignant B cells.

172 tem cells (CSCs) is necessary to permanently eradicate malignant tissues.

173 agonist in vitro enhanced their capacity to eradicate melanoma and induce autoimmune vitiligo when i

174 ng chemical and physical contaminants and on eradicating microbes; however, there is a growing awaren

175 ed to achieve radiation doses high enough to eradicate microscopic tumors.

176 d shown that such treatments are unlikely to eradicate microtumors.

177 However, single-agent venetoclcax fails to eradicate minimal residual disease in most patients.

178 two treatments for synergistic effects could eradicate more tumor cells and increase the overall surv

179 yeloid leukemia, we showed that leukemia was eradicated more effectively in DGKzeta-deficient (DGKzet

180 nterventions with the long-term potential to eradicate most cancers attributable to HPV infection.

181 raxane further potentiates immunotherapy and eradicates most MC38 tumors.

182 dies will focus on individualized therapy to eradicate MRD and result in further improvements in surv

183 gical inhibition of c-FOS, DUSP1 and BCR-ABL eradicated MRD in multiple in vivo models, as well as in

184 s, vancomycin and daptomycin, were unable to eradicate MRSA biofilms or non-biofilm persisters alongs

185 of Decolonization vs Universal Clearance to Eradicate MRSA]) showed that body surface decolonisation

186 tranasal antiseptic ointment is effective in eradicating MRSA in the nose and on the skin of patients

187 use in this population has almost completely eradicated new cases of this debilitating condition.

188 bunit expression and proteolytic activity to eradicate nuclear FOXO4 proteins from RAS-mutant cancer

189 s been directed to identifying strategies to eradicate or control HIV infection without a requirement

190 ntervention in low income countries that can eradicate or control human immunodeficiency virus (HIV)

191 to bear on the development of strategies to eradicate or develop a functional cure for HIV.

192 failure of HBV treatment is the inability to eradicate or inactivate the viral covalently closed circ

193 Despite global efforts to eradicate orthomyxoviral pathogens, these infections rem

194 D28-transduced leukemia-specific CD8 T cells eradicated otherwise lethal disease more efficiently tha

195 terial biofilms are notoriously difficult to eradicate owing to a number of tolerance mechanisms incl

196 target such processes are likely required to eradicate P vivax and achieve malaria elimination.

197 understand therapies that noncytopathically eradicate pathogens from the CNS.

198 appropriate immune responses to control and eradicate pathogens.

199 ergize with anti-androgen or chemotherapy in eradicating PC.

200 MAbs and ITs to kill HIV-infected cells and eradicate persistent reservoirs of HIV infection.

201 -approved anti-cancer drug mitomycin C (MMC) eradicates persister cells through a growth-independent

202 cell membrane function have the potential to eradicate "persister" organisms and delay the emergence

203 WR12 and D-IK8 were able to eradicate persisters, MRSA in stationary growth phase, a

204 y provide a novel translational strategy for eradicating persisting intracellular reservoirs of staph

205 Primaquine is the only licensed drug for eradicating Plasmodium vivax hypnozoites and, therefore,

206 F-managed SMNet was created as a strategy to eradicate polio by engaging >7000 frontline social mobil

207 Its unwavering commitment to eradicate polio has been vital to the success of the pro

208 the 1988 World Health Assembly resolution to eradicate polio, the government of Nigeria, with support

209 e 1988 World Health Assembly's resolution to eradicate polio.

210 ant implications in the global initiative to eradicate polio: high quality surveillance permitted ear

211 Pakistan faces huge challenges in eradicating polio due to widespread poliovirus transmiss

212 ld Health Assembly (WHA) resolved in 1988 to eradicate poliovirus, several rounds of immunization cam

213 Strikingly, RBFox2 inactivation eradicates PRC2 targeting on the majority of bivalent ge

214 The molecule is also shown to eradicate preformed bacterial biofilm in vivo in a murin

215 ously, migrated to tumor sites, and robustly eradicated primary tumors.

216 light this receptor as a potential target to eradicate primitive LSCs in AML.

217 minal splice variant of PTEN, were unable to eradicate Pseudomonas aeruginosa from the airways and co

218 ch CMR results from the inability of TKIs to eradicate quiescent CML leukaemia stem cells (LSCs).

219 e development of interventions to reduce and eradicate racial disparities in health care provision.

220 A key to reduce and eradicate racial disparities in hypertension outcomes is

221 the sick individuals above which disease is eradicated rapidly.

222 (RT) in breast cancer (BC) is often used to eradicate remaining tumor cells following surgery with t

223 cells (pre-LSCs) may be a viable strategy to eradicate residual disease and prevent leukemia relapse.

224 tro studies and was also highly effective in eradicating S. aureus biofilm infection when used in a C

225 n essential mechanism used by macrophages to eradicate Salmonella is production of reactive oxygen sp

226 of fibronectin (F8-TNF), can be exploited to eradicate sarcomas in immunocompetent mice.

227 to the primary shearing flow, we can largely eradicate shear thickening.

228 2 poliovirus the first human pathogen to be eradicated since smallpox.

229 VACV), which constitutes the vaccine used to eradicate smallpox and is a candidate vector for other i

230 First-generation vaccines used to eradicate smallpox had rates of adverse effects that are

231 Th2 ACT efficiently eradicated subcutaneous myeloma in an antigen-specific f

232 udy; indeed, the promise of the potential to eradicate such cells is clear.

233 Not only have we not eradicated syphilis, rates of infection have increased i

234 d the specific targeting guide RNAs in HIV-1-eradicated T-cells protected them against new infection

235 and selection against these variants should eradicate TH.

236 val-extinction [R-E] training) can attenuate/eradicate the ability of cues to elicit learned behavior

237 gainst Mycobacterium tuberculosis (Mtb) must eradicate the bacterium within the context of its host c

238 also be a crucial tool in ongoing efforts to eradicate the beetle from regions of the world that it h

239 e behavior by the healthy individuals cannot eradicate the disease without the preemptive measures of

240 ell death as monotherapy and are unlikely to eradicate the disease.

241 significant challenge that limits efforts to eradicate the disease.

242 ght alleviate disease symptoms but would not eradicate the disease.

243 traconazole have been used but are unable to eradicate the fungus, need to be given for long periods,

244 Antiretroviral therapy alone cannot eradicate the HIV reservoir, and viral rebound is genera

245 suppress viral replication but are unable to eradicate the infection.

246 and blocking the immune system's attempts to eradicate the infection.

247 the suppression of HIV but cannot target and eradicate the latent proviral reservoir.

248 preclinical approaches that show promise to eradicate the LSC, and future challenges on the path to

249 ively target KSHV infection are necessary to eradicate the malignancy while sparing healthy cells.

250 ting cells, whether it is necessary to fully eradicate the malignant clone to achieve cure, and how t

251 ating that suppressing RUNX activity may not eradicate the most immature LSCs.

252 n is the inability of existing treatments to eradicate the multiple HIV reservoirs in the human body,

253 y nondifferentiating mutants that ultimately eradicate the soma-producing lineage.

254 ious cellular defense mechanisms designed to eradicate the viral infection.

255 Thus, therapeutic strategies to eradicate the viral latent reservoir are critically need

256 ovides a promising strategy to reduce if not eradicate the viral reservoir.

257 virus (HIV) infection but cannot completely eradicate the virus.

258 onceptual size, both LOC and ATL stimulation eradicated the otherwise robust effect.

259 ontal lineTap at the position of d-Phe1-Pro2 eradicates the biological activity (GS mimetic 16).

260 s the group to maintain one large huddle but eradicates the phase transition, whereas inclusion of an

261 Conditional ablation of Bmp4 eradicates the phenotype produced in Ctnnb1(cKO) mice.

262 ws significant antitumor efficacy and nearly eradicates the tumor, substantiating the importance of t

263 ovement programmes aiming at controlling and eradicating the disease.

264 stention from vaccine use-were successful in eradicating the HP H5Nx viruses from poultry, these acti

265 ition mediated by a PD-L1 antibody, not only eradicating the primary 4T1 breast tumor but also signif

266 We show that controlling or eradicating the relevant invasive mammals could prevent

267 Eradicating the remaining 1% proved to be more challengi

268 Numerous approaches aimed at eradicating the virus, as well as maintaining its prolon

269 ver, because wild-type 2 poliovirus has been eradicated, the World Health Organization's (WHO's) Stra

270 However, no subject eradicated their infecting P. aeruginosa strain, and aft

271 Current efforts to eradicate these tumors focus predominantly on targeting

272 If gene drives successfully eradicated these invasive populations, many would rejoic

273 d provide a target for therapeutics aimed at eradicating these cells.

274 developing new antiviral strategies aimed at eradicating these chronic infections.

275 gest that targeting gluconeogenesis may help eradicate this deadly feature in advanced breast cancer

276 indings provide novel paths for studying and eradicating this dormant stage.

277 k of the AR-positive cells within the tumor, eradicating this population eventually leads to castrati

278 g multiple myeloma growth and simultaneously eradicating thrombus complication.

279 ts should inform the design of strategies to eradicate tumor cell communities.

280 oxicity of mTORC1 inhibitors as a therapy to eradicate tumor cells marked by high mTORC1 signaling, b

281 It is a challenge to eradicate tumor cells while sparing normal cells.

282 Although chemotherapy is designed to eradicate tumor cells, it also has significant effects o

283 lesions at the end of therapy may constitute eradicated tumor/scar tissue.

284 ls can migrate from biopolymer scaffolds and eradicate tumors more effectively than does systemic del

285 is to re-ignite T-cell immunity, in order to eradicate tumors.

286 these tumor-initiating cells is necessary to eradicate tumors.

287 o-treatment with 10mg/kg doxorubicin rapidly eradicated tumors in athymic nude mice bearing KB or MIA

288 g receptors has shown tremendous promise for eradicating tumors in clinical trials.

289 irus E7 peptide vaccine (CyaA-E7) capable of eradicating tumors in the TC-1 mouse model of cervical c

290 -tumour immune responses and synergistically eradicates tumour.

291 eing made to develop new strategies that can eradicate tumours selectively without detrimental effect

292 rapy potently reverses immunosuppression and eradicates tumours via an intricate interplay between IF

293 with the antibiotic ciprofloxacin completely eradicates UPEC from the urinary tract and prevents the

294 In 2015, the Coalition to Eradicate Viral Hepatitis in Asia Pacific gathered leadi

295 etroviral therapy was proposed as a means to eradicate viral reservoirs.

296 can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs.

297 Failure of the immune system to eradicate viruses results in chronic viral infections, w

298 rates in obese versus lean individuals were eradicated when normalised to whole-body fat mass (P = 0

299 To eradicate yaws by 2020, WHO has launched a campaign of m

300 World Health Organization (WHO) strategy to eradicate yaws.