1 s an anchor to mediate NOTCH function on the ERBB-2 gene.

2  important regulator of transcription of the erbB-2 gene.

3 -regulating the expression of the endogenous ERBB-2 gene.

4 long a 1.4 kb promoter fragment of the human ErbB-2 gene.

5  8q24 and 17q12 encompassing the c-myc and c-erbB-2 genes and apparent homozygous deletions in 3p21,

6 ns in the transmembrane domain of the Neu (c-ErbB-2) gene are the driver mutations in ENU-induced mal

7 om other tumor-promoting genes in that the c-erbB-2 gene can enhance the intrinsic metastatic potenti

8                      Overexpression of the c-erbB-2 gene-encoded p185 has been reported in approximat

9                                Regulation of erbB-2 gene expression was observed in cells derived fro

10 cancer cells, we have introduced the human c-erbB-2 gene into the very low p185-expressing MDA-MB-435

11              Control of transcription of the erbB-2 gene is an important determinant of receptor expr

12    Southern blot analysis indicates that the erbB-2 gene is not amplified in these cells.

13 present within the 5' untranslated region of erbB-2 gene on human chromosome 17.

14                                        The c-erbB-2 gene overexpression plays a major role in the pat

15                                          The ErbB-2 gene product is a transmembrane glycoprotein belo

16                             Within the human ERBB-2 gene promoter, a 100-base pair region 5' to the T

17 ion (MAR) in the immediate vicinity of the c-erbB-2 gene promoter.

18  of this strategy in gene control, the human erbB-2 gene was chosen as a model.

19    Transgenic mice bearing the rat wild-type erbB-2 gene were used to study the effects of short-term