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1  placebo (n=286), erenumab 70 mg (n=191), or erenumab 140 mg (n=190).
2  to subcutaneous placebo, erenumab 70 mg, or erenumab 140 mg, given every 4 weeks for 12 weeks.
3 andomly assigned to receive placebo (n=286), erenumab 70 mg (n=191), or erenumab 140 mg (n=190).
4                                              Erenumab 70 mg and 140 mg reduced monthly migraine days
5 RETATION: In patients with chronic migraine, erenumab 70 mg and 140 mg reduced the number of monthly
6 ly assigned (3:2:2) to subcutaneous placebo, erenumab 70 mg, or erenumab 140 mg, given every 4 weeks
7       We assessed the efficacy and safety of erenumab, a fully human monoclonal antibody against the
8                                    We tested erenumab, a fully human monoclonal antibody that inhibit
9                                              Erenumab administered subcutaneously at a monthly dose o
10 rates of adverse events were similar between erenumab and placebo.
11  understand long-term efficacy and safety of erenumab, and the applicability of this study to real-wo
12 cal laboratory values, vital signs, and anti-erenumab antibodies.
13 o receive a subcutaneous injection of either erenumab, at a dose of 70 mg or 140 mg, or placebo month
14 group and three in the 140 mg group had anti-erenumab binding antibodies; none had anti-erenumab neut
15  similar to placebo, providing evidence that erenumab could be a potential therapy for migraine preve
16 nd, placebo-controlled, multicentre study of erenumab for adults aged 18-65 years with chronic migrai
17  achieved for 43.3% of patients in the 70-mg erenumab group and 50.0% of patients in the 140-mg erenu
18 ication was reduced by 1.1 days in the 70-mg erenumab group and by 1.6 days in the 140-mg erenumab gr
19 mber of days was reduced by 3.2 in the 70-mg erenumab group and by 3.7 in the 140-mg erenumab group,
20 andomization: 317 were assigned to the 70-mg erenumab group, 319 to the 140-mg erenumab group, and 31
21  the 70-mg erenumab group, 319 to the 140-mg erenumab group, and 319 to the placebo group.
22 erenumab group and by 1.6 days in the 140-mg erenumab group, as compared with 0.2 days in the placebo
23 0-mg erenumab group and by 3.7 in the 140-mg erenumab group, as compared with 1.8 days in the placebo
24 ab group and 50.0% of patients in the 140-mg erenumab group, as compared with 26.6% in the placebo gr
25 y 4.2 and 4.8 points in the 70-mg and 140-mg erenumab groups, respectively, as compared with 2.4 poin
26 y 5.5 and 5.9 points in the 70-mg and 140-mg erenumab groups, respectively, as compared with 3.3 poin
27 i-erenumab binding antibodies; none had anti-erenumab neutralising antibodies.
28 -term safety and durability of the effect of erenumab require further study.

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