ライフサイエンスコーパス: ergosterol

1 nding interaction between amphotericin B and ergosterol.

2 cloheximide and resulted in new synthesis of ergosterol.

3 Here, we demonstrate that Sre1-Scp1 senses ergosterol.

4 en these states is cooperatively mediated by ergosterol.

5 ogenesis of phospholipids, sphingolipids, or ergosterol.

6 n the biosynthesis of fungal membrane sterol ergosterol.

7 lated sterols or a decrease in the amount of ergosterol.

8 t both scavenges cholesterol and synthesizes ergosterol.

9 btain a strain that accumulated biosynthetic ergosterol.

10 ugh classified as a fungus, P. carinii lacks ergosterol.

11 a hem 1Delta strain grown in the presence of ergosterol.

12 ) as the principal sterol, with no traces of ergosterol.

13 ltrasound-assisted extraction conditions for ergosterol.

14 inhibiting the production of fumonisins and ergosterol.

15 aflatoxins (B1, B2, G1 and G2), patulin, and ergosterol.

16 HMG-CoA reductase protein and total cellular ergosterol.

17 hosphatidylcholine (DMPC), cholesterol/DMPC, ergosterol/1-palmitoyl-2-oleoyl-L-alpha-phosphatidylchol

18 Soxhlet extraction, yielding 671.5 +/- 0.5mg ergosterol/100 g dw.

19 ntaining the "promoter" sterols cholesterol, ergosterol, 25-hydroxycholesterol, epicholesterol, or di

20 In a mixture [POPC/POPE/POPS/PI/ergosterol (30:20:5:20:25)] which mimicked the lipid com

21 Ergosterol (5,7,22-ergostatrien-3beta-ol) and ergosteryl

22 horus marzuolus presented high quantities of ergosterol (6.4-6.8 mg/g, dry matter) followed by Pleuro

23 A mammalian analog of ergosterol, 7-dehydrocholesterol (7-DHC), accumulates in

24 -bonded ergosterol precursors and only 4% of ergosterol (74% ergosterol in wild-type cells), exhibite

25 pt found in the host strain, and synthesized ergosterol, a Delta(5,6) sterol.The Darlington strain wa

26 Surprisingly ergosterol, a fungal sterol, and 7-dehydrocholesterol, a

27 AmB primarily kills yeast by simply binding ergosterol, a lipid that is vital for many aspects of ye

28 Ergosterol, a molecule with high commercial value, is th

29 sterol concentrations), production (based on ergosterol accrual in ingrowth cores), and turnover rate

30 s (cholesterol, cholestanol, brassicasterol, ergosterol), allochthonous (stigmasterol, beta-sitostero

31 ornucopioides, contained significantly lower ergosterol amounts (0.2-0.4 mg/g).

32 2AR, as shown with control experiments using ergosterol and a control membrane protein (KpOmpA).

33 es its occupancy time on many of the induced ergosterol and anaerobic gene promoters, increases its a

34 DPPC vesicles; approximately 7 vol% more for ergosterol and approximately 10 vol% more for cholestero

35 enrichment in gene families associated with ergosterol and cell wall biosynthesis, cell growth, iron

36 These data support the idea that ergosterol and cholesterol do enhance survivability for

37 rdering and in the distributions of the drug-ergosterol and drug-cholesterol complexes within the mem

38 major sterol of Acanthamoeba castellanii is ergosterol and identify novel putative precursors and in

39 studied by quantification of their marker - ergosterol and important mycotoxins (aflatoxins B1, B2,

40 ane density (K(a) approximately 750 for DPPC/ergosterol and K(a) approximately 1100 mN/m for DPPC/cho

41 . bellinii mycelia showed higher contents of ergosterol and phenolic compounds (also higher in its fr

42 resistance to methotrexate and antimony, for ergosterol and phospholipid metabolism genes in resistan

43 However, ergosterol and Prm1 have independent functions and only

44 ich is a vital enzyme in the biosynthesis of ergosterol and related 24-alkyl sterols.

45 Ergosterol and sphingolipid biosynthetic pathways had bl

46 Isolation of ergosterol and sphingolipid-enriched Chlamydomonas flage

47 ly synthesized lanosterol can substitute for ergosterol and support growth.

48 ons of REO, the effects on the production of ergosterol and the biomass of mycelium varied, as did th

49 technique allowed a rapid separation of free ergosterol and two ergosteryl derivatives occurring in m

50 rts the hypothesis that yeast cells increase ergosterol and unsaturated lipid content to prevent inte

51 Surprisingly, C2'deOAmB binds ergosterol and, within the limits of detection of this e

52 over a wide range of sterol (cholesterol and ergosterol) and ethanol concentrations.

53 cillium and Aspergillus spp., beta-D-glucan, ergosterol, and bacterial or fungal quantitative polymer

54 holesterol, lathosterol, dihydrocholesterol, ergosterol, and desmosterol), and six do not (25-hydroxy

55 ed one of the sterol molecules: cholesterol, ergosterol, and lanosterol.

56 hosphatidylethanolamine, diacylglycerol, and ergosterol) are essential.

57 ne cholesterol may have been used to replace ergosterol, as has been reported in vitro.

58 fects of ergosterol on ERG3 are specific for ergosterol, as several ergosterol derivatives failed to

59 he key pathway metabolites MEV, squalene and ergosterol, as well as the farnesyl pyrophosphate (FPP)-

60 A new ergosterol auxotroph unable to grow on 3-ketosterols wit

61 An ergosterol auxotroph unable to synthesize sterol or grow

62 An ergosterol auxotroph, erg25, which fails to demethylate

63 the nonvesicular transfer of cholesterol and ergosterol between membranes in vitro.

64 EMM C was determined by the analysis of ergosterol (biomass), chitin (total bio- and necromass)

65 orters (pmr1, pdr5, and vacuolar H+-ATPase), ergosterol biosynthesis (erg3, erg6, and erg24), intrace

66 uction of TD in parallel with a reduction of ergosterol biosynthesis and an unexpected increase in th

67 tion of GPI biosynthesis in C. albicans with ergosterol biosynthesis and hyphal morphogenesis.

68 w oxygen, Sre1p activates genes required for ergosterol biosynthesis and iron uptake.

69 catalyzes the first postcyclization step in ergosterol biosynthesis and is inhibited by triazole dru

70 itive regulators, highlighting key roles for ergosterol biosynthesis and N-linked glycosylation.

71 PI19, of GPI-GnT exhibit opposite effects on ergosterol biosynthesis and Ras signaling (which determi

72 GPI-GnT subunits independently interact with ergosterol biosynthesis and Ras signaling.

73 xposure primarily affected genes involved in ergosterol biosynthesis and sterol uptake; caspofungin e

74 agas disease, Trypanosoma cruzi, by blocking ergosterol biosynthesis at the level of inhibition of la

75 500 mug/mL, and 4000 and 5000 mug/mL reduced ergosterol biosynthesis by 57% and 100%, respectively.

76 nt strains or wild-type strains inhibited in ergosterol biosynthesis by antifungal agents.

77 in 80% or greater inhibition of overall mean ergosterol biosynthesis compared to that in the drug-fre

78 Phylogenetic trees inferred from an ergosterol biosynthesis gene (erg-3) were highly discord

79 cluding a coinduction of anaerobic genes and ergosterol biosynthesis genes, biosynthesis of basic ami

80 eroxide stress with concurrent repression of ergosterol biosynthesis in an SRX1-independent manner.

81 entified gene encoding an enzyme involved in ergosterol biosynthesis in Saccharomyces cerevisiae has

82 As a model system, we studied ergosterol biosynthesis in single living fission yeast c

83 uced expression of genes encoding enzymes of ergosterol biosynthesis in yeast (ERG genes).

84 fungal infections and functions by blocking ergosterol biosynthesis in yeast.

85 the clones were also highly resistant to the ergosterol biosynthesis inhibitor posaconazole, a drug p

86 growth in the presence of low levels of the ergosterol biosynthesis inhibitors, itraconazole and 25-

87 the presence of nonlethal concentrations of ergosterol biosynthesis inhibitors, Ustilago maydis alte

88 e typically treated with azole inhibitors of ergosterol biosynthesis often leading to drug resistance

89 these subunits indicates that GPI19 controls ergosterol biosynthesis through ERG11 levels, whereas GP

90 Inhibition of ergosterol biosynthesis was detected at a concentration

91 acid metabolism, adherence, drug resistance, ergosterol biosynthesis, and beta-glucan synthesis.

92 1 are required for both normoxic and hypoxic ergosterol biosynthesis, and therefore cells lacking SRE

93 expression in response to a block in de novo ergosterol biosynthesis, brought about by antifungal dru

94 n of ERG2, ERG6 and ERG9, genes required for ergosterol biosynthesis, during both aerobic and hypoxic

95 ly, high copies of a single gene involved in ergosterol biosynthesis, ERG25, rescued this growth defe

96 a broad-spectrum antifungal agent inhibiting ergosterol biosynthesis, exhibits synergy with the beta-

97 ions in any of ERG genes 3-6, lacking normal ergosterol biosynthesis, have fragmented vacuoles.

98 Saccharomyces cerevisiae ergosterol biosynthesis, like cholesterol biosynthesis i

99 tifungal drugs, due to its ability to modify ergosterol biosynthesis, mitochondrial function, or anti

100 conazole, an antimicrobial drug that targets ergosterol biosynthesis, only affected the lipogenesis i

101 These include ergosterol biosynthesis, phosphatidylinositol (4,5)-bisp

102 g the enzyme that catalyzes the last step of ergosterol biosynthesis, that impair both shmoo formatio

103 ylase (CYP51) genes, which are essential for ergosterol biosynthesis, to restrict fungal infection.

104 desaturase gene (ERG3), essential for yeast ergosterol biosynthesis, was cloned and sequenced from C

105 , and because fluconazole acts by inhibiting ergosterol biosynthesis, we developed a novel method to

106 nes revealed a specific biochemical pathway--ergosterol biosynthesis--where the expression of multipl

107 arbon 24 in the final step of cholesterol or ergosterol biosynthesis.

108 enzyme, Erg11p, a key regulatory protein in ergosterol biosynthesis.

109 enes, including three ERG genes required for ergosterol biosynthesis.

110 ads to defects in several enzymatic steps in ergosterol biosynthesis.

111 also of genes associated with virulence and ergosterol biosynthesis.

112 ignated ERG28, was strongly coregulated with ergosterol biosynthesis.

113 oding the C-22 sterol desaturase required in ergosterol biosynthesis.

114 2p and Ecm22p, bind to the promoters of most ergosterol biosynthetic (ERG) genes, including ERG2 and

115 two phospholipid methyltransferases, several ergosterol biosynthetic enzymes, and a group of bacteria

116 st that proper transcriptional regulation of ergosterol biosynthetic genes by Mot3 is important for n

117 s can be mediated by increased expression of ergosterol biosynthetic intermediates.

118 All but two genes involved in the ergosterol biosynthetic pathway in Saccharomyces cerevis

119 disruption, but instead by disruption of the ergosterol biosynthetic pathway via inhibition of the 14

120 important for the expression of genes in the ergosterol biosynthetic pathway, including the rate-limi

121 onstrated a heme-related function within the ergosterol biosynthetic pathway.

122 tion, and ERG6 is a methyltransferase in the ergosterol biosynthetic pathway.

123 am of the sites of TBF and ITZ action in the ergosterol biosynthetic pathway.

124 Here we demonstrate a link between TAFC and ergosterol biosynthetic pathways, which are both critica

125 complex that is tethered to the membrane by Ergosterol biosynthetic protein28 (ERG28).

126 ns in yeast and analyzed compounds that bind ergosterol biosynthetic proteins and protein kinases.

127 lase as treatment inhibits the production of ergosterol, but results in the accumulation of the lanos

128 1) at 1.5-1.9 A resolution in complexes with ergosterol, cholesterol, and 7-, 20- and 25-hydroxychole

129 drogenase-like)), an essential enzyme in the ergosterol/cholesterol biosynthesis pathway.

130 orm membrane pores due to aggregation of AmB-ergosterol complexes.

131 of membrane pores via the aggregation of AmB-ergosterol complexes.

132 ls a clear quantitative relationship between ergosterol concentration in the endoplasmic reticulum an

133 ncile an equilibration process with the high ergosterol concentration of the PM relative to ER, we no

134 s study, EFM standing biomass (based on soil ergosterol concentrations), production (based on ergoste

135 or mevalonate, iron starvation decreased the ergosterol content and composition, a phenotype that is

136 Furthermore, ergosterol content increases during filamentous growth.

137 ceptible isolates showed a mean reduction in ergosterol content of 72% after exposure to 1 microg of

138 resistant isolates showed mean reductions in ergosterol content of only 25, 38, 53, and 84% after exp

139 branes in spf1 cells become similar in their ergosterol content to mitochondrial membranes.

140 The ergosterol content varied considerably depending on the

141 No significant differences in mean ergosterol content were observed between any of the isol

142 n distribution in yeast strains with reduced ergosterol content, they phenocopied the loss of Spf1.

143 ntration of AmB also had the lowest membrane ergosterol content.

144 ignificantly correlated with the patulin and ergosterol contents in mouldy and hidden mould hazelnuts

145 significant correlation between patulin and ergosterol contents of mouldy and hidden mould hazelnuts

146 e that, upon introduction of cholesterol and ergosterol, contrary to previous belief the mechanical s

147 It is proposed that ergosterol-dependent inhibition of membrane proteins is

148 If a mating pair forms between ergosterol-depleted cells despite the attenuated pheromo

149 esults have led to a model in which heme and ergosterol depletion alters membrane fluidity, thereby a

150 Ergosterol depletion independently inhibits two aspects

151 ERG3 are specific for ergosterol, as several ergosterol derivatives failed to elicit the same control

152 A series of stigmasterol and ergosterol derivatives, characterized by the presence of

153 In this study, the ergosterol-derived photoproducts previtamin D(2), lumist

154 We now find that the "regulatory lipids" ergosterol, diacylglycerol and 3- and 4-phosphoinositide

155 homotypic fusion requires regulatory lipids (ergosterol, diacylglycerol, and phosphoinositides), the

156 oefficient for partitioning of nystatin into ergosterol/dimyristoyl-L-alpha-phosphatidylcholine (DMPC

157 he lifetime of a phospholipid molecule in an ergosterol-dipalmitoylphosphatidylcholine complex is est

158 In ergosterol/DMPC bilayers, for example, there is a >3-fol

159 .2, 0.222, and 0.25 sterol mole fractions in ergosterol/DMPC mixtures.

160 ng in the purification and identification of ergosterol endoperoxide, a B-ring oxysterol.

161 orded the compounds alpha-linolenic acid and ergosterol endoperoxide, which were active against Crypt

162 Ergosterol (ERG) had a weak antagonistic effect.

163 ), phosphatidic acid (PA), cardiolipin (CL), ergosterol (ERG), diacylglycerol (DAG), and phosphatidyl

164 channels in membranes containing the sterol, ergosterol (erg).

165 (1.4-fold), free fatty acids (1.7-fold), and ergosterol ester (1.8-fold), and a decrease in diacylgly

166 results demonstrate for the first time that ergosterol exerts a regulatory effect on gene transcript

167 lower eukaryotes including fungi (containing ergosterol) exhibit an intermediate degree of sensitivit

168 It required ergosterol for growth and produced E,E-farnesol.

169 The need for ergosterol for vacuole priming underscores the role of l

170 ways in transporting the major yeast sterol, ergosterol, from its site of synthesis to the PM.

171 thyl groups leading to cholesterol (animal), ergosterol (fungal), and stigmasterol (plant) biosynthes

172 ls on fusion rates, we utilized the nystatin/ergosterol fusion assay to measure fusion of liposomes t

173 d into planar lipid bilayers by the nystatin/ergosterol fusion technique.

174 ith n-hexane extracts with higher purity (mg ergosterol/g extract) were obtained.

175 robic AR1b elements act in trans to regulate ergosterol gene expression.

176 unique within the Fungi, such as the lack of ergosterol, genetic complexity of surface antigens, and

177 osure, that is, sum of indicators for fungi (ergosterol), Gram-positive (muramic acid) bacteria, and

178 Ergosterol has been shown to be required for endocytosis

179 Oxygen-requiring biosynthetic pathways for ergosterol, heme, sphingolipid, and ubiquinone were prim

180 ette aspiration suggest that cholesterol and ergosterol impact the order and microstructure of the ge

181 t approximately 40 mol% both cholesterol and ergosterol impart similar condensation to the membrane (

182 efects and the accumulation of intracellular ergosterol in drs2 mutants.

183 pecific enzymatic steps in the production of ergosterol in fungi or phytosterols in plants.

184 ey enzyme intermediating the biosynthesis of ergosterol in fungi, and the target of azole fungicides.

185 e generation of non-vitamin D(2) products of ergosterol in mushrooms has not been reported.

186 The production of vitamin D(2) from ergosterol in mushrooms upon exposure to ultraviolet (UV

187 contained sphingomyelin in place of DPPC, or ergosterol in place of cholesterol, it appeared that thi

188 ycerides, diglycerides, free fatty acids and ergosterol in salmon oil.

189 pid (DPPC), an unsaturated lipid (DOPC), and ergosterol in the presence of high ethanol (20 vol %).

190 tion of cholesterol and, to a lesser extent, ergosterol in vitro, but restores ergosteryl oleate form

191 ol precursors and only 4% of ergosterol (74% ergosterol in wild-type cells), exhibited the first phas

192 il and verapamil inhibited the production of ergosterol in wild-type Saccharomyces cerevisiae and in

193 lls and also for inhibition of biosynthesis: ergosterol in yeasts and cholesterol in human cells.

194 ylcholine (DPPC) and sterols (cholesterol or ergosterol) in water and water/ethanol solutions have be

195 The stability of ergosterol, in terms of the formation of ergosterol pero

196 also applied to biosynthetically 13C-labeled ergosterol incorporated into phosphatidylcholine bilayer

197 Furthermore, the presence of cholesterol and ergosterol increases acyl chain order in the liquid crys

198 Binding ergosterol, independent of channel formation, is the pri

199 brane requirements, a small concentration of ergosterol is absolutely necessary for growth.

200 We find that although sphingolipid-free ergosterol is concentrated at sites of cell-cell contact

201 e to ER, we note that a large fraction of PM ergosterol is found condensed with sphingolipids in memb

202 is optimally required during aerobiosis when ergosterol is plentiful.

203 nding interaction between amphotericin B and ergosterol is required for both forming ion channels and

204 a two-atom change in the aliphatic moiety of ergosterol is sufficient to obstruct cell shape remodeli

205 Ergosterol is thought to form microdomains within the me

206 heme is still required for the synthesis of ergosterol, its precursor, lanosterol, is instead incorp

207 ), 25-epiminolanosterol (Ki value of 49 nm), ergosterol (Ki value of 27 microm) and 26,27-dehydrozymo

208 ome resistant to BFA, indicating that proper ergosterol levels are needed for antifungal drug resista

209 Higher ergosterol levels in combination with the proteins Fhn1,

210 f Hhp2 increases Sre1N protein stability and ergosterol levels in the presence of oxygen.

211 Sterol analyses showed that ergosterol levels were significantly decreased (P < 0.00

212 The ergosterol ligands filipin, nystatin and amphotericin B

213 synthetic similarities, we hypothesized that ergosterol, like heme, may have a regulatory function.

214 fic interaction with the main fungal sterol, ergosterol, often resulting in membrane permeabilization

215 The observed regulatory effects of ergosterol on ERG3 are specific for ergosterol, as sever

216 Ergosterol or cholesterol delivery to wild-type vacuoles

217 d clinically for deep mycosis act by binding ergosterol or disrupting its biosynthesis.

218 ith model membranes containing stigmasterol, ergosterol, or lanosterol.

219 free energy profiles for the dimerization in ergosterol- or cholesterol-containing and sterol-free me

220 ) and the radiation time (10 min), the lower ergosterol oxidation was observed.

221 Supplementation with ergosterol partially suppressed the shmooing defect but

222 In signaling, ergosterol participates in the recruitment of Ste5 to a

223 (ERG6) of the 13 subsequent reactions of the ergosterol pathway are inactive.

224 ncreases and decreases in the level of these ergosterol pathway intermediates induce Sre1 proteolysis

225 ich bears genes expressing the enzyme in the ergosterol pathway targeted by azole drugs, efflux pumps

226 ted not by iron but by an end product of the ergosterol pathway.

227 e also demonstrate that the oxidized sterol, ergosterol peroxide, is necessary and sufficient for Vms

228 of ergosterol, in terms of the formation of ergosterol peroxide, was evaluated under different stora

229 t vacuole fusion requires regulatory lipids (ergosterol, phosphoinositides, and diacylglycerol), the

230 t(1/2) approximately 10-15 min) of ER and PM ergosterol pools via a bidirectional, nonvesicular proce

231 eoyl-L-alpha-phosphatidylcholine (POPC), and ergosterol/POPC/1-palmitoyl-2-oleoyl-L-alpha-phosphatidy

232 aining 94% of aberrant delta-8 double-bonded ergosterol precursors and only 4% of ergosterol (74% erg

233 study, we show that the accumulation of only ergosterol precursors with a conjugated double bond in t

234 Accumulation of only ergosterol precursors with a conjugated double bond in t

235 er is upregulated in strains that accumulate ergosterol precursors.

236 te (7-DHC and desmosterol) and evolutionary (ergosterol) precursors of cholesterol on membrane dipole

237 her found that not only cholesterol but also ergosterol present in protozoa was palmitoylated by PlaC

238 ly complemented the erg6 mutation, restoring ergosterol production and conferring resistance to cyclo

239 uconazole-resistant isolates by quantitating ergosterol production in cells grown in 0, 1, 4, 16, or

240 The effects of GEO on fumonisin and ergosterol production were evaluated at concentrations o

241 ,7 sterol isomerase activity (i.e. wild-type ergosterol production) by enhanced resistance to the ant

242 Like mutants that affect ergosterol production, the viable combinations of OSH de

243 Thus, the sphingolipid-free pool of ergosterol promotes plasma membrane fusion.

244 ows that increasing unsaturated lipid and/or ergosterol protects the membrane by preventing the forma

245 cyclolaudenol, 24(28)-methylenecycloartanol, ergosterol, protothecasterol, 4alpha-methylergostanol, 4

246 Leishmania synthesize ergosterol rather than cholesterol, making this pathway

247 Ten SDD isolates showed mean ergosterol reductions of 38, 57, 73, and 99% after expos

248 final synthetic step of the membrane sterol ergosterol, renders yeast sensitive to anthracyclines an

249 The absence of ergosterol resulted in a 35-fold increase in the express

250 hat perturbs synthesis of the membrane lipid ergosterol results in potent, synergistic fungicidal act

251 The opposite results were observed with ergosterol-rich procyclic cells.

252 edure by applying it to identify a model for ergosterol sensing by the proteins Sre1 and Scp1 in fiss

253 Interestingly, when grown in the presence of ergosterol set1Delta cells become resistant to BFA, indi

254 e or zero amounts of aflatoxins, patulin and ergosterol, so they posed no risk for the consumer when

255 endocytosis) and endogenous (biosynthesis of ergosterol) sources.

256 Treatment with ergosterol-specific amphotericin B does not.

257 This is attributable to ergosterol-specific and reversible inhibition of membran

258 ing protein homologue Kes1/Osh4 and regulate ergosterol subcellular distribution.

259 gly, when erg27 was grown on cholesterol- or ergosterol-supplemented media, the endogenous compounds

260 qualene epoxidase) strain also was viable in ergosterol-supplemented media.

261 y both CoCl2 and low oxygen were involved in ergosterol synthesis and in iron/copper transport.

262 to stabilize Erg11p, which in turn regulates ergosterol synthesis and MMS resistance.

263 terol, a sterol found in the cholesterol and ergosterol synthesis pathways, do not exhibit coexisting

264 ein Erg11/Cyp51 catalyzes a critical step in ergosterol synthesis, and the azole class of antifungal

265 and virulence, including those in late stage ergosterol synthesis, or early steps in fatty acid or ri

266 responsible for the final reduction step in ergosterol synthesis.

267 es apoptosis-like changes and alterations in ergosterol synthesis.

268 from B311 but not from Dar-1 showed restored ergosterol synthesis.

269 ed genes were in the pathways of protein and ergosterol synthesis.

270 constructed a phase diagram of the DPPC/DOPC/ergosterol system at 20 vol % ethanol.

271 Screening for resistance to the ergosterol-targeting fungicide amphotericin B (AmB) reve

272 ificantly less favorable in the bilayer with ergosterol than in the cholesterol-containing or sterol-

273 ecifically with membrane sterols, especially ergosterol (the major sterol in fungal cells).

274 ol for all YLR228c and UPC2 combinations was ergosterol, the consensus yeast sterol.

275 s the role of the ARE2 enzyme is to esterify ergosterol, the end product of the pathway.

276 enes encoding biosynthetic enzymes that make ergosterol, the major fungal membrane sterol, are regula

277 Ergosterol, the predominant sterol of fungi, is postulat

278 T protein, but low in vivo esterification of ergosterol, the predominant yeast sterol.

279 rs to be required for the regulatory role of ergosterol; therefore, development of inhibitors of the

280 cells allows sterols such as cholesterol and ergosterol to be actively taken up under aerobic conditi

281 iculum (ER) and redistribution of endogenous ergosterol to intracellular membranes, phenotypes that a

282 contact sites depends on a balanced ratio of ergosterol to sphingolipids.

283 to show that transport of newly synthesized ergosterol to the PM is unaltered in cells defective in

284 ion of DAN1 and PDR11, two genes involved in ergosterol uptake.

285 Ergosterol was found to bind many proteins and may funct

286 Ergosterol was identified by its unique spectrophotometr

287 Ergosterol was isolated from whole yeast cells by saponi

288 All aflatoxins, patulin and ergosterol were determined by high performance liquid ch

289 nd relative abundances of all isotopomers of ergosterol whose carbon atoms in the 5,7-diene moiety of

290 38F for ferric heme lowers the production of ergosterol with respect to wild-type Dap1p in S. pombe,