ライフサイエンスコーパス: error-prone

1 logeny, ancestral sequence reconstruction is error prone.

2 lty is that realistic quantum links are very error prone.

3 rally slow (taking days to weeks) and highly error prone.

4 ng for analysis, which is time consuming and error prone.

5 However, sequencing in bulk is error prone.

6 esion synthesis, yet they also can be highly error prone.

7 sequences can be costly, time consuming and error prone.

8 onal mechanisms underlying CNV formation are error prone.

9 multiple environments are time consuming and error prone.

10 containing A and U, is particularly slow and error-prone.

11 experience, despite the fact that gossip is error-prone.

12 anually, which is time-consuming and usually error-prone.

13 assembly of different genes is difficult and error-prone.

14 DNA polymerase iota (hpol iota) is the most error-prone.

15 g an explanation for why MI in mammals is so error-prone.

16 some segregation in female meiosis I (MI) is error-prone.

17 arative genomics, is a difficult problem and error-prone.

18 process is subjective, nonquantitative, and error-prone.

19 obtain inverse probability weights are often error-prone.

20 ing individual atoms remains challenging and error-prone.

21 Furthermore, end resection promotes error-prone A-EJ.

22 ts as a backup attempt to intercept the more error-prone alternative NHEJ repair pathway by recruitin

23 An error-prone, alternative form of end joining, operating

24 n 1 (XRCC1), all essential components of the error-prone, alternative nonhomologous end-joining (alt-

25 le preparation is still a time-consuming and error prone analytical step.

26 esion DNA polymerases that are intrinsically error prone and associated with mutagenesis, drug resist

27 ted control make the human oocyte inherently error prone and contribute to the age-related increase i

28 d for this correction are time consuming and error prone and existing programs are often platform spe

29 genomes were probably both small and highly error prone and hence RNA virus-like.

30 ng sample records and pedigrees can often be error prone and incomplete.

31 owever, manual assembly planning is complex, error prone and not scalable.

32 ocess of the ASFV virus genome; it is highly error prone and plays an important role during the strat

33 alian oocytes, meiosis I (MI) is notoriously error prone and polar-displaced chromosomes do not preve

34 ly constructing DC libraries is challenging, error prone and time consuming.

35 users, to make specification of models less error prone and to improve workflows.

36 ithout relying on generic assembly, which is error-prone and computationally expensive for complex da

37 cted via NGS, the reads generated by NGS are error-prone and even a single nucleotide error precludes

38 ts showed that UNG activity can promote both error-prone and high fidelity repair of U:G lesions.

39 e of the synthetic site, bringing about less error-prone and kinetically optimized isoleucyl-tRNA(Ile

40 decision-making requires balancing fast but error-prone and more accurate but slower decisions throu

41 plants and animals have polymerases that are error-prone and produce complex populations of related,

42 because cell division in polyploid cells is error-prone and produces aneuploid cells.

43 previously described plasmids using ad hoc, error-prone and time-consuming curation processes becaus

44 folding in the endoplasmic reticulum (ER) is error prone, and ER quality control (ERQC) processes ens

45 lts challenge the ideology that pol kappa is error prone, and suggest that DNA polymerases with compl

46 However, the techniques are error prone, and the methods commonly used to control fo

47 users, to make specification of models less error prone, and to improve workflows.

48 Meiosis in human oocytes is highly error-prone, and defective eggs are the leading cause of

49 The process is error-prone, and error-correction mechanisms exist to sw

50 I find that RNA polymerase is error-prone, and these errors can result in splicing def

51 Lig4(R278H) activity renders NHEJ to be more error-prone, and they predict increased error-prone NHEJ

52 f prototyping device designs can be tedious, error-prone, and time-consuming.

53 91A/M184V and Q91N/M184V, are found to be as error prone as the wild-type enzyme.

54 monstrate that bypass of LdG modification is error prone as well as slow compared to that across the

55 ly using a DNA sequence editor which becomes error-prone as scale and complexity of the construction

56 bly, even though Pols eta and iota are quite error-prone at inserting nucleotides opposite 1-MeA, TLS

57 Finally, HIV-1 RT becomes more error-prone at rNMP sites with an elevated mismatch exte

58 ) to low-fidelity translesion DNA synthesis (error-prone) at DNA damage sites.

59 Instead of such error-prone automatic annotations, functional interpreta

60 cient NHEJ, but also its contribution to the error-prone behavior of Polmu at 2-nt gaps.

61 in particular subjective assessments are an error-prone, biased, and expensive method by which to as

62 DNA synthesis by purified Poldelta-R696W was error-prone, but not to the extent that could account fo

63 polymerases and often requires the action of error prone bypass polymerases.

64 Thus, WRN limits the error-prone bypass of 8-oxo-dG by hpol kappa, which coul

65 By contrast, proteins involved in the error-prone bypass of DNA damage (Rev3, Rev1, PCNA, Rad1

66 A small portion of Pol II undergoes slow, error-prone bypass of the phenanthriplatin-dG lesion, wh

67 Here we describe a method by which even error-prone cells can perform purification: groups of ce

68 The basis for particularly error-prone chromosome segregation in human oocytes is n

69 ngency of checkpoint signaling, resulting in error-prone chromosome segregation.

70 ined uncoupled from APC activity, leading to error-prone chromosome segregation.

71 han 100 live human oocytes and identified an error-prone chromosome-mediated spindle assembly mechani

72 found that RNA replication was intrinsically error-prone compared to DNA, suggesting that total genom

73 We substantiated this by showing that under error-prone conditions S. griseus IleRS is able to rescu

74 However, Pol IV is error-prone, contributing to both DNA damage-induced and

75 However, because of the incomplete and error-prone datasets currently available, such methods h

76 consequence, haplotyping methods suffer from error-prone discrete SNP genotypes (AA, AB, BB) and DNA

77 Given the error-prone disposition of PrimPol, we propose a mechani

78 general stress-response-controlled switch to error-prone DNA break (double-strand break, DSB) repair-

79 ries in CML cells and stimulates activity of error-prone DNA damage repair, in association with acqui

80 Our findings implicate low-fidelity, error-prone DNA polymerase activity in synthesis associa

81 We link error-prone DNA polymerase activity to the generation of

82 -strand-break (DSB) repair and requires DinB error-prone DNA polymerase and the SOS DNA-damage- and R

83 in Ab genes, indicating that DNA repair and error-prone DNA polymerase eta usage were unaffected.

84 These data indicate that the error-prone DNA polymerase IV (Dpo4) inefficiently exten

85 carbon-starved Escherichia coli result from error-prone DNA polymerase IV (Pol IV) (DinB) and that t

86 We found that recA and all of the multiple error-prone DNA polymerase V (Pol V) genes, those organi

87 plisome defects promote the participation of error-prone DNA polymerase zeta (Polzeta) in replication

88 ation- and DNA-damage-stress responses, DinB error-prone DNA polymerase, and DSB-repair proteins.

89 f translesion DNA synthesis catalyzed by any error-prone DNA polymerase.

90 enes, especially those encoding the multiple error-prone DNA polymerases, can be implicated in induce

91 utic strategies and increases utilization of error-prone DNA repair mechanisms that could contribute

92 A genes impairs homologous recombination and error-prone DNA repair, rendering FA cells sensitive to

93 ved by a CAS9/sgRNA complex that, along with error-prone DNA repair, resulted in creation of function

94 solvent-exposed conformation, which enables error-prone DNA replication past the adduct.

95 into HIV-1 containing D67N/K70R reversed the error-prone DNA synthesis at codons 65-67 in RT and impr

96 NA strand to mutagens and primes unscheduled error-prone DNA synthesis.

97 , this work elucidates a strategy for using "error-prone" DNA-repair machinery to generate precise ed

98 h-fidelity replicative polymerase, while the error-prone DnaEBs extends RNA primers before hand-off t

99 on, potentially induced by a higher level of error-prone double-strand break repair in these regions,

100 that the spliceosome "toggles" between such error-prone/efficient and hyperaccurate/inefficient conf

101 Furthermore, we show that error-prone/efficient RH alleles suppress a prp2 mutant

102 with the two structures: those that promote error-prone/efficient splicing and those that promote hy

103 his signature is consistent with alternative error-prone end-joining processes.

104 Electron microscopy imaging shows that the error-prone Escherichia coli strain lacks mature flagell

105 re thus inherently approximate, ambiguous or error prone, especially, for genomes with complex struct

106 identifies specific homopolymer sequences in error-prone EST/cDNA data or RNA-Seq data at a speed app

107 es bypass 1,N(6)-gamma-HMHP-dA lesions in an error-prone fashion, potentially contributing to A-->T a

108 ove lesions or bypass them in a more or less error-prone fashion.

109 analysis and avoid the complexities of using error prone flat-files.

110 In addition to an error-prone genome replication mechanism, RVs can increa

111 Viruses rapidly evolve due to their error-prone genome replication, and identifying which mu

112 With error prone high throughput NGS reads and genomic repeat

113 is fueled, in part, by the presumably highly error-prone HIV polymerase reverse transcriptase (RT).

114 erent to UDS methodology or a consequence of error-prone HIV-1 replication.

115 TEAM generated point mutations occur through error-prone homologous recombination (HR) and depend on

116 ecombination (SCR), generating error-free or error-prone homologous recombination (HR) outcomes.

117 Transforming error-prone immunosequencing datasets into Ab repertoire

118 Mammalian oocytes are particularly error prone in segregating their chromosomes during thei

119 We show that HR is error-prone in this context because of DNA damage checkp

120 istractor images during more stable and less error prone "in the zone" epochs compared with suboptima

121 the SAC is weak, and chromosome segregation error-prone, in mammalian oocytes.

122 pol delta L606G is highly error prone, incorporating single noncomplementary nucle

123 d AP residue in HEK293T cells was moderately error-prone, inducing a total of approximately 26% singl

124 mologous DNA appears to divert cells towards error-prone instead of error-free repair pathways, drama

125 nclude only 15-40 pesticides, which leads to error-prone interpretations.

126 re not affected by the loss of error-free or error-prone lesion bypass pathways, they are completely

127 s (TLS), this comes at a cost of potentially error-prone lesion bypass.

128 by fluorescence-activated cell sorting of an error-prone library based on fine discrimination between

129 lly terminates SDSA, thereby suppressing the error-prone LTGC outcome.

130 TS is mainly error-free, TLS can work in an error-prone manner and, as such, the regulation of these

131 T4 DNA polymerase replicating 8-oxo-G in an error-prone manner, they display remarkably low efficien

132 ereas in the other, poltheta functions in an error-prone manner.

133 It can replace expensive and error-prone manual parsing and standardization of scient

134 of this cache of data for Galaxy has been an error-prone manual process lacking reproducibility and p

135 we emphasise that it is likely to be a very error-prone measure of merit that is qualitative, not qu

136 f citations a paper receives is an extremely error-prone measure of scientific merit.

137 Different error-prone mechanisms appear to operate in different re

138 nd shifting DNA repair from high fidelity to error-prone mechanisms.

139 th mutations to a protein called SPOP use an error-prone method to repair broken DNA strands.

140 10 genes) in Escherichia coli using a highly error-prone microchip-synthesized oligo pool (479 oligos

141 DNA double-strand breaks, referred to as the error-prone microhomology-mediated end-joining (MMEJ) pa

142 G-->T transversion, possibly associated with error-prone mismatch repair.

143 he deamination of deoxycytidine, followed by error-prone mismatch- or base-excision DNA repair.

144 fzr/Cdh1 overexpression also resulted in an error-prone mitosis with amplified centrosomes and high

145 th', with an annotation process that is less error-prone, more efficient, and more consistent with co

146 Certain PheRSs are naturally error prone, most notably a Mycoplasma example that disp

147 In contrast, error-prone mtPheRS, editing-deficient ctPheRS, and thei

148 city, chromosome structural aberrations, and error-prone mutagenic DNA repair following exposure to I

149 ivator RpoS, were upregulated by a ribosomal error-prone mutation.

150 cess DNA-based data storage system that uses error-prone nanopore sequencers, while still producing e

151 The error prone nature of HIV-1 replication has resulted in

152 We describe an approach that exploits the error-prone nature of genome editing-induced double-stra

153 Thus, N-MC-dATP corrects the error-prone nature of hpol iota by preventing the Hoogst

154 We propose that the error-prone nature of restarted forks contributes to the

155 The error-prone nature of TLS may provide mechanistic unders

156 However, high-throughput sequencing remains error-prone, necessitating variant confirmation in order

157 ng-strand genes, activating an Mfd-dependent error-prone NER mechanism.

158 more error-prone, and they predict increased error-prone NHEJ activity and A-EJ suppression as the ca

159 More recent experiments identified a highly error-prone NHEJ pathway, termed alternative NHEJ (aNHEJ

160 thway becomes repressed giving way to a more error-prone NHEJ pathway.

161 hile reducing unwanted mutagenesis caused by error-prone NHEJ.

162 reased levels of the alternative, and highly error-prone, NHEJ pathway protein PARP1, explaining the

163 d DDSB are preferentially repaired using the error-prone non-homologous end joining (NHEJ) pathway.

164 mbination (HR) while stymieing repair by the error-prone non-homologous end joining (NHEJ) pathway.

165 site which then can become the substrate for error-prone non-homologous end joining (NHEJ), generatin

166 ntroduce mutation (insertion or deletion) by error-prone non-homologous end joining DNA repairing.

167 combination repair (HR), while counteracting error-prone non-homologous end joining of DNA double-str

168 However, mutagenic events caused by error-prone non-homologous end-joining (NHEJ)-mediated r

169 ge repair (DDR) mechanisms: the dominant but error-prone nonhomologous end joining (NHEJ) pathway, an

170 ent protein kinase substrates and stimulates error-prone nonhomologous end joining (NHEJ) selectively

171 ly generate knockout cells and organisms via error-prone nonhomologous end joining (NHEJ), but the ef

172 nation repair, increasing the involvement of error-prone nonhomologous end joining (NHEJ).

173 cing DNA double-strand breaks that stimulate error-prone nonhomologous end joining or homology-direct

174 d consequently triggers an activation of the error-prone nonhomologous end joining response.

175 been recently demonstrated that HSCs use the error-prone nonhomologous end-joining (NHEJ) pathway of

176 A damage likely because they mainly used the error-prone nonhomologous end-joining pathway to repair

177 ERG gene breakpoint of proteins that promote error-prone nonhomologous end-joining.

178 the MRE11/RAD50/NBS1 complex and favors the error-prone nonhomologous-end-joining (NHEJ) DNA-repair

179 a perversion of faithful DNA repair towards error-prone outcomes.

180 These polymerases are inherently error prone, owing to their lack of a proofreading (3'-

181 rprinting is one of the most challenging and error-prone parts of the analytical procedure.

182 icrohomology-mediated end joining (MMEJ), an error-prone pathway for DNA double-strand break (DSB) re

183 -homologous end-joining (NHEJ) is a critical error-prone pathway of double strand break repair.

184 gen M. tuberculosis, elaborate an additional error-prone pathway of DSB repair via non-homologous end

185 y the replisome without the need to activate error-prone pathways.

186 Escherichia coli lsr operon promoters using error-prone PCR (ePCR) and selected for promoters that p

187 Furthermore, the error-prone PCR alone introduced the mutation with high

188 a high-throughput screening method utilizing error-prone PCR and next-generation sequencing to compre

189 of a novel technique that incorporates both error-prone PCR and recombineering.

190 A single round of error-prone PCR and selection yielded variant ALR(Y274F)

191 so identified after mutagenesis of FXYD2b by error-prone PCR coupled with a selection for cell prolif

192 er improvements were facilitated by targeted error-prone PCR mutagenesis of loop-7, and additional PT

193 h this inhibitor, we randomly mutagenized by error-prone PCR the E. coli dsbB gene and selected dsbB

194 When mutations are enhanced through error-prone PCR, in vitro M2-seq experimentally resolves

195 olution, using active-site randomization and error-prone PCR, yielded a MetRS variant (designated Pra

196 yield higher-performing variants faster than error-prone PCR-derived libraries.

197 brary of amide synthetase mutants created by error-prone PCR.

198 te familiar face recognition but also to our error-prone performance with unfamiliar faces.

199 The error-prone Pol zeta can also participate in replication

200 show that broken fork repair initially uses error-prone Pol32-dependent synthesis, but that mutageni

201 t DNA is first exponentially amplified using error-prone polymerase chain reaction (PCR) and then lin

202 this study, a combination of both whole-gene error-prone polymerase chain reaction and site-saturatio

203 deleterious and, fueled by the drug-induced error-prone polymerase Pol IV, overwhelms cells with tox

204 iously shown to dominate the spectrum of the error-prone polymerase Pol zeta, suggesting that low-fid

205 tion (HR) and depend on resectioning and the error-prone polymerase Pol zeta.

206 fected tandem mutations generated by another error-prone polymerase, Pol zeta.

207 zaki fragment processing, DNA synthesized by error-prone polymerase-alpha (Pol-alpha) is retained in

208 es a simple explanation for the existence of error-prone polymerases and yields a formal counter-argu

209 hance access to AID, DNA repair factors, and error-prone polymerases and, hence, to maximize variabil

210 disturbances that trigger the recruitment of error-prone polymerases in the absence of DNA damage and

211 Error-prone polymerases overcome this blockade by synthe

212 spiral is fueled by specialized proteins and error-prone polymerases that change DNA sequences.

213 d by exogenous agents, and the activities of error-prone polymerases.

214 Cells employ error-free or error-prone postreplication repair (PRR) processes to to

215 l assumptions is not straight-forward and is error-prone, potentially causing misleading results.

216 lassical NHEJ (c-NHEJ) and a poorly defined, error-prone process termed alternative NHEJ (a-NHEJ).

217 ce in the absence of centrosomes, this is an error-prone process that opens up the fly to development

218 replicate past damaged DNA in a potentially error-prone process.

219 ny dataset manipulation a time-consuming and error-prone process.

220 erated through a novel mechanism mediated by error-prone processing of AP sites accumulated in the st

221 gamma-HOPdG was accomplished only following error-prone purine nucleotide incorporation.

222 s and to behavior that is stimulus bound and error prone rather than flexibly guided by context.

223 eralize de Bruijn graphs for assembling long error-prone reads and describe the ABruijn assembler, wh

224 paired-end, short sequence reads to identify error-prone reads in marker gene analyses and their cont

225 novo genome assemblies, but fully exploiting error-prone reads to resolve repeats remains a challenge

226 The recent breakthroughs in assembling long error-prone reads were based on the overlap-layout-conse

227 only practical paradigm for assembling long error-prone reads.

228 sed proliferation, premature senescence, and error-prone recovery from serum deprivation after immort

229 eavage enzymes may occur if DNA cleavage and error prone repair does not render the viral episome rep

230 ubiquitylate an unknown protein(s) to limit error-prone repair during V(D)J recombination.

231 either endonuclease activity and subsequent error-prone repair have left a mutational footprint on t

232 This error-prone repair pathway is triggered upon telomere de

233 Whereas SHM involves an error-prone repair process that introduces novel point m

234 owever, nonhomologous end-joining (NHEJ), an error-prone repair, acts concurrently, reducing the rate

235 The resultant apurinic lesion is subject to error-prone repair, consistent with the occurrence about

236 Because apurinic sites are subject to error-prone repair, leading to substitution and short fr

237 ecision between homologous recombination and error-prone repair.

238 ated lesions are processed by error-free and error-prone repair.

239 uits low fidelity DNA polymerases to promote error-prone replication across DNA lesions.

240 ence variability of the virus resulting from error-prone replication has thwarted the discovery of a

241 analyzing pol I mutations generated through error-prone replication of ColE1 plasmids.

242 that carries out translesion synthesis, the error-prone replication of damaged DNA.

243 ive RNA replicons: (a) small size imposed by error-prone replication, (b) high G + C content to incre

244 icient than that in smaller RNA viruses with error-prone replication, as seen via signatures of selec

245 ation may reflect that patients who are more error prone require stronger activation in these regions

246 the level of nucleotides becomes tedious and error prone, requiring a new generation of computer-aide

247 usceptibility to UNG-triggered error-free or error-prone resolution.

248 ically uridylylated and that this priming is error prone, resulting in the loss of sequence informati

249 vealed that post-lesion synthesis was highly error-prone, resulting in mutations opposite the adducte

250 bonucleotides are removed by NER followed by error-prone resynthesis with DnaE.

251 DNA sequence evolution through a specialized error-prone reverse transcription process.

252 fluenza A viruses (IAV) acquired through the error-prone RNA-dependent RNA polymerase (RdRP) or throu

253 hniques, they often can produce only partial error-prone scaffold assemblies.

254 ve features without relying on a potentially error-prone segmentation module.

255 tion and remains the most time-consuming and error-prone step.

256 ts transcription, and deleting DsrA from the error-prone strain restores motility.

257 trate that an increased level of DsrA in the error-prone strain suppresses motility through the H-NS

258 RpoS contribute to peroxide tolerance in the error-prone strain, and a small RNA DsrA, which controls

259 polyploid papillar divisions are frequently error prone, suggesting papillar structures may accumula

260 However, copying DNA into RNA was very error-prone, suggesting that attempts to return to the R

261 2 position of guanine significantly increase error-prone synthesis catalyzed by pol eta when replicat

262 ted into the single-strand nick required for error-prone synthesis is an open question.

263 approximately 4, helps rationalize the more error-prone synthesis opposite the lesion by hpol eta.

264 odel specification, avoiding the tedious and error prone task of manually enumerating all species and

265 This strategy should reduce the number of error-prone, tedious and time-consuming weighing procedu

266 agreement by showing that HIV RT is not more error prone than other RTs and, when assayed under physi

267 suggest that, although object naming is more error prone than reading, subjects can afford to rely mo

268 Pol IV transcription is considerably more error-prone than Pols II or V, which may be tolerable in

269 larativity, making it more flexible and less error-prone than traditional approaches.

270 cription of the mitochondrial genome is more error-prone than transcription in the nucleus.

271 Because DNA repair is error prone, the virus can be neutralized after repeated

272 But since qubits are noisy and error-prone, they will depend on fault-tolerant quantum

273 erases stalled by DNA damage are replaced by error-prone TLS enzymes responsible for the majority of

274 cooperatively carry out the majority of the error-prone TLS of dG-C8-IQ, whereas pol eta is involved

275 derma pigmentosum variant (XPV) results from error-prone TLS of UV-damaged DNA.

276 complex formation of POLD3 with Rev1 and the error-prone TLS polymerase Pol zeta, and elevates mutage

277 oleta exhibit increased recruitment of other error-prone TLS polymerases (Polkappa and Poliota) after

278 sis (TLS) allows bypass of DNA lesions using error-prone TLS polymerases.

279 e, we show that Spartan negatively regulates error-prone TLS that is dependent on POLD3, the accessor

280 a previously unrecognized regulatory step in error-prone TLS.

281 ching in the lac operon (with and without an error-prone transcription slippage sequence), partial ph

282 s that are genetically engineered to display error-prone transcription.

283 reventing untimely tRNA and mRNA binding and error prone translation.

284 e filling in of single-stranded DNA regions, error-prone translesion DNA polymerases appear to produc

285 the primary repair/tolerance mechanism over error-prone translesion DNA polymerases.

286 products (e.g., REV1, REV3L) involved in the error-prone translesion DNA synthesis pathway can sensit

287 esult from DNA damage are the consequence of error-prone translesion DNA synthesis, which could be re

288 by downstream DNA "repair" enzymes including error-prone translesion polymerases.

289 udied the cell's reliance on the potentially error-prone translesion synthesis (TLS), and an error-fr

290 Unexpectedly, replicative pol delta and the error-prone translesion synthesis pol zeta were able to

291 ccurate genome-replicating category or is an error-prone translesion synthesis polymerase.

292 f B-cell lymphoma to interrogate the role of error-prone translesional DNA synthesis in chemotherapy-

293 equence contexts that may have arisen due to error-prone translesional synthesis.

294 of waking life and is often associated with error-prone, variable behavior.

295 HIV infection is characterized by rapid and error-prone viral replication resulting in genetically d

296 labeling variants as causal or benign can be error prone, which is problematic for training supervise

297 owever, both NGS data and their analysis are error-prone, which can lead to the generation of false p

298 Current sequencing methods are error-prone, which precludes the identification of low f

299 ll studied archaeal homologues of pol IV, an error prone Y-family polymerase from Escherichia coli.

300 A polymerases but are presumably bypassed by error-prone Y-family DNA polymerases at the expense of r