ライフサイエンスコーパス: erythraea

1 1, Nocardia farcinica, and Saccharopolyspora erythraea.

2 in (Er)-producing organism Saccharopolyspora erythraea.

3 r macrolides when compared with wild-type S. erythraea.

4 oter/activator functions appropriately in S. erythraea.

5 ere cloned in pCJR24 and overexpressed in S. erythraea after integration of the vector into the chrom

6 ulator of the ery biosynthetic genes from S. erythraea and found that this protein appears to directl

7 the erythromycin producer Saccharopolyspora erythraea and in other actinomycetes.

8 the erythromycin producer Saccharopolyspora erythraea and the nucleotide sequences of a c.

9 Recombinant S. erythraea BldD bound to all five regions containing prom

10 e cassettes, in strains of Saccharopolyspora erythraea blocked in erythromycin biosynthesis, to inves

11 d roots of five centaury species (Centaurium erythraea, C. tenuiflorum, C. littorale ssp. uliginosum,

12 mplete 6-deoxyerythronolide B synthase of S. erythraea can be replaced by functionally related domain

13 Deletion of bldD in S. erythraea decreased the erythromycin titer in a liquid c

14 this finding, when oleG2 was expressed in S. erythraea DM, 3-O-rhamnosyl-erythronolide B and 3-O-rham

15 the polyketide synthase (eryA) genes from S. erythraea DM, creating the triple mutant SGT2.

16 gene responsible for THN biosynthesis in S. erythraea E_8-7 was amplified by polymerase chain reacti

17 lide B synthase (DEBS1) of Saccharopolyspora erythraea ER720 were replaced with three heterologous AT

18 derivatives by the engineered strains of S. erythraea ER720.

19 omycin-producing strain of Saccharopolyspora erythraea, for detection of hybrid glycoside formation,

20 ed-brown pigment-producing (rpp) locus in S. erythraea, generating a mutant that displayed an albino

21 The S. erythraea genome contains at least 25 gene clusters for

22 etic gene (ery) cluster of Saccharopolyspora erythraea has been examined by a variety of methods, inc

23 de B (6-DEB) synthase from Saccharopolyspora erythraea, in which the methylmalonate-specifying AT6 do

24 Saccharopolyspora erythraea is used for the industrial-scale production of

25 purified from recombinant Saccharopolyspora erythraea JCB101 by a new, high-yielding procedure consi

26 Saccharopolyspora erythraea makes erythromycin, an antibiotic commonly use

27 genes were expressed individually in the S. erythraea mutant SGT2, which is blocked both in endogeno

28 First, the S. erythraea mutant strain DM was created by deletion of bo

29 omycin-producing strain of Saccharopolyspora erythraea, O-methyltransferases from the spinosyn biosyn

30 ified this protein (M(r) = 18 kDa) as the S. erythraea ortholog of BldD, a key regulator of developme

31 the erythromycin producer Saccharopolyspora erythraea produced several novel antibiotic erythromycin

32 rown pigment produced by a Saccharopolyspora erythraea "red variant" has been shown to contain glycos

33 e pathway was expressed in Saccharopolyspora erythraea, resulting in the conversion of erythromycin t

34 acetyltransferase AcuA of Saccharopolyspora erythraea (SacAcuA, SACE_5148) as the enzyme responsible

35 ified in the culture supernatant, whereas S. erythraea SGT2 (spnH) was without effect.

36 O-methylrhamnosyl)-erythronolide B by the S. erythraea SGT2 (spnI) strain only.

37 olide B was, in turn, fed to a culture of S. erythraea SGT2 (spnK), 3-O-(2',3'-bis-O-methylrhamnosyl)

38 nt amino sugar, tylM2 was integrated into S. erythraea SGT2, and the resulting strain was fed with th

39 mnosyl-erythronolide precursors using the S. erythraea strain SGT2 housing EryCIII, the desosaminyltr

40 ares well with a high-producing mutant of S. erythraea that has been incrementally enhanced over deca

41 oduced by the actinomycete Saccharopolyspora erythraea that synthesizes the macrocyclic core of the a

42 genetic manipulation and fermentation of S. erythraea, the ability to produce megalomicin in this st

43 ized by the soil bacterium Saccharopolyspora erythraea through the action of a multifunctional polyke

44 onstruction of novel mutants containing a S. erythraea transcriptional terminator within the eryAI, e

45 ycin A titre, which has been observed for S. erythraea variants.

46 r) biosynthesis cluster in Saccharopolyspora erythraea was sequenced.

47 he availability of the genome sequence of S. erythraea will improve insight into its biology and faci

48 Moreover, an industrial strain of S. erythraea with a higher titer of erythromycin expressed

49 hydroxylase P450eryF from Saccharopolyspora erythraea with androstenedione and 9-aminophenanthrene.