ライフサイエンスコーパス: erythro-sphingosine

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1 o-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-D-erythro-sphingosine).

2 ion in the cellular levels of sphingosine (D-erythro-sphingosine).

3 sistance to the antimicrobial sphingolipid D-erythro-sphingosine.

4 C18-ceramine, IC50 0.62 mol %), 1-O-methyl-D-erythro-sphingosine (1-O-Me-Sph), cis-D-erythro-sphingos

5 zido-beta-hydroxyester 10a is converted to D-erythro-sphingosine 2a via simultaneous reduction of the

6 ceramide (cis-D-e-C16-Cer) and 3-O-methyl-D-erythro-sphingosine (3-O-Me-Sph).

7 and indolactam-V) and two PKC antagonists (D-erythro-sphingosine and chelerythrine) on input-output (

8 The enzyme specifically phosphorylated D-erythro-sphingosine and did not catalyze the phosphoryla

9 ine kinase shows substrate specificity for D-erythro-sphingosine and does not catalyze the phosphoryl

10 Using D-erythro-sphingosine and lauric acid as substrates, the r

11 ors of the two substrates were identified, l-erythro-sphingosine and myristaldehyde, and inhibition s

12 deletion produced sensitivity to exogenous D-erythro-sphingosine and phytosphingosine and intracellul

13 tions antipodal to that found in mammalian D-erythro-sphingosine but prevalent among invertebrate-der

14 4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-d-erythro -sphingosine (C(5)-DMB-ceramide) relocation to t

15 have previously demonstrated that hexanoyl-D-erythro-sphingosine (C(6)-ceramide), an anti-mitogenic c

16 yl-D-erythro-sphingosine (1-O-Me-Sph), cis-D-erythro-sphingosine (cis-D-e-Sph), (2S)-3-ketosphingosin

17 robenz-2-oxa-1,3-diazol-4-yl-aminocaproyl)-D-erythro-sphingosine confirmed that gL was found primaril

18 r), and a new ceramide derivative, N-octyl-D-erythro-sphingosine (D-e-C8-Ceramine), to induce apoptos

19 -bora-3a,4a-diaza-s-indacene-3-pentanoyl)-d- erythro-sphingosine (DMB-Cer).

20 -erythro-sphingosine (Sph) or N,N-dimethyl-d-erythro-sphingosine (DMS), but not by ceramide, Sph-1-P,

21 drosphingosine was a better substrate than d-erythro-sphingosine for SPHK2.

22 he enzyme showed the highest activity with d-erythro-sphingosine (Km of 0.16 mol %, and Vmax of 0.3 m

23 ranging from 0.04 to 0.14 mol %, N-methyl-D-erythro-sphingosine (N-Me-Sph, IC50 0.13 mol %); and (3)

24 otein kinases are known to be activated by d-erythro-sphingosine (Sph) or N,N-dimethyl-d-erythro-sphi

25 hereas the LacCer analog with the natural (D-erythro) sphingosine stereochemistry is internalized mai

26 zyme that catalyzes the phosphorylation of d-erythro-sphingosine to produce the key signaling lipid,

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